Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of aloe components

Journal of Ethnopharmacology

Volumn 103, Issue 3, 2006, Pages 468-477

  Beppu, Hidehiko ^a   Shimpo, Kan ^a   Chihara, Takeshi ^a   Kaneko, Takaaki ^a   Tamai, Ikuko ^a   Yamaji, Sachiyo ^a   Ozaki, Sayaka ^a   Kuzuya, Hiroshi ^a   Sonoda, Shigeru ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

Aloe arborescens; Aloe vera; Anti diabetes; Insulitis; Langerhans islets; Low dose streptozotocin induced diabetes

Indexed keywords

ALOE ARBORESCENS EXTRACT; GLUCOSE; INSULIN; PHENOL DERIVATIVE; PLANT EXTRACT; STREPTOZOCIN; UNCLASSIFIED DRUG;

ABSORPTION; ALOE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG INHIBITION; FEMALE; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULITIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PANCREAS ISLET; RAT; STREPTOZOCIN DIABETES; ULTRAFILTRATION;

ALOE; ANIMALS; ANTHRACENES; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIET; EMODIN; FEMALE; GLUCOSIDES; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; ISLETS OF LANGERHANS; MICE; MICE, INBRED ICR; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TISSUE DISTRIBUTION;

ALOE; ALOE ARBORESCENS; ALOE VERA; ANIMALIA;

EID: 31344476763     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.10.034     Document Type: Article

References (33)

1. M.K. Agarwal Streptozotocin: mechanisms of action FEBS Letters 120 1980 1 3
2. M.A. Ajabnoor Effect of aloes on blood glucose levels in normal and alloxan diabetic mice Journal of Ethnopharmacology 28 1990 215 220
3. F.J. Alarcon-Aguilara, R. Roman-Ramos, S. Perez-Gutierrez, A. Aguilar-Contreras, C.C. Contreras-Weber, and J.L. Flores-Saenz Study of the anti-hyperglycemic effect of plants used as antidiabetics Journal of Ethnopharmacology 61 1998 101 110
4. B. Appels, V. Burkart, G. Kantwerkfunke, J. Funda, V. Kolb-bachofen, and H. Kolb Spontaneous cytotoxicity of macrophages against pancreatic islet cells Journal of Immunology 142 1989 3803 3808
5. H. Beppu, K. Maruta, T. Kurner, and H. Kolb Diabetogenic action of streptozotoc: essential role of membrane permeability Acta Endocrinologica (Copenh) 114 1987 90 95
6. H. Beppu, K. Kawai, and K. Fujita Anti-diabetic effect of Kidachi aloe (3rd report): isolation and chemical characteristics of hypoglycemic action substance from Kidachi aloe Fujita-Gakuen Igakaishi (Bulletin of the Fujita Medical Society) 14 1990 168 (in Japanese)
7. H. Beppu, K. Kawai, T. Chihara, K. Shimpo, and K. Fujita Hypoglycemic effects of Aloe arborescens var., natalensis on spontaneously diabetic mouse Medicine and Biology 120 1990 151 156 (in Japanese)
8. H. Beppu, Y. Nagamura, and K. Fujita Hypoglycaemic and antidiabetic effects in mice of Aloe arborescens Miller var. natalensis berger Phytotherapy Research 7 1993 37 42
9. H. Beppu, T. Koike, K. Shimpo, T. Chihara, M. Hoshino, C. Ida, and H. Kuzuya Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats Journal of Ethnopharmacology 89 2003 37 45
10. H. Beppu, K. Shimpo, T. Chihara, I. Tamai, Nomoto-Yamaji, S. Ozaki, S. Ito, and H. Kuzuya Inhibitory effects of Aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets Phytomedicine 13 2006 49 60
11. S.J. Cooperstein, and D. Watkins Action of toxic drugs islet cells in the islets of langerhans S.J. Cooperstein D. Watkins Biochemistry Physiology and Pathology 1981 Academic Press New York 387 425
12. M. Eddouks, H. Jouad, M. Maghrani, A. Lemhadri, and R. Burcelin Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice Phytomedicine 10 2003 594 599
13. N. Ghannam, M. Kingston, I.A. Al-Meshaal, M. Tariq, N.S. Parman, and N. Woodhouse The anti-diabetic activity of aloes: preliminary clinical and experimental observations Hormone Research 24 1986 288 294
14. H. Hikino, M. Takahashi, M. Murakami, C. Konno, Y. Mirin, M. Karikura, and T. Hayashi Isolation and hypoglycemic activity of arborans A and B, glycans of Aloe arborescens var. natalensis leaves International Journal of Crude Drug Research 24 1986 183 186
15. H. Hikino, M. Ishiyama, Y. Suzuki, and C. Konno Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies Planta Medica 55 1989 423 428
16. K. Kawai, H. Beppu, H. Shimpo, T. Chihara, N. Yamamoto, T. Nagatsu, H. Ueda, and Y. Yamada In vivo effects of Aloe arborescens Miller var. natalensis Berger (kidachi aloe) on experimental tinea pedis in guinea-pig feet Phytotherapy Research 12 1998 178 182
17. C. Konno, M. Murayama, K. Sugiyama, M. Arai, M. Murakami, M. Takahashi, and H. Hikino Isolation and hypoglycemic activity of aconitans A, B, C and D, glycans of Aconitum Carmichaeli roots Planta Medica 51 1985 160 161
18. M.W.L. Koo Aloe vera antiulcer and antidiabetic effects Phytotherpy Research 8 1994 461 464
19. A.A. Like, M.C. Appel, R.M. Williams, and A.A. Rossini Streptozotocin-induced pancreatic insulitis in mice. Morphologic and physiologic studies Laboratory Investigation 38 1978 470 486
20. A. Okyar, A. Can, N. Akev, G. Baktir, and N. Sutltipinar Effect of Aloe vera leaves on blood glucose level in type and type diabetic rat models Phytotherapy Research 15 2001 157 161
21. R. Roman-Ramos, J.L. Flores-Saenz, and F.J. Alarcon-Aguilar Anti-hyperglycemic effect of some edible plants Journal of Ethnopharmacology 48 1995 25 32
22. T. Reynolds, and A.C. Dweck Aloe vera leaf gel: a review update Journal of Ethnopharmacology 68 1999 3 37
23. S. Sandier, and L. Jansson Vascular permeability of pancreatic islets after administration of streptozotocin Virchows Archiv A, Pathological Anatomy Histopathology 407 1985 359 367
24. K. Shimpo, M. Obata, K. Yamada, H. Beppu, R. Luchetta, and W.E. Winter Relationship of insulitis and A β and T-cell receptor β [(NOD × NZW)F1 × NOD] first backross mice Medicine and Biology 120 1990 185 190 (in Japanese)
25. K. Shimpo, T. Chihara, H. Beppu, C. Ida, T. Kaneko, M. Hoshino, and H. Kuzuya Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens Miller var. natalensis Asian Pacific Journal of Cancer Prevention 4 2003 247 251
26. K. Shimpo, H. Beppu, T. Chihara, M. Hoshino, C. Ida, and H. Kuzuya DPPH radical scavenging activity of Kidachi aloe and its phenolic compound Fujita-Gakuen Igakaishi (Bulletin of the Fujita Medical Society) 27 2003 105 111 (in Japanese)
27. M. Takahashi, C. Konno, and H. Hikino Isolation and hypoglycemic activity of anemarans A, B, C and D, glycans of Anemarrhena asphodeloides rhizomes Planta Medica 51 1985 100 102
28. M. Tomoda, K. Shimada, C. Konno, M. Murakami, and H. Hikino Structure of aconitan A, a hypoglycemic glycan of Aconitum Carmichaeli roots Carbohydrate Research 147 1986 160 164
29. M. Tomoda, R. Gonda, R. Kasahara, and H. Hikino Glycan structures of ganoderans B and C, hypoglycemic glycans of Ganoderma lucidum fruit bodies Phytochemistry 25 1986 2817 2820
30. M. Tomoda, N. Shimizu, R. Gonda, M. Kanari, H. Yamada, and H. Hikino Anti-complementary and hypoglycemic activities of the glycans from the seeds of Malva verticillata Planta Medica 56 2 1990 168 170
31. A. Yagi, A. Kabash, N. Okamura, H. Haraguchi, S.M. Moustafa, and T.I. Khalifa Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera Planta Medica 68 2002 957 960
32. M. Yamamoto, T. Masui, K. Sugiyama, M. Yokota, K. Nakagomi, and H. Nakazawa Anti-inflammatory active constituents of Aloe arborescens Miller Agricultural and Biological Chemistry 55 1991 1627 1629
33. G.Y. Yeh, D.M. Eisenberg, T.J. Kaptchuk, and R.S. Phillips Systematic review of herbs and dietary supplements for glycemic control in diabetes Diabetes Care 26 2003 1277 1294