Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors

FEBS Letters

Volumn 581, Issue 20, 2007, Pages 3789-3794

  Yamaji, Nahoko ^a   Sugase, Kenji ^a   Nakajima, Terumi ^a   Miki, Takafumi ^b   Wakamori, Minoru ^b   Mori, Yasuo ^b   Iwashita, Takashi ^a  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Agelenin; Insect calcium channel; NMR; Spider toxin; Structure

Indexed keywords

AGELENIN; AMINO ACID; ARGININE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; INSECT PROTEIN; INSECT VENOM; INSECTICIDE; PHENYLALANINE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSECT; ISOLATION PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARALYSIS; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SPIDER; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; CALCIUM CHANNEL BLOCKERS; CELL LINE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GRYLLIDAE; HUMANS; INSECTICIDES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PATCH-CLAMP TECHNIQUES; PEPTIDES; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SPIDER VENOMS; SPIDERS;

AGELENA OPULENTA; AGELENIDAE; ARANEAE; HEXAPODA;

EID: 34547124845     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.06.077     Document Type: Article

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