A novel monocarbonyl analogue of curcumin, (1E,4E)-1,5-Bis (2,3-dimethoxyphenyl)penta-1,4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway

Journal of Medicinal Chemistry

Volumn 54, Issue 11, 2011, Pages 3768-3778

  Wang, Yi ^a   Xiao, Jian ^a   Zhou, Huiping ^c   Yang, Shulin ^b   Wu, Xiaoping ^a   Jiang, Chengxi ^a   Zhao, Yunjie ^a   Liang, Donglou ^a   Li, Xiaokun ^a,d   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d Basic Medical College   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 BIS(2,3 DIMETHOXYPHENYL)PENTA 1,4 DIEN 3-ONE; ANTINEOPLASTIC AGENT; CASPASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR VOLUME; XENOGRAFT;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMIN; ENDOPLASMIC RETICULUM; FEMALE; HUMANS; LENTIVIRUS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; OXIDATIVE STRESS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79958116796     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200017g     Document Type: Article

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