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Volumn 76, Issue 5, 2008, Pages 645-653

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro

Author keywords

Adhesion molecules; Flavonoids; Human neutrophils; Inflammation; Intracellular calcium; Quercetin metabolites

Indexed keywords

BETA2 INTEGRIN; CALCIUM; CD16 ANTIGEN; CELL ADHESION MOLECULE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLUCURONIDE; L SELECTIN; LIPOPOLYSACCHARIDE; QUERCETIN; QUERCETIN 3 GLUCURONIDE; QUERCETIN 3' SULFATE; SULFATE; UNCLASSIFIED DRUG;

EID: 49149102015     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.06.010     Document Type: Article
Times cited : (45)

References (42)
  • 2
    • 22344443770 scopus 로고    scopus 로고
    • Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control
    • Tintinger G., Steel H.C., and Anderson R. Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control. Clin Exp Immunol 141 (2005) 191-200
    • (2005) Clin Exp Immunol , vol.141 , pp. 191-200
    • Tintinger, G.1    Steel, H.C.2    Anderson, R.3
  • 4
    • 0025285857 scopus 로고
    • Biochemistry of endotoxins
    • Raetz C.R. Biochemistry of endotoxins. Annu Rev Biochem 59 (1990) 129-170
    • (1990) Annu Rev Biochem , vol.59 , pp. 129-170
    • Raetz, C.R.1
  • 5
    • 0025020108 scopus 로고
    • Lipopolysaccharide modulates chemotactic peptide-induced actin polymerization in neutrophils
    • Howard T.H., Wang D., and Berkow R.L. Lipopolysaccharide modulates chemotactic peptide-induced actin polymerization in neutrophils. J Leukoc Biol 47 (1990) 13-24
    • (1990) J Leukoc Biol , vol.47 , pp. 13-24
    • Howard, T.H.1    Wang, D.2    Berkow, R.L.3
  • 7
    • 41149111364 scopus 로고    scopus 로고
    • Evaluation of the effect of human beta-defensins on neutrophil apoptosis
    • Nagaoka I., Niyonsaba F., Tsutsumi-Ishii Y., Tamura H., and Hirata M. Evaluation of the effect of human beta-defensins on neutrophil apoptosis. Int Immunol 20 (2008) 543-553
    • (2008) Int Immunol , vol.20 , pp. 543-553
    • Nagaoka, I.1    Niyonsaba, F.2    Tsutsumi-Ishii, Y.3    Tamura, H.4    Hirata, M.5
  • 8
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C., Williamson G., Morand C., Scalbert A., and Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81 (2005) 230S-242S
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 9
    • 0030068760 scopus 로고    scopus 로고
    • Flavonoid intake and coronary mortality in Finland: a cohort study
    • Knekt P., Jarvinen R., Reunanen A., and Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ 312 (1996) 478-481
    • (1996) BMJ , vol.312 , pp. 478-481
    • Knekt, P.1    Jarvinen, R.2    Reunanen, A.3    Maatela, J.4
  • 11
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
    • Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., and Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342 (1993) 1007-1011
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 12
    • 0030973745 scopus 로고    scopus 로고
    • Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study
    • Hertog M.G., Sweetnam P.M., Fehily A.M., Elwood P.C., and Kromhout D. Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study. Am J Clin Nutr 65 (1997) 1489-1494
    • (1997) Am J Clin Nutr , vol.65 , pp. 1489-1494
    • Hertog, M.G.1    Sweetnam, P.M.2    Fehily, A.M.3    Elwood, P.C.4    Kromhout, D.5
  • 13
    • 0343247685 scopus 로고    scopus 로고
    • Antioxidant flavonols and coronary heart disease risk
    • Hertog M.G., Feskens E.J., and Kromhout D. Antioxidant flavonols and coronary heart disease risk. Lancet 349 (1997) 699
    • (1997) Lancet , vol.349 , pp. 699
    • Hertog, M.G.1    Feskens, E.J.2    Kromhout, D.3
  • 14
    • 0035810344 scopus 로고    scopus 로고
    • Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography-tandem mass spectrometry
    • Wittig J., Herderich M., Graefe E.U., and Veit M. Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B: Biomed Sci Appl 753 (2001) 237-243
    • (2001) J Chromatogr B: Biomed Sci Appl , vol.753 , pp. 237-243
    • Wittig, J.1    Herderich, M.2    Graefe, E.U.3    Veit, M.4
  • 15
    • 0035692180 scopus 로고    scopus 로고
    • Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin
    • Day A.J., Mellon F., Barron D., Sarrazin G., Morgan M.R., and Williamson G. Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 35 (2001) 941-952
    • (2001) Free Radic Res , vol.35 , pp. 941-952
    • Day, A.J.1    Mellon, F.2    Barron, D.3    Sarrazin, G.4    Morgan, M.R.5    Williamson, G.6
  • 16
    • 8444233189 scopus 로고    scopus 로고
    • Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection
    • Mullen W., Boitier A., Stewart A.J., and Crozier A. Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection. J Chromatogr A 1058 (2004) 163-168
    • (2004) J Chromatogr A , vol.1058 , pp. 163-168
    • Mullen, W.1    Boitier, A.2    Stewart, A.J.3    Crozier, A.4
  • 17
    • 33746698897 scopus 로고    scopus 로고
    • Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
    • Mullen W., Edwards C.A., and Crozier A. Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr 96 (2006) 107-116
    • (2006) Br J Nutr , vol.96 , pp. 107-116
    • Mullen, W.1    Edwards, C.A.2    Crozier, A.3
  • 18
    • 20444447208 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine
    • Wang L., and Morris M.E. Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine. J Chromatogr B: Anal Technol Biomed Life Sci 821 (2005) 194-201
    • (2005) J Chromatogr B: Anal Technol Biomed Life Sci , vol.821 , pp. 194-201
    • Wang, L.1    Morris, M.E.2
  • 19
    • 34250746390 scopus 로고    scopus 로고
    • Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation
    • Saeed S.A., Connor J.D., Imran, Quadri J., Tasneem S., Ahmed S., et al. Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation. Pharmacol Rep 59 (2007) 238-243
    • (2007) Pharmacol Rep , vol.59 , pp. 238-243
    • Saeed, S.A.1    Connor, J.D.2    Imran3    Quadri, J.4    Tasneem, S.5    Ahmed, S.6
  • 20
    • 33645299344 scopus 로고    scopus 로고
    • The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils
    • Liu J., Li X., Yue Y., Li J., He T., and He Y. The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Cell Mol Immunol 2 (2005) 455-460
    • (2005) Cell Mol Immunol , vol.2 , pp. 455-460
    • Liu, J.1    Li, X.2    Yue, Y.3    Li, J.4    He, T.5    He, Y.6
  • 21
    • 29944432474 scopus 로고    scopus 로고
    • Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils
    • Liu J.J., Song C.W., Yue Y., Duan C.G., Yang J., He T., et al. Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils. Inflamm Res 54 (2005) 500-507
    • (2005) Inflamm Res , vol.54 , pp. 500-507
    • Liu, J.J.1    Song, C.W.2    Yue, Y.3    Duan, C.G.4    Yang, J.5    He, T.6
  • 22
    • 0030787566 scopus 로고    scopus 로고
    • Inhibition of N-formylmethionyl-leucyl-phenylalanine-stimulated tyrosine phosphorylation and phospholipase D activation by quercetin in rabbit neutrophils
    • Takemura O.S., Banno Y., and Nozawa Y. Inhibition of N-formylmethionyl-leucyl-phenylalanine-stimulated tyrosine phosphorylation and phospholipase D activation by quercetin in rabbit neutrophils. Biochem Pharmacol 53 (1997) 1503-1510
    • (1997) Biochem Pharmacol , vol.53 , pp. 1503-1510
    • Takemura, O.S.1    Banno, Y.2    Nozawa, Y.3
  • 23
    • 12344307318 scopus 로고    scopus 로고
    • Effect of Cleome arabica leaf extract, rutin and quercetin on soybean lipoxygenase activity and on generation of inflammatory eicosanoids by human neutrophils
    • Bouriche H., Miles E.A., Selloum L., and Calder P.C. Effect of Cleome arabica leaf extract, rutin and quercetin on soybean lipoxygenase activity and on generation of inflammatory eicosanoids by human neutrophils. Prostaglandins Leukot Essent Fatty Acids 72 (2005) 195-201
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.72 , pp. 195-201
    • Bouriche, H.1    Miles, E.A.2    Selloum, L.3    Calder, P.C.4
  • 24
    • 1542286868 scopus 로고    scopus 로고
    • Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo
    • de Pascual-Teresa S., Johnston K.L., DuPont M.S., O'Leary K.A., Needs P.W., Morgan L.M., et al. Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo. J Nutr 134 (2004) 552-557
    • (2004) J Nutr , vol.134 , pp. 552-557
    • de Pascual-Teresa, S.1    Johnston, K.L.2    DuPont, M.S.3    O'Leary, K.A.4    Needs, P.W.5    Morgan, L.M.6
  • 25
    • 33744906324 scopus 로고    scopus 로고
    • Convenient syntheses of metabolically important quercetin glucuronides and sulfates
    • Needs P.W., and Kroon P.A. Convenient syntheses of metabolically important quercetin glucuronides and sulfates. Tetrahedron 62 (2006) 6862-6868
    • (2006) Tetrahedron , vol.62 , pp. 6862-6868
    • Needs, P.W.1    Kroon, P.A.2
  • 26
    • 35648965154 scopus 로고    scopus 로고
    • Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA
    • Nieman D.C., Henson D.A., Davis J.M., Angela M.E., Jenkins D.P., Gross S.J., et al. Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol 103 (2007) 1728-1735
    • (2007) J Appl Physiol , vol.103 , pp. 1728-1735
    • Nieman, D.C.1    Henson, D.A.2    Davis, J.M.3    Angela, M.E.4    Jenkins, D.P.5    Gross, S.J.6
  • 27
    • 38949207932 scopus 로고    scopus 로고
    • Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity
    • Loke W.M., Proudfoot J.M., Stewart S., McKinley A.J., Needs P.W., Kroon P.A., et al. Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol 75 (2008) 1045-1053
    • (2008) Biochem Pharmacol , vol.75 , pp. 1045-1053
    • Loke, W.M.1    Proudfoot, J.M.2    Stewart, S.3    McKinley, A.J.4    Needs, P.W.5    Kroon, P.A.6
  • 28
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer T.A. Adhesion receptors of the immune system. Nature 346 (1990) 425-434
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 29
    • 0029033422 scopus 로고
    • The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites
    • Ruotsalainen M., and Savolainen K.M. The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites. Toxicology 99 (1995) 67-76
    • (1995) Toxicology , vol.99 , pp. 67-76
    • Ruotsalainen, M.1    Savolainen, K.M.2
  • 30
    • 0030997435 scopus 로고    scopus 로고
    • Granules of the human neutrophilic polymorphonuclear leukocyte
    • Borregaard N., and Cowland J.B. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89 (1997) 3503-3521
    • (1997) Blood , vol.89 , pp. 3503-3521
    • Borregaard, N.1    Cowland, J.B.2
  • 31
    • 0035450154 scopus 로고    scopus 로고
    • Effect of three flavonoids, 5,7,3′,4′-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil
    • Lu H.W., Sugahara K., Sagara Y., Masuoka N., Asaka Y., Manabe M., et al. Effect of three flavonoids, 5,7,3′,4′-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil. Arch Biochem Biophys 393 (2001) 73-77
    • (2001) Arch Biochem Biophys , vol.393 , pp. 73-77
    • Lu, H.W.1    Sugahara, K.2    Sagara, Y.3    Masuoka, N.4    Asaka, Y.5    Manabe, M.6
  • 32
    • 0035498834 scopus 로고    scopus 로고
    • Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils
    • Selloum L., Reichl S., Muller M., Sebihi L., and Arnhold J. Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils. Arch Biochem Biophys 395 (2001) 49-56
    • (2001) Arch Biochem Biophys , vol.395 , pp. 49-56
    • Selloum, L.1    Reichl, S.2    Muller, M.3    Sebihi, L.4    Arnhold, J.5
  • 35
    • 39449137141 scopus 로고    scopus 로고
    • Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells
    • Tribolo S., Lodi F., Connor C., Suri S., Wilson V.G., Taylor M.A., et al. Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells. Atherosclerosis 197 (2008) 50-56
    • (2008) Atherosclerosis , vol.197 , pp. 50-56
    • Tribolo, S.1    Lodi, F.2    Connor, C.3    Suri, S.4    Wilson, V.G.5    Taylor, M.A.6
  • 36
    • 0035046916 scopus 로고    scopus 로고
    • Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells
    • Koga T., and Meydani M. Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. Am J Clin Nutr 73 (2001) 941-948
    • (2001) Am J Clin Nutr , vol.73 , pp. 941-948
    • Koga, T.1    Meydani, M.2
  • 37
    • 44049084958 scopus 로고    scopus 로고
    • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids
    • Kawai Y., Nishikawa T., Shiba Y., Saito S., Murota K., Shibata N., et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 283 (2008) 9424-9434
    • (2008) J Biol Chem , vol.283 , pp. 9424-9434
    • Kawai, Y.1    Nishikawa, T.2    Shiba, Y.3    Saito, S.4    Murota, K.5    Shibata, N.6
  • 38
    • 0035201891 scopus 로고    scopus 로고
    • Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation
    • Shimoi K., Saka N., Nozawa R., Sato M., Amano I., Nakayama T., et al. Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. Drug Metab Dispos 29 (2001) 1521-1524
    • (2001) Drug Metab Dispos , vol.29 , pp. 1521-1524
    • Shimoi, K.1    Saka, N.2    Nozawa, R.3    Sato, M.4    Amano, I.5    Nakayama, T.6
  • 39
    • 0031908477 scopus 로고    scopus 로고
    • Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study
    • Janssen K., Mensink R.P., Cox F.J., Harryvan J.L., Hovenier R., Hollman P.C., et al. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Am J Clin Nutr 67 (1998) 255-262
    • (1998) Am J Clin Nutr , vol.67 , pp. 255-262
    • Janssen, K.1    Mensink, R.P.2    Cox, F.J.3    Harryvan, J.L.4    Hovenier, R.5    Hollman, P.C.6
  • 40
    • 13244275108 scopus 로고    scopus 로고
    • Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans
    • Hubbard G.P., Wolffram S., Lovegrove J.A., and Gibbins J.M. Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. J Thromb Haemost 2 (2004) 2138-2145
    • (2004) J Thromb Haemost , vol.2 , pp. 2138-2145
    • Hubbard, G.P.1    Wolffram, S.2    Lovegrove, J.A.3    Gibbins, J.M.4
  • 41
    • 2442543550 scopus 로고    scopus 로고
    • Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway
    • Hubbard G.P., Stevens J.M., Cicmil M., Sage T., Jordan P.A., Williams C.M., et al. Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. J Thromb Haemost 1 (2003) 1079-1088
    • (2003) J Thromb Haemost , vol.1 , pp. 1079-1088
    • Hubbard, G.P.1    Stevens, J.M.2    Cicmil, M.3    Sage, T.4    Jordan, P.A.5    Williams, C.M.6
  • 42
    • 0042830450 scopus 로고    scopus 로고
    • Antibacterial peptides: basic facts and emerging concepts
    • Boman H.G. Antibacterial peptides: basic facts and emerging concepts. J Intern Med 254 (2003) 197-215
    • (2003) J Intern Med , vol.254 , pp. 197-215
    • Boman, H.G.1


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