Scanning mutagenesis of ω-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels

Journal of Biological Chemistry

Volumn 279, Issue 42, 2004, Pages 44133-44140

  Tedford, Hugo W ^a   Gilles, Nicolas ^b   Ménez, André ^b   Doering, Clinton J ^c,d   Zamponi, Gerald W ^c,d   King, Glenn F ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b DIF   (France)

^c UNIVERSITY OF CALGARY   (Canada)

^d ALBERTA ENVIRONMENT AND PARKS   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE MUTANTS; INSECT SELECTIVITY; MUTANT TOXINS; SCANNING MUTAGENESIS;

BIOASSAY; CALCIUM; INSECTICIDES; LIVING SYSTEMS STUDIES; MEMBRANES; TOXIC MATERIALS;

MUTAGENESIS;

ALANINE; ARGININE; ASPARAGINE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; EPITOPE; INSECTICIDE; NEUROTOXIN; OMEGA ATRACOTOXIN HV 1A; PROLINE; UNCLASSIFIED DRUG;

ACHETA DOMESTICA; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; COCKROACH; CONTROLLED STUDY; EMBRYO; HOUSE FLY; HUMAN; HUMAN CELL; INSECT; INSECTICIDAL ACTIVITY; ISOTOPE LABELING; LETHALITY; MUTAGENESIS; MUTANT; NERVE CELL MEMBRANE; NONHUMAN; PERIPLANETA AMERICANA; PRIORITY JOURNAL; RADIOASSAY;

AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; COCKROACHES; GRYLLIDAE; HOUSEFLIES; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RATS; SPIDER VENOMS; SPIDERS;

ACHETA; ANIMALIA; BLATTARIA; BLATTIDAE; GRYLLIDAE; INSECTA; MUSCA DOMESTICA; PERIPLANETA; PERIPLANETA AMERICANA;

EID: 6344287807     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404006200     Document Type: Article

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