Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability

Clinical Cancer Research

Volumn 15, Issue 2, 2009, Pages 747-

  Kurien, Biji T ^a   Scofield, R Hal ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CURCUMIN;

DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MECHANISM; DRUG SOLUBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LETTER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN MODIFICATION; SPECTROPHOTOMETRY;

ADMINISTRATION, ORAL; ALDEHYDES; BIOLOGICAL AVAILABILITY; CLINICAL TRIALS AS TOPIC; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HOT TEMPERATURE; HUMANS; NEOPLASMS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 59449093810     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-1957     Document Type: Letter

References (6)

1. Dhillon N, Aggarwal BB, Newman RA, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008;14: 4491 -9.
2. Lao CD, Ruffin MT IV, Normolle D, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006;6:10.
3. Li L, Aggarwal BB, Shishodia S, et al. Nuclear factor-κB and IκB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 2004;101:2351 -62.
4. Kurien BT, Singh A, Matsumoto H, et al. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug DevTechnol 2007;5:567-76.
5. Kurien BT, Scofield RM. In vitro modification of solid phase multiple antigenic peptides/autoantigens with 4-hydroxy-2-nonenal (HNE) provide ideal substrates for detection of anti-HNE antibodies and peptide antioxidants. J Immunol Methods 2005;303:66-75.
6. Kurien BT, Scofield RH. Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification-an in vitro study. J Ethnopharmacol 2007;110:368-73.