Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

Cancer Chemotherapy and Pharmacology

Volumn 69, Issue 1, 2012, Pages 65-70

  Kanai, Masashi ^a   Imaizumi, Atsushi ^b   Otsuka, Yoshihiko ^b   Sasaki, Hiroki ^b   Hashiguchi, Momo ^c   Tsujiko, Kazu ^c   Matsumoto, Shigemi ^a   Ishiguro, Hiroshi ^a   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b Theravalues Corporation   (Japan)

^c Pharma Eight Co Ltd   (Japan)

Author keywords

Bioavailability; Curcumin; Nanotechnology; THERACURMIN

Indexed keywords

CURCUMIN; NANOPARTICLE; THERACURMIN; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; DIARRHEA; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG SCREENING; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; NANOPARTICLES; SOLUBILITY;

EID: 84856725493     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1673-1     Document Type: Article

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