Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges

Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2001, Pages 873-885

  Wright, A D ^a   Wang, H ^b   Gurrath, M ^c   Konig G M ^a   Kocak, G ^b   Neumann, G ^b   Loria, P ^b   Foley, M ^b   Tilley, L ^b  

^a UNIVERSITY OF BONN   (Germany)

^b LA TROBE UNIVERSITY   (Australia)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7 ISOCYANO 15 ISOTHIOCYANATOAMPHILECTA 11(20) ENE; 7 ISOCYANOAMPHILECTA 11(20),15 DIENE; AXISONITRILE 3; DIISOCYANOADOCIANE; HEME DERIVATIVE; ISONITRILE DERIVATIVE; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DETOXIFICATION; DRUG ISOLATION; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SPONGE (PORIFERA);

ANIMALS; ANTIMALARIALS; HEME; HEMEPROTEINS; MASS SPECTROMETRY; MODELS, MOLECULAR; NITRILES; OCEANS AND SEAS; PORIFERA; PYRENES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPIRO COMPOUNDS; TERPENES;

EID: 0035866625     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0010724     Document Type: Article

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