-
1
-
-
0036020061
-
Tissue-specific regulation of expression and activity of P-glycoprotein in adjuvant arthritis rats
-
Achira M, Totsuka R, Fujimura H, and Kume T (2002) Tissue-specific regulation of expression and activity of P-glycoprotein in adjuvant arthritis rats. Eur J Pharm Sci 16:29-36.
-
(2002)
Eur J Pharm Sci
, vol.16
, pp. 29-36
-
-
Achira, M.1
Totsuka, R.2
Fujimura, H.3
Kume, T.4
-
2
-
-
0032900953
-
Biochemical, cellular and pharmacological aspects of the multidrug transporter
-
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Fasten I, and Gottesman MM (1999) Biochemical, cellular and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361-398.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 361-398
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Fasten, I.5
Gottesman, M.M.6
-
3
-
-
0034072174
-
Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
-
Bakos E, Evers R, Sinko E, Varadi A, Borst P, and Sarkadi B (2000) Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol 57:760-768.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 760-768
-
-
Bakos, E.1
Evers, R.2
Sinko, E.3
Varadi, A.4
Borst, P.5
Sarkadi, B.6
-
5
-
-
0346728729
-
The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
-
Chan LM, Lowes S, and Hirst BH (2004) The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 21:25-51.
-
(2004)
Eur J Pharm Sci
, vol.21
, pp. 25-51
-
-
Chan, L.M.1
Lowes, S.2
Hirst, B.H.3
-
6
-
-
0029616643
-
Differences between nuclear run-off and mRNA levels for multidrug resistance gene expression in the cephalocaudal axis of the mouse intestine
-
Chianale J, Vollrath V, Wielandt AM, Miranda S, Gonzalez R, Fresno AM, Quintana C, Gonzalez S, Andrade L, and Guzman S (1995) Differences between nuclear run-off and mRNA levels for multidrug resistance gene expression in the cephalocaudal axis of the mouse intestine. Biochim Biophys Acta 1264:369-376.
-
(1995)
Biochim Biophys Acta
, vol.1264
, pp. 369-376
-
-
Chianale, J.1
Vollrath, V.2
Wielandt, A.M.3
Miranda, S.4
Gonzalez, R.5
Fresno, A.M.6
Quintana, C.7
Gonzalez, S.8
Andrade, L.9
Guzman, S.10
-
7
-
-
0037099541
-
Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu and pi expression in gastrointestinal tract mucosa of normal individuals
-
Coles BF, Chen G, Kadlubar FF, and Radominska-Pandya A (2002) Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu and pi expression in gastrointestinal tract mucosa of normal individuals. Arch Biochem Biophys 403:270-276.
-
(2002)
Arch Biochem Biophys
, vol.403
, pp. 270-276
-
-
Coles, B.F.1
Chen, G.2
Kadlubar, F.F.3
Radominska-Pandya, A.4
-
8
-
-
0344665555
-
ABC of oral bioavailability: Transporters as gatekeepers in the gut
-
Dietrich CG, Geier A, and Oude Elferink RP (2003) ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut 52:1788-1795.
-
(2003)
Gut
, vol.52
, pp. 1788-1795
-
-
Dietrich, C.G.1
Geier, A.2
Oude Elferink, R.P.3
-
9
-
-
0029986277
-
Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation
-
Fricker G, Drewe J, Huwyler J, Gutmann H, and Beglinger C (1996) Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation. Br J Pharmacol 118:1841-1847.
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1841-1847
-
-
Fricker, G.1
Drewe, J.2
Huwyler, J.3
Gutmann, H.4
Beglinger, C.5
-
10
-
-
0034723163
-
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)
-
Hirohashi T, Suzuki H, Takikawa H, and Sugiyama Y (2000) ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem 275:2905-2910.
-
(2000)
J Biol Chem
, vol.275
, pp. 2905-2910
-
-
Hirohashi, T.1
Suzuki, H.2
Takikawa, H.3
Sugiyama, Y.4
-
11
-
-
0007630205
-
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells
-
Horio M, Gottesman MM, and Pastan I (1988) ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci USA 85:3580-3584.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 3580-3584
-
-
Horio, M.1
Gottesman, M.M.2
Pastan, I.3
-
12
-
-
0034730755
-
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
-
Jedlitschky G, Burchell B, and Keppler D (2000) The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem 275:30069-30074.
-
(2000)
J Biol Chem
, vol.275
, pp. 30069-30074
-
-
Jedlitschky, G.1
Burchell, B.2
Keppler, D.3
-
13
-
-
0030668526
-
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
-
Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B, and Keppler D (1997) ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327 (Pt 1):305-310.
-
(1997)
Biochem J
, vol.327
, Issue.PART 1
, pp. 305-310
-
-
Jedlitschky, G.1
Leier, I.2
Buchholz, U.3
Hummel-Eisenbeiss, J.4
Burchell, B.5
Keppler, D.6
-
14
-
-
0032781499
-
Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)
-
Kawabe T, Chen ZS, Wada M, Uchiumi T, Ono M, Akiyama S, and Kuwano M (1999) Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett 456:327-331.
-
(1999)
FEBS Lett
, vol.456
, pp. 327-331
-
-
Kawabe, T.1
Chen, Z.S.2
Wada, M.3
Uchiumi, T.4
Ono, M.5
Akiyama, S.6
Kuwano, M.7
-
15
-
-
17144465167
-
ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2
-
Keppler D, Leier I, Jedlitschky G, and Konig J (1998) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2. Chem-Biol Interact 111-112:153-161.
-
(1998)
Chem-Biol Interact
, vol.111-112
, pp. 153-161
-
-
Keppler, D.1
Leier, I.2
Jedlitschky, G.3
Konig, J.4
-
16
-
-
13044294031
-
MRP3, an organic anion transporter able to transport anti-cancer drugs
-
Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, et al. (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci USA 96:6914-6919.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6914-6919
-
-
Kool, M.1
Van Der Linden, M.2
De Haas, M.3
Scheffer, G.L.4
De Vree, J.M.5
Smith, A.J.6
Jansen, G.7
Peters, G.J.8
Ponne, N.9
Scheper, R.J.10
-
17
-
-
0037122743
-
Role of transporters in the tissue-selective distribution and elimination of drugs: Transporters in the liver, small intestine, brain and kidney
-
Kusuhara H and Sugiyama Y (2002) Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Controlled Release 78:43-54.
-
(2002)
J Controlled Release
, vol.78
, pp. 43-54
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
18
-
-
0030830598
-
Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene
-
Lee CG, Jeang KT, Martin MA, Pastan I, and Gottesman MM (1997) Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene. Antisense Nucleic Acid Drug Dev 7:511-522.
-
(1997)
Antisense Nucleic Acid Drug Dev
, vol.7
, pp. 511-522
-
-
Lee, C.G.1
Jeang, K.T.2
Martin, M.A.3
Pastan, I.4
Gottesman, M.M.5
-
19
-
-
0042626576
-
Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines
-
Li Q, Sai Y, Kato Y, Tamai I, and Tsuji A (2003) Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines. Pharm Res (NY) 20:1119-1124.
-
(2003)
Pharm Res (NY)
, vol.20
, pp. 1119-1124
-
-
Li, Q.1
Sai, Y.2
Kato, Y.3
Tamai, I.4
Tsuji, A.5
-
20
-
-
0038236976
-
Variable expression of CYP and Pgp genes in the human small intestine
-
Lindell M, Karlsson MO, Lennernas H, Pahlman L, and Lang MA (2003) Variable expression of CYP and Pgp genes in the human small intestine. Eur J Clin Investig 33:493-499.
-
(2003)
Eur J Clin Investig
, vol.33
, pp. 493-499
-
-
Lindell, M.1
Karlsson, M.O.2
Lennernas, H.3
Pahlman, L.4
Lang, M.A.5
-
21
-
-
0028113492
-
Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test
-
Lown KS, Kolars JC, Thummel KE, Barnett JL, Kunze KL, Wrighton SA, and Watkins PB (1994) Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. Drug Metab Dispos 22:947-955.
-
(1994)
Drug Metab Dispos
, vol.22
, pp. 947-955
-
-
Lown, K.S.1
Kolars, J.C.2
Thummel, K.E.3
Barnett, J.L.4
Kunze, K.L.5
Wrighton, S.A.6
Watkins, P.B.7
-
22
-
-
12644272784
-
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
-
Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, and Watkins PB (1997) Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 62:248-260.
-
(1997)
Clin Pharmacol Ther
, vol.62
, pp. 248-260
-
-
Lown, K.S.1
Mayo, R.R.2
Leichtman, A.B.3
Hsiao, H.L.4
Turgeon, D.K.5
Schmiedlin-Ren, P.6
Brown, M.B.7
Guo, W.8
Rossi, S.J.9
Benet, L.Z.10
Watkins, P.B.11
-
23
-
-
0034119967
-
Expression and localization of multidrug resistant protein mrp2 in rat small intestine
-
Mottino AD, Hoffman T, Jennes L, and Vore M (2000) Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J Pharmacol Exp Ther 293:717-723.
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 717-723
-
-
Mottino, A.D.1
Hoffman, T.2
Jennes, L.3
Vore, M.4
-
24
-
-
0142010611
-
P-glycoprotein increases from proximal to distal regions of human small intestine
-
Mouly S and Paine MF (2003) P-glycoprotein increases from proximal to distal regions of human small intestine. Pharm Res (NY) 20:1595-1599.
-
(2003)
Pharm Res (NY)
, vol.20
, pp. 1595-1599
-
-
Mouly, S.1
Paine, M.F.2
-
25
-
-
18244390013
-
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues and colorectal adenocarcinomas
-
Nakamura T, Sakaeda T, Ohmoto N, Tamura T, Aoyama N, Shirakawa T, Kamigaki T, Kim KI, Kim SR, Kuroda Y, et al. (2002) Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues and colorectal adenocarcinomas. Drug Metab Dispos 30:4-6.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 4-6
-
-
Nakamura, T.1
Sakaeda, T.2
Ohmoto, N.3
Tamura, T.4
Aoyama, N.5
Shirakawa, T.6
Kamigaki, T.7
Kim, K.I.8
Kim, S.R.9
Kuroda, Y.10
-
26
-
-
0037252475
-
Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines
-
Pfrunder A, Gutmann H, Beglinger C, and Drewe J (2003) Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. J Pharm Pharmacol 55:59-66.
-
(2003)
J Pharm Pharmacol
, vol.55
, pp. 59-66
-
-
Pfrunder, A.1
Gutmann, H.2
Beglinger, C.3
Drewe, J.4
-
27
-
-
0043132421
-
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
-
Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, and Borst P (2003) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 100:9244-9249.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9244-9249
-
-
Reid, G.1
Wielinga, P.2
Zelcer, N.3
Van Der Heijden, I.4
Kuil, A.5
De Haas, M.6
Wijnholds, J.7
Borst, P.8
-
28
-
-
0036080426
-
Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine
-
Rost D, Mahner S, Sugiyama Y, and Stremmel W (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am J Physiol 282:G720-G726.
-
(2002)
Am J Physiol
, vol.282
-
-
Rost, D.1
Mahner, S.2
Sugiyama, Y.3
Stremmel, W.4
-
29
-
-
0031158805
-
The physiological function of drug-transporting P-glycoproteins
-
Schinkel AH (1997) The physiological function of drug-transporting P-glycoproteins. Semin Cancer Biol 8:161-170.
-
(1997)
Semin Cancer Biol
, vol.8
, pp. 161-170
-
-
Schinkel, A.H.1
-
30
-
-
0031982725
-
Pharmacological insights from P-glycoprotein knockout mice
-
Schinkel AH (1998) Pharmacological insights from P-glycoprotein knockout mice. Int J Clin Pharmacol Ther 36:9-13.
-
(1998)
Int J Clin Pharmacol Ther
, vol.36
, pp. 9-13
-
-
Schinkel, A.H.1
-
31
-
-
0031850954
-
Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene
-
Schuetz EG, Yasuda K, Arimori K, and Schuetz JD (1998) Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. Arch Biochem Biophys 350:340-347.
-
(1998)
Arch Biochem Biophys
, vol.350
, pp. 340-347
-
-
Schuetz, E.G.1
Yasuda, K.2
Arimori, K.3
Schuetz, J.D.4
-
32
-
-
0032879904
-
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
-
Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, and Fridland A (1999) MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5:1048-1051.
-
(1999)
Nat Med
, vol.5
, pp. 1048-1051
-
-
Schuetz, J.D.1
Connelly, M.C.2
Sun, D.3
Paibir, S.G.4
Flynn, P.M.5
Srinivas, R.V.6
Kumar, A.7
Fridland, A.8
-
34
-
-
0035146553
-
Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human epithelia
-
Stephens RH, O'Neill CA, Warhurst A, Carlson GL, Rowland M, and Warhurst G (2001) Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human epithelia. J Pharmacol Exp Ther 296:584-591.
-
(2001)
J Pharmacol Exp Ther
, vol.296
, pp. 584-591
-
-
Stephens, R.H.1
O'Neill, C.A.2
Warhurst, A.3
Carlson, G.L.4
Rowland, M.5
Warhurst, G.6
-
35
-
-
0034811602
-
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
-
Taipalensuu J, Tornblom H, Lindberg G, Einarsson C, Sjoqvist F, Melhus H, Garberg P, Sjostrom B, Lundgren B, and Artursson P (2001) Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 299:164-170.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 164-170
-
-
Taipalensuu, J.1
Tornblom, H.2
Lindberg, G.3
Einarsson, C.4
Sjoqvist, F.5
Melhus, H.6
Garberg, P.7
Sjostrom, B.8
Lundgren, B.9
Artursson, P.10
-
36
-
-
0141569628
-
Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAs in small intestine
-
Takara K, Ohnishi N, Horibe S, and Yokoyama T (2003) Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAs in small intestine. Drug Metab Dispos 31:1235-1239.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1235-1239
-
-
Takara, K.1
Ohnishi, N.2
Horibe, S.3
Yokoyama, T.4
-
37
-
-
0344822637
-
Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals
-
Vernhet L, Allain N, Bardiau C, Anger JP, and Fardel O (2000) Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals. Toxicology 142:127-134.
-
(2000)
Toxicology
, vol.142
, pp. 127-134
-
-
Vernhet, L.1
Allain, N.2
Bardiau, C.3
Anger, J.P.4
Fardel, O.5
-
38
-
-
0036893815
-
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells
-
Wielinga PR, Reid G, Challa EE, van der Heijden I, van Deemter L, de Haas M, Mol C, Kuil AJ, Groeneveld E, Schuetz JD, et al. (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol 62:1321-1331.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1321-1331
-
-
Wielinga, P.R.1
Reid, G.2
Challa, E.E.3
Van Der Heijden, I.4
Van Deemter, L.5
De Haas, M.6
Mol, C.7
Kuil, A.J.8
Groeneveld, E.9
Schuetz, J.D.10
-
39
-
-
12944270590
-
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
-
Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, et al. (2000) Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97:7476-7481.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7476-7481
-
-
Wijnholds, J.1
Mol, C.A.2
Van Deemter, L.3
De Haas, M.4
Scheffer, G.L.5
Baas, F.6
Beijnen, J.H.7
Scheper, R.J.8
Hatse, S.9
De Clercq, E.10
|