Mitochondrial complex I defects in aging

Molecular and Cellular Biochemistry

Volumn 174, Issue 1-2, 1997, Pages 329-333

  Lenaz, Giorgio ^a   Bovina, Carla ^a   Castelluccio, Cinzia ^a   Fato, Romana ^a   Formiggini, Gabriella ^a   Genova, Maria Luisa ^a   Marchetti, Mario ^a   Pich, Milena Merlo ^a   Pallotti, Francesco ^a   Castelli, Giovanna Parenti ^a   Biagini, Graziella ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Ageing; Complex I; Platelet mitochondrion; Rotenone sensitivity

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; UBIQUINONE;

AEROBIC METABOLISM; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; ENZYME SUBUNIT; HEART MITOCHONDRION; LIVER MITOCHONDRION; MALE; MUSCLE MITOCHONDRION; NONHUMAN; OXIDATION; RAT; SYNAPSE; THROMBOCYTE MEMBRANE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; BLOOD PLATELETS; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); ORGAN SPECIFICITY; RATS; RATS, WISTAR;

ANIMALIA;

EID: 9844226198     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006854619336     Document Type: Article

References (20)

1. Miquel J, Economes AC, Fleming JE, Johnson JE: Mitochondrial role in cell ageing. Exp Gerontol 15: 575-591, 1980
2. Linnane AW, Ozawa T, Marzuki S, Tanaka M: Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet i: 642-645, 1989
3. Miquel J, Fleming JE: A two-step hypothesis on the mechanism of in vitro cell ageing: cellular differentiation followed by intrinsic mitochondrial mutagenesis. Exp Gerontol 19: 31-36, 1984
4. Tzagoloff A, Myers AM: Genetics of mitochondrial biogenesis. Ann Rev Biochem 55: 249-285, 1986
5. Yen TC, Su JH, King KL, Wei YH: Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 178: 124-131, 1991
6. Cooper JM, Mann VM, Schapira AHV: Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci 113: 91-98, 1992
7. Sugiyama S, Takasawa M, Hayakawa M, Ozawa T: Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem Mol Biol Int 30: 937-944, 1993
8. Castelluccio C, Baracca A, Fato R, Pallotti F, Maranesi M, Barzanti V, Gorini A, Villa RF, Parenti Castelli G, Marchetti M, Lenaz G: Mitochondrial activities of rat heart during ageing. Mech Ageing Dev 76: 73-88, 1994
9. Walker JE: The NADH:ubiquinone oxidoreductase (Complex I) of respiratory chains. Q Rev Biophys 25: 255-324, 1992
10. Degli Esposti M, Carelli V, Ghelli A, Crimi M, Sangiorgi S, Montagna P, Lenaz G, Lugaresi E, Cortelli P: Functional alterations of mitochondrially encoded ND-4 subunit associated with Leber's hereditary optic neuropathy. FEBS Lett 352: 375-379, 1994
11. Genova ML, Castelluccio C, Fato R, Parenti Castelli G, Merlo Pich M, Formiggini G, Bovina C, Marchetti M, Lenaz G: Major changes in Complex I activity in mitochondria from aged rats may not be detected by direct assay of NADH:Coenzyme Q reductase. Biochem J 311: 105-109, 1995
12. Battino M, Gorini A, Villa RF, Genova ML, Bovina C, Sassi S, Littarru GP, Lenaz G: Coenzyme Q content in synaptic and nonsynaptic mitochondria from different brain regions of the ageing rat. Mech Ageing Dev 78: 173-187, 1995
13. Merlo Pich M, Bovina C, Formiggini G, Cometti G, Ghelli A, Genova ML, Parenti Castelli G, Marchetti M, Semeraro S, Lenaz G: Inhibitor sensitivity of respiratory Complex I in human platelets: a possible biomarker of ageing. FEBS Lett 380: 176-178, 1996
14. Fato R, Estornell E, Di Bernardo S, Pallotti F, Parenti Castelli G, Lenaz G: Steady-state kinetics of the reduction of Coenzyme Q analogs by Complex I in bovine heart mitochondria and submitochondrial particles. Biochemistry 35: 2705-2716, 1996
15. Estornell E, Fato R, Pallotti F, Lenaz G: Assay conditions for the mitochondrial NADH Coenzyme Q oxidoreductase. FEBS Lett 332: 127-131, 1993
16. Lenaz G, Fato R, Genova ML, Formiggini G, Parenti Castelli G, Bovina C: Underevaluation of Complex I activity by the direct assay of NADH:Coenzyme Q reductase in rat liver mitochondria. FEBS Lett 366: 119-121, 1995
17. Kröger A, Klingenberg M: The kinetics of redox reactions of ubiquinone related to the electron transport activity of the respiratory chain. Eur J Biochem 34: 358-368, 1973
18. Degli Esposti M, Ghelli A: The mechanism of proton and electron transport in mitochondrial Complex I. Biochim Biophys Acta 1187: 116-120, 1994
19. Paradies G, Ruggiero FM, Petrosillo G, Quagliariello E: Age-dependent decrease in the cytochrome c oxidase activity and changes in phospholipids in rat heart mitochondria. Arch Gerontol Geriatr 16: 263-272, 1993
20. Corral-Debrinski M, Shoffner JM, Lott MT, Wallace DC: Association of mitochondrial DNA damage with ageing and coronary atherosclerotic heart disease. Mutation Res 275: 169-180, 1992