메뉴 건너뛰기




Volumn 9, Issue 3, 2013, Pages 267-285

The effects of flavonoids on the ABC transporters: Consequences for the pharmacokinetics of substrate drugs

Author keywords

ABC transporters; Breast cancer resistance protein; Flavonoids; Multidrug resistance protein 1; Multidrug resistance protein 2; P glycoprotein

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; APIGENIN; AURANTIIN; CATECHIN; CHALCONE; CHRYSIN; EPIGALLOCATECHIN GALLATE; FLAVANOL DERIVATIVE; FLAVANONE; FLAVONE; FLAVONOID; FLAVONOL; GLUCURONIDE; ISOFLAVONE; LUTEOLIN; MORIN; MYRICETIN; NARINGENIN; PINOCEMBRINE; QUERCETIN;

EID: 84874081668     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2013.749858     Document Type: Review
Times cited : (36)

References (153)
  • 2
    • 52949122177 scopus 로고    scopus 로고
    • Antioxidant phytochemicals against type 2 diabetes
    • Dembinska-Kiec A, Mykkanen O, Kiec-Wilk B, et al. Antioxidant phytochemicals against type 2 diabetes. Br J Nutr 2008;99 E(Suppl 1):ES109-17
    • (2008) Br J Nutr , vol.99 E , Issue.SUPPL. 1
    • Dembinska-Kiec, A.1    Mykkanen, O.2    Kiec-Wilk, B.3
  • 3
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003;3(10):768-80
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.J.1
  • 4
    • 0344823703 scopus 로고    scopus 로고
    • Neuroprotection by bioactive components in medicinal and food plant extracts
    • DOI 10.1016/j.mrrev.2003.06.017
    • Aruoma OI, Bahorun T, Jen L-S. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutat ResRev Mutat Res 2003;544(2-3):203-15 (Pubitemid 37487662)
    • (2003) Mutation Research - Reviews in Mutation Research , vol.544 , Issue.2-3 , pp. 203-215
    • Aruoma, O.I.1    Bahorun, T.2    Jen, L.-S.3
  • 6
    • 77957594068 scopus 로고    scopus 로고
    • Interactions of dietary phytochemicals with ABC transporters: Possible implications for drug disposition and multidrug resistance in cancer
    • Li Y, Revalde JL, Reid G, et al. Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer. Drug Metab Rev 2010;42(4):590-611
    • (2010) Drug Metab Rev , vol.42 , Issue.4 , pp. 590-611
    • Li, Y.1    Revalde, J.L.2    Reid, G.3
  • 7
    • 74049143120 scopus 로고    scopus 로고
    • Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response
    • Alvarez AI, Real R, Perez M, et al. Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response. J Pharm Sci 2010;99(2):598-617
    • (2010) J Pharm Sci , vol.99 , Issue.2 , pp. 598-617
    • Alvarez, A.I.1    Real, R.2    Perez, M.3
  • 9
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism
    • DOI 10.1016/j.tiv.2005.06.048, PII S0887233305002080
    • Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol in vitro 2006;20(2):187-210 (Pubitemid 43087702)
    • (2006) Toxicology in Vitro , vol.20 , Issue.2 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 11
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • DOI 10.1146/annurev.biochem.71.102301.093055
    • Borst P, Elferink RO. Mammalian ABC transporters in health and disease. Annu Rev Biochem 2002;71:537-92 (Pubitemid 34800230)
    • (2002) Annual Review of Biochemistry , vol.71 , pp. 537-592
    • Borst, P.1    Oude Elferink, R.2
  • 12
    • 0037457798 scopus 로고    scopus 로고
    • Drug transport proteins in the liver
    • DOI 10.1016/S0169-409X(02)00173-4, PII S0169409X02001734
    • Faber KN, Muller M, Jansen PL. Drug transport proteins in the liver. Adv Drug Deliv Rev 2003;55(1):107-24 (Pubitemid 36082884)
    • (2003) Advanced Drug Delivery Reviews , vol.55 , Issue.1 , pp. 107-124
    • Faber, K.N.1    Muller, M.2    Jansen, P.L.M.3
  • 13
    • 33644847684 scopus 로고    scopus 로고
    • Transporters as a determinant of drug clearance and tissue distribution
    • DOI 10.1016/j.ejps.2005.12.003, PII S0928098705003465, Drug Transporters: Integration in Understanding ADME
    • Shitara Y, Horie T, Sugiyama Y. Transporters as a determinant of drug clearance and tissue distribution. Eur J Pharm Sci 2006;27(5):425-46 (Pubitemid 43363338)
    • (2006) European Journal of Pharmaceutical Sciences , vol.27 , Issue.5 , pp. 425-446
    • Shitara, Y.1    Horie, T.2    Sugiyama, Y.3
  • 14
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system
    • DOI 10.1152/physrev.00037.2005
    • Sarkadi B, Homolya L, Szakacs G, et al. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol Rev 2006;86(4):1179-236 (Pubitemid 44521651)
    • (2006) Physiological Reviews , vol.86 , Issue.4 , pp. 1179-1236
    • Sarkadi, B.1    Homolya, L.2    Szakacs, G.3    Varadi, A.4
  • 15
    • 68949192657 scopus 로고    scopus 로고
    • Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
    • Stanley LA, Horsburgh BC, Ross J, et al. Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior. Drug Metab Rev 2009;41(1):27-65
    • (2009) Drug Metab Rev , vol.41 , Issue.1 , pp. 27-65
    • Stanley, L.A.1    Horsburgh, B.C.2    Ross, J.3
  • 17
    • 84869804156 scopus 로고    scopus 로고
    • Drug efflux transporters and multidrug resistance in acute leukemia: Therapeutic impact and novel approaches to mediation
    • Xia C, Smith PG. Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation. Mol Pharmacol 2012;82(6):1008-21
    • (2012) Mol Pharmacol , vol.82 , Issue.6 , pp. 1008-1021
    • Xia, C.1    Smith, P.G.2
  • 18
    • 0033859612 scopus 로고    scopus 로고
    • Flavonoids as antioxidants
    • Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000;63(7):1035-42
    • (2000) J Nat Prod , vol.63 , Issue.7 , pp. 1035-1042
    • Pietta, P.G.1
  • 19
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000;55(6):481-504
    • (2000) Phytochemistry , vol.55 , Issue.6 , pp. 481-504
    • Harborne, J.B.1    Williams, C.A.2
  • 20
    • 79959714144 scopus 로고    scopus 로고
    • Characterization of grape seed aqueous extract and possible applications in biological systems
    • Ignat I, Stingu A, Volf I, et al. Characterization of grape seed aqueous extract and possible applications in biological systems. Cellulose Chem Technol 2011;45(3-4):205-9
    • (2011) Cellulose Chem Technol , vol.45 , Issue.3-4 , pp. 205-209
    • Ignat, I.1    Stingu, A.2    Volf, I.3
  • 21
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medical significance of the flavonoids
    • DOI 10.1016/S0163-7258(02)00298-X, PII S016372580200298X
    • Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 2002;96(2-3):67-202 (Pubitemid 35356564)
    • (2002) Pharmacology and Therapeutics , vol.96 , Issue.2-3 , pp. 67-202
    • Havsteen, B.H.1
  • 22
    • 11844269306 scopus 로고    scopus 로고
    • Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans
    • Walle T, Browning AM, Steed LL, et al. Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans. J Nutr 2005;135(1):48-52 (Pubitemid 40094319)
    • (2005) Journal of Nutrition , vol.135 , Issue.1 , pp. 48-52
    • Walle, T.1    Browning, A.M.2    Steed, L.L.3    Reed, S.G.4    Walle, U.K.5
  • 23
    • 0032759560 scopus 로고    scopus 로고
    • The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
    • Hollman PC, Bijsman MN, van Gameren Y, et al. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 1999;31(6):569-73
    • (1999) Free Radic Res , vol.31 , Issue.6 , pp. 569-573
    • Hollman, P.C.1    Bijsman, M.N.2    Van Gameren, Y.3
  • 24
    • 0028793218 scopus 로고
    • Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
    • Hollman PC, de Vries JH, van Leeuwen SD, et al. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 1995;62(6):1276-82
    • (1995) Am J Clin Nutr , vol.62 , Issue.6 , pp. 1276-1282
    • Hollman, P.C.1    De Vries, J.H.2    Van Leeuwen, S.D.3
  • 25
    • 0033735623 scopus 로고    scopus 로고
    • Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption
    • Walle T, Otake Y, Walle UK, et al. Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. J Nutr 2000;130(11):2658-61
    • (2000) J Nutr , vol.130 , Issue.11 , pp. 2658-2661
    • Walle, T.1    Otake, Y.2    Walle, U.K.3
  • 27
    • 0037371414 scopus 로고    scopus 로고
    • Metabolism of flavonoids via enteric recycling: Role of intestinal disposition
    • DOI 10.1124/jpet.102.046409
    • Chen J, Lin H, Hu M. Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J Pharmacol Exp Ther 2003;304(3):1228-35 (Pubitemid 36254436)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.304 , Issue.3 , pp. 1228-1235
    • Chen, J.1    Lin, H.2    Hu, M.3
  • 28
    • 84861916495 scopus 로고    scopus 로고
    • The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics
    • Li Y, Lu J, Paxton JW. The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics. Curr Drug Metab 2012;13(5):624-39
    • (2012) Curr Drug Metab , vol.13 , Issue.5 , pp. 624-639
    • Li, Y.1    Lu, J.2    Paxton, J.W.3
  • 29
    • 52649175489 scopus 로고    scopus 로고
    • Human cytochromes P450 in the metabolism of drugs: New molecular models of enzyme-substrate interactions
    • Lewis DF, Ito Y. Human cytochromes P450 in the metabolism of drugs: new molecular models of enzyme-substrate interactions. Expert Opin Drug Metab Toxicol 2008;4(9):1181-6
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , Issue.9 , pp. 1181-1186
    • Lewis, D.F.1    Ito, Y.2
  • 30
    • 37549017270 scopus 로고    scopus 로고
    • Biotransformation of green tea polyphenols and the biological activities of those metabolites
    • Lambert JD, Sang S, Yang CS. Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol Pharm 2007;4(6):819-25
    • (2007) Mol Pharm , vol.4 , Issue.6 , pp. 819-825
    • Lambert, J.D.1    Sang, S.2    Yang, C.S.3
  • 31
    • 35348923465 scopus 로고    scopus 로고
    • Tea and cancer prevention: Molecular mechanisms and human relevance
    • DOI 10.1016/j.taap.2006.11.024, PII S0041008X06004522
    • Yang CS, Lambert JD, Ju J, et al. Tea and cancer prevention: molecular mechanisms and human relevance. Toxicol Appl Pharmacol 2007;224(3):265-73 (Pubitemid 47592860)
    • (2007) Toxicology and Applied Pharmacology , vol.224 , Issue.3 , pp. 265-273
    • Yang, C.S.1    Lambert, J.D.2    Ju, J.3    Lu, G.4    Sang, S.5
  • 32
    • 4043130207 scopus 로고    scopus 로고
    • Properties of quercetin conjugates: Modulation of LDL oxidation and binding to human serum albumin
    • DOI 10.1080/10715760410001728415
    • Janisch KM, Williamson G, Needs P, et al. Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin. Free Radic Res 2004;38(8):877-84 (Pubitemid 39077375)
    • (2004) Free Radical Research , vol.38 , Issue.8 , pp. 877-884
    • Janisch, K.M.1    Williamson, G.2    Needs, P.3    Plumb, G.W.4
  • 33
    • 37549066909 scopus 로고    scopus 로고
    • Intestinal and hepatic glucuronidation of flavonoids
    • Zhang L, Zuo Z, Lin G. Intestinal and hepatic glucuronidation of flavonoids. Mol Pharm 2007;4(6):833-45
    • (2007) Mol Pharm , vol.4 , Issue.6 , pp. 833-845
    • Zhang, L.1    Zuo, Z.2    Lin, G.3
  • 34
    • 0034896025 scopus 로고    scopus 로고
    • Morphine-6-glucuronide: An analgesic of the future?
    • Lotsch J, Geisslinger G. Morphine-6-glucuronide: an analgesic of the future? Clin Pharmacokinet 2001;40(7):485-99 (Pubitemid 32738656)
    • (2001) Clinical Pharmacokinetics , vol.40 , Issue.7 , pp. 485-499
    • Lotsch, J.1    Geisslinger, G.2
  • 36
    • 49149102015 scopus 로고    scopus 로고
    • A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro
    • Suri S, Taylor MA, Verity A, et al. A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro. Biochem Pharmacol 2008;76(5):645-53
    • (2008) Biochem Pharmacol , vol.76 , Issue.5 , pp. 645-653
    • Suri, S.1    Taylor, M.A.2    Verity, A.3
  • 37
    • 0034672514 scopus 로고    scopus 로고
    • Conjugation position of quercetin glucuronides and effect on biological activity
    • Day AJ, Bao Y, Morgan MR, et al. Conjugation position of quercetin glucuronides and effect on biological activity. Free Radic Biol Med 2000;29(12):1234-43
    • (2000) Free Radic Biol Med , vol.29 , Issue.12 , pp. 1234-1243
    • Day, A.J.1    Bao, Y.2    Morgan, M.R.3
  • 38
    • 0037300834 scopus 로고    scopus 로고
    • Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: The role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
    • DOI 10.1016/S0006-2952(02)01510-1, PII S0006295202015101
    • O'Leary KA, Day AJ, Needs PW, et al. Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol 2003;65(3):479-91 (Pubitemid 36084565)
    • (2003) Biochemical Pharmacology , vol.65 , Issue.3 , pp. 479-491
    • O'Leary, K.A.1    Day, A.J.2    Needs, P.W.3    Mellon, F.A.4    O'Brien, N.M.5    Williamson, G.6
  • 42
    • 1842610700 scopus 로고    scopus 로고
    • The ABC transporter structure and mechanism: Perspectives on recent research
    • DOI 10.1007/s00018-003-3336-9
    • Jones PM, George AM. The ABC transporter structure and mechanism: perspectives on recent research. Cell Mol Life Sci 2004;61(6):682-99 (Pubitemid 38446412)
    • (2004) Cellular and Molecular Life Sciences , vol.61 , Issue.6 , pp. 682-699
    • Jones, P.M.1    George, A.M.2
  • 44
    • 33644914487 scopus 로고    scopus 로고
    • Flavonoid-drug interactions: Effects of flavonoids on ABC transporters
    • Morris ME, Zhang S. Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci 2006;78(18):2116-30
    • (2006) Life Sci , vol.78 , Issue.18 , pp. 2116-2130
    • Morris, M.E.1    Zhang, S.2
  • 45
    • 33845937786 scopus 로고    scopus 로고
    • Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats
    • DOI 10.1124/dmd.106.011072
    • Zhang W, Tan TM, Lim LY. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats. Drug Metab Dispos 2007;35(1):110-15 (Pubitemid 46036483)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.1 , pp. 110-115
    • Zhang, W.1    Tan, T.M.C.2    Lim, L.-Y.3
  • 46
    • 0026756347 scopus 로고
    • P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain
    • Shimabuku AM, Nishimoto T, Ueda K, et al. P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain. J Biol Chem 1992;267(7):4308-11
    • (1992) J Biol Chem , vol.267 , Issue.7 , pp. 4308-4311
    • Shimabuku, A.M.1    Nishimoto, T.2    Ueda, K.3
  • 47
    • 0034061961 scopus 로고    scopus 로고
    • Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers
    • Soldner A, Benet L, Mutschler E, et al. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers. Br J Pharmacol 2000;129(6):1235-43 (Pubitemid 30153981)
    • (2000) British Journal of Pharmacology , vol.129 , Issue.6 , pp. 1235-1243
    • Soldner, A.1    Benet, L.Z.2    Mutschler, E.3    Christians, U.4
  • 48
    • 0031667511 scopus 로고    scopus 로고
    • P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene
    • DOI 10.1002/(SICI)1097-0215(19 981005)78:2<176::AID-IJC 10>3.0.CO;2-9
    • Gifford AJ, Kavallaris M, Madafiglio J, et al. P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene. Int J Cancer 1998;78(2):176-81 (Pubitemid 28443174)
    • (1998) International Journal of Cancer , vol.78 , Issue.2 , pp. 176-181
    • Gifford, A.J.1    Kavallaris, M.2    Madafiglio, J.3    Matherly, L.H.4    Stewart, B.W.5    Haber, M.6    Norris, M.D.7
  • 49
    • 0023447098 scopus 로고
    • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F, Tsuruo T, Hamada H, et al. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 1987;84:7735-8
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 52
    • 0037196568 scopus 로고    scopus 로고
    • Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols
    • Jodoin J, Demeule M, Beliveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta 2002;1542(1-3):149-59
    • (2002) Biochim Biophys Acta , vol.1542 , Issue.1-3 , pp. 149-159
    • Jodoin, J.1    Demeule, M.2    Beliveau, R.3
  • 53
    • 0043127383 scopus 로고    scopus 로고
    • Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells
    • DOI 10.1023/A:1025044913766
    • Zhang S, Morris ME. Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells. Pharm Res 2003;20(8):1184-91 (Pubitemid 36951843)
    • (2003) Pharmaceutical Research , vol.20 , Issue.8 , pp. 1184-1191
    • Zhang, S.1    Morris, M.E.2
  • 54
    • 0035964385 scopus 로고    scopus 로고
    • Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: Structure-activity relationships for flavonoid binding
    • DOI 10.1021/bi010657c
    • de Wet H, McIntosh DB, Conseil G, et al. Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse Pglycoprotein: structure-activity relationships for flavonoid binding. Biochemistry (Mosc) 2001;40(34):10382-91 (Pubitemid 32800145)
    • (2001) Biochemistry , vol.40 , Issue.34 , pp. 10382-10391
    • De Wet, H.1    McIntosh, D.B.2    Conseil, G.3    Baubichon-Cortay, H.4    Krell, T.5    Jault, J.-M.6    Daskiewicz, J.-B.7    Barron, D.8    Di Pietro, A.9
  • 55
    • 0032544087 scopus 로고    scopus 로고
    • Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP-and steroid-binding sites on mouse P-glycoprotein
    • Conseil G, Baubichon-Cortay H, Dayan G, et al. Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP-and steroid-binding sites on mouse P-glycoprotein. Proc Natl Acad Sci USA 1998;95(17):9831-6
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.17 , pp. 9831-9836
    • Conseil, G.1    Baubichon-Cortay, H.2    Dayan, G.3
  • 56
    • 0037371275 scopus 로고    scopus 로고
    • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
    • DOI 10.1124/jpet.102.044412
    • Zhang S, Morris ME. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther 2003;304(3):1258-67 (Pubitemid 36254439)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.304 , Issue.3 , pp. 1258-1267
    • Zhang, S.1    Morris, M.E.2
  • 57
    • 0030782511 scopus 로고    scopus 로고
    • Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
    • Shapiro AB, Ling V. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur J Biochem 1997;250(1):130-7 (Pubitemid 27504592)
    • (1997) European Journal of Biochemistry , vol.250 , Issue.1 , pp. 130-137
    • Shapiro, A.B.1    Ling, V.2
  • 58
    • 79957551963 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein-mediated anticancer drug accumulation cytotoxicity and ATPase activity by flavonoid interactions
    • Tran VH, Marks D, Duke RK, et al. Modulation of P-glycoprotein-mediated anticancer drug accumulation, cytotoxicity, and ATPase activity by flavonoid interactions. Nutr Cancer 2011;63(3):435-43
    • (2011) Nutr Cancer , vol.63 , Issue.3 , pp. 435-443
    • Tran, V.H.1    Marks, D.2    Duke, R.K.3
  • 59
    • 0032412212 scopus 로고    scopus 로고
    • Protein kinases and multidrug resistance
    • Rumsby M, Drew L, Warr J. Protein kinases and multidrug resistance. Cytotechnology 1998;27(1-3):203-24 (Pubitemid 29025470)
    • (1998) Cytotechnology , vol.27 , Issue.1-3 , pp. 203-224
    • Rumsby, M.G.1    Drew, L.2    Roger Warr, J.3
  • 62
    • 2542432982 scopus 로고    scopus 로고
    • ABCG2 - A transporter for all seasons
    • Sarkadi B, Ozvegy-Laczka C, Nemet K, et al. ABCG2-a transporter for all seasons. FEBS Lett 2004;567(1):116-20
    • (2004) FEBS Lett , vol.567 , Issue.1 , pp. 116-120
    • Sarkadi, B.1    Ozvegy-Laczka, C.2    Nemet, K.3
  • 64
    • 71649106260 scopus 로고    scopus 로고
    • Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1
    • Dreiseitel A, Oosterhuis B, Vukman KV, et al. Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Br J Pharmacol 2009;158(8):1942-50
    • (2009) Br J Pharmacol , vol.158 , Issue.8 , pp. 1942-1950
    • Dreiseitel, A.1    Oosterhuis, B.2    Vukman, K.V.3
  • 65
    • 3042569646 scopus 로고    scopus 로고
    • Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance
    • DOI 10.1158/0008-5472.CAN-04-0078
    • Imai Y, Tsukahara S, Asada S, et al. Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res 2004;64(12):4346-52 (Pubitemid 38802442)
    • (2004) Cancer Research , vol.64 , Issue.12 , pp. 4346-4352
    • Imai, Y.1    Tsukahara, S.2    Asada, S.3    Sugimoto, Y.4
  • 66
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • DOI 10.1124/mol.65.5.1208
    • Zhang SZ, Yang XN, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 2004;65(5):1208-16 (Pubitemid 38543491)
    • (2004) Molecular Pharmacology , vol.65 , Issue.5 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 68
    • 3242698924 scopus 로고    scopus 로고
    • Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport
    • DOI 10.1023/B:PHAM.0000033015.84146.4c
    • Zhang S, Yang X, Morris ME. Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. Pharm Res 2004;21(7):1263-73 (Pubitemid 38954213)
    • (2004) Pharmaceutical Research , vol.21 , Issue.7 , pp. 1263-1273
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 69
    • 33947233105 scopus 로고    scopus 로고
    • Phytochemicals induce breast cancer resistance protein in caco-2 Cells and enhance the transport of nenzo[a]pyrene-3-sulfate
    • DOI 10.1093/toxsci/kfl147
    • Ebert B, Seidel A, Lampen A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci 2007;96(2):227-36 (Pubitemid 46436705)
    • (2007) Toxicological Sciences , vol.96 , Issue.2 , pp. 227-236
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 70
    • 79951923564 scopus 로고    scopus 로고
    • The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux
    • An G, Gallegos J, Morris ME. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab Dispos 2011;39(3):426-32
    • (2011) Drug Metab Dispos , vol.39 , Issue.3 , pp. 426-432
    • An, G.1    Gallegos, J.2    Morris, M.E.3
  • 71
    • 80255122738 scopus 로고    scopus 로고
    • In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs
    • Sim HM, Wu CP, Ambudkar SV, et al. In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs. Biochem Pharmacol 2011;82(11):1562-71
    • (2011) Biochem Pharmacol , vol.82 , Issue.11 , pp. 1562-1571
    • Sim, H.M.1    Wu, C.P.2    Ambudkar, S.V.3
  • 72
    • 61449121173 scopus 로고    scopus 로고
    • Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)- mediated interactions: Consideration of multiple binding sites in in vitro assay design
    • Giri N, Agarwal S, Shaik N, et al. Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design. Drug Metab Dispos 2009;37(3):560-70
    • (2009) Drug Metab Dispos , vol.37 , Issue.3 , pp. 560-570
    • Giri, N.1    Agarwal, S.2    Shaik, N.3
  • 73
    • 14944386980 scopus 로고    scopus 로고
    • Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A
    • DOI 10.1124/mol.104.001701
    • Ejendal KFK, Hrycyna CA. Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A. Mol Pharmacol 2005;67(3):902-11 (Pubitemid 40365337)
    • (2005) Molecular Pharmacology , vol.67 , Issue.3 , pp. 902-911
    • Ejendal, K.F.K.1    Hrycyna, C.A.2
  • 74
    • 34047109147 scopus 로고    scopus 로고
    • Interactions of cyclosporin A with breast cancer resistance protein
    • DOI 10.1124/dmd.106.011866
    • Xia CQ, Liu N, Miwa GT, et al. Interactions of Cyclosporin A with breast cancer resistance protein. Drug Metab Dispos 2007;35(4):576-82.dmd.106.011866 (Pubitemid 46513259)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.4 , pp. 576-582
    • Xia, C.Q.1    Liu, N.2    Miwa, G.T.3    Gan, L.-S.4
  • 75
    • 22144481699 scopus 로고    scopus 로고
    • Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein
    • DOI 10.1016/j.bcp.2005.05.017, PII S0006295205003485
    • Zhang S, Yang X, Coburn RA, et al. Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol 2005;70(4):627-39 (Pubitemid 40978553)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.4 , pp. 627-639
    • Zhang, S.1    Yang, X.2    Coburn, R.A.3    Morris, M.E.4
  • 76
    • 33846681607 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins 3 4, and 5
    • Borst P, de Wolf C, van de Wetering K. Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch 2007;453(5):661-73
    • (2007) Pflugers Arch , vol.453 , Issue.5 , pp. 661-673
    • Borst, P.1    De Wolf, C.2    Van De Wetering, K.3
  • 78
    • 0036137072 scopus 로고    scopus 로고
    • Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
    • DOI 10.1124/jpet.300.1.97
    • Cherrington NJ, Hartley DP, Li N, et al. Organ distribution of multidrug resistance proteins 1, 2, and 3 (mrp1, 2, and 3) mRNA and hepatic induction of mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther 2002;300(1):97-104 (Pubitemid 34028514)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.300 , Issue.1 , pp. 97-104
    • Cherrington, N.J.1    Hartley, D.P.2    Li, N.3    Johnson, D.R.4    Klaassen, C.D.5
  • 79
    • 0031043119 scopus 로고    scopus 로고
    • The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance
    • DOI 10.1097/00001813-199701000-00002
    • Kavallaris M. The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance. Anticancer Drugs 1997;8:17-25 (Pubitemid 27064745)
    • (1997) Anti-Cancer Drugs , vol.8 , Issue.1 , pp. 17-25
    • Kavallaris, M.1
  • 81
    • 0035882764 scopus 로고    scopus 로고
    • Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells
    • DOI 10.1016/S0006-2952(01)00681-5, PII S0006295201006815
    • Cullen KV, Davey RA, Davey MW. Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells. Biochem Pharm 2001;62(4):417-24 (Pubitemid 32607723)
    • (2001) Biochemical Pharmacology , vol.62 , Issue.4 , pp. 417-424
    • Cullen, K.V.1    Davey, R.A.2    Davey, M.W.3
  • 82
    • 31844450741 scopus 로고    scopus 로고
    • On the putative co-transport of drugs by multidrug resistance proteins
    • DOI 10.1016/j.febslet.2005.12.039, PII S0014579305015085, ABC Transporters
    • Borst P, Zelcer N, van de Wetering K, et al. On the putative co-transport of drugs by multidrug resistance proteins. FEBS Lett 2006;580(4):1085-93 (Pubitemid 43185288)
    • (2006) FEBS Letters , vol.580 , Issue.4 , pp. 1085-1093
    • Borst, P.1    Zelcer, N.2    Van De Wetering, K.3    Poolman, B.4
  • 83
    • 0030469817 scopus 로고    scopus 로고
    • Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds
    • Versantvoort CH, Rhodes T, Twentyman PR. Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds. Br J Cancer 1996;74(12):1949-54 (Pubitemid 27007140)
    • (1996) British Journal of Cancer , vol.74 , Issue.12 , pp. 1949-1954
    • Versantvoort, C.H.M.1    Rhodes, T.2    Twentyman, P.R.3
  • 84
    • 0035033774 scopus 로고    scopus 로고
    • Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATpase activities by interaction with dietary flavonoids
    • Leslie EM, Mao Q, Oleschuk CJ, et al. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids. Mol Pharmacol 2001;59(5):1171-80 (Pubitemid 32381597)
    • (2001) Molecular Pharmacology , vol.59 , Issue.5 , pp. 1171-1180
    • Leslie, E.M.1    Mao, Q.2    Oleschuk, C.J.3    Deeley, R.G.4    Cole, S.P.C.5
  • 85
    • 12744256734 scopus 로고    scopus 로고
    • Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2
    • van Zanden JJ, Wortelboer HM, Bijlsma S, et al. Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. Biochem Pharmacol 2005;69(4):699-708
    • (2005) Biochem Pharmacol , vol.69 , Issue.4 , pp. 699-708
    • Van Zanden, J.J.1    Wortelboer, H.M.2    Bijlsma, S.3
  • 87
    • 0013016426 scopus 로고    scopus 로고
    • Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
    • DOI 10.1124/dmd.31.1.11
    • Leslie EM, Deeley RG, Cole SP. Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). Drug Metab Dispos 2003;31(1):11-15 (Pubitemid 36735252)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.1 , pp. 11-15
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.C.3
  • 88
    • 0037311322 scopus 로고    scopus 로고
    • Effect of flavonoids on MRP1-mediated transport in Panc-1 cells
    • DOI 10.1002/jps.10283
    • Nguyen H, Zhang S, Morris ME. Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. J Pharm Sci 2003;92(2):250-7 (Pubitemid 36169297)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.2 , pp. 250-257
    • Nguyen, H.1    Zhang, S.2    Morris, M.E.3
  • 89
    • 0345299165 scopus 로고    scopus 로고
    • Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
    • Cui Y, Konig J, Buchholz JK, et al. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 1999;55:929-37 (Pubitemid 29214613)
    • (1999) Molecular Pharmacology , vol.55 , Issue.5 , pp. 929-937
    • Cui, Y.1    Konig, J.2    Buchholz, U.3    Spring, H.4    Leier, I.5    Keppler, D.6
  • 90
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • Konig J, Nies AT, Cui Y, et al. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1999;1461(2):377-94
    • (1999) Biochim Biophys Acta , vol.1461 , Issue.2 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3
  • 91
    • 33644770013 scopus 로고    scopus 로고
    • MRP2 and 3 in health and disease
    • DOI 10.1016/j.canlet.2005.05.051, PII S0304383505009250, Pharmacogenomics in Cancer Chemotherapy: Recent Advances in Drug Transporters and Genome Analysis
    • Borst P, Zelcer N, van de Wetering K. MRP2 and 3 in health and disease. Cancer Lett 2006;234(1):51-61 (Pubitemid 43343940)
    • (2006) Cancer Letters , vol.234 , Issue.1 , pp. 51-61
    • Borst, P.1    Zelcer, N.2    Van De Wetering, K.3
  • 94
    • 62749188875 scopus 로고    scopus 로고
    • Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs
    • Aszalos A. Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. Curr Drug Metab 2008;9(10):1010-18
    • (2008) Curr Drug Metab , vol.9 , Issue.10 , pp. 1010-1018
    • Aszalos, A.1
  • 95
    • 9044252313 scopus 로고    scopus 로고
    • CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells
    • Gan LS, Moseley MA, Khosla B, et al. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug Metab Dispos 1996;24(3):344-9
    • (1996) Drug Metab Dispos , vol.24 , Issue.3 , pp. 344-349
    • Gan, L.S.1    Moseley, M.A.2    Khosla, B.3
  • 96
    • 0342762062 scopus 로고    scopus 로고
    • The barrier function of CYP3A4 and P-glycoprotein in the small bowel
    • DOI 10.1016/S0169-409X(97)00041-0, PII S0169409X97000410
    • Watkins PB. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drug Deliv Rev 1997;27(2-3):161-70 (Pubitemid 27417871)
    • (1997) Advanced Drug Delivery Reviews , vol.27 , Issue.2-3 , pp. 161-170
    • Watkins, P.B.1
  • 97
    • 68849107630 scopus 로고    scopus 로고
    • Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers
    • Kim KA, Park PW, Park JY. Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers. Eur J Clin Pharmacol 2009;65(6):609-14
    • (2009) Eur J Clin Pharmacol , vol.65 , Issue.6 , pp. 609-614
    • Kim, K.A.1    Park, P.W.2    Park, J.Y.3
  • 99
    • 1842789744 scopus 로고    scopus 로고
    • Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats
    • Choi JS, Choi HK, Shin SC. Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats. Int J Pharm 2004;275(1-2):165-70
    • (2004) Int J Pharm , vol.275 , Issue.1-2 , pp. 165-170
    • Choi, J.S.1    Choi, H.K.2    Shin, S.C.3
  • 100
    • 13844256394 scopus 로고    scopus 로고
    • Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats
    • Choi JS, Shin SC. Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. Int J Pharm 2005;292(1-2):149-56
    • (2005) Int J Pharm , vol.292 , Issue.1-2 , pp. 149-156
    • Choi, J.S.1    Shin, S.C.2
  • 101
    • 1442359716 scopus 로고    scopus 로고
    • Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin
    • Choi JS, Jo BW, Kim YC. Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin. Eur J Pharm Biopharm 2004;57(2):313-18
    • (2004) Eur J Pharm Biopharm , vol.57 , Issue.2 , pp. 313-318
    • Choi, J.S.1    Jo, B.W.2    Kim, Y.C.3
  • 102
    • 34248327577 scopus 로고    scopus 로고
    • Effects of morin on the pharmacokinetics of etoposide in rats
    • DOI 10.1002/bdd.539
    • Li X, Yun JK, Choi JS. Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos 2007;28(3):151-6 (Pubitemid 46730923)
    • (2007) Biopharmaceutics and Drug Disposition , vol.28 , Issue.3 , pp. 151-156
    • Li, X.1    Yun, J.-K.2    Choi, J.-S.3
  • 103
    • 33846103811 scopus 로고    scopus 로고
    • Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats
    • Lim SC, Choi JS. Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. Biopharm Drug Dispos 2006;27(9):443-7
    • (2006) Biopharm Drug Dispos , vol.27 , Issue.9 , pp. 443-447
    • Lim, S.C.1    Choi, J.S.2
  • 104
    • 0027510377 scopus 로고
    • Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man
    • Fuhr U, Klittich K, Staib AH. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol 1993;35(4):431-6 (Pubitemid 23103386)
    • (1993) British Journal of Clinical Pharmacology , vol.35 , Issue.4 , pp. 431-436
    • Fuhr, U.1    Klittich, K.2    Staib, A.H.3
  • 105
    • 0035734306 scopus 로고    scopus 로고
    • Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds
    • Ho PC, Saville DJ, Wanwimolruk S. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci 2001;4(3):217-27 (Pubitemid 34305597)
    • (2001) Journal of Pharmacy and Pharmaceutical Sciences , vol.4 , Issue.3 , pp. 217-227
    • Ho, P.-C.1    Saville, D.J.2    Wanwimolruk, S.3
  • 106
    • 33749444911 scopus 로고    scopus 로고
    • The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms
    • DOI 10.2174/138920006778520570
    • Cermak R, Wolffram S. The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms. Curr Drug Metab 2006;7(7):729-44 (Pubitemid 44509679)
    • (2006) Current Drug Metabolism , vol.7 , Issue.7 , pp. 729-744
    • Cermak, R.1    Wolffram, S.2
  • 107
    • 33644891064 scopus 로고    scopus 로고
    • MDR-and CYP3A4-mediated drug-herbal interactions
    • Pal D, Mitra AK. MDR-and CYP3A4-mediated drug-herbal interactions. Life Sci 2006;78(18):2131-45
    • (2006) Life Sci , vol.78 , Issue.18 , pp. 2131-2145
    • Pal, D.1    Mitra, A.K.2
  • 109
    • 0347510572 scopus 로고    scopus 로고
    • Lethal quercetin-digoxin interaction in pigs
    • Wang YH, Chao PD, Hsiu SL, et al. Lethal quercetin-digoxin interaction in pigs. Life Sci 2004;74(10):1191-7
    • (2004) Life Sci , vol.74 , Issue.10 , pp. 1191-1197
    • Wang, Y.H.1    Chao, P.D.2    Hsiu, S.L.3
  • 112
    • 13444252326 scopus 로고    scopus 로고
    • Mapping of multidrug resistance gene 1 and multidrug resistance- associated protein isoform 1 to 5 mRNA expression along the human intestinal tract
    • DOI 10.1124/dmd.104.001354
    • Zimmermann C, Gutmann H, Hruz P, et al. Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract. Drug Metab Dispos 2005;33(2):219-24 (Pubitemid 40216589)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.2 , pp. 219-224
    • Zimmermann, C.1    Gutmann, H.2    Hruz, P.3    Gutzwiller, J.-P.4    Beglinger, C.5    Drewe, J.6
  • 114
    • 23044472581 scopus 로고    scopus 로고
    • Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract
    • DOI 10.1016/j.bcp.2005.05.031, PII S0006295205003709
    • Gutmann H, Hruz P, Zimmermann C, et al. Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract. Biochem Pharmacol 2005;70(5):695-9 (Pubitemid 41058704)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.5 , pp. 695-699
    • Gutmann, H.1    Hruz, P.2    Zimmermann, C.3    Beglinger, C.4    Drewe, J.5
  • 116
    • 4243139494 scopus 로고    scopus 로고
    • Disposition of flavonoids via enteric recycling: Enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates
    • DOI 10.1124/jpet.104.068403
    • Jia X, Chen J, Lin H, et al. Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. J Pharmacol Exp Ther 2004;310(3):1103-13 (Pubitemid 39108932)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.310 , Issue.3 , pp. 1103-1113
    • Jia, X.1    Chen, J.2    Lin, H.3    Hu, M.4
  • 117
    • 72749084863 scopus 로고    scopus 로고
    • Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: In vitro and in vivo
    • Zhang S, Sagawa K, Arnold RD, et al. Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo. J Pharm Sci 2010;99(1):430-41
    • (2010) J Pharm Sci , vol.99 , Issue.1 , pp. 430-441
    • Zhang, S.1    Sagawa, K.2    Arnold, R.D.3
  • 118
    • 34248512624 scopus 로고    scopus 로고
    • Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats
    • DOI 10.1016/j.ijpharm.2007.01.002, PII S0378517307000142
    • Li X, Choi JS. Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats. Int J Pharm 2007;337(1-2):188-93 (Pubitemid 46756050)
    • (2007) International Journal of Pharmaceutics , vol.337 , Issue.1-2 , pp. 188-193
    • Li, X.1    Choi, J.-S.2
  • 120
    • 78649308647 scopus 로고    scopus 로고
    • Fruit juice inhibition of uptake transport: A new type of food-drug interaction
    • Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2011;70(5):645-55
    • (2011) Br J Clin Pharmacol , vol.70 , Issue.5 , pp. 645-655
    • Bailey, D.G.1
  • 121
    • 27544453625 scopus 로고    scopus 로고
    • Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators
    • DOI 10.1124/dmd.105.005926
    • Wang X, Wolkoff AW, Morris ME. Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Dispos 2005;33(11):1666-72 (Pubitemid 41539965)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.11 , pp. 1666-1672
    • Wang, X.1    Wolkoff, A.W.2    Morris, M.E.3
  • 122
    • 79952575127 scopus 로고    scopus 로고
    • Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
    • Wong CC, Botting NP, Orfila C, et al. Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochem Pharmacol 2011;81(7):942-9
    • (2011) Biochem Pharmacol , vol.81 , Issue.7 , pp. 942-949
    • Wong, C.C.1    Botting, N.P.2    Orfila, C.3
  • 123
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • DOI 10.1124/mol.65.5.1208
    • Zhang S, Yang X, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 2004;65(5):1208-16 (Pubitemid 38543491)
    • (2004) Molecular Pharmacology , vol.65 , Issue.5 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 126
    • 80054960683 scopus 로고    scopus 로고
    • The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2)
    • An G, Morris ME. The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2). Biopharm Drug Dispos 2011;32(8):446-57
    • (2011) Biopharm Drug Dispos , vol.32 , Issue.8 , pp. 446-457
    • An, G.1    Morris, M.E.2
  • 127
    • 33846464175 scopus 로고    scopus 로고
    • Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: Potential involvement of ABCG2
    • DOI 10.1124/dmd.106.011684
    • Wang X, Morris ME. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos 2007;35(2):268-74 (Pubitemid 46148740)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.2 , pp. 268-274
    • Wang, X.1    Morris, M.E.2
  • 128
    • 11844267237 scopus 로고    scopus 로고
    • Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: A minor role of breast cancer resistance protein
    • DOI 10.1124/jpet.104.073320
    • Lee YJ, Kusuhara H, Jonker JW, et al. Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein. J Pharmacol Exp Ther 2005;312(1):44-52 (Pubitemid 40096451)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.1 , pp. 44-52
    • Lee, Y.-J.1    Kusuhara, H.2    Jonker, J.W.3    Schinkel, A.H.4    Sugiyama, Y.5
  • 129
    • 34748926909 scopus 로고    scopus 로고
    • Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens
    • DOI 10.1124/mol.107.034751
    • Enokizono J, Kusuhara H, Sugiyama Y. Effect of breast cancer resistance protein (bcrp/abcg2) on the disposition of phytoestrogens. Mol Pharmacol 2007;72(4):967-75 (Pubitemid 47481419)
    • (2007) Molecular Pharmacology , vol.72 , Issue.4 , pp. 967-975
    • Enokizono, J.1    Kusuhara, H.2    Sugiyama, Y.3
  • 130
    • 58549098231 scopus 로고    scopus 로고
    • Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice
    • Shukla S, Zaher H, Hartz A, et al. Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res 2009;26(2):480-7
    • (2009) Pharm Res , vol.26 , Issue.2 , pp. 480-487
    • Shukla, S.1    Zaher, H.2    Hartz, A.3
  • 131
    • 0034684120 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
    • Jonker JW, Smit JW, Brinkhuis RF, et al. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst 2000;92(20):1651-6
    • (2000) J Natl Cancer Inst , vol.92 , Issue.20 , pp. 1651-1656
    • Jonker, J.W.1    Smit, J.W.2    Brinkhuis, R.F.3
  • 132
    • 33646471830 scopus 로고    scopus 로고
    • ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast
    • Evseenko DA, Paxton JW, Keelan JA. ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol 2006;290(5):R1357-65
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290 , Issue.5
    • Evseenko, D.A.1    Paxton, J.W.2    Keelan, J.A.3
  • 133
    • 17844365262 scopus 로고    scopus 로고
    • The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin
    • DOI 10.1124/mol.104.010439
    • Merino G, Jonker JW, Wagenaar E, et al. The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol 2005;67(5):1758-64 (Pubitemid 40594177)
    • (2005) Molecular Pharmacology , vol.67 , Issue.5 , pp. 1758-1764
    • Merino, G.1    Jonker, J.W.2    Wagenaar, E.3    Van Herwaarden, A.E.4    Schinkel, A.H.5
  • 135
    • 1542437321 scopus 로고    scopus 로고
    • The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: Impact on therapy
    • Jager W, Gehring E, Hagenauer B, et al. The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy. Int J Clin Pharmacol Ther 2003;41(12):610-11
    • (2003) Int J Clin Pharmacol Ther , vol.41 , Issue.12 , pp. 610-611
    • Jager, W.1    Gehring, E.2    Hagenauer, B.3
  • 136
    • 0035108539 scopus 로고    scopus 로고
    • Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol
    • DOI 10.1016/S0928-0987(00)00191-3, PII S0928098700001913
    • Spahn-Langguth H, Langguth P. Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol. Eur J Pharm Sci 2001;12(4):361-7 (Pubitemid 32166734)
    • (2001) European Journal of Pharmaceutical Sciences , vol.12 , Issue.4 , pp. 361-367
    • Spahn-Langguth, H.1    Langguth, P.2
  • 137
    • 47349108866 scopus 로고    scopus 로고
    • Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats
    • DOI 10.1021/jf0728451
    • De Castro WV, Mertens-Talcott S, Derendorf H, et al. Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats. J Agric Food Chem 2008;56(12):4840-5 (Pubitemid 351999419)
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , Issue.12 , pp. 4840-4845
    • De Castro, W.V.1    Mertens-Talcott, S.2    Derendorf, H.3    Butterweck, V.4
  • 138
    • 60049089374 scopus 로고    scopus 로고
    • Concentration-dependent effect of naringin on intestinal absorption of b1-adrenoceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting polypeptide (Oatp
    • Shirasaka Y, Li Y, Shibue Y, et al. Concentration-dependent effect of naringin on intestinal absorption of b1-adrenoceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting polypeptide (Oatp). Pharm Res 2009;26(3):560-7
    • (2009) Pharm Res , vol.26 , Issue.3 , pp. 560-567
    • Shirasaka, Y.1    Li, Y.2    Shibue, Y.3
  • 142
    • 14344265920 scopus 로고    scopus 로고
    • Effect of fruit juices on the oral bioavailability of fexofenadine in rats
    • DOI 10.1002/jps.20231
    • Kamath AV, Ming Y, Zhang YP, et al. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94(2):233-9 (Pubitemid 40293320)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.2 , pp. 233-239
    • Kamath, A.V.1    Yao, M.2    Zhang, Y.3    Chong, S.4
  • 143
    • 0036091282 scopus 로고    scopus 로고
    • Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine
    • Banfield C, Gupta S, Marino M, et al. Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine. Clin Pharmacokinet 2002;41(4):311-18 (Pubitemid 34533758)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.4 , pp. 311-318
    • Banfield, C.1    Gupta, S.2    Marino, M.3    Lim, J.4    Affrime, M.5
  • 145
    • 48749111850 scopus 로고    scopus 로고
    • Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: Possible contribution of P-glycoprotein
    • Bansal T, Awasthi A, Jaggi M, et al. Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. Life Sci 2008;83(7-8):250-9
    • (2008) Life Sci , vol.83 , Issue.7-8 , pp. 250-259
    • Bansal, T.1    Awasthi, A.2    Jaggi, M.3
  • 146
    • 56749149775 scopus 로고    scopus 로고
    • Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats
    • Li C, Choi JS. Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats. Pharmazie 2008;63(11):815-18
    • (2008) Pharmazie , vol.63 , Issue.11 , pp. 815-818
    • Li, C.1    Choi, J.S.2
  • 148
    • 28644443691 scopus 로고    scopus 로고
    • Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: Contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts
    • DOI 10.1211/jpp.57.12.0006
    • Mols R, Deferme S, Augustijns P. Sulfasalazine transport in in-vitro ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts. J Pharm Pharmacol 2005;57(12):1565-73 (Pubitemid 41752270)
    • (2005) Journal of Pharmacy and Pharmacology , vol.57 , Issue.12 , pp. 1565-1573
    • Mols, R.1    Deferme, S.2    Augustijns, P.3
  • 149
    • 84863195735 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP
    • Kusuhara H, Furuie H, Inano A, et al. Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br J Pharmacol 2012;166(6):1793-803
    • (2012) Br J Pharmacol , vol.166 , Issue.6 , pp. 1793-1803
    • Kusuhara, H.1    Furuie, H.2    Inano, A.3
  • 150
    • 37549031270 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: Effects of quercetin and EGCG on biochanin A disposition in rats
    • Moon YJ, Morris ME. Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol Pharm 2007;4(6):865-72
    • (2007) Mol Pharm , vol.4 , Issue.6 , pp. 865-872
    • Moon, Y.J.1    Morris, M.E.2
  • 151
    • 14044269476 scopus 로고    scopus 로고
    • Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or MDR1A/1B (-/-) mice
    • DOI 10.1124/dmd.104.002501
    • Zhang S, Wang X, Sagawa K, et al. Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b mice. Drug Metab Dispos 2005;33(3):341-8 (Pubitemid 40279933)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.3 , pp. 341-348
    • Zhang, S.1    Wang, X.2    Sagawa, K.3    Morris, M.E.4
  • 152
    • 77955671379 scopus 로고    scopus 로고
    • Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo
    • An G, Morris ME. Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo. Biopharm Drug Dispos 2010;31(5-6):340-50
    • (2010) Biopharm Drug Dispos , vol.31 , Issue.5-6 , pp. 340-350
    • An, G.1    Morris, M.E.2
  • 153
    • 79955627074 scopus 로고    scopus 로고
    • 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice
    • An G, Wu F, Morris ME. 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. Pharm Res 2011;28(5):1090-9
    • (2011) Pharm Res , vol.28 , Issue.5 , pp. 1090-1099
    • An, G.1    Wu, F.2    Morris, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.