메뉴 건너뛰기




Volumn 44, Issue SUPPL. 19, 2009, Pages 136-141

Molecular targeted therapy for hepatocellular carcinoma

Author keywords

Chemotherapy; HCC; Hepatocellular carcinoma; Targeted therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CEDIRANIB; CETUXIMAB; CISPLATIN; CYTOTOXIC AGENT; DOXORUBICIN; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; GROWTH FACTOR; INTERFERON; LAPATINIB; MATRIX METALLOPROTEINASE; NOLATREXED; ONCOPROTEIN; OXALIPLATIN; PAZOPANIB; PLACEBO; PROTEINASE; RAPAMYCIN; SCATTER FACTOR; SORAFENIB; SUNITINIB; THALIDOMIDE; UFT; UNINDEXED DRUG;

EID: 58849136702     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-008-2252-z     Document Type: Article
Times cited : (89)

References (70)
  • 1
    • 0031048958 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials
    • Simonetti RG, Liberati A, Angiolini C, et al. Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials. Ann Oncol 1997;8:117-136.
    • (1997) Ann Oncol , vol.8 , pp. 117-136
    • Simonetti, R.G.1    Liberati, A.2    Angiolini, C.3
  • 2
    • 0034100195 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response
    • Ng IO, Liu CL, Fan ST, et al. Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response. Am J Clin Pathol 2000;113:355-363.
    • (2000) Am J Clin Pathol , vol.113 , pp. 355-363
    • Ng, I.O.1    Liu, C.L.2    Fan, S.T.3
  • 3
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoproteinmediated drug resistance
    • Endicott JA, Ling V. The biochemistry of P-glycoproteinmediated drug resistance. Annu Rev Biochem 1989;58:137-171.
    • (1989) Annu Rev Biochem , vol.58 , pp. 137-171
    • Endicott, J.A.1    Ling, V.2
  • 4
    • 0028334832 scopus 로고
    • MDR1 gene expression: Its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines
    • Park JG, Lee SK, Hong IG, et al. MDR1 gene expression: Its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. J Natl Cancer Inst 1994;86:700-705.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 700-705
    • Park, J.G.1    Lee, S.K.2    Hong, I.G.3
  • 5
    • 34447631489 scopus 로고    scopus 로고
    • Riboregulator H19 induction of MDR1-associated drug resistance in human hepatocellular carcinoma cells
    • Tsang WP, Kwok TT. Riboregulator H19 induction of MDR1-associated drug resistance in human hepatocellular carcinoma cells. Oncogene 2007;26:4877-4881.
    • (2007) Oncogene , vol.26 , pp. 4877-4881
    • Tsang, W.P.1    Kwok, T.T.2
  • 6
    • 2542424899 scopus 로고    scopus 로고
    • Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line
    • Chan KT, Lung ML. Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line. Cancer Chemother Pharmacol 2004;53:519-526.
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 519-526
    • Chan, K.T.1    Lung, M.L.2
  • 7
    • 33645092643 scopus 로고    scopus 로고
    • Hepatocyte growth factor and inducible nitric oxide synthase are involved in multidrug resistance-induced angiogenesis in hepatocellular carcinoma cell lines
    • Lasagna N, Fantappie O, Solazzo M, et al. Hepatocyte growth factor and inducible nitric oxide synthase are involved in multidrug resistance-induced angiogenesis in hepatocellular carcinoma cell lines. Cancer Res 2006;66:2673-2682.
    • (2006) Cancer Res , vol.66 , pp. 2673-2682
    • Lasagna, N.1    Fantappie, O.2    Solazzo, M.3
  • 8
    • 31344462626 scopus 로고    scopus 로고
    • Involvement of hypoxia-inducible factor-1-alpha in multidrug resistance induced by hypoxia in HepG2 cells
    • Zhu H, Chen XP, Luo SF, et al. Involvement of hypoxia-inducible factor-1-alpha in multidrug resistance induced by hypoxia in HepG2 cells. J Exp Clin Cancer Res 2005;24:565-574.
    • (2005) J Exp Clin Cancer Res , vol.24 , pp. 565-574
    • Zhu, H.1    Chen, X.P.2    Luo, S.F.3
  • 9
    • 0035845016 scopus 로고    scopus 로고
    • Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha
    • Okada Y, Tosaka A, Nimura Y, et al. Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha. Gene (Amst) 2001;272:141-148.
    • (2001) Gene (Amst) , vol.272 , pp. 141-148
    • Okada, Y.1    Tosaka, A.2    Nimura, Y.3
  • 10
    • 0036327669 scopus 로고    scopus 로고
    • Prognostic significance of DNA topoisomerase II alpha expression in human hepatocellular carcinoma
    • Watanuki A, Ohwada S, Fukusato T, et al. Prognostic significance of DNA topoisomerase II alpha expression in human hepatocellular carcinoma. Anticancer Res 2002;22:1113-1119.
    • (2002) Anticancer Res , vol.22 , pp. 1113-1119
    • Watanuki, A.1    Ohwada, S.2    Fukusato, T.3
  • 11
    • 0033087904 scopus 로고    scopus 로고
    • Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: Relationship to cell proliferation
    • Hisaka T, Yano H, Haramaki M, et al. Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: relationship to cell proliferation. Int J Oncol 1999;14:453-460.
    • (1999) Int J Oncol , vol.14 , pp. 453-460
    • Hisaka, T.1    Yano, H.2    Haramaki, M.3
  • 12
    • 0026267171 scopus 로고
    • Growth factors in liver development, regeneration and carcinogenesis
    • Fausto N. Growth factors in liver development, regeneration and carcinogenesis. Prog Growth Factor Res 1991;3:219-234.
    • (1991) Prog Growth Factor Res , vol.3 , pp. 219-234
    • Fausto, N.1
  • 13
    • 9644255742 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
    • Hopfner M, Sutter AP, Huether A, et al. Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. J Hepatol 41:1008-1016, 2004.
    • (2004) J Hepatol , vol.41 , pp. 1008-1016
    • Hopfner, M.1    Sutter, A.P.2    Huether, A.3
  • 14
    • 24344489502 scopus 로고    scopus 로고
    • Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics
    • Huether A, Hopfner M, Sutter AP, et al. Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics. J Hepatol 2005;43:661-669.
    • (2005) J Hepatol , vol.43 , pp. 661-669
    • Huether, A.1    Hopfner, M.2    Sutter, A.P.3
  • 15
    • 34548150925 scopus 로고    scopus 로고
    • Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    • Thomas MB, Chadha R, Glover K, et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer (Phila) 2007;110:1059-1067.
    • (2007) Cancer (Phila) , vol.110 , pp. 1059-1067
    • Thomas, M.B.1    Chadha, R.2    Glover, K.3
  • 16
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip PA, Mahoney MR, Allmer C, et al. Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005;23:6657-6663.
    • (2005) J Clin Oncol , vol.23 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 17
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 18
    • 0004623809 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
    • Park YN, Kim YB, Yang KM, et al. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 2000;124:1061-1065.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 1061-1065
    • Park, Y.N.1    Kim, Y.B.2    Yang, K.M.3
  • 19
    • 0037833529 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in serum of patients with hepatocellular carcinoma
    • Zhao J, Hu J, Cai J, et al. Vascular endothelial growth factor expression in serum of patients with hepatocellular carcinoma. Chin Med J (Engl) 2003;116:772-776.
    • (2003) Chin Med J (Engl) , vol.116 , pp. 772-776
    • Zhao, J.1    Hu, J.2    Cai, J.3
  • 20
    • 17144364359 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival
    • Huang GW, Yang LY, Lu WQ. Expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor in hepatocellular carcinoma: impact on neovascularization and survival. World J Gastroenterol 2005;11:1705-1708.
    • (2005) World J Gastroenterol , vol.11 , pp. 1705-1708
    • Huang, G.W.1    Yang, L.Y.2    Lu, W.Q.3
  • 21
    • 16644364559 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: Correlation with angiographically assisted CT
    • Kanematsu M, Osada S, Amaoka N, et al. Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: Correlation with angiographically assisted CT. AJR Am J Roentgenol 2004;183:1585-1593.
    • (2004) AJR Am J Roentgenol , vol.183 , pp. 1585-1593
    • Kanematsu, M.1    Osada, S.2    Amaoka, N.3
  • 22
    • 31944434717 scopus 로고    scopus 로고
    • Magnetic resonance imaging and expression of vascular endothelial growth factor in hepatocellular nodules in cirrhosis and hepatocellular carcinomas
    • Kanematsu M, Semelka RC, Osada S, et al. Magnetic resonance imaging and expression of vascular endothelial growth factor in hepatocellular nodules in cirrhosis and hepatocellular carcinomas. Top Magn Reson Imaging 2005;16:67-75.
    • (2005) Top Magn Reson Imaging , vol.16 , pp. 67-75
    • Kanematsu, M.1    Semelka, R.C.2    Osada, S.3
  • 23
    • 26044455743 scopus 로고    scopus 로고
    • Correlative study of angiogenesis and dynamic contrast-enhanced magnetic resonance imaging features of hepatocellular carcinoma
    • Wang B, Gao ZQ, Yan X. Correlative study of angiogenesis and dynamic contrast-enhanced magnetic resonance imaging features of hepatocellular carcinoma. Acta Radiol 2005;46:353-358.
    • (2005) Acta Radiol , vol.46 , pp. 353-358
    • Wang, B.1    Gao, Z.Q.2    Yan, X.3
  • 25
    • 0031171663 scopus 로고    scopus 로고
    • Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
    • Kenyon BM, Browne F, D'Amato RJ. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res 1997;64:971-978.
    • (1997) Exp Eye Res , vol.64 , pp. 971-978
    • Kenyon, B.M.1    Browne, F.2    D'Amato, R.J.3
  • 26
    • 2942711726 scopus 로고    scopus 로고
    • Thalidomid: Current role in the treatment of non-plasma cell malignancies
    • Kumar S, Witzig TE, Rajkumar SV. Thalidomid: Current role in the treatment of non-plasma cell malignancies. J Clin Oncol 2004;22:2477-2488.
    • (2004) J Clin Oncol , vol.22 , pp. 2477-2488
    • Kumar, S.1    Witzig, T.E.2    Rajkumar, S.V.3
  • 27
    • 0344305652 scopus 로고    scopus 로고
    • Low-dose thalidomide treatment for advanced hepatocellular carcinoma
    • Hsu C, Chen CN, Chen LT, et al. Low-dose thalidomide treatment for advanced hepatocellular carcinoma. Oncology 2003;65:242-249.
    • (2003) Oncology , vol.65 , pp. 242-249
    • Hsu, C.1    Chen, C.N.2    Chen, L.T.3
  • 28
    • 1542790477 scopus 로고    scopus 로고
    • Salvage therapy for hepatocellular carcinoma with thalidomide
    • Wang TE, Kao CR, Lin SC, et al. Salvage therapy for hepatocellular carcinoma with thalidomide. World J Gastroenterol 2004;10:649-653.
    • (2004) World J Gastroenterol , vol.10 , pp. 649-653
    • Wang, T.E.1    Kao, C.R.2    Lin, S.C.3
  • 29
    • 10844248554 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma
    • Lin AY, Brophy N, Fisher GA, et al. Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma. Cancer (Phila) 2005;103:119-125.
    • (2005) Cancer (Phila) , vol.103 , pp. 119-125
    • Lin, A.Y.1    Brophy, N.2    Fisher, G.A.3
  • 30
    • 13444303839 scopus 로고    scopus 로고
    • Thalidomide in the treatment of patients with hepatocellular carcinoma: A phase II trial
    • Patt YZ, Hassan MM, Lozano RD, et al. Thalidomide in the treatment of patients with hepatocellular carcinoma: A phase II trial. Cancer (Phila) 2005;103:749-755.
    • (2005) Cancer (Phila) , vol.103 , pp. 749-755
    • Patt, Y.Z.1    Hassan, M.M.2    Lozano, R.D.3
  • 31
    • 27644485445 scopus 로고    scopus 로고
    • Thalidomide in advanced hepatocellular carcinoma with optional low-dose interferonalpha2a upon progression
    • Schwartz JD, Sung M, Schwartz M, et al. Thalidomide in advanced hepatocellular carcinoma with optional low-dose interferonalpha2a upon progression. Oncologist 2005;10:718-727.
    • (2005) Oncologist , vol.10 , pp. 718-727
    • Schwartz, J.D.1    Sung, M.2    Schwartz, M.3
  • 32
    • 33746624000 scopus 로고    scopus 로고
    • Systemic therapy of advanced hepatocellular carcinoma: How hopeful should we be?
    • Zhu AX. Systemic therapy of advanced hepatocellular carcinoma: How hopeful should we be? Oncologist 2006;11:790-800.
    • (2006) Oncologist , vol.11 , pp. 790-800
    • Zhu, A.X.1
  • 33
    • 22244436300 scopus 로고    scopus 로고
    • A phase II study of epirubicin and thalidomide in unresectable or metastatic hepatocellular carcinoma
    • Zhu AX, Fuchs CS, Clark JW, et al. A phase II study of epirubicin and thalidomide in unresectable or metastatic hepatocellular carcinoma. Oncologist 2005;10:392-398.
    • (2005) Oncologist , vol.10 , pp. 392-398
    • Zhu, A.X.1    Fuchs, C.S.2    Clark, J.W.3
  • 36
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006;24:4293-4300.
    • (2006) J Clin Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 37
    • 34548720158 scopus 로고    scopus 로고
    • Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): Results of a Phase III randomized placebo-controlled trial (SHARP trial)
    • Llovet J, Ricci S, et al. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): Results of a Phase III randomized placebo-controlled trial (SHARP trial). ASCO Annual Meeting Proceedings, Part I. J Clin Oncol 25:ABA1.
    • ASCO Annual Meeting Proceedings, Part I. J Clin Oncol , vol.25
    • Llovet, J.1    Ricci, S.2
  • 38
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med 2001;7:987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 39
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004;10:145-147.
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3
  • 40
    • 33750917456 scopus 로고    scopus 로고
    • Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein
    • Schwartz MS, Lehrer D, Cohen E, Sung M, Kinkhabwala M, Siegel A, et al. Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein. ASCO Annual Meeting Proceedings. J Clin Oncol 2006;24(18 suppl):A4144.
    • (2006) ASCO Annual Meeting Proceedings. J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Schwartz, M.S.1    Lehrer, D.2    Cohen, E.3    Sung, M.4    Kinkhabwala, M.5    Siegel, A.6
  • 41
    • 38049092474 scopus 로고    scopus 로고
    • Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): Preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring
    • Malka D, Dromain C, Farace F, et al. Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): Preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring. ASCO Annual Proceedings, Part I. J Clin Oncol 2007;25:A4570.
    • (2007) ASCO Annual Proceedings, Part I. J Clin Oncol , vol.25
    • Malka, D.1    Dromain, C.2    Farace, F.3
  • 42
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP, et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006;24:1898-1903.
    • (2006) J Clin Oncol , vol.24 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 43
    • 42049095494 scopus 로고    scopus 로고
    • Modified-dose capecitabine + bevacizumab for the treatment of advanced/ metastatic hepatocellular carcinoma (HCC): A phase II, single-arm study
    • Hsu C, Hsu C, Yang T, et al. Modified-dose capecitabine + bevacizumab for the treatment of advanced/metastatic hepatocellular carcinoma (HCC): a phase II, single-arm study. ASCO Annual Proceedings, Part I. J Clin Oncol 2007;25:A15190.
    • (2007) ASCO Annual Proceedings, Part I. J Clin Oncol , vol.25
    • Hsu, C.1    Hsu, C.2    Yang, T.3
  • 44
    • 36549089272 scopus 로고    scopus 로고
    • Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): A phase II study
    • Sun W, Haller DG, Mykulowycz K, et al. Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): A phase II study. ASCO Annual Proceedings, Part I. J Clin Oncol 2007;25:A4574.
    • (2007) ASCO Annual Proceedings, Part I. J Clin Oncol , vol.25
    • Sun, W.1    Haller, D.G.2    Mykulowycz, K.3
  • 45
    • 36549072713 scopus 로고    scopus 로고
    • The combination of bevacizumab (B) and erlotinib (E) shows significant biological activity in patients with advanced hepatocellular carcinoma
    • Thomas MB, Chadha R, Iwasaki M, et al. The combination of bevacizumab (B) and erlotinib (E) shows significant biological activity in patients with advanced hepatocellular carcinoma. ASCO Annual Proceedings, Part I. J Clin Oncol 2007;25:A4567.
    • (2007) ASCO Annual Proceedings, Part I. J Clin Oncol , vol.25
    • Thomas, M.B.1    Chadha, R.2    Iwasaki, M.3
  • 46
    • 27644508837 scopus 로고    scopus 로고
    • Resveratrol inhibits hypoxiainduced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
    • Zhang Q, Tang X, Lu QY, et al. Resveratrol inhibits hypoxiainduced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol Cancer Ther 2005;4:1465-1474.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1465-1474
    • Zhang, Q.1    Tang, X.2    Lu, Q.Y.3
  • 47
    • 23844470405 scopus 로고    scopus 로고
    • Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization
    • Okano H, Shiraki K, Yamanaka Y, et al. Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization. World J Gastroenterol 2005;11:4650-4654.
    • (2005) World J Gastroenterol , vol.11 , pp. 4650-4654
    • Okano, H.1    Shiraki, K.2    Yamanaka, Y.3
  • 48
    • 0032878376 scopus 로고    scopus 로고
    • Increased activity and expression of MAP kinase in HCC model rats induced by 3′-methyl-4-dimethylamino-azobenzene
    • Toyoda M, Hashimoto N, Tokita K, et al. Increased activity and expression of MAP kinase in HCC model rats induced by 3′-methyl-4-dimethylamino-azobenzene. J Hepatol 1999;31:725-733.
    • (1999) J Hepatol , vol.31 , pp. 725-733
    • Toyoda, M.1    Hashimoto, N.2    Tokita, K.3
  • 49
    • 0030715557 scopus 로고    scopus 로고
    • Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma
    • McKillop IH, Schmidt CM, Cahill PA, et al. Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. Hepatology 1997;26:1484-1491.
    • (1997) Hepatology , vol.26 , pp. 1484-1491
    • McKillop, I.H.1    Schmidt, C.M.2    Cahill, P.A.3
  • 50
    • 17344372847 scopus 로고    scopus 로고
    • Activation of mitogenactivated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
    • Ito Y, Sasaki Y, Horimoto M, et al. Activation of mitogenactivated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 1998;27:951-958.
    • (1998) Hepatology , vol.27 , pp. 951-958
    • Ito, Y.1    Sasaki, Y.2    Horimoto, M.3
  • 51
    • 0035113393 scopus 로고    scopus 로고
    • Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance
    • Feng DY, Zheng H, Tan Y, et al. Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance. World J Gastroenterol 2001;7:33-36.
    • (2001) World J Gastroenterol , vol.7 , pp. 33-36
    • Feng, D.Y.1    Zheng, H.2    Tan, Y.3
  • 52
    • 20344404979 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent
    • Carloni V, Vizzutti F, Pantaleo P. Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent. Clin Cancer Res 2005;11:4266-4274.
    • (2005) Clin Cancer Res , vol.11 , pp. 4266-4274
    • Carloni, V.1    Vizzutti, F.2    Pantaleo, P.3
  • 53
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 54
    • 34247606468 scopus 로고    scopus 로고
    • Pleiotropic effects of PI-3′ kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis
    • Alexia C, Bras M, Fallot G, et al. Pleiotropic effects of PI-3′ kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis. Ann N Y Acad Sci 2006;1090:1-17.
    • (2006) Ann N Y Acad Sci , vol.1090 , pp. 1-17
    • Alexia, C.1    Bras, M.2    Fallot, G.3
  • 55
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • Saxena NK, Sharma D, Ding X, et al. Concomitant activation of the JAK/ STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007;67:2497-2507.
    • (2007) Cancer Res , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3
  • 56
    • 23944480924 scopus 로고    scopus 로고
    • Treating cancer by blocking cell signals
    • Adjei AA, Hidalgo M. Treating cancer by blocking cell signals. J Clin Oncol 2005;23:5279-5280.
    • (2005) J Clin Oncol , vol.23 , pp. 5279-5280
    • Adjei, A.A.1    Hidalgo, M.2
  • 57
    • 11144236505 scopus 로고    scopus 로고
    • mTOR and P70 S6 kinase expression in primary liver neoplasms
    • Sahin F, Kannangai R, Adegbola O, et al. mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004;10:8421-8425.
    • (2004) Clin Cancer Res , vol.10 , pp. 8421-8425
    • Sahin, F.1    Kannangai, R.2    Adegbola, O.3
  • 58
    • 33947501692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
    • Sieghart W, Fuereder T, Schmid K, et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 2007;83:425-432.
    • (2007) Transplantation , vol.83 , pp. 425-432
    • Sieghart, W.1    Fuereder, T.2    Schmid, K.3
  • 59
    • 27144557565 scopus 로고    scopus 로고
    • A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
    • Yeo W, Mok TS, Zee B, et al. A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst 2005;97:1532-1538.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1532-1538
    • Yeo, W.1    Mok, T.S.2    Zee, B.3
  • 60
    • 0032798501 scopus 로고    scopus 로고
    • A multi-centre randomized phase II study of nolatrexed versus doxorubicin in treatment of Chinese patients with advanced hepatocellular carcinoma
    • Mok TS, Leung TW, Lee SD, et al. A multi-centre randomized phase II study of nolatrexed versus doxorubicin in treatment of Chinese patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol 1999;44:307-311.
    • (1999) Cancer Chemother Pharmacol , vol.44 , pp. 307-311
    • Mok, T.S.1    Leung, T.W.2    Lee, S.D.3
  • 61
    • 33646575196 scopus 로고    scopus 로고
    • Results of a phase 2/3 open-label, randomized trial of T138067 versus doxorubicin (DOX) in chemotherapy-naïve, unresectable hepatocellular carcinoma (HCC)
    • Posey JJP, Mok T, et al. Results of a phase 2/3 open-label, randomized trial of T138067 versus doxorubicin (DOX) in chemotherapy-naïve, unresectable hepatocellular carcinoma (HCC). J Clin Oncol 2005;23(suppl):4035.
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL. , pp. 4035
    • Posey, J.J.P.1    Mok, T.2
  • 62
    • 34547662913 scopus 로고    scopus 로고
    • Phase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicin
    • Gish RG, Porta C, Lazar L, et al. Phase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicin. J Clin Oncol 2007;25:3069-3075.
    • (2007) J Clin Oncol , vol.25 , pp. 3069-3075
    • Gish, R.G.1    Porta, C.2    Lazar, L.3
  • 63
    • 40549098471 scopus 로고    scopus 로고
    • A phase II study of pegylated liposomial doxorubicin (PLD) and gemcitabine (G) in the treatment of hepatocellular carcinoma (HCC) not suitable for locoregional therapy
    • Pastorelli DCG, Zustovich F, et al. A phase II study of pegylated liposomial doxorubicin (PLD) and gemcitabine (G) in the treatment of hepatocellular carcinoma (HCC) not suitable for locoregional therapy. J Clin Oncol 2007;25(suppl):4585.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. , pp. 4585
    • Pastorelli, D.C.G.1    Zustovich, F.2
  • 64
    • 36549072713 scopus 로고    scopus 로고
    • The combination of bevacizumab (B) and erlotinib (E) shows significant biological activity in patients with advanced hepatocellular carcinoma (HCC)
    • Thomas MBCR, Iwasaki M, et al. The combination of bevacizumab (B) and erlotinib (E) shows significant biological activity in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2007;25(suppl):4567.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. , pp. 4567
    • Thomas, M.B.C.R.1    Iwasaki, M.2
  • 65
    • 33750915657 scopus 로고    scopus 로고
    • Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial
    • Ramanathan CPB, Singh DA, et al. Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J Clin Oncol 2006;24(18 suppl):4010.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL. , pp. 4010
    • Ramanathan, C.P.B.1    Singh, D.A.2
  • 66
    • 58849086599 scopus 로고    scopus 로고
    • A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma
    • Gruenwald LW, Gebel M, et al. A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma. J Clin Oncol 2006;24(18 suppl):14079.
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL. , pp. 14079
    • Gruenwald, L.W.1    Gebel, M.2
  • 67
    • 33750928591 scopus 로고    scopus 로고
    • Phase II study of cetuximab in patients with unresectable or metastatic hepatocellular carcinoma
    • Zhu AXBL, Enzinger PC, et al. Phase II study of cetuximab in patients with unresectable or metastatic hepatocellular carcinoma. J Clin Oncol 2006;24(suppl):14096.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. , pp. 14096
    • Zhu, A.X.B.L.1    Enzinger, P.C.2
  • 68
    • 33750929534 scopus 로고    scopus 로고
    • Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group' Study E1203
    • O'Dwyer PJGB, Levy DE, et al. Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's Study E1203. J Clin Oncol 2006;24(suppl):4143.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. , pp. 4143
    • O'Dwyer, P.J.G.B.1    Levy, D.E.2
  • 69
    • 36549089272 scopus 로고    scopus 로고
    • Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): A phase II study
    • Sun WHD, Mykulowycz K, et al. Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): A phase II study. J Clin Oncol 2007;25(suppl):4574.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. , pp. 4574
    • Sun, W.H.D.1    Mykulowycz, K.2
  • 70
    • 33947495362 scopus 로고    scopus 로고
    • Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC): Results of a phase II study
    • Louafi S, Boige V, Ducreux M, et al. Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC): results of a phase II study. Cancer (Phila) 2007;109:1384-1390.
    • (2007) Cancer (Phila) , vol.109 , pp. 1384-1390
    • Louafi, S.1    Boige, V.2    Ducreux, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.