Synthesis and SERCA activities of structurally simplified cyclopiazonic acid analogues

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4669-4678

  Yao, Sheng ^a   Gallenkamp, Daniel ^a   Wölfel, Katharina ^b   Lüke, Bettina ^b   Schindler, Michael ^b   Scherkenbeck, Jürgen ^a  

^a UNIVERSITY OF WUPPERTAL   (Germany)

^b BAYER CROPSCIENCE AG   (Germany)

Author keywords

Analogues; Cyclopiazonic acid; Indole alkaloid; SERCA; Structure activity data

Indexed keywords

2 (1 HYDROXYETHYLIDENE) 9,9 DIMETHYLPYRAZOLO [1,2 A]INDAZOLE 1,3 (2H,9H) DIONE; 3,3 DIMETHYL 2,3 DIHYDRO 1H INDAZOLE; 9,9 DIMETHYLPYRAZOLO [1,2 A]INDAZOLE 1,3 (2H,9H) DIONE; ALPHA CYCLOPIAZONIC ACID; BETA CYCLOPIAZONIC ACID; CYCLOPIAZONIC ACID; EQUISETIN; ETHYL 3 (3,3 DIMETHYL 1H INDAZOL 2 (3H) YL) 3 OXOPROPANOIC ACID; ETHYL 3 [2 [2 (2 HYDROXYPROPAN 2 YL)PHENYL]HYDRAZINYL] 3 OXOPROPANOIC ACID; IKARUGAMYCIN; INDOLE ALKALOID; RAC (2 IODO PHENYL) 2,2,2 TRIFLUOROACETYLAMINO ACETIC ACID METHYL ESTER; RAC (2 ISOPROPENYL PHENYL) (2,2,2 TRIFLUORO ACETYLAMINO)ACETIC ACID METHYL ESTER; RAC 1,1 DIMETHYL 1,2,3,4 TETRAHYDRO ISOQUINOLINE 3 CARBOXYLIC ACID METHYL ESTER; RAC 1,1 DIMETHYL 2 (2,2,2 TRIFLUORO ACETYL) 1,2,3,4 TETRAHYDRO ISOQUINOLINE 3 CARBOXYLIC ACID METHYL ESTER; RAC 2 (1 HYDROXYETHYLIDENE) 5,5 DIMETHYL 5,9B DIHYDRO 1H PYRROLO [2,1 A]ISOINDOLE 1,3 (2H) DIONE; RAC 2 (1 HYDROXYETHYLIDENE) 5,5 DIMETHYLOCTAHYDRO 1H PYRROLO [2,1 A]ISOINDOLE 1,3 (2H) DIONE; RAC 2 (1 HYDROXYETHYLIDENE) 9,9 DIMETHYLHEXAHYDROPYRAZOLO [1,2 A]INDAZOLE 1,3 (2H,4AH) DIONE; RAC 2 (2,2,2 TRIFLUOROACETYLAMINO) 3 (2 IODO PHENYL)PROPIONIC ACID METHYL ESTER; RAC 2 (2,2,2 TRIFLUOROACETYLAMINO) 3 (2 ISOPROPENYL)PROPIONIC ACID METHYL ESTER; RAC 2 [1 HYDROXY ETHYLIDENE] 5,5 DIMETHYL 10,10A DIHYDRO 5H PYRROLO [1,2 B]ISOQUINOLINE 1,2 DIONE; RAC 3,3 DIMETHYL 2,3 DIHYDRO 1H ISOINDOL 1 CARBOXYLIC ACID METHYL ESTER; RAC 3,3 DIMETHYL OCTAHYDRO ISOINDOLE 1 CARBOXYLIC ACID METHYL ESTER; RAC 9,9 DIMETHYLHEXAHYDROPYRAZOLO [1,2 A]INDAZOLE 1,3 (2H,4AH) DIONE; RAC AMINO (2 ISOPROPENYL PHENYL)ACETONITRILE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TERT BUTYL 2 [2 (2 HYDROXYPROPAN 2 YL)PHENYL]HYDRAZINE CARBOXYLIC ACID; THAPSIGARGIN; TIRANDAMYCIN A; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; EPIMERIZATION; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ENZYME INHIBITORS; INDOLES; MODELS, MOLECULAR; MOTHS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 79960557829     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.001     Document Type: Article

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