Structural and functional conservation of key domains in InsP 3 and ryanodine receptors

Nature

Volumn 483, Issue 7387, 2012, Pages 108-114

  Seo, Min Duk ^a,d   Velamakanni, Saroj ^b   Ishiyama, Noboru ^a   Stathopulos, Peter B ^a   Rossi, Ana M ^b   Khan, Samir A ^b   Dale, Philippa ^b   Li, Congmin ^c   Ames, James B ^c   Ikura, Mitsuhiko ^a   Taylor, Colin W ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Ajou University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; RYANODINE RECEPTOR; TETRAMER;

ALKALOID; CANCER; CELL ORGANELLE; MEMBRANE; MUTATION;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTRAL CORE DISEASE; MALIGNANT HYPERTHERMIA; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; APOPROTEINS; CRYOELECTRON MICROSCOPY; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; RECOMBINANT FUSION PROTEINS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

BIVALVIA; RATTUS;

EID: 84862777270     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10751     Document Type: Article

References (38)

1. Serysheva, I. (ed.) Structure and Function of Calcium Release Channels. (Academic Press, 2010).
2. Bosanac, I. et al. Structure ofthe inositol 1, 4, 5-trisphosphate receptor binding core in complex with its ligand. Nature 420, 696-700 (2002). (Pubitemid 36764504)
3. Bosanac, I. et al. Crystal structure of the ligand binding suppressor domain of type 1 inositol 1, 4, 5-trisphosphate receptor. Mol. Cell 17, 193-203 (2005). (Pubitemid 40138615)
4. 3 receptor activation. Nature Chem. Biol. 5, 631-639 (2009).
5. Uchida, K., Miyauchi, H., Furuichi, T., Michikawa, T. & Mikoshiba, K. Critical regions for activation gatingof the inositol 1, 4, 5-trisphosphate receptor. J. Biol. Chem. 278, 16551-16560 (2003). (Pubitemid 36799516)
6. Schug, Z. T. & Joseph, S. K. The role of the S4-S5 linker and C-terminal tail in inositol 1, 4, 5-trisphosphate receptor function. J. Biol. Chem. 281, 24431-24440 (2006). (Pubitemid 44274216)
7. Chan, J. et al. Structural studies of inositol 1, 4, 5-trisphosphate receptor: coupling ligand binding to channel gating. J. Biol. Chem. 285, 36092-36099 (2010).
8. Yamazaki, H., Chan, J., Ikura, M., Michikawa, T. & Mikoshiba, K. Tyr-167/Trp-168 in type1/3 inositol 1, 4, 5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. J. Biol. Chem. 285, 36081-36091 (2010).
9. Tung, C. C., Lobo, P. A., Kimlicka, L. & Van Petegem, F. The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature 468, 585-588 (2010).
10. 3R1 by cryo-EM. Structure 19, 1192-1199 (2011).
11. Amador, F. J. et al. Crystal structure of type I ryanodine receptor amino-terminal b-trefoil domain reveals a disease-associated mutation "hot spot" loop. Proc. Natl Acad. Sci. USA 106, 11040-11044 (2009).
12. Lobo, P. A. & Van Petegem, F. Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure 17, 1505-1514 (2009).
13. 3 receptors: toward understanding their activation. Cold Spring Harb. Perspect. Biol. 2, a004010 (2010).
14. Anyatonwu, G. & Joseph, S. K. Surfaceaccessibility and conformationalchanges in the N-terminal domain of type I inositol trisphosphate receptors: studies using cysteine substitution mutagenesis. J. Biol. Chem. 284, 8093-8102 (2009).
15. 21 leak in failing hearts. Cardiovasc. Res. 81, 536-545 (2009).
16. 3 receptors bysynthetic bisphosphate ligands. Chem. Commun. 14, 1204-1206 (2009).
17. Chan, J. et al. Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1, 4, 5-trisphosphate receptor. J. Mol. Biol. 373, 1269-1280 (2007). (Pubitemid 47539486)
18. Mayer, M. L. Glutamate receptors at atomic resolution. Nature 440, 456-462 (2006).
19. 3 receptor. Nature Struct. Mol. Biol. 18, 1172-1174 (2011).
20. Hamada, T., Bannister, M. L. & Ikemoto, N. Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. Biochemistry 46, 4272-4279 (2007). (Pubitemid 46559394)
21. Ramos-Franco, J., Galvan, D., Mignery, G. A. & Fill, M. Location of the permeation pathway in the recombinant type-1 inositol 1, 4, 5-trisphosphate receptor. J. Gen. Physiol. 114, 243-250 (1999). (Pubitemid 29380152)
22. Samsó, M., Feng, W., Pessah, I. N. & Allen, P. D. Coordinated movement of cytoplasmic and transmembrane domainsof RyR1 upon gating. PLoS Biol. 7, e85 (2009).
23. Iwai, M., Michikawa, T., Bosanac, I., Ikura, M. & Mikoshiba, K. Molecular basis of the isoform-specific ligand-binding affinity of inositol 1, 4, 5-trisphosphate receptors. J. Biol. Chem. 282, 12755-12764 (2007). (Pubitemid 47100588)
24. Chu, A., Diaz-Munoz, M., Hawkes, M. J., Brush, K. & Hamilton, S. L. Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel. Mol. Pharmacol. 37, 735-741 (1990). (Pubitemid 20171510)
25. 21 channel activity. J. Bioenerg. Biomembr. 21, 227-246 (1989). (Pubitemid 19143571)
26. Liu, Z. et al. Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J. Cell Sci. 123, 1775-1784 (2010).
27. George, C. H. et al. Ryanodine receptor regulation by intramolecular interactions between cytoplasmic and transmembrane domains. Mol. Biol. Cell 15, 2627-2638 (2004). (Pubitemid 38691853)
28. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997). (Pubitemid 27085611)
29. McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674 (2007). (Pubitemid 47080256)
30. 21 release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum. J. Biol. Chem. 265, 13472-13483 (1990).
31. Tovey, S. C. et al. Regulation of inositol 1, 4, 5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. J. Biol. Chem. 285, 12979-12989 (2010).
32. Kenakin, T. P. Pharmacologic Analysis of Drug-Receptor Interactions 3rd edn (Lippincott, Williams & Wilkins, 1997).
33. Murshudov, G. N., Vagin, A. A. & Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D 53, 240-255 (1997). (Pubitemid 27235885)
34. Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126-2132 (2004). (Pubitemid 41742764)
35. 21 release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. J. Biol. Chem. 265, 2244-2256 (1990).
36. 21 channels. Nature Protocols 1, 259-263 (2006).
37. Pettersen, E. F. et al. UCSF Chimera-a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605-1612 (2004).
38. Wriggers, W., Milligan, R. A. & McCammon, J. A. Situs: a package for docking crystal structures into low-resolution maps from electron microscopy. J. Struct. Biol. 125, 185-195 (1999). (Pubitemid 29402603)