Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways

Anticancer Research

Volumn 30, Issue 6, 2010, Pages 2125-2133

  Wu, Shin Hwar ^a,b   Hang, Liang Wen ^c   Yang, Jai Sing ^b   Chen, Hung Yi ^b   Lin, Hui Yi ^b   Chiang, Jo Hua ^d   Lu, Chi Cheng ^d   Yang, Jiun Long ^b   Lai, Tung Yuan ^b,c   Ko, Yang Ching ^e,f   Chung, Jing Gung ^b,g  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e ST MARTIN DE PORRES HOSPITAL   (Taiwan)

^f Health Science and Management   (Taiwan)

^g ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase cascade; Curcumin; Endoplasmic reticulum stress; G2 M arrest; Herbal medicine; Lung neoplasms

Indexed keywords

ALPHA TUBULIN; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CURCUMIN; CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYTOCHROME C; ENDONUCLEASE G; FAS LIGAND; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL GROWTH; CELL SURFACE; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INDUCTION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG NON SMALL CELL CANCER; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 8; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CURCUMIN; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 77955077389     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer Statistics, 2008. CA Cancer J Clin 58: 71-96, 2008.
2. Harvey AL: Natural products in drug discovery. Drug Discovery Today 13: 894-901, 2008.
3. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB and Aggarwal BB: Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett 267: 133-164, 2008.
4. Lin JK: Molecular targets of curcumin. Adv Exp Med Biol 595: 227-243, 2007.
5. Goel A, Kunnumakkara AB and Aggarwal BB: Curcumin as " Curecumin": from kitchen to clinic. Biochem Pharmacol 75: 787-809, 2008.
6. Hatcher H, Planalp R, Cho J, Torti FM and Torti SV: Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65: 1631-1652, 2008.
7. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC and Hsieh CY: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21: 2895-2900, 2001.
8. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V and Kurzrock R: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14: 4491-4499, 2008.
9. Ryu EK, Choe YS, Lee KH, Choi Y and Kim BT: Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J Med Chem 49: 6111-6119, 2006.
10. Ichiki K, Mitani N, Doki Y, Hara H, Misaki T and Saiki I: Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer. Clin Exp Metastasis 18: 539-545, 2000. (Pubitemid 32964315)
11. Radhakrishna Pillai G, Srivastava AS, Hassanein TI, Chauhan DP and Carrier E: Induction of apoptosis in human lung cancer cells by curcumin. Cancer Letters 208: 163-170, 2004.
12. Lin SS, Huang HP, Yang JS, Wu JY, Hsai TC, Lin CC, Lin CW, Kuo CL, Gibson Wood W and Chung JG: DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett 272: 77-90, 2008.
13. Chen HW, Lee JY, Huang JY, Wang CC, Chen WJ, Su SF, Huang CW, Ho CC, Chen JJ, Tsai MF, Yu SL and Yang PC: Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 68: 7428-7438, 2008.
14. Huang AC, Lin SY, Su CC, Lin SS, Ho CC, Hsia TC, Chiu TH, Yu CS, Ip SW, Lin TP and Chung JG: Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo. In Vivo 22: 781-785, 2008.
15. Ji BC, Hsu WH, Yang JS, Hsia TC, Lu CC, Chiang JH, Yang JL, Lin CH, Lin JJ, Wu Suen LJ, Wood WG and Chung JG: Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 57: 7596-7604, 2009.
16. Lin SY, Lai WW, Ho CC, Yu FS, Chen GW, Yang JS, Liu KC, Lin ML, Wu PP, Fan MJ and Chung JG: Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer Res 29: 327-335, 2009.
17. Gorczyca W, Melamed MR and Darzynkiewicz Z: Laser scanning cytometer (LSC) analysis of fraction of labelled mitoses (FLM). Cell Prolif 29: 539-547, 1996.
18. 2+ on rhein-induced apoptosis in A-549 human lung cancer cells. Anticancer Res 29: 309-318, 2009.
19. Kohler C, Orrenius S and Zhivotovsky B: Evaluation of caspase activity in apoptotic cells. J Immunol Methods 265: 97-110, 2002.
20. Li L, Han W, Gu Y, Qiu S, Lu Q, Jin J, Luo J and Hu X: Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore. Cancer Res 67: 4894-4903, 2007.
21. 2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res 28: 1701-1712, 2008.
22. Lin CC, Yang JS, Chen JT, Fan S, Yu FS, Yang JL, Lu CC, Kao MC, Huang AC, Lu HF and Chung JG: Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Anticancer Res 27: 3371-3378, 2007.
23. Tsou MF, Peng CT, Shih MC, Yang JS, Lu CC, Chiang JH, Wu CL, Lin JP, Lo C, Fan MJ and Chung JG: Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo. Leuk Res 33: 1505-1511, 2009.
24. Suzuki T, Fujikura K, Higashiyama T and Takata K: DNA staining for fluorescence and laser confocal microscopy. J Histochem Cytochem 45: 49-54, 1997.
25. Hsu MH, Chen CJ, Kuo SC, Chung JG, Lai YY, Teng CM, Pan SL and Huang LJ: 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells. Eur J Pharmacol 559: 14-20, 2007. (Pubitemid 46298734)
26. Hayes PC, Wolf CR and Hayes JD: Blotting techniques for the study of DNA, RNA, and proteins. BMJ 299: 965-968, 1989.
27. Chung JG, Yeh KT, Wu SL, Hsu NY, Chen GW, Yeh YW and Ho HC: Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display. Cancer Res 61: 8873-8879, 2001.
28. 1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells. In Vivo 22: 215-222, 2008.
29. Kubista M, Andrade JM, Bengtsson M, Forootan A, Jonak J, Lind K, Sindelka R, Sjoback R, Sjogreen B, Strombom L, Stahlberg A and Zoric N: The real-time polymerase chain reaction. Mol Aspects Med 27: 95-125, 2006.
30. Yang KY, Lin LC, Tseng TY, Wang SC and Tsai TH: Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chroma B 853: 183-189, 2007.
31. Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: problems and promises. Mol Pharm 4: 807-818, 2007.
32. Bush JA, Cheung KJJ and Li G: Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp Cell Res 271: 305-314, 2001.
33. Moragoda L, Jaszewski R and Majumdar AP: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 21: 873-878, 2001. (Pubitemid 32494183)
34. Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P and Aggarwal BB: Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20: 7597-7609, 2001.
35. Anto RJ, Mukhopadhyay A, Denning K and Aggarwal BB: Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-x1. Carcinogenesis 23: 143-150, 2002.
36. Micheau O, Solary E, Hammann A and Dimanche-Boitrel MT: Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J Biol Chem 274: 7987-7992, 1999. (Pubitemid 129529012)
37. Shao RG, Cao CX, Nieves-Neira W, Dimanche-Boitrel MT, Solary E and Pommier Y: Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. Oncogene 20: 1852-1859, 2001.
38. Korsmeyer SJ: BCL-2 gene family and the regulation of programmed cell death. Cancer Res 59: 1693s-1700s, 1999.
39. Nur-E-Kamal A, Gross SR, Pan Z, Balklava Z, Ma J and Liu LF: Nuclear translocation of cytochrome c during apoptosis. J Biol Chem 279: 24911-24914, 2004.
40. Bhaumik S, Anjum R, Rangaraj N, Pardhasaradhi BVV and Khar A: Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett 456: 311-314, 1999. (Pubitemid 29352314)
41. Tamura M, Tamura T, Tyagi and Lambeth JD: The superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane. Phosphatidylserine as an effector of the activated enzyme. J Biol Chem 263: 17621-17626, 1988.
42. Ikebuchi Y, Masumoto N, Tasaka K, Koike K, Kasahara K, Miyake A and Tanizawa O: Superoxide anion increases intracellular pH, intracellular free calcium, and arachidonate release in human amnion cells. J Biol Chem 266: 13233-13237, 1991.
43. Higuchi M, Honda T, Proske RJ and Yeh ET: Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene 17: 2753-2760, 1998. (Pubitemid 28554234)
44. Yoshino M, Haneda M, Naruse M, Htay HH, Tsubouchi R, Qiao SL, Li WH, Murakami K and Yokochi T: Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death. Toxicol In Vitro 18: 783-789, 2004.
45. 2+ uptake in apoptosis. Cell Calcium 40: 553-560, 2006.
46. Rao RV, Ellerby HM and Bredesen DE: Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11: 372-380, 2004.
47. Oyadomari S and Mori M: Roles of CHOP//GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389, 2003.
48. Diehl JA: Cycling to cancer with cyclin Dl. Cancer Biol Ther 1: 226-231, 2002.
49. 2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett 582: 2689-2695, 2008.
50. 2 phase of cell cycle in a p53-dependent Manner. J Biol Chem 280: 20059-20068, 2005.
51. Sa G and Das T: Anticancer effects of curcumin: cycle of life and death. Cell Div 3: 14, 2008.