Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: Application of N-Heterocyclic carbene mediated acylations in complex molecule synthesis

Journal of Organic Chemistry

Volumn 76, Issue 4, 2011, Pages 1140-1150

  Wang, Bo ^a   Huang, Po Hsien ^a   Chen, Ching Shih ^a   Forsyth, Craig J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATIONS; AMIDATION; BIOLOGICAL EVALUATION; BUILDING BLOCKES; CLASS I; COMPLEX MOLECULES; DOSE-DEPENDENT; HISTONE DEACETYLASE INHIBITOR; HISTONE DEACETYLASES; HISTONE H3; IN-CELL; MACROLACTONIZATION; N-HETEROCYCLIC CARBENES; NATURAL PRODUCTS; POTENT ACTIVITY; PROSTATE CANCER CELLS; PROTECTING GROUP; STEREOCENTERS; STRUCTURAL DOMAINS; TETRAPEPTIDE; THIAZOLINE; THIOESTERS; TOTAL SYNTHESIS;

ACETYLATION; ALDEHYDES; AMINO ACIDS; CARBON INORGANIC COMPOUNDS; CELL CULTURE; DISEASES; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

2 EPI LARGAZOLE; CARBENE; HETEROCYCLIC COMPOUND; HISTONE DEACETYLASE INHIBITOR; HISTONE H1; HISTONE H3; LARGAZOLE; UNCLASSIFIED DRUG; VALINE;

ACYLATION; ARTICLE; BIOLOGICAL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ESTERIFICATION; HUMAN; HUMAN CELL; MACROLACTONIZATION; MALE; MOLECULE;

ACYLATION; BIOLOGICAL AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HISTONE DEACETYLASE INHIBITORS; HUMANS; MALE; METHANE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 79951632653     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo102478x     Document Type: Article

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