Anti-proliferation of human cervical cancer HeLa cell line by fascaplysin through apoptosis induction

Yaoxue Xuebao

Volumn 44, Issue 9, 2009, Pages 980-986

  Lu, Xiao Ling ^a   Zheng, Yan Ling ^a   Chen, Hai Min ^a   Yan, Xiao Jun ^a   Wang, Feng ^b   Xu, Wei Feng ^b  

^a NINGBO UNIVERSITY   (China)

^b Lihuili Hospital   (China)

Author keywords

Apoptosis; Caspases activation; CDK4; Fascaplysin; Mitochondria

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYTOCHROME C; FASCAPLYSIN; PROTEIN BCL 2; PROTEIN BID; SERINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CYTOSOL; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAINING; UTERINE CERVIX CANCER; WESTERN BLOTTING;

APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; HELA CELLS; HUMANS; INDOLES; MITOCHONDRIA;

EID: 71049132728     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Alvarez-Salas LM, DiPaolo JA. Molecular approaches to cervical cancer therapy [J]. Curr Drug Discov Technol, 2007, 4: 208-219.
2. Schwartsmann G Ratain MJ, Cragg GM, et al. Anticancer drug discovery and development throughout the world [J]. J Clin Oncol, 2002, 20: 47S-59S.
3. Roll DM, Ireland CM, Lu HSM, et al. Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp [J]. J Org Chem, 1988, 53: 3276-3278.
4. Segraves NL, Lopez S, Johnson TA, et al. Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla - Fascaplysinopsis sponges and Didemnum tunicates [J]. Tetrahedron Lett, 2003, 44: 3471-3475. (Pubitemid 36398314)
5. Soni R, Muller L, Furet P, et al. Inhibition of cyclin- dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product [J]. Biochem Biophys Res Commun, 2000, 275: 877-884. (Pubitemid 30708253)
6. Lin J, Yan XJ, Chen HM. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo [J]. Cancer Chemother Pharmacol, 2007, 59: 439-445. (Pubitemid 46122322)
7. Subramanian B, Nakeff A, Tenney K, et al. A new paradigm for the development of anticancer agents from natural products [J]. J Exp Ther Oncol, 2006, 5: 195-204. (Pubitemid 43843830)
8. Calbó J, Serna C, Garriga J, et al. The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity [J]. Cell Death Differ, 2004, 11: 1055-1065. (Pubitemid 39341631)
9. Shapiro GI, Harper JW. Anticancer drug targets: cell cycle and checkpoint control [J]. J Clin Invest, 1999, 104: 1645-1653. (Pubitemid 30053178)
10. Jiang H, Chou HS, Zhu L. Requirement of cyclin E-Cdk2 inhibition in p16 (INK4a)-mediated growth suppression [J]. Mol Cell Biol, 1998, 18: 5284-5290. (Pubitemid 28388112)
11. Long S, Wilson M, Bengten E, et al. Identification and characterization of a FasL-like protein and cDNAs encoding the channel catfish death-inducing signaling complex [J]. Immunogenetics, 2004, 56: 518-530. (Pubitemid 39517833)
12. Nomura J, Matsumoto K, Iguchi-Ariga SM, et al. Mitochondria-independent induction of Fas-mediated apoptosis by MSSP [J]. Oncol Rep, 2005, 14: 1305-1309.
13. Li H, Zhu H, Xu CJ, et al. Cleavage of BID by Caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis [J]. Cell, 1998, 94: 491-501. (Pubitemid 28391865)
14. Tang Y, Zhang DY, Wu XM. Progress in small-molecule inhibitors of Bcl-2 family proteins [J]. Acta Pharm Sin 2008, 43: 669-677.
15. Kuwana T, Mackey MR, Perkins G et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane [J]. Cell, 2002, 111: 331-342.
16. Zhou P, Jiang W, Zhang YJ, et al. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells [J]. Oncogene, 1995, 11: 571-580.
17. Arber N, Doki Y, Han EK, et al. Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells [J]. Cancer Res, 1997, 57: 1569-1574. (Pubitemid 27175576)
18. Sauter ER, Nesbit M, Litwin S, et al. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas [J]. Cancer Res, 1999, 59: 4876-4881. (Pubitemid 29472891)
19. Tashiro E, Tsuchiya A, Imoto M. Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression [J]. Cancer Sci, 2007,98: 629-635. (Pubitemid 46563437)