Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells

Marine Drugs

Volumn 9, Issue 10, 2011, Pages 1995-2009

  Huang, Tsui Chin ^a   Lee, Jheng Fong ^a   Chen, Jyh Yih ^a  

^a INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Antimicrobial peptide; Apoptosis; Pardaxin

Indexed keywords

CASPASE; CASPASE 3; CASPASE 7; PARDAXIN; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FIBROSARCOMA; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL;

PARDACHIRUS MARMORATUS;

EID: 80054881646     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md9101995     Document Type: Article

References (38)

1. Ellis, H.M.; Horvitz, H.R. Genetic control of programmed cell death in the nematode C. elegans. Cell 1986, 44, 817-829. (Pubitemid 16045328)
2. Hengartner, M.O.; Horvitz, H.R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994, 76, 665-676. (Pubitemid 24070651)
3. Miura, M.; Zhu, H.; Rotello, R.; Hartwieg, E.A.; Yuan, J. Induction of apoptosis in fibroblasts by IL-1 [beta]-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 1993, 75, 653-660. (Pubitemid 23346364)
4. Chinnaiyan, A.M.; O'Rourke, K.; Lane, B.R.; Dixit, V.M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 1997, 275, 1122-1126. (Pubitemid 27097310)
5. Riedl, S.J.; Salvesen, G.S. The apoptosome: signalling platform of cell death. Nat. Rev. Mol. Cell Biol. 2007, 8, 405-413. (Pubitemid 46643237)
6. Boatright, K.M.; Salvesen, G.S. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 2003, 15, 725-731. (Pubitemid 37492933)
7. Hockenbery, D.M.; Oltvai, Z.N.; Yin, X.M.; Milliman, C.L.; Korsmeyer, S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993, 75, 241-251. (Pubitemid 23320288)
8. Gross, A.; McDonnell, J.M.; Korsmeyer, S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999, 13, 1899-1911. (Pubitemid 29407357)
9. Buttke, T.M.; Sandstrom, P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today 1994, 15, 7-10.
10. Zou, H.; Li, Y.; Liu, X.; Wang, X. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 1999, 274, 11549-11556.
11. Chang, H.Y.; Yang, X. Proteases for cell suicide: functions and regulation of caspases. Microbiol. Mol. Biol. Rev. 2000, 64, 821-846. (Pubitemid 32475932)
12. Budihardjo, I.; Oliver, H.; Lutter, M.; Luo, X.; Wang, X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 1999, 15, 269-290. (Pubitemid 32250377)
13. Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516. (Pubitemid 46911891)
14. Kerr, J.F.R.; Winterford, C.M.; Harmon, B.V. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994, 73, 2013-2026. (Pubitemid 24107952)
15. Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415, 389-395. (Pubitemid 34100944)
16. Tossi, A.; Sandri, L. Molecular diversity in gene-encoded, cationic antimicrobial polypeptides. Curr. Pharm. Des. 2002, 8, 743-761. (Pubitemid 34498563)
17. Epand, R.M.; Vogel, H.J. Diversity of antimicrobial peptides and their mechanisms of action. Biochim. Biophys. Acta 1999,1462, 11-28.
18. Brogden, K.A. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 2005, 3, 238-250. (Pubitemid 40298223)
19. Mader, J.S.; Hoskin, D.W. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin. Investig. Drugs 2006, 15, 933-946. (Pubitemid 44177845)
20. Kim, Y.J.; Varki, A. Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconj. J. 1997, 14, 569-576. (Pubitemid 27353200)
21. Clark, E.; Chao, S. A toxic secretion from the Red Sea flatfish Pardachirus marmoratus(Lacepede). Sea Fish. Res. Sta. Haifa Bull. 1973, 60, 53-56.
22. Shai, Y.; Fox, J.; Caratsch, C.; Shih, Y.L.; Edwards, C.; Lazarovici, P. Sequencing and synthesis of pardaxin, a polypeptide from the Red Sea Moses sole with ionophore activity. FEBS Lett. 1988, 242, 161-166.
23. Lelkes, P.I.; Lazarovici, P. Pardaxin induces aggregation but not fusion of phosphatidylserine vesicles. FEBS Lett. 1988, 230, 131-136. (Pubitemid 18089757)
24. Pal, R.; Barenholz, Y.; Wagner, R.R. Pardaxin, a hydrophobic toxin of the Red Sea flatfish, disassembles the intact membrane of vesicular stomatitis virus. J. Biol. Chem. 1981, 256, 10209-10212. (Pubitemid 12219414)
25. Thennarasu, S.; Nagaraj, R. Specific antimicrobial and hemolytic activities of 18-residue peptides derived from the amino terminal region of the toxin pardaxin. Protein Eng. 1996, 9, 1219-1224.
26. Hsu, J.C.; Lin, L.C.; Tzen, J.T.C.; Chen, J.Y. Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells. Peptides 2011, 32, 1110-1116.
27. Orrenius, S. Reactive oxygen species in mitochondria-mediated cell death. Drug Metab. Rev. 2007, 39, 443-455. (Pubitemid 47355728)
28. Li, P.F.; Dietz, R.; von Harsdorf, R. P53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO J. 1999, 18, 6027-6036.
29. Andreu, D.; Rivas, L. Animal antimicrobial peptides: An overview. Biopolymers 1998, 47, 415-434.
30. Matsuzaki, K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim. Biophys. Acta 1999, 1462, 1-10.
31. Brugger, B.; Erben, G.; Sandhoff, R.; Wieland, F.; Lehmann, W. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc. Natl. Acad. Sci. USA 1997, 94, 2339-2344. (Pubitemid 27136876)
32. van Meer, G.; Voelker, D.R.; Feigenson, G.W. Membrane lipids: where they are and how they behave. Nat. Rev. Mol. Cell Biol. 2008, 9, 112-124. (Pubitemid 351158912)
33. Kavanagh, K.; Dowd, S. Histatins: Antimicrobial peptides with therapeutic potential. J. Pharm. Pharmacol. 2004, 56, 285-289. (Pubitemid 38380209)
34. Zughaier, S.M.; Shafer, W.M.; Stephens, D.S. Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages. Cell Microbiol. 2005, 7, 1251-1262. (Pubitemid 41179418)
35. Bloch-Shilderman, E.; Jiang, H.; Lazarovici, P. Pardaxin, an ionophore neurotoxin, induces PC12 cell death: activation of stress kinases and production of reactive oxygen species. J. Nat. Toxins 2002, 11, 71-85. (Pubitemid 34443704)
36. Matés, J.M.; Segura, J.A.; Alonso, F.J.; Márquez, J. Intracellular redox status and oxidative stress: Implications for cell proliferation, apoptosis, and carcinogenesis. Arch. Toxicol. 2008, 82, 273-299.
37. Armstrong, J.S.; Jones, D.P. Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J. 2002, 16, 1263-1265.
38. Reed, E. Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy. Cancer Treat. Rev. 1998, 24, 331-344. (Pubitemid 28537769)