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Volumn 17, Issue 6, 2012, Pages 7083-7092

Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-κB in C2C12 myotubes

Author keywords

Astragalus polysaccharide; Insulin resistance; NF B; PTP1B

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PALMITIC ACID DERIVATIVE; POLYSACCHARIDE; PROTEIN TYROSINE PHOSPHATASE 1B;

EID: 84862989884     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17067083     Document Type: Article
Times cited : (52)

References (28)
  • 1
    • 0032772463 scopus 로고    scopus 로고
    • Vascular effects of non-esterified fatty acids: Implications for the cardiovascular risk factor cluster
    • DOI 10.1016/S0952-3278(99)80022-2
    • Egan, B. M.; Lu, G.; Greene, E. L. Vascular effects of non-esterified fatty acids: Implications for the cardiovascular risk factor cluster. Prostaglandins Leukot Essent Fatty Acids 1999, 60, 411-420. (Pubitemid 29401802)
    • (1999) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.60 , Issue.5-6 , pp. 411-420
    • Egan, B.M.1    Lu, G.2    Greene, E.L.3
  • 2
    • 0037077371 scopus 로고    scopus 로고
    • Chemical analysis of Radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations
    • DOI 10.1021/jf0202279
    • Ma, X. Q.; Shi, Q.; Duan, J. A.; Dong, T. T.; Tsim, K. W. Chemical analysis of Radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations. J. Agric. Food Chem. 2002, 50, 4861-4866. (Pubitemid 34856156)
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , Issue.17 , pp. 4861-4866
    • Ma, X.Q.1    Shi, Q.2    Duan, J.A.3    Dong, T.T.X.4    Tsim, K.W.K.5
  • 3
    • 0036000246 scopus 로고    scopus 로고
    • Medicinal plants of India with anti-diabetic potential
    • DOI 10.1016/S0378-8741(02)00059-4, PII S0378874102000594
    • Grover, J. K.; Yadav, S.; Vats, V. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol. 2002, 81, 81-100. (Pubitemid 34518472)
    • (2002) Journal of Ethnopharmacology , vol.81 , Issue.1 , pp. 81-100
    • Grover, J.K.1    Yadav, S.2    Vats, V.3
  • 4
    • 4644266305 scopus 로고    scopus 로고
    • A review of pharmacological study on Astragalus membranaceus (Fisch) Bge
    • Wu, F.; Chen, X. A review of pharmacological study on Astragalus membranaceus (Fisch) Bge. Zhong Yao Cai 2004, 27, 232-234.
    • (2004) Zhong Yao Cai , vol.27 , pp. 232-234
    • Wu, F.1    Chen, X.2
  • 5
    • 15244348325 scopus 로고    scopus 로고
    • Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B
    • DOI 10.1111/j.1745-7254.2005.00062.x
    • Wu, Y.; Ou-Yang, J. P.; Wu, K.; Wang, Y.; Zhou, Y. F.; Wen, C. Y. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol. Sin. 2005, 26, 345-352. (Pubitemid 40388072)
    • (2005) Acta Pharmacologica Sinica , vol.26 , Issue.3 , pp. 345-352
    • Wu, Y.1    Ou-Yang, J.-P.2    Wu, K.3    Wang, Y.4    Zhou, Y.-F.5    Wen, C.-Y.6
  • 6
    • 64449084587 scopus 로고    scopus 로고
    • Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism
    • Mao, X. Q.; Yu, F.; Wang, N.; Wu, Y.; Zou, F.; Wu, K.; Liu, M.; Ouyang, J. P. Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism. Phytomedicine 2009, 16, 416-425.
    • (2009) Phytomedicine , vol.16 , pp. 416-425
    • Mao, X.Q.1    Yu, F.2    Wang, N.3    Wu, Y.4    Zou, F.5    Wu, K.6    Liu, M.7    Ouyang, J.P.8
  • 7
    • 33748153705 scopus 로고    scopus 로고
    • Metabolic syndrome: Adenosine monophosphate-activated protein kinase and malonyl coenzyme A
    • Ruderman, N. B.; Saha, A. K. Metabolic syndrome: Adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity 2006, 14, 25S-33S.
    • (2006) Obesity , vol.14
    • Ruderman, N.B.1    Saha, A.K.2
  • 9
    • 74949118250 scopus 로고    scopus 로고
    • Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK
    • Zou, F.; Mao, X. Q.; Wang, N.; Liu, J.; Ou-Yang, J. P. Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK. Acta Pharmacol. Sin. 2009, 30, 1607-1615.
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 1607-1615
    • Zou, F.1    Mao, X.Q.2    Wang, N.3    Liu, J.4    Ou-Yang, J.P.5
  • 10
    • 2642541849 scopus 로고    scopus 로고
    • Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action
    • DOI 10.1074/jbc.M310688200
    • Zabolotny, J. M.; Haj, F. G.; Kim, Y. B.; Kim, H. J.; Shulman, G. I.; Kim, J. K.; Neel, B. G.; Kahn, B. B. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigenrelated phosphatase does not additively impair insulin action. J. Biol. Chem. 2004, 279, 24844-24851. (Pubitemid 38725352)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 24844-24851
    • Zabolotny, J.M.1    Haj, F.G.2    Kim, Y.-B.3    Kim, H.-J.4    Shulman, G.I.5    Kim, J.K.6    Neel, B.G.7    Kahn, B.B.8
  • 13
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
    • DOI 10.1126/science.1061620
    • Yuan, M.; Konstantopoulos, N.; Lee, J.; Hansen, L.; Li, Z. W.; Karin, M.; Shoelson, S. Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ. Science 2001, 293, 1673-1677. (Pubitemid 32807849)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.-W.5    Karin, M.6    Shoelson, S.E.7
  • 14
    • 0035411587 scopus 로고    scopus 로고
    • Role of the NF-κB pathway in the pathogenesis of human disease states
    • Yamamoto, Y.; Gaynor, R. B. Role of the NF-κB pathway in the pathogenesis of human disease states. Curr. Mol. Med. 2001, 1, 287-296. (Pubitemid 33773312)
    • (2001) Current Molecular Medicine , vol.1 , Issue.3 , pp. 287-296
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 17
    • 0035857020 scopus 로고    scopus 로고
    • New drug targets for type 2 diabetes and the metabolic syndrome
    • Moller, D. E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 2002, 414, 821-827.
    • (2002) Nature , vol.414 , pp. 821-827
    • Moller, D.E.1
  • 18
    • 72149094306 scopus 로고    scopus 로고
    • Astragalus polysaccharide improves insulin sensitivity in KKAy mice: Regulation of PKB/GLUT4 signaling in skeletal muscle
    • Liu, M.; Wu, K.; Mao, X.; Ouyang, J. Astragalus polysaccharide improves insulin sensitivity in KKAy mice: Regulation of PKB/GLUT4 signaling in skeletal muscle. J. Ethnopharmacol. 2010, 127, 32-37.
    • (2010) J. Ethnopharmacol. , vol.127 , pp. 32-37
    • Liu, M.1    Wu, K.2    Mao, X.3    Ouyang, J.4
  • 19
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • Listenberger, L. L.; Ory, D. S.; Schaffer, J. E. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J. Biol. Chem. 2001, 276, 14890-14895.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 20
    • 58149499155 scopus 로고    scopus 로고
    • Acetyl-L-carnitine inhibits TNF-á-induced insulin resistance via AMPK pathway in rat skeletal muscle cells
    • Zhang, Z.; Zhao, M.; Li, Q.; Zhao, H.; Wang, J.; Li, Y. Acetyl-L-carnitine inhibits TNF-á-induced insulin resistance via AMPK pathway in rat skeletal muscle cells. FEBS Lett. 2009, 583, 470-474.
    • (2009) FEBS Lett. , vol.583 , pp. 470-474
    • Zhang, Z.1    Zhao, M.2    Li, Q.3    Zhao, H.4    Wang, J.5    Li, Y.6
  • 21
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • Schenk, S.; Saberi, M.; Olefsky, J. M. Insulin sensitivity: Modulation by nutrients and inflammation. J. Clin. Invest. 2008, 118, 2992-3002.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 22
    • 33947596679 scopus 로고    scopus 로고
    • The GLUT4 glucose transporter
    • Huang, S.; Czech, M. P. The GLUT4 glucose transporter. Cell Metab. 2007, 5, 237-352.
    • (2007) Cell Metab. , vol.5 , pp. 237-352
    • Huang, S.1    Czech, M.P.2
  • 23
    • 77949874508 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase-1B (PTP-1B) knockdown improves palmitate-induced insulin resistance in C2C12 skeletal muscle cells
    • Bakhtiyari, S.; Meshkani, R.; Taghikhani, M.; Larijani, B.; Adeli, K. Protein tyrosine phosphatase-1B (PTP-1B) knockdown improves palmitate-induced insulin resistance in C2C12 skeletal muscle cells. Lipids 2010, 45, 237-244.
    • (2010) Lipids , vol.45 , pp. 237-244
    • Bakhtiyari, S.1    Meshkani, R.2    Taghikhani, M.3    Larijani, B.4    Adeli, K.5
  • 24
    • 24944473034 scopus 로고    scopus 로고
    • NF-κB controls the global proinflammatory response in endothelial cells: Evidence for the regulation of a pro-atherogenic program
    • Kempe, S.; Kestler, H.; Lasar, A.; Wirth, T. NF-κB controls the global proinflammatory response in endothelial cells: Evidence for the regulation of a pro-atherogenic program. Nucleic Acids Res. 2005, 33, 165308-165319.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 165308-165319
    • Kempe, S.1    Kestler, H.2    Lasar, A.3    Wirth, T.4
  • 25
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-κB
    • DOI 10.1016/S1097-2765(04)00131-5, PII S1097276504001315
    • Campbell, J. K.; Rocha, S.; Perkins, D. N. Active repression of antiapoptotic gene expression by RelA (p65) NF-κB. Mol. Cell 2004, 13, 853-865. (Pubitemid 38438480)
    • (2004) Molecular Cell , vol.13 , Issue.6 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 27
    • 71549149354 scopus 로고    scopus 로고
    • Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle
    • Zhang, L.; Keung, W.; Samokhvalov, V.; Wang, W.; Lopaschuk, G. D. Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle. Biochim. Biophys. Acta 2010, 1801, 1-22.
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 1-22
    • Zhang, L.1    Keung, W.2    Samokhvalov, V.3    Wang, W.4    Lopaschuk, G.D.5
  • 28
    • 84858966061 scopus 로고    scopus 로고
    • Inhibitory effect of Astragalus polysaccharides on lipopolysaccharide- induced TNF-á and IL-1β production in THP-1 cells
    • He, X.; Shu, J.; Xu, L.; Lu, C.; Lu, A. Inhibitory effect of Astragalus polysaccharides on lipopolysaccharide-induced TNF-á and IL-1β production in THP-1 cells. Molecules 2012, 17, 3155-3164.
    • (2012) Molecules , vol.17 , pp. 3155-3164
    • He, X.1    Shu, J.2    Xu, L.3    Lu, C.4    Lu, A.5


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