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In this study, only one of the six participants who received a 12 g/day dosage of curcuminoid mixture had plasma levels of free curcumin that reached the detection threshold (50 ng/mL). In all the other volunteers and in the six participants who received a dosage of 10 g curcumin/day, only conjugates were detected. In a recent study, none of the five cancer patients who received a daily dosage of 8 g curcumin had detectable plasma concentrations of unconjugated curcumin.; Cancer Chemother. Pharmacol. 2010, in press.
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No significant effect of curcumin on the expression of P450 or PgP was, however, reported.; Planta Med. 2010, in press.
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For sake of clarity, throughout the text curcumin refers to monomolecular 1a, while the mixture of the three curcuminoids will be referred to as natural curcumin or curcuminoids
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For sake of clarity, throughout the text curcumin refers to monomolecular 1a, while the mixture of the three curcuminoids will be referred to as natural curcumin or curcuminoids.
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A direct comparison between a clinical dosage of curcumin as Meriva and the same amount of uncomplexed curcumin was not possible because uncomplexed curcumin dœs not produce consistently detectable plasma concentrations in humans at dosages lower than 2 g. (8) On the other hand, comparison of Meriva with very high dosages of uncomplexed curcumin would be biased by saturation effects and by the nonlinearity of its absorption, (8) affording unrealistic values of improved absorption. The 1.8 g reference dosage is a compromise between detectability and clinical activity of uncomplexed curcumin.; Int. J. Clin. Pharmacol. Ther. Toxicol. 1986, 24, 651-654
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Jurenka, J. S. Altern. Med. Rev. 2009, 14, 141-153 A direct comparison between a clinical dosage of curcumin as Meriva and the same amount of uncomplexed curcumin was not possible because uncomplexed curcumin dœs not produce consistently detectable plasma concentrations in humans at dosages lower than 2 g. (8) On the other hand, comparison of Meriva with very high dosages of uncomplexed curcumin would be biased by saturation effects and by the nonlinearity of its absorption, (8) affording unrealistic values of improved absorption. The 1.8 g reference dosage is a compromise between detectability and clinical activity of uncomplexed curcumin. Satoskar, R. R.; Shah, S. J.; Shenoy, S. G. Int. J. Clin. Pharmacol. Ther. Toxicol. 1986, 24, 651-654
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It should be pointed out that the published clinical trials on curcumin are small, often nonrandomized, and essentially open-label and that some of them gave negative results, even with higher dosages (4 g/day) of curcumin than those we have used as reference (see ref 12).
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The rate of absorption of curcuminoids increased with the dosage, and the first time point (2 h) for demethoxycurcumin (1b) and bisdemethoxycurcumin (1c) at the high dosage of Meriva was also the peak concentration. It is, therefore, possible that the AUC of these compounds might, actually, be underestimated at this dosage, with the effect of lecithin formulation being overall higher than reported. We are grateful to one reviewer for bringing this issue to our attention. The effect of dosage on the rate of absorption is, undoubtedly, intriguing and well worth further investigation
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The rate of absorption of curcuminoids increased with the dosage, and the first time point (2 h) for demethoxycurcumin (1b) and bisdemethoxycurcumin (1c) at the high dosage of Meriva was also the peak concentration. It is, therefore, possible that the AUC of these compounds might, actually, be underestimated at this dosage, with the effect of lecithin formulation being overall higher than reported. We are grateful to one reviewer for bringing this issue to our attention. The effect of dosage on the rate of absorption is, undoubtedly, intriguing and well worth further investigation.
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