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2 guanosine triphosphate. When caffeine (10 mM) was used, an equivalent concentration of NaCI or K gluconate was reduced from the external or internal solution, respectively.
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note
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Disruption of the LIC is defined as a reduction, to <1%, of the geometrical average of the ratios between the peak LIC 10 to 12 min after drug application (40 to 60 min for ryanodine) and the peak LIC before drug application. A restored LIC was obtained when this ratio was not statistically different from 100% (paired t test, P > 0.05; n = 4 to 7 in all experiments).
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2+ induced by light (12-14) were most likely due to a signal-detection problem.
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40
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note
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We thank M. Schramm and H. Soreq for critical reading of the manuscript and A. Peretz, B. Gillo, and H. Cohen for help with the experiments. Supported by grants EY03529 (B.M. and Z.S.) and EY10852 (C.M) from the National Eye Institute; the U.S.-Israel Binational Science Foundation; the German Israeli Foundation; the Minerva Foundation; and the Israel Science Foundation (B.M.).
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