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Volumn 93, Issue 3, 2011, Pages 317-327

GLP-1 receptor agonists today

Author keywords

Exenatide; GLP 1 receptor agonist; Liraglutide; Type 2 diabetes

Indexed keywords

ALBIGLUTIDE; DULAGLUTIDE; ELIGEN; EXENDIN 4; GLIMEPIRIDE; GLIMEPIRIDE PLUS METFORMIN; GLIMEPIRIDE PLUS ROSIGLITAZONE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; HORMONE RECEPTOR STIMULATING AGENT; INCRETIN; INSULIN; INSULIN GLARGINE; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; METFORMIN PLUS SITAGLIPTIN; NN 9068; NN 9924; ORAL ANTIDIABETIC AGENT; PC DAC; PIOGLITAZONE; PLACEBO; SAXAGLIPTIN; SEMAGLUTIDE; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; TASPOGLUTIDE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 80052755057     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2011.01.004     Document Type: Review
Times cited : (18)

References (87)
  • 1
    • 77957172778 scopus 로고    scopus 로고
    • International Diabetes Federation
    • International Diabetes Federation The diabetes atlas 2009, 4th ed.
    • (2009) The diabetes atlas
  • 3
    • 24944452076 scopus 로고    scopus 로고
    • Glucose metabolism and regulation: beyond insulin and glucagon
    • Aronoff S.L. Glucose metabolism and regulation: beyond insulin and glucagon. Diabetes Spectrum 2004, 17:183-189.
    • (2004) Diabetes Spectrum , vol.17 , pp. 183-189
    • Aronoff, S.L.1
  • 4
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    • Stratton I.M., Adler A.I., Neil H.A., Matthews D.R., Manley S.E., Cull C.A., et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000, 321:405-412.
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3    Matthews, D.R.4    Manley, S.E.5    Cull, C.A.6
  • 5
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson R.P., Harmon J., Tran P.O., Tanaka Y., Takahashi H. Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003, 52:581-587.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 6
    • 65649106228 scopus 로고    scopus 로고
    • Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    • Ray K.K., Seshasai S.R., Wijesuriya S., Sivakumaran R., Nethercott S., Preiss D., et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 2009, 373:1765-1772.
    • (2009) Lancet , vol.373 , pp. 1765-1772
    • Ray, K.K.1    Seshasai, S.R.2    Wijesuriya, S.3    Sivakumaran, R.4    Nethercott, S.5    Preiss, D.6
  • 7
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • The ADVANCE Collaborative Group
    • The ADVANCE Collaborative Group Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008, 358:2560-2572.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
  • 8
    • 23944459590 scopus 로고    scopus 로고
    • Clinical inertia contributes to poor diabetes control in a primary care setting
    • Ziemer D.C., Miller C.D., Rhee M.K., Doyle J.P., Watkins C., Cook C.B., et al. Clinical inertia contributes to poor diabetes control in a primary care setting. Diabetes Educ 2005, 31:564-571.
    • (2005) Diabetes Educ , vol.31 , pp. 564-571
    • Ziemer, D.C.1    Miller, C.D.2    Rhee, M.K.3    Doyle, J.P.4    Watkins, C.5    Cook, C.B.6
  • 9
    • 63049108672 scopus 로고    scopus 로고
    • Incretin-based therapies: a new potential treatment approach to overcome clinical inertia in type 2 diabetes
    • Nicolucci A., Rossi M.C. Incretin-based therapies: a new potential treatment approach to overcome clinical inertia in type 2 diabetes. Acta Biomed 2008, 79:184-191.
    • (2008) Acta Biomed , vol.79 , pp. 184-191
    • Nicolucci, A.1    Rossi, M.C.2
  • 10
    • 75549091263 scopus 로고    scopus 로고
    • Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control
    • Rodbard H.W., Jellinger P.S., Davidson J.A., Einhorn D., Garber A.J., Grunberger G., et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract 2009, 15:540-559.
    • (2009) Endocr Pract , vol.15 , pp. 540-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3    Einhorn, D.4    Garber, A.J.5    Grunberger, G.6
  • 11
    • 60449089649 scopus 로고    scopus 로고
    • American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan D.M., Buse J.B., Davidson M.B., Ferrannini E., Holman R.R., Sherwin R., et al. American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009, 32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6
  • 12
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group
    • DeFronzo R.A., Goodman A.M. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 1995, 333:541-549.
    • (1995) N Engl J Med , vol.333 , pp. 541-549
    • DeFronzo, R.A.1    Goodman, A.M.2
  • 14
  • 15
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagon-like peptide 1 in the pancreas
    • Doyle M.E., Egan J.M. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther 2007, 113:546-593.
    • (2007) Pharmacol Ther , vol.113 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 16
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck M.A., Homberger E., Siegel E.G., Allen R.C., Eaton R.P., Ebert R., et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986, 63:492-498.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3    Allen, R.C.4    Eaton, R.P.5    Ebert, R.6
  • 18
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M., Stöckmann F., Ebert R., Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986, 29:46-52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 19
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti R., Zhou J., Doyle M.E., Egan J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000, 141:4600-4605.
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 20
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier J.J., Gallwitz B., Salmen S., Goetze O., Holst J.J., Schmidt W.E., et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J Clin Endocrinol Metab 2003, 88:2719-2725.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    Goetze, O.4    Holst, J.J.5    Schmidt, W.E.6
  • 21
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K., Noyan-Ashraf M.H., Hoefer J., Bolz S.S., Drucker D.J., Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008, 117:2340-2350.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 22
    • 77958052010 scopus 로고    scopus 로고
    • A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells
    • Hattori Y., Jojima T., Tomizawa A., Satoh H., Hattori S., Kasai K., et al. A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells. Diabetologia 2010, 53:2256-2263.
    • (2010) Diabetologia , vol.53 , pp. 2256-2263
    • Hattori, Y.1    Jojima, T.2    Tomizawa, A.3    Satoh, H.4    Hattori, S.5    Kasai, K.6
  • 23
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • Bose A.K., Mocanu M.M., Carr R.D., Brand C.L., Yellon D.M. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005, 54:146-151.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 24
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
    • Rachman J., Barrow B.A., Levy J.C., Turner R.C. Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM. Diabetologia 1997, 40:205-211.
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Barrow, B.A.2    Levy, J.C.3    Turner, R.C.4
  • 25
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L., Deacon C.F., Orskov C., Holst J.J. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 1999, 140:5356-5363.
    • (1999) Endocrinology , vol.140 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Holst, J.J.4
  • 26
    • 84860217884 scopus 로고    scopus 로고
    • €, Available at:[accessed 26 July 2010], Novartis
    • Novartis Galvus (vildagliptin) summary of product characteristics September 2009, Available at: http://emc.medicines.org.uk/medicine/20734/SPC/Galvus+50+mg+Tablets/€ [accessed 26 July 2010].
    • (2009) Galvus (vildagliptin) summary of product characteristics
  • 28
    • 70450141942 scopus 로고    scopus 로고
    • Available at: [accessed 26 July 2010], Bristol-Myers Squibb
    • Bristol-Myers Squibb Onglyza (saxagliptin) summary of product characteristics October 2009, Available at: http://emc.medicines.org.uk/medicine/22315/SPC/Onglyza+5mg+film-coated+tablets/ [accessed 26 July 2010].
    • (2009) Onglyza (saxagliptin) summary of product characteristics
  • 29
    • 70450141942 scopus 로고    scopus 로고
    • Available at: [accessed 26 July 2010], Amylin Pharmaceuticals/Eli Lilly
    • Amylin Pharmaceuticals/Eli Lilly Byetta (exenatide) summary of product characteristics 2009, Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000698/WC500051845.pdf [accessed 26 July 2010].
    • (2009) Byetta (exenatide) summary of product characteristics
  • 30
    • 70450141942 scopus 로고    scopus 로고
    • Available at: [accessed 26 July 2010], Novo Nordisk
    • Novo Nordisk Victoza (liraglutide) summary of product characteristics July 2009, Available at: http://emc.medicines.org.uk/medicine/21986/SPC/Victoza+6+mg%2Fml+solution+for+injection+in+pre-filled+pen/ [accessed 26 July 2010].
    • (2009) Victoza (liraglutide) summary of product characteristics
  • 31
    • 84860214361 scopus 로고    scopus 로고
    • Experimental diabetes drug taspoglutide late-stage trials suspended
    • Available at: [accessed 13 October 2010]
    • Nordqvist C. Experimental diabetes drug taspoglutide late-stage trials suspended. Medical News Today September 2010, Available at: http://www.medicalnewstoday.com/articles/200893.php [accessed 13 October 2010].
    • (2010) Medical News Today
    • Nordqvist, C.1
  • 32
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells
    • Goke R., Fehmann H.C., Linn T., Schmidt H., Krause M., Eng J., et al. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 1993, 268:19650-19655.
    • (1993) J Biol Chem , vol.268 , pp. 19650-19655
    • Goke, R.1    Fehmann, H.C.2    Linn, T.3    Schmidt, H.4    Krause, M.5    Eng, J.6
  • 33
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young A.A., Gedulin B.R., Bhavsar S., Bodkin N., Jodka C., Hansen B., et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 1999, 48:1026-1034.
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6
  • 34
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agersø H., Jensen L.B., Elbrønd B., Rolan P., Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002, 45:195-202.
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agersø, H.1    Jensen, L.B.2    Elbrønd, B.3    Rolan, P.4    Zdravkovic, M.5
  • 35
    • 70350513013 scopus 로고    scopus 로고
    • Efficacy and safety of incretin based therapies: clinical trial data
    • White J. Efficacy and safety of incretin based therapies: clinical trial data. J Am Pharm Assoc 2009, 49(Suppl. 1):S30-S40.
    • (2009) J Am Pharm Assoc , vol.49 , Issue.SUPPL. 1
    • White, J.1
  • 36
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin in patients with type 2 diabetes inadequately controlled on metformin: a 26-week, randomised, parallel-group, open-label trial
    • Pratley R.E., Nauck M., Bailey T., Montanya E., Cuddihy R., Filetti S., et al. Liraglutide versus sitagliptin in patients with type 2 diabetes inadequately controlled on metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010, 375:1447-1456.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6
  • 37
    • 50949113950 scopus 로고    scopus 로고
    • Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes
    • Pratley R.E. Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes. Medscape J Med 2008, 10:171.
    • (2008) Medscape J Med , vol.10 , pp. 171
    • Pratley, R.E.1
  • 38
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A., Henry R., Ratner R., Garcia-Hernadez P.A., Rodriguez-Pattzi H., Olvera-Alvarez I., et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009, 373:473-481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernadez, P.A.4    Rodriguez-Pattzi, H.5    Olvera-Alvarez, I.6
  • 39
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M., Shaw J., Brändle M., Bebakar W.M., Kamaruddin N.A., Strand J., et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009, 26:268-278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3    Bebakar, W.M.4    Kamaruddin, N.A.5    Strand, J.6
  • 40
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B., Gerich J., Buse J.B., Lewin A., Schwartz S., Raskin P., et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009, 32:1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6
  • 41
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU)
    • Russell-Jones D., Vaag A., Schmitz O., Sethi B., Lalic N.M., Antic S., et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU). Diabetologia 2009, 52:2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3    Sethi, B.4    Lalic, N.M.5    Antic, S.6
  • 42
    • 67649666737 scopus 로고    scopus 로고
    • A study of two glucagon like peptide-1 receptor agonists for the treatment of type 2 diabetes: liraglutide once daily compared with exenatide twice daily in a randomised, 26-week, open-label trial (LEAD-6)
    • Buse J.B., Rosenstock J., Sesti G., Schmidt W.E., Montanya E., Brett J.H., et al. A study of two glucagon like peptide-1 receptor agonists for the treatment of type 2 diabetes: liraglutide once daily compared with exenatide twice daily in a randomised, 26-week, open-label trial (LEAD-6). Lancet 2009, 374:39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6
  • 43
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes
    • Nauck M.A., Frid A., Hermansen K., Shah N.S., Tankova T., Mitha I.H., et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes. Diabetes Care 2009, 32:84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.A.1    Frid, A.2    Hermansen, K.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6
  • 44
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo R.A., Ratner R.E., Han J., Kim D.D., Fineman M.S., Baron A.D. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005, 28:1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 45
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse J.B., Henry R.R., Han J., Kim D.D., Fineman M.S., Baron A.D. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004, 27:2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 46
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall D.M., Riddle M.C., Rosenstock J., Zhuang D., Kim D.D., Fineman M.S., et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005, 28:1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6
  • 47
    • 77954738952 scopus 로고    scopus 로고
    • Impact of GLP-1 and GLP-1 receptor agonists on cardiovascular risk factors in type 2 diabetes
    • Verge D., López X. Impact of GLP-1 and GLP-1 receptor agonists on cardiovascular risk factors in type 2 diabetes. Curr Diabetes Rev 2010, 6:191-200.
    • (2010) Curr Diabetes Rev , vol.6 , pp. 191-200
    • Verge, D.1    López, X.2
  • 49
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study
    • Erratum in: Clin Ther, 2008;30:1937
    • Moretto T.J., Milton D.R., Ridge T.D., Macconell L.A., Okerson T., Wolka A.M., et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2008, 30:1448-1460. Erratum in: Clin Ther, 2008;30:1937.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3    Macconell, L.A.4    Okerson, T.5    Wolka, A.M.6
  • 50
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
    • Drucker D.J., Buse J.B., Taylor K., Kendall D.M., Trautmann M., Zhuang D., et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008, 372:1240-1250.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, D.M.4    Trautmann, M.5    Zhuang, D.6
  • 51
    • 84929170700 scopus 로고    scopus 로고
    • Available at: [accessed 8 October 2010], Novo Nordisk
    • Novo Nordisk Victoza risk evaluation and mitigation strategy (REMS) January 2010, Available at: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM202063.pdf [accessed 8 October 2010].
    • (2010) Victoza risk evaluation and mitigation strategy (REMS)
  • 52
    • 84860214380 scopus 로고    scopus 로고
    • Available at: [accessed 8 October 2010], Amylin Pharmaceuticals
    • Amylin Pharmaceuticals Byetta risk evaluation and mitigation strategy (REMS) September 2009, Available at: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM193306.pdf [accessed 8 October 2010].
    • (2009) Byetta risk evaluation and mitigation strategy (REMS)
  • 53
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • Buse J.B., Drucker D.J., Taylor K.L., Kim T., Walsh B., Hu H., et al. DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care 2010, 33:1255-1261.
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3    Kim, T.4    Walsh, B.5    Hu, H.6
  • 54
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or poiglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    • doi:10.1016/S0140-6736(10)60590-9
    • Bergenstal R.M., Wysham C., MacConell L., Malloy J., Walsh B., Yan P., et al. Efficacy and safety of exenatide once weekly versus sitagliptin or poiglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010, doi:10.1016/S0140-6736(10)60590-9.
    • (2010) Lancet
    • Bergenstal, R.M.1    Wysham, C.2    MacConell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6
  • 55
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    • Diamant M., Van Gaal L., Stranks S., Northrup J., Cao D., Taylor K., et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet 2010, 375:2234-2243.
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1    Van Gaal, L.2    Stranks, S.3    Northrup, J.4    Cao, D.5    Taylor, K.6
  • 56
    • 84860216892 scopus 로고    scopus 로고
    • Novo Nordisk, Pipeline: semaglutide, Available at: [accessed 26 July 2010].
    • Novo Nordisk, Pipeline: semaglutide, Available at: [accessed 26 July 2010]. http://www.novonordisk.com/science/pipeline/rd_pipeline.asp%3Fshowid=7.
  • 57
    • 68549099651 scopus 로고    scopus 로고
    • Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus
    • Christensen M., Knop F.K., Holst J.J., Vilsboll T. Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus. IDrugs 2009, 12:503-513.
    • (2009) IDrugs , vol.12 , pp. 503-513
    • Christensen, M.1    Knop, F.K.2    Holst, J.J.3    Vilsboll, T.4
  • 58
    • 70349923522 scopus 로고    scopus 로고
    • Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes
    • Tomkin G.H. Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes. Curr Opin Mol Ther 2009, 11:579-588.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 579-588
    • Tomkin, G.H.1
  • 59
    • 72549107810 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a long-acting GLP-1-receptor agonist, in Japanese subjects with type 2 diabetes mellitus
    • Seino Y., Nakajima H., Miyahara H., Kurita T., Bush M.A., Yang F., et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a long-acting GLP-1-receptor agonist, in Japanese subjects with type 2 diabetes mellitus. Curr Med Res Opin 2009, 25:3049-3057.
    • (2009) Curr Med Res Opin , vol.25 , pp. 3049-3057
    • Seino, Y.1    Nakajima, H.2    Miyahara, H.3    Kurita, T.4    Bush, M.A.5    Yang, F.6
  • 60
    • 76749147734 scopus 로고    scopus 로고
    • Albiglutide, a long-acting GLP-1-receptor agonist, for the treatment of type 2 diabetes: an analysis of gastrointestinal adverse events over time
    • Stewart M.W., Reusch J.E.B., Bush M.A., Yang F., Rosenstock J. Albiglutide, a long-acting GLP-1-receptor agonist, for the treatment of type 2 diabetes: an analysis of gastrointestinal adverse events over time. Diabetologia 2009, 52(Suppl. 1):S302.
    • (2009) Diabetologia , vol.52 , Issue.SUPPL. 1
    • Stewart, M.W.1    Reusch, J.E.B.2    Bush, M.A.3    Yang, F.4    Rosenstock, J.5
  • 61
    • 76749144511 scopus 로고    scopus 로고
    • Weekly, biweekly and monthly efficacy of albiglutide, a long-acting GLP-1-receptor agonist, in patients with type 2 diabetes receiving concomitant background metformin
    • Rosenstock J., Reusch J.E.B., Bush M.A., Yang F., Stewart M.W. Weekly, biweekly and monthly efficacy of albiglutide, a long-acting GLP-1-receptor agonist, in patients with type 2 diabetes receiving concomitant background metformin. Diabetologia 2009, 52(Suppl. 1):S288.
    • (2009) Diabetologia , vol.52 , Issue.SUPPL. 1
    • Rosenstock, J.1    Reusch, J.E.B.2    Bush, M.A.3    Yang, F.4    Stewart, M.W.5
  • 62
    • 0004084146 scopus 로고    scopus 로고
    • Available at: [accessed 26 July 2010], Novo Nordisk
    • Novo Nordisk Press release January 2010, Available at: http://www.novonordisk.com/press/news/news.asp?sShowNewsItemGuID=acc555cc-2124-4ebf-ad6d-7f923e2e2a78&sShowLanguageCode=en-GB&sSearchText=NN9924 [accessed 26 July 2010].
    • (2010) Press release
  • 63
    • 84860216890 scopus 로고    scopus 로고
    • Novo Nordisk, Pipeline: NN9068, Available at: [accessed 26 July 2010].
    • Novo Nordisk, Pipeline: NN9068, Available at: [accessed 26 July 2010]. http://www.novonordisk.com/science/pipeline/rd_pipeline.asp%3Fshowid=17.
  • 64
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
    • Astrup A., Rössner S., Van Gaal L., Rissanen A., Niskanen L., Al Hakim M., et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009, 374:1606-1616.
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rössner, S.2    Van Gaal, L.3    Rissanen, A.4    Niskanen, L.5    Al Hakim, M.6
  • 65
    • 75149180515 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2010
    • American Diabetes Association
    • American Diabetes Association Standards of medical care in diabetes-2010. Diabetes Care 2010, 33:S11-S61.
    • (2010) Diabetes Care , vol.33
  • 66
    • 84860221859 scopus 로고    scopus 로고
    • Haute Authorité de Santé, Traitement medicamenteux du diabete de type 2, Available at: [accessed 26 July 2010].
    • Haute Authorité de Santé, Traitement medicamenteux du diabete de type 2, Available at: [accessed 26 July 2010]. http://www.afssaps.fr/Infos-de-securite/Recommandations-de-bonne-pratique/Traitement-medicamenteux-du-diabete-de-type-2-recommandations-de-bonne-pratique/(language)/fre-FR.
  • 67
    • 84860221860 scopus 로고    scopus 로고
    • Haute Authorité de Santé, Commission de la Transparence: VICTOZA 6mg/ml, solution injectable en stylo pré rempli Available at: [accessed 26 July 2010].
    • Haute Authorité de Santé, Commission de la Transparence: VICTOZA 6mg/ml, solution injectable en stylo pré rempli Available at: [accessed 26 July 2010]. http://www.has-sante.fr/portail/upload/docs/application/pdf/2010-01/victoza_-_ct-7136.pdf.
  • 68
    • 84860221004 scopus 로고    scopus 로고
    • Haute Authorité de Santé, Commission de la Transparence: BYETTA 5 ug/ml, 10μg/ml solution injectable en stylo pré rempli, Available at: [accessed 26 July 2010].
    • Haute Authorité de Santé, Commission de la Transparence: BYETTA 5 ug/ml, 10μg/ml solution injectable en stylo pré rempli, Available at: [accessed 26 July 2010]. http://www.has-sante.fr/portail/upload/docs/application/pdf/ct-4012_byetta.pdf.
  • 69
    • 84856622892 scopus 로고    scopus 로고
    • Available at: [accessed 26 July 2010], National Institute for Clinical Excellence
    • National Institute for Clinical Excellence NICE clinical guideline 87 2009, Available at: http://www.nice.org.uk/nicemedia/pdf/CG87NICEGuideline.pdf [accessed 26 July 2010].
    • (2009) NICE clinical guideline 87
  • 70
    • 84860214565 scopus 로고    scopus 로고
    • Available at: [accessed 26 July 2010], National Institute for Clinical Excellence
    • National Institute for Clinical Excellence NICE recommends liraglutide for diabetes triple therapy 2010, Available at: http://www.nice.org.uk/newsroom/news/newsdiabetes.jsp [accessed 26 July 2010].
    • (2010) NICE recommends liraglutide for diabetes triple therapy
  • 71
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L., Bulotta A., Hirshberg B., Li Calzi S., Khoury N., Noushmehr H., et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 2003, 144:5149-5158.
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3    Li Calzi, S.4    Khoury, N.5    Noushmehr, H.6
  • 72
    • 70349320177 scopus 로고    scopus 로고
    • Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells
    • Rütti S., Ehses J.A., Sibler R.A., Prazak R., Rohrer L., Georgopoulos S., et al. Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. Endocrinology 2009, 150:4521-4530.
    • (2009) Endocrinology , vol.150 , pp. 4521-4530
    • Rütti, S.1    Ehses, J.A.2    Sibler, R.A.3    Prazak, R.4    Rohrer, L.5    Georgopoulos, S.6
  • 73
    • 0035405821 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    • Tourrel C., Bailbé D., Meile M.J., Kergoat M., Portha B. Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 2001, 50:1562-1570.
    • (2001) Diabetes , vol.50 , pp. 1562-1570
    • Tourrel, C.1    Bailbé, D.2    Meile, M.J.3    Kergoat, M.4    Portha, B.5
  • 74
    • 10744230106 scopus 로고    scopus 로고
    • GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics
    • Sturis J., Gotfredsen C.F., Rømer J., Rolin B., Ribel U., Brand C.L., et al. GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics. Br J Pharmacol 2003, 140:123-132.
    • (2003) Br J Pharmacol , vol.140 , pp. 123-132
    • Sturis, J.1    Gotfredsen, C.F.2    Rømer, J.3    Rolin, B.4    Ribel, U.5    Brand, C.L.6
  • 75
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff D.C., Buse J.B., Nielsen L.L., Guan X., Bowlus C.L., Holcombe J.H., et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 2008, 24:275-286.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3    Guan, X.4    Bowlus, C.L.5    Holcombe, J.H.6
  • 76
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L., Klein E.J., Han J., Zhang B., Mac S.M., Poon T.H., et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 2006, 8:436-447.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3    Zhang, B.4    Mac, S.M.5    Poon, T.H.6
  • 77
    • 84860216891 scopus 로고    scopus 로고
    • National Institute for Clinical Excellence, NICE: the guidelines manual-chapter 7: assessing cost effectiveness, Available at: [accessed 26 July 2010]
    • National Institute for Clinical Excellence, NICE: the guidelines manual-chapter 7: assessing cost effectiveness, Available at: [accessed 26 July 2010]. http://www.nice.org.uk/media/68D/29/The_guidelines_manual_2009_-_Chapter_7_Assessing_cost_effectiveness.pdf.
  • 78
    • 38549104931 scopus 로고    scopus 로고
    • Estimating the long-term cost-effectiveness of exenatide in the United States: an adjunctive treatment for type 2 diabetes mellitus
    • Minshall M.E., Oglesby A.K., Wintle M.E., Valentine W.J., Roze S., Palmer A.J. Estimating the long-term cost-effectiveness of exenatide in the United States: an adjunctive treatment for type 2 diabetes mellitus. Value Health 2008, 11:22-33.
    • (2008) Value Health , vol.11 , pp. 22-33
    • Minshall, M.E.1    Oglesby, A.K.2    Wintle, M.E.3    Valentine, W.J.4    Roze, S.5    Palmer, A.J.6
  • 79
    • 70350165090 scopus 로고    scopus 로고
    • Evaluation of exenatide vs. insulin glargine in type 2 diabetes: cost-effectiveness analysis in the German setting
    • Mittendorf T., Smith-Palmer J., Timlin L., Happich M., Goodall G. Evaluation of exenatide vs. insulin glargine in type 2 diabetes: cost-effectiveness analysis in the German setting. Diabetes Obes Metab 2009, 11:1068-1079.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1068-1079
    • Mittendorf, T.1    Smith-Palmer, J.2    Timlin, L.3    Happich, M.4    Goodall, G.5
  • 81
    • 52749093529 scopus 로고    scopus 로고
    • Evaluation of the cost effectiveness of exenatide versus insulin glargine in patients with sub-optimally controlled type 2 diabetes in the United Kingdom
    • Woehl A., Evans M., Tetlow A.P., McEwan P. Evaluation of the cost effectiveness of exenatide versus insulin glargine in patients with sub-optimally controlled type 2 diabetes in the United Kingdom. Cardiovasc Diabetol 2008, 7:24.
    • (2008) Cardiovasc Diabetol , vol.7 , pp. 24
    • Woehl, A.1    Evans, M.2    Tetlow, A.P.3    McEwan, P.4
  • 82
    • 70350520817 scopus 로고    scopus 로고
    • A simulation of the comparative long-term effectiveness of liraglutide and glimepiride monotherapies in patients with type 2 diabetes mellitus
    • Sullivan S.D., Alfonso-Cristancho R., Conner C., Hammer M., Blonde L. A simulation of the comparative long-term effectiveness of liraglutide and glimepiride monotherapies in patients with type 2 diabetes mellitus. Pharmacotherapy 2009, 29:1280-1288.
    • (2009) Pharmacotherapy , vol.29 , pp. 1280-1288
    • Sullivan, S.D.1    Alfonso-Cristancho, R.2    Conner, C.3    Hammer, M.4    Blonde, L.5
  • 83
    • 80052781289 scopus 로고    scopus 로고
    • Cost-effectiveness of liraglutide compared to exenatide in combination with metformin and/or sulphonylurea
    • Poster 406
    • Smith I.C., Chubb B., Valentine W. Cost-effectiveness of liraglutide compared to exenatide in combination with metformin and/or sulphonylurea. Diabet Med 2010, 27(Suppl. 1). Poster 406.
    • (2010) Diabet Med , vol.27 , Issue.SUPPL. 1
    • Smith, I.C.1    Chubb, B.2    Valentine, W.3
  • 84
    • 80052735581 scopus 로고    scopus 로고
    • Liraglutide: a cost effective treatment option when added to OAD monotherapy
    • Poster 409
    • Chubb B., Smith I., Valentine W. Liraglutide: a cost effective treatment option when added to OAD monotherapy. Diabet Med 2010, 27(Suppl. 1). Poster 409.
    • (2010) Diabet Med , vol.27 , Issue.SUPPL. 1
    • Chubb, B.1    Smith, I.2    Valentine, W.3
  • 85
    • 70450199755 scopus 로고    scopus 로고
    • Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the helping evaluate exenatide in patients with diabetes compared with long-acting insulin (HEELA) study
    • Davies M.J., Donnelly R., Barnett A.H., Jones S., Nicolay C., Kilcoyne A. Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the helping evaluate exenatide in patients with diabetes compared with long-acting insulin (HEELA) study. Diabetes Obes Metab 2009, 11:1153-1162.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1153-1162
    • Davies, M.J.1    Donnelly, R.2    Barnett, A.H.3    Jones, S.4    Nicolay, C.5    Kilcoyne, A.6
  • 86
    • 48949098988 scopus 로고    scopus 로고
    • Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus
    • Sheffield C.A., Kane M.P., Busch R.S., Bakst G., Abelseth J.M., Hamilton R.A. Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus. Endocr Pract 2008, 14:285-292.
    • (2008) Endocr Pract , vol.14 , pp. 285-292
    • Sheffield, C.A.1    Kane, M.P.2    Busch, R.S.3    Bakst, G.4    Abelseth, J.M.5    Hamilton, R.A.6
  • 87
    • 68649099986 scopus 로고    scopus 로고
    • Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting
    • Yoon N., Cavaghan M., Brunelle R., Roach P. Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting. Clin Ther 2009, 31:1511-1523.
    • (2009) Clin Ther , vol.31 , pp. 1511-1523
    • Yoon, N.1    Cavaghan, M.2    Brunelle, R.3    Roach, P.4


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