Curcumin inhibits telomerase activity in human cancer cell lines

International Journal of Molecular Medicine

Volumn 18, Issue 2, 2006, Pages 227-231

  Cui, Shu Xiang ^a   Qu, Xian Jun ^b   Xie, Yan Ying ^a   Zhou, Ling ^a   Nakata, Munehiro ^b,d   Makuuchi, Masatoshi ^c   Tang, Wei ^a,c  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKAI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cancer; Curcumin; Telomerase

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN; ENZYME INHIBITOR; TELOMERASE;

ANIMAL; APOPTOSIS; ARTICLE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MICE; TELOMERASE;

EID: 33751384016     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.18.2.227     Document Type: Article

References (35)

1. D'Incalci M, Steward WP and Gescher AJ: Use of cancer chemopreventive phytochemicals as antineoplastic agents. Lancet Oncol 6: 899-904, 2005.
2. Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N and Moore MA: Cancer prevention by natural compounds. Drug Metab Pharmacokinet 19: 245-263, 2004.
3. Kawanishi S, Oikawa S and Murata M: Evaluation for safety of antioxidant chemopreventive agents. Antioxid Redox Signal 7: 1728-1739, 2005.
4. Sharma RA, Gescher AJ and Steward WP: Curcumin: the story so far. Eur J Cancer 41: 1955-1968, 2005.
5. Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M and Diederich M: Chemopreventive and therapeutic effects of curcumin. Cancer Lett 223: 181-190, 2005.
6. Ramachandran C and You W: Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res Treat 54: 269-278, 1999. (Pubitemid 29322350)
7. Moos PJ, Edes K, Mullally JE and Fitzpatrick FA: Curcumin impairs tumor suppressor p53 function in colon cancer cells. Carcinogenesis 25: 1611-1617, 2004.
8. Mondello C and Scovassi AI: Telomeres, telomerase, and apoptosis. Biochem Cell Biol 82: 498-507, 2004.
9. Zhang Z, Liong EC, Lau TY, Leung KM, Fung PC and Tipoe GL: Induction of apoptosis by hexamethylene bisacetamide is p53- dependent associated with telomerase activity but not with terminal differentiation. Int J Oncol 16: 887-892, 2000.
10. Carmichael J, DeGraff WG, Gazdar AF, Minna JD and Mitchell JB: Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942, 1987. (Pubitemid 17027905)
11. Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, Bianco AR and Tortora G: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6: 2053-2063, 2000.
12. Cohen JJ: Apoptosis. Immunol Today 14: 126-130, 1993.
13. Ostling O and Johanson KJ: Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commun 123: 291-298, 1984.
14. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139: 271-279, 1991.
15. Nemos C, Remy-Martin JP, Adami P, Arbez-Gindre F, Schaal JP, Jouvenot M and Delage-Mourroux R: Improved TRAP-silver staining versus conventional radioactive TRAP assays: quantification of telomerase activity during immortalization and in pathological human endometrium. Clin Biochem 36: 621-628, 2003.
16. Wang L and Zhu X: Spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase during mouse postnatal development. Acta Pharmacol Sin 24: 965-974, 2003.
17. Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23: 363-398, 2003. (Pubitemid 36361976)
18. Aragona M, Maisano R, Panetta S, Giudice A, Morelli M, La Torre I and La Torre F: Telomere length maintenance in aging and carcinogenesis. Int J Oncol 17: 981-989, 2000.
19. Harrington L and Robinson MO: Telomere dysfunction: multiple paths to the same end. Oncogene 21: 592-597, 2002.
20. Hsu YH and Lin JJ: Telomere and telomerase as targets for anti-cancer and regeneration therapies. Acta Pharmacol Sin 26: 513-518, 2005.
21. Smogorzewska A and de Lange T: Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73: 177-208, 2004.
22. Boldrini L, Faviana P, Gisfredi S, Donati V, Zucconi Y, Ursino S, Simi P, Baldinotti F, Berti P, Galleri D, Materazzi G, Basolo F, Miccoli P, Pingitore R and Fontanini G: Regulation of telomerase and its hTERT messenger in colorectal cancer. Oncol Rep 11: 395-400, 2004.
23. Kanamaru T, Tanaka K, Kotani J, Ueno K, Yamamoto M, Idei Y, Hisatomi H and Takeyama Y: Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer. Int J Mol Med 10: 205-210, 2002.
24. Hahn WC and Meyerson M: Telomerase activation, cellular immortalization and cancer. Ann Med 33: 123-129, 2001.
25. Kiyozuka Y, Asai A, Senzaki H, Uemura Y, Nakashima A, Morimoto J, Matsuzawa A and Tsubura A: Telomere length, telomerase activity and telomerase RNA expression during mouse mammary tumor progression. Int J Mol Med 2: 437-444, 1998.
26. Lin JK: Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin. Arch Pharm Res 27: 683-692, 2004.
27. Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta GK, Das T and Sa G: Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem Biophys Res Commun 288: 658-665, 2001.
28. Jiang MC, Yang-Yen HF, Lin JK and Yen JJ: Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. Oncogene 13: 609-616, 1996.
29. Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH and Jankun J: Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 12: 17-24, 2003.
30. Balasubramanyam M, Koteswari AA, Kumar RS, Monicraraj SF, Mahesari SU, Mohan V: Curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J Biosci 28: 715-721, 2003. (Pubitemid 37522778)
31. Shao ZM, Shen ZZ, Liu CH, Sartippour MR, Go VL, Heber D and Nguyen M: Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int J Cancer 98: 234-240, 2002. (Pubitemid 34150808)
32. Ireson C, Orr S, Jone DJ, Verschoyle R, Lim CK, Luo JL, Howells L, Plummer S, Jukes R, Williams M, Steward WP and Gescher A: Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 61: 1058-1064, 2001.
33. Skrzypczak-Jankun E, McCabe NP, Selman SH and Jankun J: Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence. Int J Mol Med 6: 521-526, 2000.
34. Korutla L and Kumar R: Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim Biophys Acta 1224: 597-600, 1994.
35. Anto RJ, Venkatraman M and Karunagaran D: Inhibition of NF-κB sensitizes A431 cells to epidermal growth factor-induced apoptosis, whereas its activation by ectopic expression of RelA confers resistance. J Biol Chem 278: 25490-25498, 2003.