메뉴 건너뛰기




Volumn 74, Issue 4, 2011, Pages 664-669

Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; DRUG METABOLITE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

EID: 79955411920     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np1007262     Document Type: Article
Times cited : (320)

References (46)
  • 13
    • 53349161258 scopus 로고    scopus 로고
    • In this study, only one of the six participants who received a 12 g/day dosage of curcuminoid mixture had plasma levels of free curcumin that reached the detection threshold (50 ng/mL). In all the other volunteers and in the six participants who received a dosage of 10 g curcumin/day, only conjugates were detected. In a recent study, none of the five cancer patients who received a daily dosage of 8 g curcumin had detectable plasma concentrations of unconjugated curcumin.; Cancer Chemother. Pharmacol. 2010, in press.
    • Vareed, S. K.; Kakarala, M.; Ruffin, M. T.; Crowell, J. A.; Normolle, D. P.; Djuric, Z.; Brenner, D. E. Cancer Epidemiol. Biomarkers Prev. 2008, 17, 1411-1417 In this study, only one of the six participants who received a 12 g/day dosage of curcuminoid mixture had plasma levels of free curcumin that reached the detection threshold (50 ng/mL). In all the other volunteers and in the six participants who received a dosage of 10 g curcumin/day, only conjugates were detected. In a recent study, none of the five cancer patients who received a daily dosage of 8 g curcumin had detectable plasma concentrations of unconjugated curcumin. Kanai, M.; Yoshimura, K.; Asada, M.; Imaizumi, A.; Suzuki, C.; Matsumoto, S.; Nishimura, T.; Mori, Y.; Masui, Tl; Kawuguchi, Y.; Yanagihara, K.; Yazumi, S.; Chiba, T.; Aggarwal, B. B. Cancer Chemother. Pharmacol. 2010, in press.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 1411-1417
    • Vareed, S.K.1    Kakarala, M.2    Ruffin, M.T.3    Crowell, J.A.4    Normolle, D.P.5    Djuric, Z.6    Brenner, D.E.7    Kanai, M.8    Yoshimura, K.9    Asada, M.10    Imaizumi, A.11    Suzuki, C.12    Matsumoto, S.13    Nishimura, T.14    Mori, Y.15    Masui, T.16    Kawuguchi, Y.17    Yanagihara, K.18    Yazumi, S.19    Chiba, T.20    more..
  • 14
    • 79955382907 scopus 로고    scopus 로고
    • See: http://www.bioperine.com/curcumin.html.
  • 21
    • 79955401544 scopus 로고    scopus 로고
    • For sake of clarity, throughout the text curcumin refers to monomolecular 1a, while the mixture of the three curcuminoids will be referred to as natural curcumin or curcuminoids
    • For sake of clarity, throughout the text curcumin refers to monomolecular 1a, while the mixture of the three curcuminoids will be referred to as natural curcumin or curcuminoids.
  • 24
    • 79955440657 scopus 로고    scopus 로고
    • Phospholipid complexes of curcumin having improved bioavailability
    • EP1837030.
    • Giori, A.; Franceschi, F. Phospholipid complexes of curcumin having improved bioavailability. Eur. Pat. Appl. EP1837030, 2006.
    • (2006) Eur. Pat. Appl.
    • Giori, A.1    Franceschi, F.2
  • 26
    • 67650973761 scopus 로고    scopus 로고
    • A direct comparison between a clinical dosage of curcumin as Meriva and the same amount of uncomplexed curcumin was not possible because uncomplexed curcumin dœs not produce consistently detectable plasma concentrations in humans at dosages lower than 2 g. (8) On the other hand, comparison of Meriva with very high dosages of uncomplexed curcumin would be biased by saturation effects and by the nonlinearity of its absorption, (8) affording unrealistic values of improved absorption. The 1.8 g reference dosage is a compromise between detectability and clinical activity of uncomplexed curcumin.; Int. J. Clin. Pharmacol. Ther. Toxicol. 1986, 24, 651-654
    • Jurenka, J. S. Altern. Med. Rev. 2009, 14, 141-153 A direct comparison between a clinical dosage of curcumin as Meriva and the same amount of uncomplexed curcumin was not possible because uncomplexed curcumin dœs not produce consistently detectable plasma concentrations in humans at dosages lower than 2 g. (8) On the other hand, comparison of Meriva with very high dosages of uncomplexed curcumin would be biased by saturation effects and by the nonlinearity of its absorption, (8) affording unrealistic values of improved absorption. The 1.8 g reference dosage is a compromise between detectability and clinical activity of uncomplexed curcumin. Satoskar, R. R.; Shah, S. J.; Shenoy, S. G. Int. J. Clin. Pharmacol. Ther. Toxicol. 1986, 24, 651-654
    • (2009) Altern. Med. Rev. , vol.14 , pp. 141-153
    • Jurenka, J.S.1    Satoskar, R.R.2    Shah, S.J.3    Shenoy, S.G.4
  • 27
    • 70350102346 scopus 로고    scopus 로고
    • It should be pointed out that the published clinical trials on curcumin are small, often nonrandomized, and essentially open-label and that some of them gave negative results, even with higher dosages (4 g/day) of curcumin than those we have used as reference (see ref 12).
    • Kuptniratsaikul, V.; Thanakhumtorn, S.; Chinswangwatanakul, P.; Wattanamongkonsil, L.; Thamlikitkul, V. J. Compl. Altern. Med. 2009, 15, 891-897 It should be pointed out that the published clinical trials on curcumin are small, often nonrandomized, and essentially open-label and that some of them gave negative results, even with higher dosages (4 g/day) of curcumin than those we have used as reference (see ref 12).
    • (2009) J. Compl. Altern. Med. , vol.15 , pp. 891-897
    • Kuptniratsaikul, V.1    Thanakhumtorn, S.2    Chinswangwatanakul, P.3    Wattanamongkonsil, L.4    Thamlikitkul, V.5
  • 31
    • 79955414472 scopus 로고    scopus 로고
    • The rate of absorption of curcuminoids increased with the dosage, and the first time point (2 h) for demethoxycurcumin (1b) and bisdemethoxycurcumin (1c) at the high dosage of Meriva was also the peak concentration. It is, therefore, possible that the AUC of these compounds might, actually, be underestimated at this dosage, with the effect of lecithin formulation being overall higher than reported. We are grateful to one reviewer for bringing this issue to our attention. The effect of dosage on the rate of absorption is, undoubtedly, intriguing and well worth further investigation
    • The rate of absorption of curcuminoids increased with the dosage, and the first time point (2 h) for demethoxycurcumin (1b) and bisdemethoxycurcumin (1c) at the high dosage of Meriva was also the peak concentration. It is, therefore, possible that the AUC of these compounds might, actually, be underestimated at this dosage, with the effect of lecithin formulation being overall higher than reported. We are grateful to one reviewer for bringing this issue to our attention. The effect of dosage on the rate of absorption is, undoubtedly, intriguing and well worth further investigation.
  • 32
    • 0037373519 scopus 로고    scopus 로고
    • In the case of flax lignans, it is, however, the para -oxygenated function that is reductively removed by gut microorganisms., ()
    • In the case of flax lignans, it is, however, the para -oxygenated function that is reductively removed by gut microorganisms. Lampe, J. W. J. Nutr. 2003, 133 (Suppl. 3) 956S-964S
    • (2003) J. Nutr. , vol.133 , Issue.SUPPL. 3
    • Lampe, J.W.1
  • 41
    • 0003764798 scopus 로고    scopus 로고
    • Interestingly, turmeric is mainly consumed in fatty dishes (; CRC Press: Boca Raton, FL), potentially increasing the bioavailability of "dietary" curcumin.
    • Interestingly, turmeric is mainly consumed in fatty dishes (Duke, J. A. CRC Handbook of Medicinal Spices; CRC Press: Boca Raton, FL, 2003; pp 137 - 144), potentially increasing the bioavailability of "dietary" curcumin.
    • (2003) CRC Handbook of Medicinal Spices , pp. 137-144
    • Duke, J.A.1
  • 45
    • 78751591000 scopus 로고    scopus 로고
    • Helix pomatia β-glucuronidase has also sulfatase activity and is routinely used for the complete hydrolysis of phase-2 conjugates of phenolic compounds.
    • Helix pomatia β-glucuronidase has also sulfatase activity and is routinely used for the complete hydrolysis of phase-2 conjugates of phenolic compounds. Vœlkel, W.; Kiranoglu, M.; Fromme, H. Environ. Res. 2011, 111, 143-148
    • (2011) Environ. Res. , vol.111 , pp. 143-148
    • Vœlkel, W.1    Kiranoglu, M.2    Fromme, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.