Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner

Biochemical and Biophysical Research Communications

Volumn 340, Issue 2, 2006, Pages 560-566

  Fujiwara, Yusuke ^a   Kawada, Kei ^a   Takano, Daiki ^a   Tanimura, Susumu ^a   Ozaki, Kei Ichi ^a   Kohno, Michiaki ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Combination therapy; Doxorubicin; LY294002; p53; PI3 kinase Akt pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; ETOPOSIDE; MITOMYCIN C; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P53; TOPOTECAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; CHROMONES; DOXORUBICIN; HUMANS; MORPHOLINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 29644442524     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.039     Document Type: Article

References (24)

1. I. Vivanco, and C.L. Sawyers The phsophatidylinositol 3-kinase-Akt pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
2. K.M. Nicholson, and N.G. Anderson The protein kinase B/Akt signaling pathway in human malignancy Cell. Signal. 14 2002 381 395
3. I. Sansal, and W.R. Sellers The biology and clinical relevance of the PTEN tumor suppressor pathway J. Clin. Oncol. 22 2004 2954 2963
4. R. Hoshino, Y. Chatani, T. Yamori, T. Tsuruo, H. Oka, O. Yoshida, Y. Shimada, S. Ari-I, H. Wada, J. Fujimoto, and M. Kohno Constitutive activation of the 41-/43-kDa mitogen activated protein kinase signaling pathway in human tumors Oncogene 18 1999 813 822
5. Kip1 J. Biol. Chem. 276 2001 2686 2692
6. S. Iwasaki, M. Iguchi, K. Watanabe, R. Hoshino, M. Tsujimoto, and M. Kohno Specific activation of the p38 Mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2 J. Biol. Chem. 274 1999 26503 26510
7. S. Tanimura, K. Nomura, K. Ozaki, M. Tsujimoto, T. Kondo, and M. Kohno Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility J. Biol. Chem. 277 2002 28256 28264
8. C.J. Vlahos, W.F. Matter, K.H. Hui, and R.F. Brown A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- one (LY294002) J. Biol. Chem. 269 1994 5241 5248
9. Z. Darzynkiewicz, G. Juan, X. Li, W. Gorczyca, T. Murakami, and F. Traganos Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis) Cytometry 27 1999 1 20
10. L.H. Hurley DNA and its associated processes as targets for cancer therapy Nat. Rev. Cancer 2 2002 188 200
11. L. Yang, H.C. Dan, M. Sun, Q. Liu, X. Sun, R.I. Feldman, A.D. Hamilton, M. Polokoff, S.V. Nicosia, M. Herlyn, S.M. Sebti, and J.Q. Cheng Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt Cancer Res. 64 2004 4394 4399
12. T. Fernandes-Alnemri, R.C. Armstrong, J. Krebs, S.M. Srinivasula, L. Wang, F. Bullrich, L.C. Fritz, J.A. Trapani, K.J. Tomaselli, G. Litwack, and E.S. Alnemri In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cystein protease containing two FADD-like domains Proc. Natl. Acad. Sci. USA 93 1996 7464 7469
13. D.W. Nicholson, A. All, N.A. Thornberry, J.P. Vailliancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnik, N.A. Munday, S.M. Raju, M.E. Smulson, T.T. Yamin, V.L. Yu, and D.K. Miller Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis Nature 376 1995 37 43
14. H.C. Dan, M. Sun, S. Kaneko, R.I. Feldman, S.V. Nicosia, H.G. Wang, B.K. Tsang, and J.Q. Cheng Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP) J. Biol. Chem. 279 2004 5405 5412
15. M. Holcik, H. Gibson, and R.G. Korneluk XIAP: apoptotic brake and promising therapeutic target Apoptosis 6 2001 253 261
16. S.W. Lowe, S. Bodis, A. McClatchey, L. Remington, H.E. Ruley, D.E. Fisher, D.E. Housman, and T. Jacks p53 status and the efficacy of cancer therapy in vivo Science 266 1994 807 810
17. 2- and p53-dependent pathways J. Biol. Chem. 279 2004 25535 25543
18. W.P. Tsang, S.P.Y. Chau, S.K. Kong, K.P. Fung, and T.T. Kwok Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis Life Sci. 73 2003 2047 2058
19. H. Matsumoto, M. Shimura, T. Omatsu, K. Okaichi, H. Majima, and T. Ohnishi p53 proteins accumulated by heat stress associate with heat shock proteins HSP72/HSC73 in human glioblastoma cell line Cancer Lett. 87 1994 39 46
20. A.G. Carroll, H.J. Voeller, L. Sugars, and E.P. Gelmann p53 oncogene mutations in three human prostate cancer cell lines Prostate 23 1993 123 134
21. M.J. Cooper, J.J. Haluschak, D. Johnson, S. Schwartz, L.J. Morrison, M. Lippa, G. Hatzivassiliou, and J. Tan p53 mutations in bladder carcinoma cell lines Oncol. Res. 6 1994 569 579
22. N.R. Rodrigues, A. Rowan, M.E.F. Smith, I.B. Kerr, W.F. Bodmer, J.V. Gannon, and D.P. Lane p53 mutations in colorectal cancer Proc. Natl. Acad. Sci. USA 87 1990 7555 7559
23. P.M. O'Conner, J. Jackman, I. Bae, T.G. Myers, S. Fan, M. Mutoh, D.A. Scudiero, A. Monks, E.A. Sausville, J.N. Weinstein, S. Friend, A.J. Fornace, and K.W. Kohn Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents Cancer Res. 57 1997 4285 4300
24. J. Yu, and L. Zhang The transcriptional targets of p53 in apoptosis control Biochem. Biophys. Res. Commun. 331 2005 851 858