Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities

Chemistry - A European Journal

Volumn 12, Issue 29, 2006, Pages 7615-7626

  Dawei, Ma ^a   Zou, Bin ^a   Cai, Guorong ^b   Hu, Xiaoyi ^c   Liu, Jun O ^c  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b FUDAN UNIVERSITY   (China)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aldol reaction; Cell cycle; Cyclic depsipeptides; Cylotoxlcity; Total synthesis

Indexed keywords

ALDOL REACTION; CELL CYCLE; CYCLIC DEPSIPEPTIDES; CYLOTOXICITY; TOTAL SYNTHESIS;

CELLS; REACTION KINETICS; SYNTHESIS (CHEMICAL); TOXICITY;

TOXIC MATERIALS;

ANTINEOPLASTIC AGENT; APRATOXIN A; BACTERIAL TOXIN; CYCLOPEPTIDE; DEPSIPEPTIDE; OXAZOLE DERIVATIVE;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; DRUG EFFECT; HELA CELL; HUMAN; METHYLATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BACTERIAL TOXINS; CELL CYCLE; CELL PROLIFERATION; DEPSIPEPTIDES; G1 PHASE; HELA CELLS; HUMANS; METHYLATION; OXAZOLES; PEPTIDES, CYCLIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750012824     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200600599     Document Type: Article

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