Discovery of anticancer drugs from antimalarial natural products: A MEDLINE literature review

Drug Discovery Today

Volumn 17, Issue 17-18, 2012, Pages 942-953

  Duffy, Robert ^a   Wade, Christine ^a   Chang, Raymond ^a  

^a Institute of East West Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABRUS PRECATORIUS EXTRACT; ACACIA NILOTICA EXTRACT; ACHILLEA MILLEFOLIUM EXTRACT; ALSTONIA SCHOLARIS EXTRACT; AMODIAQUINE; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ARTEETHER; ARTEMETHER; ARTEMISININ; ARTESUNATE; ATOVAQUONE; CHLOROQUINE; CLINDAMYCIN; CYCLOGUANIL; DIHYDROARTEMISININ; DOXYCYCLINE; GARLIC EXTRACT; HALOFANTRINE; HYDROXYCHLOROQUINE; MEFLOQUINE; NATURAL PRODUCT; ONION EXTRACT; PRIMAQUINE; PROGUANIL; PYRIMETHAMINE; QUININE; SULFADOXINE; TETRACYCLINE; UNINDEXED DRUG;

ALGORITHM; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GENETICS; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; HUMAN; MALARIA; MEDLINE; NEOPLASM; NONHUMAN; PLASMODIUM MALARIAE; PUBLICATION; REVIEW;

EID: 84865458429     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.03.013     Document Type: Short Survey

References (81)

1. J. Boyle World Cancer Report 2008 WHO
2. A. Kamb Why is cancer drug discovery so difficult? Nat. Rev. Drug Discov. 6 2007 115 120 (Pubitemid 46745339)
3. J. Li, and J. Vederas Drug discovery and natural products: end of an era or an endless frontier? Science 325 2009 161 165
4. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70 2007 461 477 (Pubitemid 46595760)
5. Anon. (2001) Chinese remedy 'may fight cancer'. BBC News (http://news.bbc.co.uk/1/hi/health/1678469.stm )
6. T. Cavalier-Smith Only six kingdoms of life Proc. Biol. Sci. 22 2004 1251 1262 (Pubitemid 38789317)
7. T. Efferth Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells Curr. Drug Targets 7 2006 14
8. T. Efferth Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin: from bench to bedside Planta Med. 73 2007 299 309 (Pubitemid 46910410)
9. K. Kaur Antimalarials from nature Bioorg. Med. Chem. 17 2009 3229 3235
10. M. Thomas A database model for integrating and facilitating collaborative ethnomedicinal research Pharm. Biol. 39 Suppl. 1 2001 41 52
11. K. Boehm An overview of 45 published database resources for complementary and alternative medicine Health Info. Libr. J. 27 2010 1471 1482
12. Anon. (2010) WHO Guidelines for the Treatment of Malaria. WHO
13. S. Khan, and M.J. Balick Therapeutic plants of Ayurveda: a review of selected clinical and other studies for 166 species J. Altern. Complement. Med. 7 2001 405 515 (Pubitemid 33062562)
14. M. Willcox, Traditional Medicinal Plants and Malaria 2004 CRC Press
15. C. Wright Traditional antimalarials and the development of novel antimalarial drugs J. Ethnopharmacol. 100 2005 67 71 (Pubitemid 41073524)
16. D. Laurent, and F. Pietra Antiplasmodial marine natural products in the perspective of current chemotherapy and prevention of malaria: a review Mar. Biotechnol. 8 2006 433 447 (Pubitemid 44663641)
17. M. Frederich Potential antimalarial activity of indole alkaloids Trans. R. Soc. Trop. Med. Hyg. 102 2008 11 19 (Pubitemid 350177430)
18. R. Batista Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products Molecules 14 2009 3037 3072
19. E. Fattorusso, and O. Taglialatela-Scafati Marine antimalarials Mar. Drugs 7 2009 130 152
20. S. Nobili Natural compounds for cancer treatment and prevention Pharmacol. Res. 59 2009 365 378
21. D. Bensky, Chinese Herbal Medicine: Materia Medica 2003 Eastland Press
22. D. Chen Tea polyphenols, their biological effects and potential molecular targets Histol. Histopathol. 23 2008 487 496 (Pubitemid 351552334)
23. M. Lee Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract Cancer Epidemiol. Biomarkers Prev. 13 2004 132 137 (Pubitemid 38116630)
24. A. Halder Black tea (Camellia sinensis) as a chemopreventive agent in oral precancerous lesions J. Environ. Pathol. Toxicol. Oncol. 24 2005 141 144
25. Z. Wang Combined therapy of brain metastasis in lung cancer Chin. J. Integr. Trad. West. Med. 10 1992 609 610
26. S. Pongnikorn Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy J. Med. Assoc. Thai. 86 2003 61 68 (Pubitemid 36534714)
27. B. Blumberg Hepatitis B virus and primary hepatocellular carcinoma: treatment of HBV carriers with Phyllanthus amarus Vaccine 8 Suppl. 1990 S86 S92
28. M. Bayet-Robert Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer Cancer Biol. Ther. 9 2010 8 14
29. J. Jurenka Antiinflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research Altern. Med. Rev. 14 2009 141 153
30. I. Villegas New mechanisms and therapeutic potential of curcumin for colorectal cancer Mol. Nutr. Food Res. 52 2008 1040 1061
31. H. Hatcher Curcumin: from ancient medicine to current clinical trials Cell. Mol. Life Sci. 65 2008 1631 1652
32. J. Johnson Curcumin for chemoprevention of colon cancer Cancer Lett. 255 2007 170 181 (Pubitemid 47268637)
33. J. Joshi Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers J. Assoc. Phys. India 51 2003 1055 1060 (Pubitemid 41279813)
34. A. Cheng Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions Anticancer Res. 21 2001 2895 2900
35. S. Pisanti Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents Best Pract. Res. Clin. Endocrinol. Metab. 23 2009 117 131
36. S. Oka A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas Hiroshima J. Med. Sci. 59 2010 1 6
37. G. Chan Supplements for immune enhancement in hematologic malignancies Hematol. Am. Soc. Hematol. Educ. Program 2009 313 319
38. S. Zhuang Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy Phytother. Res. 23 2009 785 790
39. X. Chen Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer Int. Immunopharmacol. 6 2006 499 508 (Pubitemid 43124011)
40. Y. Gao Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients Immunol. Invest. 32 2003 201 215 (Pubitemid 36962040)
41. T. Taguchi Effects of lentinan in advanced or recurrent cases of gastric, colorectal, and breast cancer Gan. To. Kagaku. Ryoho. 2 1983 387 393 (Pubitemid 13136616)
42. A. Kosaka Effect of lentinan administration of adrenalectomized rats and patients with breast cancer Gan. To. Kagaku. Ryoho. 9 1982 1474 1481 (Pubitemid 13250057)
43. G. Cardinali Place of Vinca rosea alkaloids (Catharanthus roseus) in the treatment of Hodgkin's disease Haematologica 53 1973 51 64
44. K. Ramasamy Multitargeted therapy of cancer by silymarin Cancer Lett. 269 2008 352 362
45. S. Sagar Future directions for research on Silybum marianum for cancer patients Integr. Cancer Ther. 6 2007 166 173 (Pubitemid 46871841)
46. C. Tamayo Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.) Integr. Cancer Ther. 6 2007 146 157 (Pubitemid 46871845)
47. G. Deep Chemopreventive efficacy of silymarin in skin and prostate cancer Integr. Cancer Ther. 6 2007 130 145 (Pubitemid 46871840)
48. M.H. Pittler, and E. Ernst Clinical effectiveness of garlic (Allium sativum) Mol. Nutr. Food Res. 51 2007 1382 1385 (Pubitemid 350195611)
49. E. Lansky Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer J. Ethnopharmacol. 109 2007 177 206 (Pubitemid 44959707)
50. J. Golenser Current perspectives on the mechanisms of action of artemisinins Int. J. Parasitol. 36 2006 1427 1441 (Pubitemid 44751746)
51. S. Toovey Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity Basic Clin. Pharmacol. Toxicol. 103 2008 209 213
52. A. Mercer The role of heme and the mitochondrion in the chemical and molecular mechanisms of cell death induced by artemisinin antimalarials J. Biol. Chem. 286 2011 987 996
53. K. Kaur Quinolines and structurally related heterocycles as antimalarials Eur. J. Med. Chem. 45 2010 3245 3264
54. S. Kumar Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update Life Sci. 80 2007 813 828 (Pubitemid 46149853)
55. A. Mercer The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials Curr. Opin. Drug Discov. Devel. 12 2009 125 132
56. E. Kim Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells Neurol. Oncol. 12 2010 389 400
57. V. Solomon, and H. Lee Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies Eur. J. Pharmacol. 625 2009 220 233
58. P. O'Neill The molecular mechanism of action of artemisinin: the debate continues Molecules 15 2010 1705 1721
59. V. Kumar Synthetic medicinal chemistry of selected antimalarial natural products Bioorg. Med. Chem. 17 2009 2236 2275
60. A. Beekman Artemisinin-derived sesquiterpene lactones as potential antitumor compounds: cytotoxic action against bone marrow and tumor cells Planta Med. 64 1998 615 619 (Pubitemid 28481473)
61. M. Richardson Inhibition by doxycycline of angiogenesis in the chicken chorioallantoic membrane Cancer Chemother. Pharmacol. 56 2005 1 9 (Pubitemid 41201749)
62. J. Zhou Atovaquone derivatives as potent cytotoxic and apoptosis-inducing agents Bioorg. Med. Chem. Lett. 19 2009 5091 5094
63. F. Janku Autophagy as a target for anticancer therapy Rev. Clin. Oncol. 8 2011 528 539
64. R. Fujita Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine Methods Find. Exp. Clin. Pharmacol. 22 2000 281 284 (Pubitemid 30664413)
65. K. McKibbon How good are medline searches? Comp. Biomed. Res. 23 1990 583 593
66. R. Raffauf Antitumor plants B. Constituents of Cinchona pubescens Lloydia 41 1978 432 434
67. S. Jenks AACR highlights: promise for treating pancreatic cancer J. Natl. Cancer Inst. 103 2011 786 787
68. A. Munshi Chloroquine in glioblastoma: new horizons for an old drug Cancer 115 2009 2380 2383
69. M. Vingerhoeds Immunoliposomes in vivo ImmunoMethods 4 1995 259 272 (Pubitemid 24318709)
70. M. Bychkov Delagil treatment of tumorous pleurisy Voprosy Onkol. 24 1978 85 88 (Pubitemid 8285310)
71. C. Boyd 125I-labelled chloroquine analog in the diagnosis of ocular melanomas J. Nucl. Med. 12 1971 601 605
72. C. Boyd Diagnostic efficacy of a radioiodinated chloroquine analog in patients with malignant melanoma J. Nucl. Med. 8 1970 479 486
73. L. Rosa Cytotoxic, immunosuppressive, trypanocidal, and antileishmanial activities of Basidiomycota fungi present in Atlantic Rainforest of Brazil Antonie Van Leeuwenhock 95 2009 227 237
74. M. Baniecki High-throughput Plasmodium falciparum growth assay for malarial drug discovery Antimicrob. Agents Chemother. 51 2007 716 723 (Pubitemid 46185294)
75. A. Ghantous What made sesquiterpene lactones reach cancer clinical trials? Drug Discov. Today 15 2010 668 678
76. N. Singh Case report of a pituitary macroadenoma treated with artemether Integr. Cancer Ther. 5 2006 391 394 (Pubitemid 44722000)
77. N. Valecha Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India Malar. J. 8 2009 107
78. U. Martinez-Outschoorn Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors Cell Cycle 9 2010 2423 2433
79. P. Soubeyran A phase II study for the evaluation of quinine as a modulator of multidrug resistance in non-Hodgkin's lymphoma Eur. J. Cancer 43 2007 53 54 (Pubitemid 46054464)
80. C. Richards Antimicrobial and non-antimicrobial tetracyclines in human cancer trials Pharmacol. Res. 63 2011 151 156
81. M. Huie Phase II study of interferon-alpha and doxycycline for advanced renal cell carcinoma Invest. New Drugs 24 2006 255 260 (Pubitemid 43723901)