Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39328-39335

  Zierler, Susanna ^a,c   Yao, Guangmin ^b,d   Zhang, Zheng ^a   Kuo, W Cedric ^b   Pörzgen, Peter ^b   Penner, Reinhold ^a   Horgen, F David ^b   Fleig, Andrea ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b HAWAII PACIFIC UNIVERSITY   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER THERAPEUTICS; CHEMICAL LIBRARIES; CYTOSOLIC; HUMAN CARCINOMA CELLS; ION CHANNEL; KEY REGULATORS; KINASE DOMAINS; LEUKEMIA CELLS; MAMMALIAN CELLS; SPECIFIC INHIBITORS; T CELLS; THERAPEUTIC POTENTIALS; TRANSIENT RECEPTOR POTENTIALS;

BINDING SITES; CELL PROLIFERATION; DISEASES; ENZYMES; GROWTH KINETICS; MAGNESIUM; MAMMALS; MARINE BIOLOGY;

CELLS;

CALCIUM ION; MAGNESIUM ION; NATURAL PRODUCT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; UNCLASSIFIED DRUG; WAIXENICIN A;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CURRENT; CELL PROLIFERATION; CONTROLLED STUDY; CORAL; DRUG ACTIVITY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; SARCOTHELIA EDMONDSONI;

ACETATES; ANIMALS; ANTHOZOA; BINDING SITES; CELL PROLIFERATION; DITERPENES; HEK293 CELLS; HUMANS; JURKAT CELLS; MAGNESIUM; MEMBRANE TRANSPORT MODULATORS; PROTEIN STRUCTURE, TERTIARY; RATS; TRPM CATION CHANNELS;

ALCYONACEA; MAMMALIA; RATTUS;

EID: 80655144731     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.264341     Document Type: Article

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