A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators

Inflammation

Volumn 35, Issue 2, 2012, Pages 594-604

  Wang, Yi ^a   Yu, Congcong ^a   Pan, Yong ^a   Yang, Xuyi ^a   Huang, Yi ^a   Feng, Zhiguo ^a   Li, Xiaokun ^a,b   Yang, Shulin ^c   Liang, Guang ^a,c  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b Basic Medical College   (China)

^c NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Anti inflammation; Curcumin analogue; Immunosuppressant drug; Inflammatory mediators

Indexed keywords

2,5 BIS[4 [3 (DIMETHYLAMINO)PROPOXY]BENZYLIDENE]CYCLOPENTANONE; A 13; ACETIC ACID; ANTIINFLAMMATORY AGENT; AUTACOID; CARRAGEENAN; CYCLOOXYGENASE 2; DEXAMETHASONE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRITE; PROSTAGLANDIN E SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SAFETY; HEPATITIS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; LIVER PARENCHYMA; LUNG INJURY; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAW EDEMA; PERITONEUM MACROPHAGE; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOXICITY TESTING; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAPILLARY PERMEABILITY; CELLS, CULTURED; CURCUMIN; CYCLOPENTANES; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; LUNG; MACROPHAGE ACTIVATION; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; NITRIC OXIDE; PNEUMONIA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84863776767     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9350-4     Document Type: Article

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