Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 27, 2005, Pages 9607-9612

  Wehrens, Xander H T ^a   Lehnart, Stephan E ^a   Reiken, Steven ^a   Van Der Nagel, Roel ^b   Morales, Raymond ^a   Sun, Jie ^a   Cheng, Zhenzhuang ^a   Deng, Shi Xiang ^a   De Windt, Leon J ^b   Landry, Donald W ^a   Marks, Andrew R ^a  

^a Columbia University ^*  (United States)

^b HUBRECHT INSTITUTE   (Netherlands)

Author keywords

Calcium; Contractility; FKBP12.6; Myocardial infarction

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; BENZOTHIAZEPINE DERIVATIVE; CALCIUM; CALCIUM BINDING PROTEIN; CALSTABIN; CALSTABIN 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; PLACEBO; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART EJECTION FRACTION; HEART FAILURE; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; HISTOLOGY; IMMUNOPRECIPITATION; MOUSE; MUSCLE FATIGUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SKELETAL MUSCLE; TRANSTHORACIC ECHOCARDIOGRAPHY; VOLTAGE CLAMP; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; ECHOCARDIOGRAPHY; HEART FAILURE, CONGESTIVE; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MYOCARDIAL CONTRACTION; MYOCARDIUM; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TACROLIMUS BINDING PROTEINS; THIAZEPINES;

EID: 22144480949     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500353102     Document Type: Article

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