Calcium Channels as Molecular Target Sites of Novel Insecticides

Advances in Insect Physiology

Volumn 44, Issue , 2013, Pages 287-347

  Lümmen, Peter ^a  

^a BAYER CROPSCIENCE AG   (Germany)

Author keywords

Calcium homeostasis; Calcium signaling; Diamide insecticides; Inhibitor cystine knot peptides; Peptide toxins; Ryanodine receptor; Voltage gated calcium channels

Indexed keywords

EID: 84873495817     PISSN: 00652806     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394389-7.00005-3     Document Type: Chapter

References (321)

1. Altafaj X., Cheng W., Esteve E., Urbani J., Grunwald D., Sabatier J.M., Coronado R., De We M., Ronjat M. Maurocalcine and domain A of the II-III loop of the dihydropyridine receptor Cav 1.1 subunit share common binding sites on the skeletal ryanodine receptor. J. Biol. Chem. 2005, 280:4013-4016.
2. 2+ release channel complex. J. Biol. Chem. 1989, 264:1329-1335.
3. Andersson A., Baell J.B., Duggan P.J., Graham J.E., Lewis R.J., Lumsden N.G., Tranberg C.E., Tuck K.L., Yang A. Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine. Bioorg. Med. Chem. 2009, 17:6659-6670.
4. Aracena-Parks P., Goonasekera S.A., Gilman C.P., Dirksen R.T., Hidalgo C., Hamilton S.L. Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1. J. Biol. Chem. 2006, 281:40354-40368.
5. Arnon A., Cook B.J., Montell C., Selinger Z., Minke B. Calmodulin regulation of calcium stores in phototransduction of Drosophila. Science 1997, 275:1119-1121.
6. Baell J.B., Duggan P.J., Forsyth S.A., Lewis R.J., Lok Y.P., Schroeder C.I., Shepherd N.E. Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of ω-conotoxin GVIA. Tetrahedron 2006, 62:7284-7292.
7. Bai J., Binari R., Ni J.-Q., Vijayakanthan M., Li H.-S., Perrimon N. RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development 2008, 135:1439-1449.
8. Balshaw D., Gao L., Meissner G. Luminal loop of the ryanodine receptor: a pore-forming segment?. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:3345-3347.
9. Banerjee S., Lee J., Venkatesh K., Wu C.F., Hasan G. Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila. J. Neurosci. 2004, 24:7869-7878.
10. Bannister M.L., Hamada T., Murayama T., Harvey P.J., Casarotto M.G., Dulhunty A.F., Ikemoto N. Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochem. J. 2007, 401:333-339.
11. Bass C., Field L.M. Gene amplification and insecticide resistance. Pest Manag. Sci. 2011, 67:886-890.
12. 2+ currents in embryonic cockroach brain neurons. J. Neurophysiol. 1999, 82:2284-2293.
13. Bhat M.B., Zhao J., Takeshima H., Ma J. Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor. Biophys. J. 1997, 73:1329-1336.
14. Blayney L.M., Jones J.L., Griffiths J., Lai F.A. A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201. Cardiovasc. Res. 2010, 85:68-78.
15. Bloomquist J.R. Ion channels as targets for insecticides. Annu. Rev. Entomol. 1996, 41:163-190.
16. Boncompagni S., Loy R.E., Dirksen R.T., Franzini-Armstrong C. The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell 2010, 9:958-970.
17. Bootman M.D., Collins T.J., Peppiatt C.M., Prothero L.S., MacKenzie L., De Smet P., Travers M., Tovey S.C., Seo J.T., Berridge M.J., Ciccolini F., Lipp P. Calcium signalling-an overview. Semin. Cell Dev. Biol. 2001, 12:3-10.
18. Branton W.D., Kolton L., Jan Y.N., Jan L.Y. Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J. Neurosci. 1987, 7:4195-4200.
19. Brini M. Ryanodine receptor defects in muscle genetic diseases. Biochem. Biophys. Res. Commun. 2004, 322:1245-1255.
20. 2+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium. Cold Spring Harb. Perspect. Biol. 2011, 3:1-15.
21. 2+ release channel. J. Biol. Chem. 1994, 269:15876-15884.
22. Cao C.W., Zhang J., Gao X.W., Liang P., Guo H.L. Overexpression of carboxylesterase gene associated with organophosphorous insecticide resistance in cotton aphids, Aphis gossypii (Glover). Pestic. Biochem. Physiol. 2008, 90:175-180.
23. Capes E.M., Loaiza R., Valdivia H.H. Ryanodine receptors. Skeletal Muscle 2011, 1:1-18.
24. Carafoli E., Coletto L., Brini M. Plasma membrane calcium pumps. Handbook of ATPases. Biochemistry, Cell Biology, Pathophysiology 2004, Wiley-VCH, Weinheim. M. Futai, Y. Wada, J.H. Kaplan (Eds.).
25. Carney J., Mason S., Viero C., Williams A.J. The ryanodine receptor pore: is there a consensus view?. Curr. Top. Membr. 2010, 66:49-67.
26. Cartwright E.I.J., Mohamed T., Oceandy D., Neyses L. Calcium signaling dysfunction in heart disease. Biofactors 2011, 37:175-181.
27. Casida J.E. Pest toxicology: the primary mechanisms of pesticide action. Chem. Res. Toxicol. 2009, 22:609-619.
28. Caspar, T., Cordova, D., Gutteridge, S., Rauh, J.J., Smith, R.M., Wu, L., Tao, Y., 2003. Isolation and use of ryanodine receptors. WO patent application number 2004027042.
29. Catterall W.A. Excitation-contraction coupling in vertebrate skeletal muscle: a tale of two calcium channels. Cell 1991, 64:871-874.
30. 2+ channels. Ann. N. Y. Acad. Sci. 1993, 707:1-19.
31. Catterall W.A. Signaling complexes of voltage-gated sodium and calcium channels. Neurosci. Lett. 2010, 486:107-116.
32. Catterall W.A. Voltage-gated calcium channels. Cold Spring Harb. Perspect. Biol. 2011, 3:a003947.
33. Catterall W.A., Few A.P. Calcium channel regulation and presynaptic plasticity. Neuron 2008, 59:882-901.
34. Catterall W.A., Yarov-Yarovoy V. Helical motion of an S4 voltage sensor revealed by gating pore currents. Channels 2010, 4:75-77.
35. Charalambous K., Wallace B.A. NaChBac: the long lost sodium channel ancestor. Biochemistry 2011, 50:6742-6752.
36. 2+ release channel (ryanodine receptor) in ryanodine interaction. Biophys. J. 2002, 82:2436-2447.
37. 2+ channels. Nature 2004, 429:675-680.
38. Chong Y., Hayes J.L., Sollod B., Wen S., Wilson D.T., Hains P.G., Hodgson W.C., Broady K.W., King G.F., Nicholson G.M. The omega-atracotoxins: selective blockers of insect M-LVA and HVA calcium channels. Biochem. Pharmacol. 2007, 74:623-638.
39. Clapham D.E. Calcium signaling. Cell 1995, 80:259-268.
40. Colgrave M.L., Kotze A.C., Huang Y.H., Ogrady J., Simonsen S.M., Craik D.J. Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry 2008, 47:5581-5589.
41. Cordova D., Benner E.A., Sacher M.D., Rauh J.J., Sopa J.S., Lahm G.P., Salby T.P., Stevenson T.M., Flexner L., Gutteridge S., Rhoades D.F., Wu L., Smith R.M., Tao Y. Anthranilic diamides: a new class of insecticides with a novel mode of action, ryanodine receptor activation. Pestic. Biochem. Physiol. 2006, 84:196-214.
42. Cordova D., Benner E.A., Sacher M.D., Rauh J.J., Sopa J.S., Lahm G.P., Selby T.P., Stevenson T.M., Flexner L., Gutteridge S., Rhoades D.F., WUu L., Smith R.M., Tao Y. The novel mode of action of anthranilic diamide insecticides: ryanodine receptor activation. ACS Symp. Ser. 2007, 948:223-234.
43. Damann N., Voets T., Nilius B. TRPs in our senses. Curr. Biol. 2008, 18:R880-R889.
44. Davies S.A., Terhzaz S. Organellar calcium signalling mechanisms in Drosophila epithelial function. J. Exp. Biol. 2009, 212:387-400.
45. 2+ signals at the Drosophila larval NMJ. J. Neurophysiol. 2011, 106:710-721.
46. 2+ regulation that influence synaptic transmission: comparison between crayfish and Drosophila neuromuscular junctions. Synapse 2009, 63:1100-1121.
47. 2+ exchanger in regulation of heart rate in larval Drosophila. Open Physiol. J. 2010, 3:16-36.
48. 2+ ATPase of animal cells: structure, function and regulation. Arch. Biochem. Biophys. 2008, 476:65-74.
49. Dijulio D.H., Watson E.L., Pessah I.N., Jacobson K.L., Ott S.M., Buck E.D., Singh J.C. Ryanodine receptor type III (Ry3R) identification in mouse parotid acini. Properties and modulation of [3H]ryanodine-binding sites. J. Biol. Chem. 1997, 272:15687-15696.
50. Dinsmore A.J., Rees-Blanchard W., Bentley P., Lewis T., Kahl S.D., McPherson P.S., Mullinnix M.J., Campbell K.P., Windass J.D., Earley F.G.P. Characterization of antibody models of the ryanodine receptor for use in high-throughput screening. Pestic. Sci. 1998, 54:345-352.
51. Dooley D.J., Lickert M., Lupp A., Osswald H. Distribution of [125I]ω-conotoxin GVIA and [3H]isradipine binding sites in the central nervous system of rats of different ages. Neurosci. Lett. 1988, 93:318-823.
52. Down R.E., Fitches E.C., Wiles D.P., Corti P., Bell H.A., Gatehouse J.A., Edwards J.P. Insecticidal spider venom toxin fused to snowdrop lectin is toxic to the peach-potato aphid, Myzus persicae (Hemiptera: Aphididae) and the rice brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae). Pest Manag. Sci. 2006, 62:77-85.
53. + conduction and selectivity. Science 1998, 280:69-77.
54. Du Y., Dong K. Molecular basis of knockdown resistance to pyrethroid insecticides. Recent Advances in Insect Physiology, Toxicology and Molecular Biology 2008, 29-40. Research Signpost, Kerala, India. N. Liu (Ed.).
55. 2+ release channel (ryanodine receptor isoform 2). J. Biol. Chem. 2001, 276:31760-31771.
56. 2+ depletion. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:13625-13630.
57. 2+ release. Biochem. J. 2004, 382:557-564.
58. Dube K., McDonald D.G., O'Donnell M.J. Calcium transport by isolated anterior and posterior Malpighian tubules of Drosophila melanogaster: roles of sequestration and secretion. J. Insect Physiol. 2000, 46:1449-1460.
59. Dulhunty A.F., Pouliquin P. What we don't know about the structure of ryanodine receptor calcium release channels. Clin. Exp. Pharmacol. Physiol. 2003, 30:713-723.
60. Dulhunty A.F., Beard N.A., Pouliquin P., Casarotto M.G. Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?. Pharmacol. Ther. 2007, 113:247-263.
61. 2+ release channels in insects. Cell Calcium 2006, 39:21-33.
62. Ebbinghaus-Kintscher U., Lümmen P., Raming K., Masaki T., Yasokawa N. Flubendiamide, the first insecticide with a novel mode of action on insect ryanodine receptors. Pflanzenschutz-Nachr. Bayer (Engl. Ed.) 2007, 60:117-140.
63. Enayati A.A., Ranson H., Hemingway J. Insect glutathione transferases and insecticide resistance. Insect Mol. Biol. 2005, 14:3-8.
64. Escoubas P., King G.F. Venomics as a drug discovery platform. Expert Rev. Proteomics 2009, 6:221-224.
65. 2+ release efficacy of maurocalcine in skeletal muscle cells. J. Biol. Chem. 2003, 278:37822-37831.
66. Fahrner M., Muik M., Derler I., Schindl R., Fritsch R., Frischauf I., Romanin C. Mechanistic view on domains mediating STIM1-Orai coupling. Immunol. Rev. 2009, 231:99-112.
67. FAO The State of the World's Land and Water Resources for Food and Agriculture (SOLAW)-managing Systems at Risk 2011, Food and Agriculture Organization of the United Nations, Rome and Earthscan, London.
68. Federspiel, N., Stricker, J., Winberg, M., Tintrup, H., Yu, Y.-T., Zhou, L., Munagala, N., 2006a. Polynucleotides encoding insect plasma membrane Ca2+ ATPase. US patent application 20060269938.
69. Federspiel, N.D., Tintrup, H., Hanel, A., Breach, J.-C., 2006b. The SERCA calcium pump of Heliothis virescens and a cDNA encoding it and use of the ATPase as a target for insecticides. DE Patent application 2004-102004062248.
70. Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006, 441:179-185.
71. Feyereisen R. Evolution of insect P450. Biochem. Soc. Trans. 2006, 34:1252-1255.
72. Feyereisen R. Arthropod CYPomes illustrate the tempo and mode in P450 evolution. Biochim. Biophys. Acta 2011, 1814:19-28.
73. ffrench-Constant R.H. Target site mediated insecticide resistance: what questions remain?. Insect Biochem. Mol. Biol. 1999, 29:397-403.
74. Findeisen F., Minor D.L. Progress in the structural understanding of voltage-gated calcium channel (Cav) function and modulation. Channels 2010, 4:459-474.
75. Fitches E., Edwards M.G., Mee C., Grishin E., Gatehouse A.M., Edwards J.P., Gatehouse J.A. Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion. J. Insect Physiol. 2004, 50:61-71.
76. Fletcher J.I., Smith R., O'Donoghue S.I., Nilges M., Connor M., Howden M.E., Christie M.J., King G.F. The structure of a novel insecticidal neurotoxin, ω-atracotoxin-HV1, from the venom of an Australian funnel web spider. Nat. Struct. Biol. 1997, 4:559-566.
77. 2+-release channel dysfunction. Curr. Pharm. Des. 2007, 13:3195-3211.
78. Gielow M.L., Gu G.G., Singh S. Resolution and pharmacological analysis of the voltage-dependent calcium channels of Drosophila larval muscles. J. Neurosci. 1995, 15:6085-6093.
79. Gonzalez D.R., Treuer A.V., Castellanos J., Dulce R.A., Hare J.M. Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure. J. Biol. Chem. 2010, 285:28938-28945.
80. Grabner M., Bachmann A., Rosenthal F., Striessnig J., Schultz C., Tautz D., Glossmann H. Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle. FEBS Lett. 1994, 339:189-194.
81. Grabner M., Wang Z., Mitterdorfer J., Rosenthal F., Charnet P., Savchenko A., Hering S., Ren D., Hall L.M., Glossmann H. Cloning and functional expression of a neuronal calcium channel beta subunit from house fly (Musca domestica). J. Biol. Chem. 1994, 269:23668-23674.
82. 2+ -mobilizing second messenger. Cell. Signal. 1999, 11:309-316.
83. 2+-signaling and cell function. Curr. Mol. Med. 2002, 2:273-282.
84. Gwack Y., Srikanth S., Feske S., Cruz-Guilloty F., Oh-Hora M., Neems D.S., Hogan P.G., Rao A. Biochemical and functional characterization of Orai proteins. J. Biol. Chem. 2007, 282:16232-16243.
85. Hall L.M., Ren D., Feng G., Eberl D.F., Dubald M., Yang M., Hannan F., Kousky C.T., Zheng W. Calcium channel as a new potential target for insecticides. Molecular Action of Insecticides on Ion Channels 1995, 162-172. ACS Symposium Series, Washington, DC. J.M. Clark (Ed.).
86. Hamada T., Bannister M.L., Ikemoto N. Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. Biochemistry 2007, 46:4272-4279.
87. Hamaguchi H., Hirooka T., Masaki T., Lahm G.P., Cordova D., Barry J.D., Andaloro J.T., Annan I.B., Marcon P.C., Portillo H.E., Stevenson T.M., Selby T.P. Insecticides affecting calcium homeostasis. Modern Crop Protection Compounds 2012, 1389-1425. Wiley-VCH, Weinheim. W. Krämer, U. Schirmer, P. Jeschke, M. Witschel (Eds.).
88. Hamilton S.L. Ryanodine receptors. Cell Calcium 2005, 38:253-260.
89. Hamilton S.L., Serysheva I.I. Ryanodine receptor structure: progress and challenges. J. Biol. Chem. 2009, 284:4047-4051.
90. A receptor. Eur. J. Pharmacol. 2005, 519:199-207.
91. Hansen S.B., Sulzenbacher G., Huxford T., Marchot P., Taylor P., Bourne Y. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J. 2005, 24:3635-3646.
92. Heinemann S.H., Terlau H., Stuhmer W., Imoto K., Numa S. Calcium channel characteristics conferred on the sodium channel by single mutations. Nature 1992, 356:441-443.
93. Hemingway J., Field L., Vontas J. An overview of insecticide resistance. Science 2002, 298:96-97.
94. Herrmann-Frank A., Richter M., Sarkozi S., Mohr U., Lehmann-Horn F. 4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor. Biochim. Biophys. Acta 1996, 1289:31-40.
95. Herzig V., Wood D.L., Newell F., Chaumeil P.A., Kaas Q., Binford G.J., Nicholson G.M., Gorse D., King G.F. ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures. Nucleic Acids Res. 2011, 39:D653-D657.
96. Hirota K., Lambert D.G. Measurement of [3H]PN200-110 and [125I]omega-conotoxin MVIIA binding. Methods Mol. Biol. 2006, 312:147-159.
97. Ho H.-T., Stevens S.C.W., Terentyeva R., Carnes C.A., Terentyev D., Gyorke S. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J. Physiol. 2011, 589:4697-4708.
98. Huke S., Bers D.M. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem. Biophys. Res. Commun. 2008, 376:80-85.
99. 2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem. J. 2007, 404:431-438.
100. Ikura M. Calcium binding and conformational response in EF-hand proteins. Trends Biochem. Sci. 1996, 21:14-17.
101. 3H]ryanodine. Chem. Res. Toxicol. 2012, 25:1571-1573.
102. 2+ exchange as a drug target-insights from molecular pharmacology and genetic engineering. Ann. N. Y. Acad. Sci. 2007, 1099:516-528.
103. 2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc. Hematol. Disord. Drug Targets 2007, 7:188-198.
104. Jacobson A.R., Moe S.T., Allen P.D., Fessenden J.D. Structural determinants of 4-chloro-m-cresol required for activation of ryanodine receptor type 1. Mol. Pharmacol. 2006, 70:259-266.
105. Jayaraman T., Brillantes A.M., Timerman A.P., Fleischer S., Erdjument-Bromage H., Tempst P., Marks A.R. FK506 binding protein associated with the calcium release channel (ryanodine receptor). J. Biol. Chem. 1992, 267:9474-9477.
106. Jenden D.J., Fairhurst A.S. The pharmacology of ryanodine. Pharmacol. Rev. 1969, 21:1-25.
107. Jones P.P., Meng X., Xiao B., Cai S., Bolstad J., Wagenknecht T., Liu Z., Chen S.R.W. Localization of PKA phosphorylation site, Ser 2030, in the three-dimensional structure of cardiac ryanodine receptor. Biochem. J. 2008, 410:261-270.
108. Joshi R., Venkatesh K., Srinivas R., Nair S., Hasan G. Genetic dissection of itpr gene function reveals a vital requirement in aminergic cells of Drosophila larvae. Genetics 2004, 166:225-236.
109. 2+ release channel. Biochemistry 2009, 48:10342-10352.
110. Kawasaki F., Collins S.C., Ordway R.W. Synaptic calcium-channel function in Drosophila: analysis and transformation rescue of temperature-sensitive paralytic and lethal mutations of cacophony. J. Neurosci. 2002, 22:5856-5864.
111. Ketterman A.J., Saisawang C., Wongsantichon J. Insect glutathione transferases. Drug Metab. Rev. 2011, 43:253-265.
112. Khan S.A., Zafar Y., Briddon R.W., Malik K.A., Mukhtar Z. Spider venom toxin protects plants from insect attack. Transgenic Res. 2006, 15:349-357.
113. Kimlicka L., Van Petegem F. The structural biology of ryanodine receptors. Sci. China Life Sci. 2011, 54:712-724.
114. v channels by peptidic spider toxins. Toxicon 2007, 49:513-530.
115. v channels. Channels 2008, 2:100-116.
116. Kissin I., Szallasi A. Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. Curr. Top. Med. Chem. 2011, 11:2159-2170.
117. Kobayashi S., Bannister M.L., Gangopadhyay J.P., Hamada T., Parness J., Ikemoto N. Dantrolene stabilizes domain interactions within the ryanodine receptor. J. Biol. Chem. 2004, 280:6580-6587.
118. Kobayashi S., Yano M., Suetomi T., Ono M., Tateishi H., MochiZzuki M., Xu X.J., Uchinoumi H., Okuda S., Yamamoto T., Koseki N., Kyushiki H., Ikemoto N., Matsuzaki M. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J. Am. Coll. Cardiol. 2009, 53:1993-2005.
119. 2+/calmodulin-dependent protein kinase II. Circ. Res. 2006, 99:333-335.
120. Kono Y., Tomita T. Amino acid substitutions conferring insecticide insensitivity in Ace-paralogous acetylcholinesterase. Pestic. Biochem. Physiol. 2006, 85:123-132.
121. Kushnir A., Mollah A.K.M.M., Wehrens X.H.T. Evolution of the ryanodine receptor gene family. Ryanodine Receptors. Structure, Function and Dysfunction in Clinical Disease 2005, 1-8. Springer-Verlag, Berlin. X.H.T. Wehrens, A.R. Marks (Eds.).
122. Lacava C., Sgaragli G., Fusi F. 3,5-di-t-butylcatechol as a ryanodine receptor agonist in rat intact skeletal muscle fibers. Drug Dev. Res. 2012, 73:138-145.
123. Lahm G.P., Selby T.P., Freudenberger J.H., Stevenson T.M., Myers B.J., Seburyamo G., Smith B.K., Flexner L., Clark C.E., Cordova D. Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators. Bioorg. Med. Chem. Lett. 2005, 15:4898-4906.
124. Lanner J.T., Georgiou D.K., Joshi A.D., Hamilton S.L. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb. Perspect. Biol. 2010, 2:a003996.
125. Lanzafame A.A., Christopoulos A., Mitchelson F. Cellular signaling mechanisms for muscarinic acetylcholine receptors. Receptors Channels 2003, 9:241-260.
126. 2+ sites. Clin. Exp. Pharmacol. Physiol. 2007, 34:889-896.
127. 2+ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains. Eur. Biophys. J. 2009, 39:19-26.
128. Laver D.R., Lenz G.K.E., Lamb G.D. Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine. J. Physiol. 2001, 537:763-778.
129. Lee H.C. Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose. J. Biol. Chem. 1993, 268:293-299.
130. + channel and its dependence on the lipid membrane. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:15441-15446.
131. Lehmberg E., Casida J.E. Similarity of insect and mammalian ryanodine binding sites. Pestic. Biochem. Physiol. 1994, 48:145-152.
132. Lehnart S.E., Terrenoire C., Reiken S., Wehrens X.H.T., Song L.S., Tillman E.J., Mancarella S., Coromilas J., Lederer W.J., Kass R.S., Marks A.R. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:7906-7910.
133. Leung H.T., Branton W.D., Phillips H.S., Jan L., Byerly L. Spider toxins selectively block calcium currents in Drosophila. Neuron 1989, 3:767-772.
134. Leung F.P., Yung L.M., Yao X., Laher I., Huang Y. Store-operated calcium entry in vascular smooth muscle. Br. J. Pharmacol. 2008, 153:846-857.
135. Lewis R.J. Conotoxin venom peptide therapeutics. Adv. Exp. Med. Biol. 2009, 655:44-48.
136. Liang X., Hu X., Hu J. Dynamic inter-receptor coupling: a novel working mechanism of 2-D ryanodine receptor array. Biophys. J. 2007, 92:1215-1223.
137. Liang X., Hu X.F., Hu J. Dynamic interreceptor coupling contributes to the consistent open duration of ryanodine receptors. Biophys. J. 2009, 96:4826-4833.
138. Liao J., Li H., Zeng W., Sauer D.B., Belmares R., Jiang Y. Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science 2012, 335:686-690.
139. Lindsay A.R., Williams A.J. Functional characterisation of the ryanodine receptor purified from sheep cardiac muscle sarcoplasmic reticulum. Biochim. Biophys. Acta 1991, 1064:89-102.
140. Littleton J.T., Ganetzky B. Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 2000, 26:35-43.
141. Liu Y., Porta M., Qin J., Ramos J., Nani A., Shannon T.R., Fill M. Flux regulation of cardiac ryanodine receptor channels. J. Gen. Physiol. 2010, 135:15-27.
142. Liu Z., Wang R., Tian X., Zhong X., Gangopadhyay J., Cole R., Ikemoto N., Chen S.R.W., Wagenknecht T. Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J. Cell Sci. 2010, 123:1775-1784.
143. Lobo P.A., Van Petegem F. Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure 2009, 17:1505-1514.
144. 2+-ATPase from Heliothis virescens. Biochim. Biophys. Acta 1998, 1369:14-18.
145. Ludtke S.J., Serysheva I.I., Hamilton S.L., Chiu W. The pore structure of the closed RyR1 channel. Structure 2005, 13:1203-1211.
146. Lümmen P., Ebbinghaus-Kintscher U., Funke C., Fischer R., Masaki T., Yasokawa N., Tohnishi M. Phthalic acid diamides activate insect ryanodine receptors. ACS Symp. Ser. 2007, 948:235-248.
147. 2+ transport. Biochem. J. 2007, 406:365-382.
148. Ma J., Hayek S.M., Bhat M.B. Membrane topology and membrane retention of the ryanodine receptor calcium release channel. Cell Biochem. Biophys. 2004, 40:207-224.
149. Mack M.M., Molinski T.F., Buck E.D., Pessah I.N. Novel modulators of skeletal muscle FKBP12/calcium channel complex from Lanthella basta. Role of FKBP12 in channel gating. J. Biol. Chem. 1994, 269:23236-23249.
150. MacKinnon R., Cohen S.L., Kuo A., Lee A., Chait B.T. Structural conservation in prokaryotic and eukaryotic potassium channels. Science 1998, 280:106-109.
151. Marks A.R. Immunophilin modulation of calcium channel gating. Methods 1996, 9:177-187.
152. 2+-channel modify fusion-pore kinetics. Channels 2007, 1:377-386.
153. Masaki T. Study on the mechanism of insecticidal activity through disruption of intracellular calcium homeostasis. J. Pestic. Sci. 2008, 33:271-277.
154. 2+ pump activity coupled to RyR-mediated calcium release in lepidopterous insects. Pesticide Chemistry 2007, 137-140. Wiley-VCH, Weinheim. H. Ohkawa, H. Miyagawa, P.W. Lee (Eds.).
155. 2+ release channel (ryanodine receptor). J. Biol. Chem. 2003, 278:3786-3792.
156. 2+ channel complex. J. Med. Chem. 2006, 49:4497-4511.
157. 2+-ATPase by phospholamban and sarcolipin. Handbook of ATPases 2004, 25-62. Wiley-VCH, Weinheim. M. Futai, Y. Wada, J.H. Kaplan (Eds.).
158. 2+ release in sarcoplasmic reticulum. J. Biol. Chem. 1984, 259:2365-2374.
159. 2+ release channel. Mol. Cell. Biochem. 1992, 114:119-123.
160. 2+ and monovalent cations and anions. J. Biol. Chem. 1997, 272:1628-1638.
161. Meli A.C., Refaat M.M., Dura M., Reiken S., Wronska A., Wojciak J., Carroll J., Scheinman M.M., Marks A.R. A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ. Res. 2011, 109:281-290.
162. Meng X., Xiao B., Cai S., Huang X., Li F., Bolstad J., Trujillo R., Airey J., Chen S.R.W., Wagenknecht T., Liu Z. Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor. J. Biol. Chem. 2007, 282:25929-25939.
163. Messutat S., Heine M., Wicher D. Calcium-induced calcium release in neurosecretory insect neurons: fast and slow responses. Cell Calcium 2001, 30:199-211.
164. 2+ in bacteria: a role for EF-hand proteins?. Trends Microbiol. 2002, 10:87-93.
165. 2+ signalling. J. Neurochem. 2011, 118:695-713.
166. Minke B. Light-induced reduction in excitation efficiency in the trp mutant of Drosophila. J. Gen. Physiol. 1982, 79:361-385.
167. Minke B. The history of the Drosophila TRP channel: the birth of a new channel superfamily. J. Neurogenet. 2010, 24:216-233.
168. 2+-ATPase pump. Curr. Opin. Struct. Biol. 2005, 15:387-393.
169. Monma S., Sunazuka T., Nagai K., Arai T., Shiomi K., Matsui R., Omura S. Verticilide: elucidation of absolute configuration and total Synthesis. Org. Lett. 2006, 8:5601-5604.
170. Montell C., Rubin G.M. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 1989, 2:1313-1323.
171. Mosbah A., Kharrat R., Fajloun Z., Renisio J.G., Blanc E., Sabatier J.M., El Ayeb M., Darbon H. A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel. Proteins: Struct. Funct. Bioinformat. 2000, 40:436-442.
172. Mukherjee A.K., Sollod B.L., Wikel S.K., King G.F. Orally active acaricidal peptide toxins from spider venom. Toxicon 2006, 47:182-187.
173. Nagata K. TRP channels as target sites for insecticides: physiology, pharmacology and toxicology. Invert. Neurosci. 2007, 7:31-37.
174. 3 production following G- protein-coupled-receptor activation. Biochem. J. 2001, 356:137-142.
175. Nauen R. Insecticide mode of action: return of the ryanodine receptor. Pest Manag. Sci. 2006, 62:690-692.
176. Niggli E. Ryanodine receptors: waking up from refractoriness. Cardiovasc. Res. 2011, 91:563-564.
177. 2+-ATPase in cell function. EMBO Rep. 2007, 8:228-232.
178. Norton R.S., McDonough S.I. Peptides targeting voltage-gated calcium channels. Curr. Pharm. Des. 2008, 14:2480-2491.
179. Norton R.S., Pallaghy P.K. The cystine knot structure of ion channel toxins and related polypeptides. Toxicon 1998, 36:1573-1583.
180. Oberwinkler J. Calcium homeostasis in fly photoreceptor cells. Adv. Exp. Med. Biol. 2002, 514:539-583.
181. Oerke E.-C. Crop losses to pests. J. Agric. Sci. 2006, 144:31-43.
182. Oerke E.C., Dehne H.W. Safeguarding production-losses in major crops and the role of crop protection. Crop Protect. 2004, 23:275-285.
183. Ogunbayo O.A., Zhu Y., Rossi D., Sorrentino V., Ma J., Zhu M.X., Evans A.M. Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels. J. Biol. Chem. 2011, 286:9136-9140.
184. Olivera B.M., Imperial J.S., Cruz L.J., Bindokas V.P., Venema V.J., Adams M.E. Calcium channel-targeted polypeptide toxins. Ann. N. Y. Acad. Sci. 1991, 635:114-122.
185. Orlova E.V., Serysheva I.I., Van Heel M., Hamilton S.L., Chiu W. Two structural configurations of the skeletal muscle calcium release channel. Nat. Struct. Biol. 1996, 3:547-552.
186. Ortega C., Ortolando S., Carafoli E. The plasma membrane calcium pump. New Compr. Biochem. 2007, 41:179-197.
187. 2+ by caffeine and ryanodine induces apoptosis of chinese hamster ovary cells transfected with ryanodine receptor. J. Biol. Chem. 2000, 275:19978-19984.
188. Paolini C., Protasi F., Franzini-Armstrong C. The relative position of RyR feet and DHPR tetrads in skeletal muscle. J. Mol. Biol. 2004, 342:145-153.
189. Paolini C., Fessenden J.D., Pessah I.N., Franzini-Armstrong C. Evidence for conformational coupling between two calcium channels. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:12748-12752.
190. Paul-Pletzer K., Yamamoto T., Bhat M.B., Ma J., Ikemoto N., Jimenez L.S., Morimoto H., Williams P.G., Parness J. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. J. Biol. Chem. 2002, 277:34918-34923.
191. 2+ channel blockers in the Drosophila nervous system. Biochemistry 1987, 26:6311-6315.
192. Payandeh J., Scheuer T., Zheng N., Catterall W.A. The crystal structure of a voltage-gated sodium channel. Nature 2011, 475:353-358.
193. Peixoto A.A., Smith L.A., Hall J.C. Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene. Genetics 1997, 145:1003-1013.
194. 2+ channels in Drosophila brain membranes. EMBO J. 1989, 8:2365-2371.
195. + channel homeostatic regulation. J. Neurosci. 2007, 27:1072-1081.
196. Percival A.L., Williams A.J., Kenyon J.L., Grinsell M.M., Airey J.A., Sutko J.L. Chicken skeletal muscle ryanodine receptor isoforms: ion channel properties. Biophys. J. 1994, 67:1834-1850.
197. Perry T., Batterham P., Daborn P.J. The biology of insecticidal activity and resistance. Insect Biochem. Mol. Biol. 2011, 41:411-422.
198. Pessah I.N. Chemical effectors of the ryanodine receptor: a novel strategy for insect control. Spec. Publ. Roy. Soc. Chem. 1990, 79:278-296.
199. 2+ release channel of sarcoplasmic reticulum from skeletal and cardiac muscle: evidence for a sequential mechanism in ryanodine action. Mol. Pharmacol. 1991, 39:679-689.
200. 2+, caffeine, and adenine nucleotides. Mol. Pharmacol. 1987, 31:232-238.
201. Pi C., Liu J., Peng C.C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L., Dong M., Chen S., Xu A. Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 2006, 88:809-819.
202. Powl A.M., O'Reilly A.O., Miles A.J., Wallace B.A. Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in channel assembly. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:14064-14069.
203. Pringos E., Vignes M., Martinez J., Rolland V. Peptide neurotoxins that affect voltage-gated calcium channels: a close-up on omega-agatoxins. Toxins 2011, 3:17-42.
204. Protasi F., Franzini-Armstrong C., Allen P.D. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J. Cell Biol. 1998, 140:831-842.
205. Puente E., Suner M., Evans A.D., McCaffery A.R., Windass J.D. Identification of a polymorphic ryanodine receptor gene from Heliothis virescens (Lepidoptera: Noctuidae). Insect Biochem. Mol. Biol. 2000, 30:335-347.
206. Qazi S., Trimmer B.A. The role of inositol 1,4,5-trisphosphate 5-phosphatase in inositol signaling in the CNS of larval Manduca sexta. Insect Biochem. Mol. Biol. 1999, 29:161-175.
207. Randall A.D., Tsien R.W. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology 1997, 36:879-893.
208. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 1995, 15:2995-3012.
209. Ranson H., Hemingway J. Mosquito glutathione transferases. Methods Enzymol. 2005, 401:226-241.
210. Ren D., Navarro B., Xu H., Yue L., Shi Q., Clapham D.E. A prokaryotic voltage-gated sodium channel. Science 2001, 294:2372-2375.
211. 2+ channel ß-subunits: structural insights AID our understanding. Trends Pharmacol. Sci. 2004, 25:626-632.
212. Rodney G.G., Moore C.P., Williams B.Y., Zhang J.-Z., Krol J., Pedersen S.E., Hamilton S.L. Calcium binding to calmodulin leads to an N-terminal shift in its binding site on the ryanodine receptor. J. Biol. Chem. 2001, 276:2069-2074.
213. Rogers E.F., Koniuszy F.R., Shavel J., Folkers K. Plant Insecticides. I. Ryanodine, a new alkaloid from Ryania speciosa Vahl. J. Am. Chem. Soc. 1948, 70:3086-3088.
214. Rosay P., Davies S.A., Yu Y., Sozen A., Kaiser K., Dow J.A. Cell-type specific calcium signalling in a Drosophila epithelium. J. Cell Sci. 1997, 110:1683-1692.
215. 2+-release channels. Cell Calcium 2002, 32:307-319.
216. 2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds. Arch. Biochem. Biophys. 1988, 267:75-86.
217. Ruiz-Meana M., Fernandez-Sanz C., Garcia-Dorado D. The SR-mitochondria interaction: a new player in cardiac pathophysiology. Cardiovasc. Res. 2010, 88:30-39.
218. V2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. J. Physiol. 2012, 590:809-825.
219. Saez N.J., Senff S., Jensen J.E., Er S.Y., Herzig V., Rash L.D., King G.F. Spider-venom peptides as therapeutics. Toxins 2010, 2:2851-2871.
220. Sagara Y., Wade J.B., Inesi G. A conformational mechanism for formation of a dead-end complex by the sarcoplasmic reticulum ATPase with thapsigargin. J. Biol. Chem. 1992, 267:1286-1292.
221. Samso M., Wagenknecht T., Allen P.D. Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat. Struct. Biol. 2005, 12:539-544.
222. Sander T., Bruun A.T., Balle T. Docking to flexible nicotinic acetylcholine receptors: a validation study using the acetylcholine binding protein. J. Mol. Graph. Model. 2010, 29:415-424.
223. Sanyal S., Consoulas C., Kuromi H., Basole A., Mukai L., Kidokoro Y., Krishnan K.S., Ramaswami M. Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability. Genetics 2005, 169:737-750.
224. Sattelle D.B., Cordova D., Cheek T.R. Insect ryanodine receptors: molecular targets for novel pest control chemicals. Invert. Neurosci. 2008, 8:107-119.
225. 2+-channel effectors and ryanodine in Periplaneta americana-possible targets for new insecticides. Pestic. Sci. 1996, 48:375-385.
226. Schmitt M., Turberg A., Londershausen M. Characterization of a ryanodine receptor in Periplaneta americana. J. Recept. Signal Transduct. Res. 1997, 17:185-197.
227. Schwarz E.M., Benzer S. Calx, a Na-Ca exchanger gene of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:10249-10254.
228. 2+ release channel from the thoracic tissues of the lepidopteran insect Heliothis virescens. J. Membr. Biol. 2001, 179:127-141.
229. Selby T.P., Lahm G.P., Stevenson T.M., Hughes K.A., Annan I.B., Cordova D., Bellin C.A., Benner E.A., Wing K.D., Barry J.D., Currie M.J., Pahutski T.F. Discovery of Cyazypyr™: a new cross-spectrum insecticide from the anthranilic diamide class of ryanodine receptor activators 2008.
230. 3 and ryanodine receptors. Nature 2012, 483:108-112.
231. Serysheva I.I., Ludtke S.J., Baker M.R., Chiu W., Hamilton S.L. Structure of the voltage-gated L-type Ca 2+ channel by electron cryomicroscopy. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10370-10375.
232. Serysheva I.I., Ludtke S.J., Baker M.L., Cong Y., Topf M., Eramian D., Sali A., Hamilton S.L., Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:9610-9615.
233. Shafrir Y., Durell S.R., Guy H.R. Models of voltage-dependent conformational changes in NaChBac channels. Biophys. J. 2008, 95:3663-3676.
234. Shiomi K., Matsui R., Kakei A., Yamaguchi Y., Masuma R., Hatano H., Arai N., Isozaki M., Tanaka H., Kobayashi S., Turberg A., Omura S. Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J. Antibiot. 2010, 63:77-82.
235. 2+-permeable nonselective cation channel. Am. J. Physiol. 2009, 297:C1533-C1543.
236. Sitsapesan R., Williams A.J. Mechanisms of caffeine activation of single calcium-release channels of sheep cardiac sarcoplasmic reticulum. J. Physiol. 1990, 423:425-439.
237. 2+ release channel. Am. J. Physiol. 1995, 268:C1235-C1240.
238. 2+-release channel. Circ. Res. 1994, 75:596-600.
239. Smith L.A., Wang X., Peixoto A.A., Neumann E.K., Hall L.M., Hall J.C. A Drosophila calcium channel α1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J. Neurosci. 1996, 16:7868-7879.
240. Spassova M.A., Soboloff J., He L.P., Hewavitharana T., Xu W., Venkatachalam K., van Rossum D.B., Patterson R.L., Gill D.L. Calcium entry mediated by SOCs and TRP channels: variations and enigma. Biochim. Biophys. Acta 2004, 1742:9-20.
241. Srikanth S., Wang Z., Hasan G., Bezprozvanny I. Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor. FEBS Lett. 2004, 575:95-98.
242. Srikanth S., Wang Z., Tu H., Nair S., Mathew M.K., Hasan G., Bezprozvanny I. Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants. Biophys. J. 2004, 86:3634-3646.
243. Steinbeck J.A., Henke N., Opatz J., Gruszczynska-Biegala J., Schneider L., Theiss S., Hamacher N., Steinfarz B., Golz S., Brüstle O., Kuznicki J., Methner A. Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy. Exp. Neurol. 2011, 232:185-194.
244. Strehler E.E. Plasma-membrane calcium pump: structure and function. Encycl. Biol. Chem. 2004, 3:385-389.
245. Sullivan K.M., Scott K., Zuker C.S., Rubin G.M. The ryanodine receptor is essential for larval development in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:5942-5947.
246. 2 tension and S-nitrosoglutathione. Biochemistry 2008, 47:13985-13990.
247. 2+ releaser in skeletal muscle sarcoplasmic reticulum. Eur. J. Pharmacol. 1999, 372:97-102.
248. 2+ release units in arthropod body muscle indicates an indirect mechanism for excitation-contraction coupling. Biophys. J. 2002, 83:2742-2753.
249. Takeshima H., Nishi M., Iwabe N., Miyata T., Hosoya T., Masai I., Hotta Y. Isolation and characterization of a gene for a ryanodine receptor/calcium release channel in Drosophila melanogaster. FEBS Lett. 1994, 337:81-87.
250. 2+ leak in failing hearts. Cardiovasc. Res. 2009, 81:536-545.
251. Taylor D.A., Sack J.S., Maune J.F., Beckingham K., Quiocho F.A. Structure of a recombinant calmodulin from Drosophila melanogaster refined at 2.2-A resolution. J. Biol. Chem. 1991, 266:21375-21380.
252. Tedford H.W., Fletcher J.I., King G.F. Functional significance of the beta hairpin in the insecticidal neurotoxin ω-atracotoxin-Hv1a. J. Biol. Chem. 2001, 276:26568-26576.
253. Tedford H.W., Gille N., Ménez A., Doehring C.J., Zamponi G.W., King G.F. Scanning mutagenesis of ω-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels. J. Biol. Chem. 2004, 279:44133-44140.
254. 2+-ATPase. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:2466-2470.
255. 2+ release. Wiley Interdiscip. Rev. Membr. Transp. Signal. 2012, 1:383-397. 10.1002/wmts.34.
256. Thomas J.M., Masgrau R., Churchill G.C., Galione A. Pharmacological characterization of the putative cADP-ribose receptor. Biochem. J. 2001, 359:451-457.
257. Tohnishi M., Nako H., Furuja T., Seo A., Kodama H., Tsubata K., Fujioka S., Hirooka T., Nishimatsu T. Flubendiamide, a novel class insecticide with high lepidopterous activity. J. Pestic. Sci. 2005, 30:354-360.
258. Tomizawa M., Casida J.E. Molecular recognition of neonicotinoid insecticides: the determinants of life or death. Acc. Chem. Res. 2009, 42:260-269.
259. Tomizawa M., Casida J.E. Unique neonicotinoid binding conformations conferring selective receptor interactions. J. Agric. Food Chem. 2011, 59:2825-2828.
260. Toyoshima C., Nomura H. Structural changes in the calcium pump accompanying the dissociation of calcium. Nature 2002, 418:605-611.
261. Toyshima C., Naksako M., Nomura H., Ogawa H. Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 angstrom resolution. Nature 2000, 405:647-655.
262. Troczka B., Zimmer C.T., Elias J., Schorn C., Bass C., Davies T.G.E., Field L.M., Williamson M.S., Slater R., Nauen R. Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae) is associated with a mutation in the membrane-spanning domain of the ryanodine receptor. Insect Biochem. Mol. Biol. 2012, 42:873-880.
263. Tsetlin V.I., Hucho F. Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications. FEBS Lett. 2004, 557:9-13.
264. Tung C.C., Lobo P.A., Kimlicka L., van Petegem F. The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature 2010, 468:585-588.
265. Usherwood P.N.R. The action of the alkaloid ryanodine on insect skeletal muscle. Comp. Biochem. Physiol. 1962, 6:181-199.
266. Usherwood P.N., Vais H. Towards the development of ryanoid insecticides with low mammalian toxicity. Toxicol. Lett. 1995, 82-83:247-254.
267. Vais H., Usherwood P.N. Novel actions of ryanodine and analogues-perturbers of potassium channels. Biosci. Rep. 1995, 15:515-530.
268. Van Leeuwen T., Vontas J., Tsagkarakou A., Dermauw W., Tirry L. Acaricide resistance mechanisms in the two-spotted spider mite Tetranychus urticae and other important Acari: a review. Insect Biochem. Mol. Biol. 2010, 40:563-572.
269. 2+ -ATPase. J. Cell Sci. 2003, 116:2483-2494.
270. Venkatesh K., Hasan G. Disruption of the IP3 receptor gene of Drosophila affects larval metamorphosis and ecdysone release. Curr. Biol. 1997, 7:500-509.
271. 2+ entry are required in Drosophila neurons for flight. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10326-10331.
272. Verkhratsky A. The endoplasmic reticulum and neuronal calcium signalling. Cell Calcium 2002, 32:393-404.
273. 2+-regulated structural changes in troponin. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:5038-5043.
274. Vonarx E.J., Tyler M.I., Atkinson R.K., Howden M.E.H. Characterization of insecticidal peptides from venom of Australian funnel-web spiders. J. Venom. Anim. Toxins 2006, 12:215-233.
275. Voss A.A., Lango J., Ernst-Russell M., Morin D., Pessah I.N. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. J. Biol. Chem. 2004, 279:34514-34520.
276. Voss A.A., Allen P.D., Pessah I.N., Perez C.F. Allosterically coupled calcium and magnesium binding sites are unmasked by ryanodine receptor chimeras. Biochem. Biophys. Res. Commun. 2008, 366:988-993.
277. V2.2) expressed BHK cells and mice brain lacking the α1B subunits. Neurochem. Res. 2005, 30:1045-1054.
278. Wagenknecht T.C., Liu Z. Electron microscopy of ryanodine receptors. Curr. Top. Membr. 2010, 66:27-47.
279. Wang X.-H., Smith R., Fletcher J.I., Wilson H.I., Wood C.J., Howden M.E.H., King G.F. Structure-function studies of ω-atracotoxin, a potent antagonist of insect voltage-gated calcium channels. Eur. J. Biochem. 1999, 264:488-494.
280. Wang X.-H., Connor M., Wilson D.T., Wilson H.I., Nicholson G.M., Smith R., Shaw D., Mackay J.P., Alewood P.F., Christie M.J., King G.F. Discovery and structure of a potent and highly specific blocker of insect calcium channels. J. Biol. Chem. 2001, 276:40306-40312.
281. Wang M.C., Velarde G., Ford R.C., Berrow N.S., Dolphin A.C., Kitmitto A. 3D structure of the skeletal muscle dihydropyridine receptor. J. Mol. Biol. 2002, 323:85-98.
282. 2+: a versatile master key for intracellular signaling cascades. Sci. China Life Sci. 2011, 54:683-685.
283. Wang J., Li Y., Han Z., Zhu Y., Xie Z., Wang J., Liu Y., Li X. Molecular characterization of a ryanodine receptor gene in the rice leaffolder, Cnaphalocrocis medinalis (Guenee). PLoS One 2012, 7:e36623.
284. Wang X., Wu S., Yang Y., Wu Y. Molecular cloning, characterization and mRNA expression of a ryanodine receptor gene from diamondback moth, Plutella xylostella. Pestic. Biochem. Physiol. 2012, 102:204-212.
285. Waterhouse A.L., Pessah I.N., Francini A.O., Casida J.E. Structural aspects of ryanodine action and selectivity. J. Med. Chem. 1987, 30:710-716.
286. Wehrens X.H.T., Lehnart S.E., Marks A.R. Intracellular calcium release and cardiac disease. Annu. Rev. Physiol. 2005, 67:69-98.
287. Wehrens X.H.T., Lehnart S.E., Reiken S., v.d.Nagel R., Morales R., Sun J., Cheng Z., Deng S.X., de Windt L.J., Landry D.W., Marks A.R. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9607-9612.
288. Wehrens X.H.T., Lehnart S.E., Reiken S., Vest J.A., Wronska A., Marks A.R. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:511-518.
289. 2+ channels. J. Biol. Chem. 1991, 266:21943-21947.
290. Welch W., Williams A.J., Tinker A., Mitchell K.E., Deslongchamps P., Lamothe J., Gerzon K., Bidasee K.R., Besch H.R., Airey J.A., Sutko J.L., Ruest L. Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function. Biochemistry 1997, 36:2939-2950.
291. 2+ currents in central insect neurons: electrophysiological and pharmacological properties. J. Neurophysiol. 1997, 77:186-199.
292. Williams R.J. The evolution of calcium biochemistry. Biochim. Biophys. Acta 2006, 1763:1139-1146.
293. 2+ -release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels. Q. Rev. Biophys. 2001, 34:61-104.
294. Windley M.J., Herzig V., Dziemborowicz S.A., Hardy M.C., King G.F., Nicholson G.M. Spider-venom peptides as bioinsecticides. Toxins 2012, 4:191-227.
295. Winterfield J.R., Swartz K.J. A hot spot for the interaction of gating modifier toxins with voltage-dependent in channels. J. Gen. Physiol. 2000, 116:637-644.
296. 2+ release channel with an azido derivative of ryanodine. J. Biol. Chem. 1994, 269:13076-13079.
297. Wu L.G., Westenbroek R.E., Borst J.G., Catterall W.A., Sakmann B. Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J. Neurosci. 1999, 19:726-736.
298. 2+ regulation and its alternative splicing modification. J. Mol. Biol. 2009, 387:104-112.
299. 2+ exchanger reveal incremental conformational transitions. J. Biol. Chem. 2010, 285:2554-2561.
300. Xiao B., Zhong G., Obayashi M., Yang D., Chen K., Walsh M.P., Shimoni Y., Cheng H., ter Keurs H., Chen S.R.W. Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon b-adrenergic stimulation in normal and failing hearts. Biochem. J. 2006, 396:7-16.
301. Xu X., Bhat M.B., Nishi M., Takeshima H., Ma J. Molecular cloning of cDNA encoding a Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel. Biophys. J. 2000, 78:1270-1281.
302. 2+ ATPase SERCA. J. Biol. Chem. 2004, 279:17973-17979.
303. Yamaji N., Sugase K., Nakajima T., Miki T., Wakamori M., Mori Y., Iwashita T. Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors. FEBS Lett. 2007, 581:3789-3794.
304. Yan S., Cui F., Qiao C. Structure, function and applications of carboxylesterases from insects for insecticide resistance. Protein Pept. Lett. 2009, 16:1181-1188.
305. Yáñez M., Gil-Longo J., Campos-Toimil M. Calcium binding proteins. Calcium Signaling. Advances in Experimental Medicine and Biology 2012, 461-482. Springer-Berlag, Berlin. S. Islam (Ed.).
306. Yao S., Gallenkamp D., Wölfel K., Lüke B., Schindler M., Scherkenbeck J. Synthesis and SERCA activities of structurally simplified cyclopiazonic acid analogues. Bioorg. Med. Chem. 2011, 19:4669-4678.
307. Yarov-Yarovoy V., Baker D., Catterall W.A. Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:7292-7297.
308. Yarov-Yarovoy V., DeCaen P.G., Westenbroek R.E., Pan C.-Y., Scheuer T., Baker D., Catterall W.A. Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E93-E102.
309. Yatime L., Buch-Pedersen M.J., Musgaard M., Morth J.P., Lund Winther A.M., Pedersen B.P., Olesen C., Andersen J.P., Vilsen B., Schiott B., Palmgren M.G., Møller J.V., Nissen P., Fedosova N. P-type ATPases as drug targets: tools for medicine and science. Biochim. Biophys. Acta 2009, 1787:207-220.
310. Ye Y., Yaeger D., Owen L.J., Escobedo J.O., Wang J., Singer J.D., Strongin R.M., Abramson J.J. Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol. Pharmacol. 2012, 81:53-62.
311. Yu F.H., Catterall W.A. The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis. Sci. STKE 2004, 2004:re15.
312. Yuchi Z., van Petegem F. Common allosteric mechanisms between ryanodine and inositol-1,4,5-triphosphate receptors. Channels 2011, 5:120-123.
313. Yue L., Navarro B., Ren D., Ramos A., Clapham D.E. The cation selectivity filter of the bacterial sodium channel, NaChBac. J. Gen. Physiol. 2002, 120:845-853.
314. Zhao F., Li P., Chen S.R.W., Louis C.F., Fruen B.R. Dantrolene inhibition of the ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. J. Biol. Chem. 2001, 276:13810-13816.
315. Zheng W., Feng G., Ren D., Eberl D.F., Hannan F., Dubald M., Hall L.M. Cloning and characterization of a calcium channel α1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform. J. Neurosci. 1995, 15:1132-1143.
316. Zhou Y., Yang W., Kirberger M., Lee H.W., Ayalasomayajula G., Yang J.J. Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins. Proteins 2006, 65:643-655.
317. Zhu X., Ghanta J., Walker J.W., Allen P.D., Valdivia H.H. The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain. Cell Calcium 2004, 35:165-177.
318. Zieminska E., Stafiej A., Pitsinos E.N., Couladouros E.A., Moutsos V., Kozlowska H., Toczylowska B., Lazarewicz J.W. Synthetic bastadins modify the activity of ryanodine receptors in cultured cerebellar granule cells. Neurosignals 2007, 15:283-292.
319. Zissimopoulos S., Lai F.A. Redox regulation of the ryanodine receptor/calcium release channel. Biochem. Soc. Trans. 2006, 34:919-921.
320. Zuccotti A., Clementi S., Reinbothe T., Torrente A., Vandael D.H., Pirone A. Structural and functional differences between L-type calcium channels: crucial issues for future selective targeting. Trends Pharmacol. Sci. 2011, 32:366-375.
321. Zwaal, R., Kaletta, T., van den Craen, M., Logghe, M., Smits, E., van Creikinge, W., Bogaert, T., 2002. Methods for identifying pesticidal compounds using gene sca-1 for sarco-endoplasmic reticulum Ca2+ ATPase cloned from C. elegans. WO patent application number 2002033405.