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Volumn 16, Issue 7, 2011, Pages 5629-5646

A survey of marine natural compounds and their derivatives with anti-Cancer activity reported in 2010

Author keywords

Cancer; Marine anticancer compounds; Natural analogues; Synthetic derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; PLANT MEDICINAL PRODUCT;

EID: 79960812511     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16075629     Document Type: Review
Times cited : (36)

References (102)
  • 1
    • 84856975606 scopus 로고    scopus 로고
    • WHO. accessed on 20 March 2011
    • WHO. Fact Sheet No297. Available online: http://www.who.int/mediacentre/ factsheets/fs297/en/ (accessed on 20 March 2011).
    • Fact Sheet , Issue.297
  • 2
    • 77955505177 scopus 로고    scopus 로고
    • A review of trabectedin (ET-743): A unique mechanism of action
    • D'Incalci, M.; Galmarini, C.M. A review of trabectedin (ET-743): A unique mechanism of action. Mol. Cancer Ther. 2010, 9, 2157-2163.
    • (2010) Mol. Cancer Ther , vol.9 , pp. 2157-2163
    • D'Incalci, M.1    Galmarini, C.M.2
  • 3
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • DOI 10.1021/np068054v
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 2007, 70, 461-477. (Pubitemid 46595760)
    • (2007) Journal of Natural Products , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 4
    • 77957374075 scopus 로고    scopus 로고
    • Microtubule-binding agents: A dynamic field of cancer therapeutics
    • Dumontet, C.; Jordan, M.A. Microtubule-binding agents: A dynamic field of cancer therapeutics. Nat. Rev. Drug Discov. 2010, 9, 790-803.
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 790-803
    • Dumontet, C.1    Jordan, M.A.2
  • 6
    • 77952189751 scopus 로고    scopus 로고
    • Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders
    • Villa, F.A.; Gerwick, L. Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders. Immunopharmacol. Immunotoxicol. 2010, 32, 228-237.
    • (2010) Immunopharmacol. Immunotoxicol , vol.32 , pp. 228-237
    • Villa, F.A.1    Gerwick, L.2
  • 8
    • 78649907427 scopus 로고    scopus 로고
    • Photosynthetic marine organisms as a source of anticancer compounds
    • Folmer, F.; Jaspars, M.; Dicato, M.; Diederich, M. Photosynthetic marine organisms as a source of anticancer compounds. Phytochem. Rev. 2010, 9, 557-479.
    • (2010) Phytochem. Rev , vol.9 , pp. 557-479
    • Folmer, F.1    Jaspars, M.2    Dicato, M.3    Diederich, M.4
  • 9
    • 0025248103 scopus 로고
    • Some marine ecological phenomena: Chemical basis and biomedical potential
    • Scheuer, P.J. Some marine ecological phenomena: Chemical basis and biomedical potential. Science 1990, 248, 173-177.
    • (1990) Science , vol.248 , pp. 173-177
    • Scheuer, P.J.1
  • 12
    • 77957774472 scopus 로고    scopus 로고
    • Marine biodiversity in the australian region
    • Butler, A.J.; Rees, T.; Beesley, P.; Bax, N.J. Marine biodiversity in the Australian region. PLoS One 2010, 5, e11831.
    • (2010) PLoS One , vol.5
    • Butler, A.J.1    Rees, T.2    Beesley, P.3    Bax, N.J.4
  • 13
    • 84856970429 scopus 로고    scopus 로고
    • accessed on 20 March
    • Census of marine life. Available online: http://www.coml.org/about- census/ (accessed on 20 March 2011).
    • (2011) Census of Marine Life
  • 16
    • 33744537000 scopus 로고    scopus 로고
    • Combinatorial biosynthesis-Potential and problems
    • DOI 10.1016/j.jbiotec.2005.12.001, PII S0168165605007558
    • Floss, H.G. Combinatorial biosynthesis-Potential and problems. J. Biotechnol. 2006, 124, 242-257. (Pubitemid 43816127)
    • (2006) Journal of Biotechnology , vol.124 , Issue.1 , pp. 242-257
    • Floss, H.G.1
  • 17
    • 79955553260 scopus 로고    scopus 로고
    • Organic synthesis toward small-molecule probes and drugs special feature: Design, syn thesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity
    • Wender, P.A.; Baryza, J.L.; Brenner, S.E.; Dechristopher, B.A.; Loy, B.A.; Schrier, A.J.; Verma, V.A. Organic synthesis toward small-molecule probes and drugs special feature: Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity. Proc. Natl. Acad. Sci. USA 2011, 108, 6721-6726.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 6721-6726
    • Wender, P.A.1    Baryza, J.L.2    Brenner, S.E.3    Dechristopher, B.A.4    Loy, B.A.5    Schrier, A.J.6    Verma, V.A.7
  • 18
    • 67650527061 scopus 로고    scopus 로고
    • Synthesis at the molecular frontier
    • Wender, P.A.; Miller, B.L. Synthesis at the molecular frontier. Nature 2009, 460, 197-201.
    • (2009) Nature , vol.460 , pp. 197-201
    • Wender, P.A.1    Miller, B.L.2
  • 19
    • 77952495893 scopus 로고    scopus 로고
    • Development of novel drugs from marine surface associated microorganisms
    • Penesyan, A.; Kjelleberg, S.; Egan, S. Development of novel drugs from marine surface associated microorganisms. Mar. Drugs 2010, 8, 438-459.
    • (2010) Mar. Drugs , vol.8 , pp. 438-459
    • Penesyan, A.1    Kjelleberg, S.2    Egan, S.3
  • 20
    • 77649213543 scopus 로고    scopus 로고
    • Bioactive sesterterpenes and triterpenes from marine sponges: Occurrence and pharmacological significance
    • Ebada, S.S.; Lin, W.; Proksch, P. Bioactive sesterterpenes and triterpenes from marine sponges: Occurrence and pharmacological significance. Mar. Drugs 2010, 8, 313-346.
    • (2010) Mar. Drugs , vol.8 , pp. 313-346
    • Ebada, S.S.1    Lin, W.2    Proksch, P.3
  • 21
    • 77953485046 scopus 로고    scopus 로고
    • Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources
    • Lin, X.; Liu, M.; Hu, C.; Liao, D.J. Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources. Curr. Drug Targets 2010, 11, 708-715.
    • (2010) Curr. Drug Targets , vol.11 , pp. 708-715
    • Lin, X.1    Liu, M.2    Hu, C.3    Liao, D.J.4
  • 23
    • 79960802666 scopus 로고    scopus 로고
    • Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer
    • doi:10.1016/j.biotechadv.2011.02.002
    • Schumacher, M.; Kelkel, M.; Dicato, M.; Diederich, M. Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer. Biotechnol. Adv. 2011, doi:10.1016/j.biotechadv.2011.02.002.
    • (2011) Biotechnol. Adv
    • Schumacher, M.1    Kelkel, M.2    Dicato, M.3    Diederich, M.4
  • 25
    • 37849022679 scopus 로고    scopus 로고
    • Marine natural products as targeted modulators of the transcription factor NF-kappaB
    • Folmer, F.; Jaspars, M.; Dicato, M.; Diederich, M. Marine natural products as targeted modulators of the transcription factor NF-kappaB. Biochem. Pharmacol. 2008, 75, 603-617.
    • (2008) Biochem. Pharmacol , vol.75 , pp. 603-617
    • Folmer, F.1    Jaspars, M.2    Dicato, M.3    Diederich, M.4
  • 26
    • 77953015002 scopus 로고    scopus 로고
    • Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria
    • Oh, H.; Jensen, P.R.; Murphy, B.T.; Fiorilla, C.; Sullivan, J.F.; Ramsey, T.; Fenical, W. Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria. J. Nat. Prod. 2010, 73, 998-1001.
    • (2010) J. Nat. Prod , vol.73 , pp. 998-1001
    • Oh, H.1    Jensen, P.R.2    Murphy, B.T.3    Fiorilla, C.4    Sullivan, J.F.5    Ramsey, T.6    Fenical, W.7
  • 28
    • 84861528700 scopus 로고    scopus 로고
    • A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis
    • Epub ahead of print
    • Guzman, E.A.; Johnson, J.D.; Linley, P.A.; Gunasekera, S.E.; Wright, A.E. A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis. Invest. New Drugs 2010, Epub ahead of print.
    • (2010) Invest. New Drugs
    • Guzman, E.A.1    Johnson, J.D.2    Linley, P.A.3    Gunasekera, S.E.4    Wright, A.E.5
  • 30
    • 0033989478 scopus 로고    scopus 로고
    • Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa
    • DOI 10.1016/S0039-128X(99)00083-5, PII S0039128X99000835
    • Garrido, L.; Zubia, E.; Ortega, M.J.; Salva, J. Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa. Steroids 2000, 65, 85-88. (Pubitemid 30009770)
    • (2000) Steroids , vol.65 , Issue.2 , pp. 85-88
    • Garrido, L.1    Zubia, E.2    Ortega, M.J.3    Salva, J.4
  • 31
    • 46949087664 scopus 로고    scopus 로고
    • First synthesis of 3,16,20-polyoxygenated cholestanes, new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa
    • Boonananwong, S.; Kongkathip, B.; Kongkathip, N. First synthesis of 3,16,20-polyoxygenated cholestanes, new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa. Steroids 2008, 73, 1123-1127.
    • (2008) Steroids , vol.73 , pp. 1123-1127
    • Boonananwong, S.1    Kongkathip, B.2    Kongkathip, N.3
  • 32
    • 77950629832 scopus 로고    scopus 로고
    • Further study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agents
    • Bunyathaworn, P.; Boonananwong, S.; Kongkathip, B.; Kongkathip, N. Further study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agents. Steroids 2010, 75, 432-444.
    • (2010) Steroids , vol.75 , pp. 432-444
    • Bunyathaworn, P.1    Boonananwong, S.2    Kongkathip, B.3    Kongkathip, N.4
  • 34
    • 77950385053 scopus 로고    scopus 로고
    • Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula
    • Kwan, J.C.; Teplitski, M.; Gunasekera, S.P.; Paul, V.J.; Luesch, H. Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. J. Nat. Prod. 2010, 73, 463-466.
    • (2010) J. Nat. Prod , vol.73 , pp. 463-466
    • Kwan, J.C.1    Teplitski, M.2    Gunasekera, S.P.3    Paul, V.J.4    Luesch, H.5
  • 36
    • 16244407997 scopus 로고    scopus 로고
    • Evaluation of hepatoprotective potential of HESA-A (a marine compound) pretreatment against thioacetamide-induced hepatic damage in rabbits
    • Ahmadi, A.; Naderi, G.; Asgary, S. Evaluation of hepatoprotective potential of HESA-A (a marine compound) pretreatment against thioacetamide-induced hepatic damage in rabbits. Drugs Exp. Clin. Res. 2005, 31, 1-6. (Pubitemid 40461565)
    • (2005) Drugs under Experimental and Clinical Research , vol.31 , Issue.1 , pp. 1-6
    • Ahmadi, A.1    Naderi, G.A.2    Asgary, S.3
  • 37
    • 79952017785 scopus 로고    scopus 로고
    • Anticancer effects of HESA-A: An herbal marine compound
    • Amrollah, A.; Gholamreza, H.; Mehdi, F. Anticancer effects of HESA-A: An herbal marine compound. Chin. J. Integr. Med. 2010, 16, 366-367.
    • (2010) Chin. J. Integr. Med , vol.16 , pp. 366-367
    • Amrollah, A.1    Gholamreza, H.2    Mehdi, F.3
  • 38
    • 79960749789 scopus 로고    scopus 로고
    • Teratogenic effects of HESA-A, a natural anticancer product from Iran, in mice
    • doi:10.1177/0960327110379521
    • Moallem, S.; Ahmadi, A.; Moshafi, M.; Taghavi, M. Teratogenic effects of HESA-A, a natural anticancer product from Iran, in mice. Hum. Exp. Toxicol. 2010, doi:10.1177/0960327110379521.
    • (2010) Hum. Exp. Toxicol
    • Moallem, S.1    Ahmadi, A.2    Moshafi, M.3    Taghavi, M.4
  • 40
    • 70349446258 scopus 로고    scopus 로고
    • The EFFEct of HESA-A (natural drug) on visual acuity in age related macular degeneration: A randomized double blind controlled clinical trial
    • Ahmadi, A.; Ghanbari, H.; Soheilian, M.; Naseri, M. The EFFEct of HESA-A (natural drug) on visual acuity in age related macular degeneration: A randomized double blind controlled clinical trial. Afr. J. Tradit. Complement. Altern. Med. 2009, 6, 549-553.
    • (2009) Afr. J. Tradit. Complement. Altern. Med , vol.6 , pp. 549-553
    • Ahmadi, A.1    Ghanbari, H.2    Soheilian, M.3    Naseri, M.4
  • 42
    • 0027482896 scopus 로고
    • Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin
    • Bai, R.; Cichacz, Z.A.; Herald, C.L.; Pettit, G.R.; Hamel, E. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. Mol. Pharmacol. 1993, 44, 757-766. (Pubitemid 23317288)
    • (1993) Molecular Pharmacology , vol.44 , Issue.4 , pp. 757-766
    • Bai, R.1    Cichacz, Z.A.2    Herald, C.L.3    Pettit, G.R.4    Hamel, E.5
  • 44
    • 51649114209 scopus 로고    scopus 로고
    • Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP
    • Schyschka, L.; Rudy, A.; Jeremias, I.; Barth, N.; Pettit, G.R.; Vollmar, A.M. Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP. Leukemia 2008, 22, 1737-1745.
    • (2008) Leukemia , vol.22 , pp. 1737-1745
    • Schyschka, L.1    Rudy, A.2    Jeremias, I.3    Barth, N.4    Pettit, G.R.5    Vollmar, A.M.6
  • 45
    • 70350212784 scopus 로고    scopus 로고
    • BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells
    • Schneiders, U.M.; Schyschka, L.; Rudy, A.; Vollmar, A.M. BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells. Mol. Cancer Ther. 2009, 8, 2914-2925.
    • (2009) Mol. Cancer Ther , vol.8 , pp. 2914-2925
    • Schneiders, U.M.1    Schyschka, L.2    Rudy, A.3    Vollmar, A.M.4
  • 47
    • 22744452190 scopus 로고    scopus 로고
    • The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
    • DOI 10.1039/b504151a
    • Paterson, I.; Chen, D.Y.K.; Coster, M.J.; Aceña, J.L.; Bach, J.; Wallace, D.J. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation. Org. Biomol. Chem. 2005, 3, 2431-2440. (Pubitemid 41028053)
    • (2005) Organic and Biomolecular Chemistry , vol.3 , Issue.13 , pp. 2431-2440
    • Paterson, I.1    Chen, D.Y.-K.2    Coster, M.J.3    Acena, J.L.4    Bach, J.5    Wallace, D.J.6
  • 48
    • 36448978918 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of analogs of altohyrtin C (spongistatin 2)
    • DOI 10.1016/j.tet.2007.10.065, PII S0040402007018005
    • Wagner, C.E.; Wang, Q.; Melamed, A.; Fairchild, C.R.; Wild, R.; Heathcock, C.H. Synthesis and biological evaluation of analogs of altohyrtin C (spongistatin 2). Tetrahedron 2008, 64, 124-136. (Pubitemid 350161799)
    • (2008) Tetrahedron , vol.64 , Issue.1 , pp. 124-136
    • Wagner, C.E.1    Wang, Q.2    Melamed, A.3    Fairchild, C.R.4    Wild, R.5    Heathcock, C.H.6
  • 49
    • 77951154733 scopus 로고    scopus 로고
    • Design synthesis, and biological evaluation of EF- and ABEF- analogues of (+)-spongistatin 1
    • Smith, A.B., 3rd; Risatti, C.A.; Atasoylu, O.; Bennett, C.S.; Tendyke, K.; Xu, Q. Design, synthesis, and biological evaluation of EF- and ABEF- analogues of (+)-spongistatin 1. Org. Lett. 2010, 12, 1792-1795.
    • (2010) Org. Lett , vol.12 , pp. 1792-1795
    • Smith III, A.B.1    Risatti, C.A.2    Atasoylu, O.3    Bennett, C.S.4    Tendyke, K.5    Xu, Q.6
  • 50
    • 0025076413 scopus 로고
    • Ageliferins, potent actomyosin ATPase activators from the Okinawan marine sponge Agelas sp.
    • DOI 10.1016/S0040-4020(01)87756-5
    • Kobayashi, J.; Tsuda, M.; Murayama, T.; Nakamura, H.; Ohizumi, Y.; Ishibashi, M.; Iwamura, M.; Ohta, T.; Nozoe, S. Ageliferins, potent actomyosin Atpase activators from the Okinawan marine sponge Agelas sp. Tetrahedron 1990, 46, 5579-5586. (Pubitemid 20282416)
    • (1990) Tetrahedron , vol.46 , Issue.16 , pp. 5579-5586
    • Kobayashi, J.1    Tsuda, M.2    Murayama, T.3    Nakamura, H.4    Ohizumi, Y.5    Ishibashi, M.6    Iwamura, M.7    Ohta, T.8    Nozoe, S.9
  • 53
    • 0031019142 scopus 로고    scopus 로고
    • Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana
    • DOI 10.1021/np9606106
    • Pettit, G.R.; McNulty, J.; Herald, D.L.; Doubek, D.L.; Chapuis, J.C.; Schmidt, J.M.; Tackett, L.P.; Boyd, M.R. Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana. J. Nat. Prod. 1997, 60, 180-183. (Pubitemid 27098570)
    • (1997) Journal of Natural Products , vol.60 , Issue.2 , pp. 180-183
    • Pettit, G.R.1    McNulty, J.2    Herald, D.L.3    Doubek, D.L.4    Chapuis, J.-C.5    Schmidt, J.M.6    Tackett, L.P.7    Boyd, M.R.8
  • 54
    • 77249087185 scopus 로고    scopus 로고
    • In vitro and in vivo antineoplastic activity of a novel bromopyrrole and its potential mechanism of action
    • Xiong, S.; Pang, H.D.; Fan, J.; Ge, F.; Yang, X.X.; Liu, Q.Y.; Liao, X.J.; Xu, S.H. In vitro and in vivo antineoplastic activity of a novel bromopyrrole and its potential mechanism of action. Br. J. Pharmacol. 2010, 159, 909-918.
    • (2010) Br. J. Pharmacol , vol.159 , pp. 909-918
    • Xiong, S.1    Pang, H.D.2    Fan, J.3    Ge, F.4    Yang, X.X.5    Liu, Q.Y.6    Liao, X.J.7    Xu, S.H.8
  • 55
    • 77449150089 scopus 로고    scopus 로고
    • A marine natural compound, inhibits cell motility in a variety of cancer cell lines
    • Cipres, A.; O'Malley, D.P.; Li, K.; Finlay, D.; Baran, P.S.; Vuori, K. Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines. ACS Chem. Biol. 2010, 5, 195-202.
    • (2010) ACS Chem. Biol , vol.5 , pp. 195-202
    • Cipres, A.1    O'Malley, D.P.2    Li, K.3    Finlay, D.4    Baran, P.S.5    Sceptrin, V.K.6
  • 58
  • 60
    • 65649110929 scopus 로고    scopus 로고
    • 5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa
    • Till, M.; Prinsep, M.R. 5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa. J. Nat. Prod. 2009, 72, 796-798.
    • (2009) J. Nat. Prod , vol.72 , pp. 796-798
    • Till, M.1    Prinsep, M.R.2
  • 61
    • 33744924243 scopus 로고    scopus 로고
    • Identification of norharman as the cytotoxic compound produced by the sponge (Hymeniacidon perleve)-associated marine bacterium Pseudoalteromonas piscicida and its apoptotic effect on cancer cells
    • DOI 10.1042/BA20050176
    • Zheng, L.; Yan, X.; Han, X.; Chen, H.; Lin, W.; Lee, F.S.; Wang, X. Identification of norharman as the cytotoxic compound produced by the sponge (Hymeniacidon perleve)-associated marine bacterium Pseudoalteromonas piscicida and its apoptotic effect on cancer cells. Biotechnol. Appl. Biochem. 2006, 44, 135-142. (Pubitemid 43844651)
    • (2006) Biotechnology and Applied Biochemistry , vol.44 , Issue.3 , pp. 135-142
    • Zheng, L.1    Yan, X.2    Han, X.3    Chen, H.4    Lin, W.5    Lee, F.S.C.6    Wang, X.7
  • 62
    • 0035204029 scopus 로고    scopus 로고
    • New cytotoxic N-methylated β-carboline alkaloids from the marine ascidian Eudistoma gilboverde
    • DOI 10.1021/np010214+
    • Rashid, M.A.; Gustafson, K.R.; Boyd, M.R. New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde. J. Nat. Prod. 2001, 64, 1454-1456. (Pubitemid 33116691)
    • (2001) Journal of Natural Products , vol.64 , Issue.11 , pp. 1454-1456
    • Rashid, M.A.1    Gustafson, K.R.2    Boyd, M.R.3
  • 63
  • 66
    • 34648830279 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products
    • DOI 10.1021/jm0700870
    • Hoang, H.; LaBarbera, D.V.; Mohammed, K.A.; Ireland, C.M.; Skibo, E.B. Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products. J. Med. Chem. 2007, 50, 4561-4571. (Pubitemid 47463232)
    • (2007) Journal of Medicinal Chemistry , vol.50 , Issue.19 , pp. 4561-4571
    • Hoang, H.1    LaBarbera, D.V.2    Mohammed, K.A.3    Ireland, C.M.4    Skibo, E.B.5
  • 67
    • 10444221780 scopus 로고    scopus 로고
    • Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products
    • DOI 10.1016/j.bmc.2004.10.016, PII S0968089604007904
    • Labarbera, D.V.; Skibo, E.B. Synthesis of imidazo[1,5,4-de]quinoxalin-9- ones, benzimidazole analogues of pyrroloiminoquinone marine natural products. Bioorg. Med. Chem. 2005, 13, 387-395. (Pubitemid 39642921)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.2 , pp. 387-395
    • LaBarbera, D.V.1    Skibo, E.B.2
  • 68
    • 34247334648 scopus 로고    scopus 로고
    • Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition, and anticancer activity
    • DOI 10.1016/j.bmcl.2007.02.065, PII S0960894X07002624
    • Shinkre, B.A.; Raisch, K.P.; Fan, L.; Velu, S.E. Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition, and anticancer activity. Bioorg. Med. Chem. Lett. 2007, 17, 2890-2893. (Pubitemid 46636250)
    • (2007) Bioorganic and Medicinal Chemistry Letters , vol.17 , Issue.10 , pp. 2890-2893
    • Shinkre, B.A.1    Raisch, K.P.2    Fan, L.3    Velu, S.E.4
  • 69
    • 40749112696 scopus 로고    scopus 로고
    • Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines
    • DOI 10.1016/j.bmc.2007.11.051, PII S096808960701019X
    • Shinkre, B.A.; Raisch, K.P.; Fan, L.; Velu, S.E. Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines. Bioorg. Med. Chem. 2008, 16, 2541-2549. (Pubitemid 351380929)
    • (2008) Bioorganic and Medicinal Chemistry , vol.16 , Issue.5 , pp. 2541-2549
    • Shinkre, B.A.1    Raisch, K.P.2    Fan, L.3    Velu, S.E.4
  • 70
    • 77955285978 scopus 로고    scopus 로고
    • A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: In vitro and in vivo activity and mechanisms of action
    • Wang, W.; Rayburn, E.R.; Velu, S.E.; Chen, D.; Nadkarni, D.H.; Murugesan, S.; Zhang, R. A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: In vitro and in vivo activity and mechanisms of action. Breast Cancer Res. Treat. 2010, 123, 321-331.
    • (2010) Breast Cancer Res. Treat , vol.123 , pp. 321-331
    • Wang, W.1    Rayburn, E.R.2    Velu, S.E.3    Chen, D.4    Nadkarni, D.H.5    Murugesan, S.6    Zhang, R.7
  • 71
    • 66149180566 scopus 로고    scopus 로고
    • In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues
    • Wang, W.; Rayburn, E.R.; Velu, S.E.; Nadkarni, D.H.; Murugesan, S.; Zhang, R. In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues. Clin. Cancer Res. 2009, 15, 3511-3518.
    • (2009) Clin. Cancer Res , vol.15 , pp. 3511-3518
    • Wang, W.1    Rayburn, E.R.2    Velu, S.E.3    Nadkarni, D.H.4    Murugesan, S.5    Zhang, R.6
  • 74
    • 0017617146 scopus 로고
    • Sesquiterpene antitumor agents: Inhibitors of cellular metabolism
    • Lee, K.H.; Hall, I.H.; Mar, E.C.; Starnes, C.O.; ElGebaly, S.A.; Waddell, T.G.; Hadgraft, R.I.; Ruffner, C.G.; Weidner, I. Sesquiterpene antitumor agents: Inhibitors of cellular metabolism. Science 1977, 196, 533-536. (Pubitemid 8090468)
    • (1977) Science , vol.196 , Issue.4289 , pp. 533-536
    • Lee, K.H.1    Hall, I.H.2    Mar, E.C.3
  • 75
    • 0015883675 scopus 로고
    • Study of a renal microsomal inhibitor of hepatic cholesterol synthesis in intact cell systems
    • Haven, G.T.; Krzemien, J.R.; Nguyen, T.T. Study of a renal microsomal inhibitor of hepatic cholesterol synthesis in intact cell systems. Res. Commun. Chem. Pathol. Pharmacol. 1973, 6, 253-262.
    • (1973) Res. Commun. Chem. Pathol. Pharmacol , vol.6 , pp. 253-262
    • Haven, G.T.1    Krzemien, J.R.2    Nguyen, T.T.3
  • 77
    • 33751161701 scopus 로고    scopus 로고
    • Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: Role of the IkappaB kinase/nuclear factor-kappaB pathway
    • Ciucci, A.; Gianferretti, P.; Piva, R.; Guyot, T.; Snape, T.J.; Roberts, S.M.; Santoro, M.G. Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: Role of the IkappaB kinase/nuclear factor-kappaB pathway. Mol. Pharmacol. 2006, 70, 1812-1821.
    • (2006) Mol. Pharmacol , vol.70 , pp. 1812-1821
    • Ciucci, A.1    Gianferretti, P.2    Piva, R.3    Guyot, T.4    Snape, T.J.5    Roberts, S.M.6    Santoro, M.G.7
  • 78
    • 0037192632 scopus 로고    scopus 로고
    • Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells
    • DOI 10.1038/sj.onc.1205293
    • Hsiang, C.H.; Straus, D.S. Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells. Oncogene 2002, 21, 2212-2226. (Pubitemid 34311375)
    • (2002) Oncogene , vol.21 , Issue.14 , pp. 2212-2226
    • Hsiang, C.-H.1    Straus, D.S.2
  • 79
    • 75149198747 scopus 로고    scopus 로고
    • Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp
    • Ogi, T.; Margiastuti, P.; Teruya, T.; Taira, J.; Suenaga, K.; Ueda, K. Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp. Mar. Drugs 2009, 7, 816-832.
    • (2009) Mar. Drugs , vol.7 , pp. 816-832
    • Ogi, T.1    Margiastuti, P.2    Teruya, T.3    Taira, J.4    Suenaga, K.5    Ueda, K.6
  • 80
    • 76849108776 scopus 로고    scopus 로고
    • Trichoderone a novel cytotoxic cyclopentenone and cholesta-7, 22-diene-3 beta, 5 alpha, 6 beta-triol, with new activities from the marine-derived fungus Trichoderma sp
    • You, J.; Dai, H.; Chen, Z.; Liu, G.; He, Z.; Song, F.; Yang, X.; Fu, H.; Zhang, L.; Chen, X. Trichoderone, a novel cytotoxic cyclopentenone and cholesta-7, 22-diene-3 beta, 5 alpha, 6 beta-triol, with new activities from the marine-derived fungus Trichoderma sp. J. Ind. Microbiol. Biotechnol. 2010, 37, 245-252.
    • (2010) J. Ind. Microbiol. Biotechnol , vol.37 , pp. 245-252
    • You, J.1    Dai, H.2    Chen, Z.3    Liu, G.4    He, Z.5    Song, F.6    Yang, X.7    Fu, H.8    Zhang, L.9    Chen, X.10
  • 81
  • 87
    • 71349086366 scopus 로고    scopus 로고
    • A spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death
    • Schumacher, M.; Cerella, C.; Eifes, S.; Chateauvieux, S.; Morceau, F.; Jaspars, M.; Dicato, M.; Diederich, M. Heteronemin, a spongean sesterterpene, inhibits TNF alpha-induced NF-kappa B activation through proteasome inhibition and induces apoptotic cell death. Biochem. Pharmacol. 2010, 79, 610-622.
    • (2010) Biochem. Pharmacol , vol.79 , pp. 610-622
    • Schumacher, M.1    Cerella, C.2    Eifes, S.3    Chateauvieux, S.4    Morceau, F.5    Jaspars, M.6    Dicato, M.7    Heteronemin, D.M.8
  • 90
    • 23744475536 scopus 로고
    • A new 2-thiazolidinone macrolide from the marine sponge latrunculia magnifica
    • Kashman, Y.; Groweiss, A.; Shmueli, U. Latrunculin, a new 2-thiazolidinone macrolide from the marine sponge latrunculia magnifica. Tetrahedron Lett. 1980, 21, 3629-3632.
    • (1980) Tetrahedron Lett , vol.21 , pp. 3629-3632
    • Kashman, Y.1    Groweiss, A.2    Latrunculin, S.U.3
  • 91
    • 0020698663 scopus 로고
    • Latrunculins: Novel marine toxins that disrupt microfilament organization in cultured cells
    • Spector, I.; Shochet, N.R.; Kashman, Y.; Groweiss, A. Latrunculins: Novel marine toxins that disrupt microfilament organization in cultured cells. Science 1983, 219, 493-495. (Pubitemid 13189272)
    • (1983) Science , vol.219 , Issue.4584 , pp. 493-495
    • Spector, I.1    Shochet, N.R.2    Kashman, Y.3    Groweiss, A.4
  • 92
    • 33644905862 scopus 로고    scopus 로고
    • Bioactive natural and semisynthetic latrunculins
    • El Sayed, K.A.; Youssef, D.T.; Marchetti, D. Bioactive natural and semisynthetic latrunculins. J. Nat. Prod. 2006, 69, 219-223.
    • (2006) J. Nat. Prod , vol.69 , pp. 219-223
    • El Sayed, K.A.1    Youssef, D.T.2    Marchetti, D.3
  • 93
    • 31444435675 scopus 로고    scopus 로고
    • Characterization of the activities of actin-affecting drugs on tumor cell migration
    • DOI 10.1016/j.taap.2005.06.006, PII S0041008X05003625
    • Hayot, C.; Debeir, O.; Van Ham, P.; Van Damme, M.; Kiss, R.; Decaestecker, C. Characterization of the activities of actin-affecting drugs on tumor cell migration. Toxicol. Appl. Pharmacol. 2006, 211, 30-40. (Pubitemid 43152095)
    • (2006) Toxicology and Applied Pharmacology , vol.211 , Issue.1 , pp. 30-40
    • Hayot, C.1    Debeir, O.2    Van Ham, P.3    Van Damme, M.4    Kiss, R.5    Decaestecker, C.6
  • 94
  • 95
    • 4344650390 scopus 로고    scopus 로고
    • Marine natural products and related compounds in clinical and advanced preclinical trials
    • DOI 10.1021/np040031y
    • Newman, D.J.; Cragg, G.M. Marine natural products and related compounds in clinical and advanced preclinical trials. J. Nat. Prod. 2004, 67, 1216-1238. (Pubitemid 39145623)
    • (2004) Journal of Natural Products , vol.67 , Issue.8 , pp. 1216-1238
    • Newman, D.J.1    Cragg, G.M.2
  • 96
    • 0036889051 scopus 로고    scopus 로고
    • Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy
    • DOI 10.2174/1568009023333791
    • Newman, D.J.; Cragg, G.M.; Holbeck, S.; Sausville, E.A. Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy. Curr. Cancer Drug Targets 2002, 2, 279-308. (Pubitemid 35303466)
    • (2002) Current Cancer Drug Targets , vol.2 , Issue.4 , pp. 279-308
    • Newman, D.J.1    Cragg, G.M.2    Holbeck, S.3    Sausville, E.A.4
  • 97
    • 0033775855 scopus 로고    scopus 로고
    • Latrunculin alters the actin-monomer subunit interface to prevent polymerization
    • Morton, W.M.; Ayscough, K.R.; McLaughlin, P.J. Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat. Cell Biol. 2000, 2, 376-378.
    • (2000) Nat. Cell Biol , vol.2 , pp. 376-378
    • Morton, W.M.1    Ayscough, K.R.2    McLaughlin, P.J.3
  • 98
    • 56749165108 scopus 로고    scopus 로고
    • Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges
    • Amagata, T.; Johnson, T.A.; Cichewicz, R.H.; Tenney, K.; Mooberry, S.L.; Media, J.; Edelstein, M.; Valeriote, F.A.; Crews, P. Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges. J. Med. Chem. 2008, 51, 7234-7242.
    • (2008) J. Med. Chem , vol.51 , pp. 7234-7242
    • Amagata, T.1    Johnson, T.A.2    Cichewicz, R.H.3    Tenney, K.4    Mooberry, S.L.5    Media, J.6    Edelstein, M.7    Valeriote, F.A.8    Crews, P.9
  • 99
    • 33845951511 scopus 로고    scopus 로고
    • Latrunculin analogues with improved biological profiles by "diverted total synthesis": Preparation, evaluation, and computational analysis
    • DOI 10.1002/chem.200601136
    • Furstner, A.; Kirk, D.; Fenster, M.D.; Aissa, C.; De Souza, D.; Nevado, C.; Tuttle, T.; Thiel, W.; Muller, O. Latrunculin analogues with improved biological profiles by "diverted total synthesis": Preparation, evaluation, and computational analysis. Chemistry 2007, 13, 135-149. (Pubitemid 46033861)
    • (2007) Chemistry - A European Journal , vol.13 , Issue.1 , pp. 135-149
    • Furstner, A.1    Kirk, D.2    Fenster, M.D.B.3    Aissa, C.4    De Souza, D.5    Nevado, C.6    Tuttle, T.7    Thiel, W.8    Muller, O.9
  • 100
    • 75749095171 scopus 로고    scopus 로고
    • Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: Biological evaluations, preliminary structure-activity relationship and molecular modeling studies
    • Khanfar, M.A.; Youssef, D.T.; El Sayed, K.A. Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: Biological evaluations, preliminary structure-activity relationship and molecular modeling studies. ChemMedChem 2010, 5, 274-285.
    • (2010) ChemMedChem , vol.5 , pp. 274-285
    • Khanfar, M.A.1    Youssef, D.T.2    El Sayed, K.A.3


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