Structural determinants of 4-chloro-m-cresol required for activation of ryanodine receptor type 1

Molecular Pharmacology

Volumn 70, Issue 1, 2006, Pages 259-266

  Jacobson, Alan R ^a   Moe, Scott T ^a   Allen, P D ^b   Fessenden, James D ^b,c  

^a Absolute Science Inc   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 3 CRESOL DERIVATIVE; CRESOL; PHENOL DERIVATIVE; RYANODINE RECEPTOR; RYANODINE RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CRESOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; MUSCLE FIBERS; RADIOLIGAND ASSAY; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 33745273632     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.022491     Document Type: Article

References (26)

1. Baur CP, Bellon L, Felleiter P, Fiege M, Fricker R, Glahn K, Heffron JJ, Herrmann-Frank A, Jurkat-Rott K, Klingler W, et al. (2000) A multicenter study of 4-chlorom-cresol for diagnosing malignant hyperthermia susceptibility. Anesth Analg 90:200-205.
2. 2+ release from sarcoplasmic reticulum vesicles by 4-alkylphenols. Arch Biochem Biophys 301:216-220.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. 2+ sensor. J Biol Chem 273:14675-14678.
5. 2+ release by 4-chloro-m-cresol (4-CmC) in intact and chemically skinned ferret cardiac ventricular fibers. J Pharmacol Exp Ther 290:578-586.
6. 2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1). Proc Natl Acad Sci USA 99:16725-16730.
7. 2+ release. J Biol Chem 270:15634-15638.
8. Fessenden JD, Feng W, Pessah IN, and Allen PD (2004) Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1. J Biol Chem 279:53028-53035.
9. Fessenden JD, Feng W, Pessah IN, and Allen PD (2006) Identification of a dipeptide segment (Gln4020/Lys4021) of the ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. Biophys J 90:a1876.
10. Fessenden JD, Perez CF, Goth S, Pessah IN, and Allen PD (2003) Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chlorom-cresol. J Biol Chem 278:28727-28735.
11. Fessenden JD, Wang Y, Moore RA, Chen SRW, Allen PD, and Pessah IN (2000) Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line. Biophys J 79:2509-2525.
12. Herrmann-Frank A, Richter M, and Lehmann-Horn F (1996a) 4-Chloro-m-cresol: a specific tool to distinguish between malignant hyperthermia-susceptible and normal muscle. Biochem Pharmacol 52:149-155.
13. Herrmann-Frank A, Richter M, Sarkozi S, Mohr U, and Lehmann-Horn F (1996b) 4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor. Biochim Biophys Acta 1289:31-40.
14. 2+ channel is expressed in nonexcitable cells. Mol Pharmacol 47:21-28.
15. Matyash M, Matyash V, Nolte C, Sorrentino V, and Kettenmann H (2002) Requirement of functional ryanodine receptor type 3 for astrocyte migration. FASEB J 16:84-86.
16. Moore RA, Nguyen H, Galceran J, Pessah IN, and Allen PD (1998) A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function. J Cell Biol 140:843-851.
17. 2+ release by organic polyamines. J Biol Chem 262:6149-6154.
18. Perez CF, Voss A, Pessah IN, and Allen PD (2003) RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. Biophys J 84:2655-2663.
19. 2+, caffeine and adenine nucleotides. Mol Pharmacol 31:232-238.
20. Pessah IN, Waterhouse AL, and Casida JE (1985) The calcium-ryanodine receptor complex of skeletal and cardiac muscle. Biochem Biophys Res Commun 128:449-456.
21. Wang Y, Fraefel C, Protasi F, Moore RA, Fessenden JD, Pessah IN, DiFrancesco A, Breakefield X, and Allen PD (2000) HSV-1 amplicon vectors are a highly efficient gene delivery system for skeletal muscle myoblasts and myotubes. Am J Physiol 278:C619-C626.
22. 2+ release channel. Biochemistry 37:4804-4814.
23. 2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity. Biophys J 90:173-182.
24. 2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. J Biol Chem 265:2244-2256.
25. 2+ release. Mol Pharmacol 44:1192-1201.
26. 2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states. Pharmacol Rev 49:1-51.