Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin

Journal of the American Chemical Society

Volumn 132, Issue 9, 2010, Pages 3063-3077

  Tannert, René ^a,b   Milroy, Lech Gustav ^a,b   Ellinger, Bernhard ^a,b   Hu, Tai Shan ^a,b   Arndt, Hans Dieter ^a,b   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL DATA; COMPOUND LIBRARIES; CYCLODEPSIPEPTIDES; CYTOTOXIC; EUKARYOTIC CELLS; F-ACTIN; FUNCTIONALIZED; FUTURE DESIGNS; HIGH RESOLUTION; HYBRID STRUCTURE; INHIBITORY EFFECT; JASPLAKINOLIDE; MACROCYLIZATION; NATURAL PRODUCTS; PHARMACOPHORES; POLYKETIDES; RESEARCH EFFORTS; RING CLOSING METATHESIS; SECONDARY METABOLITES; SMALL MOLECULES; SOLID-PHASE; STABILIZING PROPERTIES; STRUCTURAL BASIS; STRUCTURAL COMPONENT; STRUCTURAL DATA; STRUCTURE-ACTIVITY; STRUCTURE-FUNCTION STUDIES; SYNTHETIC ROUTES; TOTAL SYNTHESIS;

BIOLOGY; CLIMATE MODELS; COMPLEXATION; LAWS AND LEGISLATION; LIBRARIES; METABOLITES; PROTEINS; RUTHENIUM;

SYNTHESIS (CHEMICAL);

CYCLODEXTRIN DERIVATIVE; F ACTIN; JASPAMIDE; NATURAL PRODUCT; RUTHENIUM;

ARTICLE; CATALYSIS; CYTOTOXICITY; DRUG SYNTHESIS; METABOLITE; MOLECULAR MODEL; PHARMACOPHORE; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RING CLOSING METATHESIS; SOLID; STEREOCHEMISTRY;

ACTINS; ANIMALS; ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; BIOLOGICAL FACTORS; CELL LINE; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN STABILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949391413     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja9095126     Document Type: Article

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