Structural basis of the α1-β subunit interaction of voltage-gated Ca2+ channels

Nature

Volumn 429, Issue 6992, 2004, Pages 675-680

  Chen, Yu Hang ^a   Li, Ming Hui ^a   Zhang, Yun ^a   He, Lin Ling ^a   Yamada, Yoichi ^a   Fitzmaurice, Alleen ^a   Shen, Yang ^a   Zhang, Hailong ^a   Tong, Liang ^a   Yang, Jian ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIODIVERSITY; CALCIUM; CRYSTAL STRUCTURE; ELECTRIC POTENTIAL; POSITIVE IONS;

Β-SUBUNITS; PROTEIN INTERACTING MODULES;

PROTEINS;

PROTEIN SUBUNIT; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL ALPHA1 SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL ALPHA2 BETA SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL BETA SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL BETA3 SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL BETA4 SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL GAMMA SUBUNIT; CALCIUM CHANNEL;

NANOTECHNOLOGY;

ANIMAL CELL; ARTICLE; BETA INTERACTING DOMAIN; BETA INTERACTION DOMAIN; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; FEMALE; GUANYLATE KINASE DOMAIN; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SRC HOMOLOGY DOMAIN; XENOPUS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM CHANNELS; CRYSTALLOGRAPHY, X-RAY; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; SEQUENCE ALIGNMENT; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2942598131     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02641     Document Type: Article

References (30)

1. 2+ channels. Annu. Rev. Cell Dev. Biol. 16, 521-555 (2000).
2. Birnbaumer, L. et al. Structures and functions of calcium channel beta subunits. J. Bioenerg. Biomembr. 30, 357-375 (1998).
3. Arikkath, J. & Campbell, K. P. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr. Opin. Neurobiol. 13, 298-307 (2003).
4. Dolphin, A. C. β subunits of voltage-gated calcium channels. J. Bioenerg. Biomembr. 55, 607-627 (2003).
5. 2+ channel regulation by a conserved beta subunit domain. Neuron 13, 495-503 (1994).
6. 2+ channels. FEBS Lett. 380, 272-276 (1996).
7. 1-subunit. Nature 368, 67-70 (1994).
8. Canti, C. et al. Evidence for two concentration-dependent processes for β-subunit effects on α1B calcium channels. Biophys. J. 81, 1439-1451 (2001).
9. Opatowsky, Y., Chomsky-Hecht, O., Kang, M. G., Campbell, K. P. & Hirsch, J. A. The voltage-dependent calcium channel beta subunit contains two stable interacting domains. J. Biol. Chem. 278, 52323-52332 (2003).
10. 2+ channel beta subunit as a basis for understanding its functional properties. FEBS Lett. 445, 366-370 (1999).
11. Hendrickson, W. A. Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science 254, 51-58 (1991).
12. Tavares, G. A., Panepucci, E. H. & Brunger, A. T. Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. Mol. Cell 8, 1313-1325 (2001).
13. Zarrinpar, A., Bhattacharyya, R. P. & Lim, W. A. The structure and function of proline recognition domains. Sci. STKE 2003, RE8 (2003).
14. Larson, S. M. & Davidson, A. R. The identification of conserved interactions within the SH3 domain by alignment of sequences and structures. Protein Sci. 9, 2170-2180 (2000).
15. Blaszcyk, J., Li, Y., Yan, H. & Ji, X. Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes. J. Mol. Biol. 307, 247-257 (2001).
16. Sheng, M. & Pak, D. T. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu. Rev. Physiol. 62, 755-778 (2000).
17. 2+ channel expression at the cell surface by the small G-protein kir/ Gem. Nature 411, 701-706 (2001).
18. Finlin, B. S., Crump, S. M., Satin, J. & Andres, D. A. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. Proc. Natl Acad. Sci. USA 100, 14469-14474 (2003).
19. McGee, A. W. et al. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol. Cell 8, 1291-1301 (2001).
20. Garcia, E. P. et al. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 21, 727-739 (1998).
21. Maximov, A., Sudhof, T. C. & Bezprozvanny, 1. Association of neuronal calcium channels with modular adaptor proteins. J. Biol. Chem. 274, 24453-24456 (1999).
22. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
23. Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D 55, 849-861 (1999).
24. Jones, T. A., Zou, I. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
25. Brunger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921 (1998).
26. Jogl, G., Tao, X., Xu, Y. & Tong, L. COMO: a program for combined molecular replacement. Acta Crystallogr. D 57, 1127-1134 (2001).
27. Wu, L., Bauer, C. S., Zhen, X. G., Xie, C. & Yang, J. Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2. Nature 419, 947-952 (2002).
28. Carson, M. Ribbon models of macromolecules. J. Mol. Graph. 5, 103-106 (1987).
29. Nicholls, A., Sharp, K. & Honig, B. H. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins Struct. Funct. Genet. 11, 281-296 (1991).
30. Kraulis, P. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950 (1991).