Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors

Journal of Physiology

Volumn 589, Issue 19, 2011, Pages 4697-4708

  Ho, Hsiang Ting ^a   Stevens, Sarah C W ^a   Terentyeva, Radmila ^a,b   Carnes, Cynthia A ^a,c   Terentyev, Dmitry ^a,b   Györke, Sandor ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CARDIAC GLYCOSIDE; DIGITOXIN; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RYANODINE RECEPTOR 2; THIOL; TIOPRONIN; XANTHINE OXIDASE;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM SIGNALING; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE CELL; HEART VENTRICLE; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; RAT; SARCOPLASMIC RETICULUM;

ANIMALS; ANTIOXIDANTS; ARRHYTHMIAS, CARDIAC; CALCIUM; CARDIAC GLYCOSIDES; DIGITOXIN; GLYCINE; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCYTES, CARDIAC; NADPH OXIDASE; OXIDATION-REDUCTION; RATS; REACTIVE OXYGEN SPECIES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SULFHYDRYL COMPOUNDS;

EID: 80053415953     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.210005     Document Type: Article

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