P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene

International Journal of Cancer

Volumn 78, Issue 2, 1998, Pages 176-181

  Gifford, Andrew J ^a   Kavallaris, Maria ^a   Madafiglio, Janice ^a   Matherly, Larry H ^b   Stewart, Bernard W ^a   Haber, Michelle ^a   Norris, Murray D ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FOLIC ACID; METHOTREXATE;

ARTICLE; DRUG ACCUMULATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; HETEROZYGOSITY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; POINT MUTATION; PRIORITY JOURNAL; STOP CODON;

AMINO ACID SEQUENCE; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARRIER PROTEINS; DNA, NEOPLASM; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, T-CELL; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; POINT MUTATION; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0031667511     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19981005)78:2<176::AID-IJC10>3.0.CO;2-9     Document Type: Article

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