Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation

Journal of Medicinal Chemistry

Volumn 54, Issue 21, 2011, Pages 7453-7463

  Bhansali, Pravin ^a   Hanigan, Christin L ^b   Casero, Robert A ^b   Tillekeratne, L M Viranga ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; LARGAZOLE; LARGAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHELATION; CHEMICAL REACTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING;

ACETYLATION; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL PROLIFERATION; CHELATING AGENTS; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; ISOENZYMES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; ZINC;

EID: 80455162618     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200432a     Document Type: Article

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