Conotoxin venom peptide therapeutics

Advances in Experimental Medicine and Biology

Volumn 655, Issue , 2009, Pages 44-48

  Lewis, Richard J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CONOTOXIN; ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CGX 1160; CONANTOKIN T; CONOTOXIN; CONTULAKIN G; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTENSIN RECEPTOR ANTAGONIST; NICOTINIC RECEPTOR; NORADRENALIN TRANSPORTER; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN MVIIA; SODIUM CHANNEL BLOCKING AGENT; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; XEN 2147; XEN 2174; AMINO ACID; NORADRENALIN; PEPTIDE; VENOM;

AMINO ACID SEQUENCE; ARTICLE; CANCER PAIN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; HUMAN; IMMUNOTHERAPY; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; DRUG DESIGN; METABOLISM; MOLECULAR GENETICS; NEOPLASM; REVIEW;

ANIMALIA; GASTROPODA;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CONOTOXINS; DRUG DESIGN; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; NOREPINEPHRINE; PEPTIDES; RECEPTORS, NICOTINIC; SODIUM CHANNEL BLOCKERS; VENOMS;

EID: 77954415694     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1132-2_5     Document Type: Article

References (16)

1. Lewis RJ. Garcia ML. Therapeutic potential of venom peprides . Nature Reviews Drug Discovery 2003 ; 2:790-802.
2. Lewis RJ, Nielsen KJ, Craik DJ et al. Novel ω-conoroxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem 2000: 275:35335-35344.
3. Malmberg AB. Yaksh TL. Effect of continuous int rathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 1995: 60:83-90 .
4. Smith M. Cabot PJ. Ross FB et al. The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain 2002: 96:119-127. (Pubitemid 34270634)
5. Nielsen K. Schroeder T. Lewis RJ. Structure-activity relationships of ω-conoroxins at N-type voltage-sensitive calcium channels . J Mol Recognition 2000 ; 13:55-70. (Pubitemid 30257940)
6. Schroeder CI . Smythe ML. Lewis RJ. Development of small molecules that mimic the binding of ω-conoroxins at the N-type voltage-gated calcium channel. Molec Diversity 2004; 8:127-134. (Pubitemid 39012548)
7. WoodJN, Boorman J. Voltage-gatedsodium channel blockers; target validation and therapeutic potential Curr Top Med Chem 2005; 5:529-537. (Pubitemid 41052325)
8. Ekberg J, Jayamanne A, Vaughan CW et al. μO-conotoxin MrVIB selectively blocks Na, 1.8 sensory neuron specific sodium channels and chronic pain without motor deficits. Proc Nad Acad Sci 2006; 103:17030-17035. (Pubitemid 44737372)
9. Nicke A, Wonnacott S, Lewis RJ. α-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes. Eur J Biochem 2004; 271:2305-2319. (Pubitemid 38813562)
10. Sandall DW; Satkunanathan N. KeaysDA et al. A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensoty nerves in vivo. Biochemistry 2003; 42:6904-11. (Pubitemid 36666131)
11. Sharpe IA. Gehrmann J, Loughnan ML et al. Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter. Nature Neurosci 2001; 4:902-907. (Pubitemid 32801593)
12. Nielsen CK. Lewis RJ. Alewood D et al. Anti-allodynic efficacy of the Χ-conopeptide. Xen2174, in rats with neuropathic pain. Pain 2005; 118:112-124. (Pubitemid 41566590)
13. Paczkowski FA, Sharpe IA, Dutertre S et al. Χ-conopeptide and tricyclic anti-depressant interactions at the norepinephrine transporter define a new transporter model. J Biol Chem 2007; 282:17837-17844. (Pubitemid 47100310)
14. Malmberg AB, Gilbert H, McCabe RT et al. Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain 2003; 101:109-116. (Pubitemid 36044658)
15. Craig AG, Norberg T, Griffin D et al. Contulakin-G, an O-glycosylated invertebrate neurotensin, J Biol Chem 1999; 274:13752-9.
16. Allen JW, Hofer K. McCumber D et al. An assessment of the antinociceptivc efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesth Analg 2007; 104:1505-13. (Pubitemid 46791293)