Role of AP-1 and HIF-1 transcription factors in TGF-β activation of VEGF expression

Growth Factors

Volumn 19, Issue 1, 2001, Pages 19-34

  Shih, S C ^a   Claffey, K P ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CURCUMIN; DNA; GENISTEIN; MESSENGER RNA; MITHRAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN C JUN; PROTEIN TYROSINE KINASE INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR HIF 1; TRANSCRIPTION FACTOR NF 1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CELL HYPOXIA; CELL NUCLEUS; CONTROLLED STUDY; DNA BINDING; EXTRACT; FIBROSARCOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; SOLID TUMOR; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR CELL LINE; TURNOVER TIME;

EID: 0034791260     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.3109/08977190109001073     Document Type: Article

References (54)

1. Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways
2. Genistein, a specific inhibitor of tyrosine-specific protein kinases
3. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
4. Transforming growth factor and cell cycle regulation
5. An essential role for p300/CBP in the cellular response to hypoxia
6. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
7. TGF-β in prostate cancer: A growth inhibitor that can enhance tumorigenicity
8. Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-β
9. Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter
10. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo
11. Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulate VEGF expression only
12. Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine
13. Mechanism of transforming growth factor-beta1-induced expression of vascular endothelial growth factor in murine osteoblastic MC3T3-E1 cells
14. Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
15. Human transforming growth factor-b complementary DNA sequence and expression in normal and transformed cells
16. Defective haematopoiesis and vasculogenesis in transforming growth factor-1 knock out mice
17. TGF beta-1 regulation of VEGF production by breast cancer cells
18. Constitutive expression of mature transforming growth factor 1 in the liver accelerates hepatocarcinogenesis in transgenic mice
19. Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor
20. Angiogenesis in cancer, vascular, rheumatoid and other disease
21. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
22. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
23. Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1
24. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
25. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
26. Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis
27. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
28. Vascular endothelial growth factor production is stimulated by gangliosides and TGF-β isoforms in human glioma cells in vitro
29. A mechanism of repression of TGF/Smad signaling by oncogenic Ras
30. TGF-β1 Stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-δ and p38, but not erk1/erk2
31. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
32. Regulation of immune responses by TGF-β
33. Loss of transforming growth factor b1 (TGF-β1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells
34. TGF-β signal transduction
35. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
36. The expression of vascular endothelial growth factor and transforming growth factor-beta associates with angiogenesis in epithelial ovarian cancer
37. Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells
38. Angiogenesis-regulating cytokines: Activities and interactions
39. Physical and functional interaction of SMADs and p300/CBP
40. Oncogenes as inducers of tumor angiogenesis
41. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
42. Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1
43. Loss of growth factor dependence and conversion of transforming growth factor-1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts
44. Regulation of human vascular endothelial growth factor. mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L
45. Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells
46. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
47. p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor beta1
48. Production and responsiveness to transforming growth factor-b in normal and oncogene-transformed human mammary epithelial cells
49. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
50. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
51. Mechanism of activation of the TGF-β receptor
52. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-Iα/ARNT
53. Smad3 and Smad4 cooperate with c-jun/c-fos to mediate TGF-β-induced transcription
54. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation