Functional Significance of the β-Hairpin in the Insecticidal Neurotoxin ω-Atracotoxin-Hv1a

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 26568-26576

  Tedford, Hugo W ^a   Fletcher, Jamie I ^b   King, Glenn F ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; INSECTICIDES; LEAD COMPOUNDS; MUTAGENESIS; PROTEINS;

TOXIN ACTIVITY;

BIOCHEMISTRY;

AMINO ACID; ARGININE; ASPARAGINE; CALCIUM CHANNEL; CALCIUM ION; DISULFIDE; DOUBLE STRANDED DNA; INSECTICIDE; ION CHANNEL; NEUROTOXIN; OMEGA ATRACOTOXIN HV1A; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; OMEGA ATRACOTOXIN HV1; OMEGA-ATRACOTOXIN-HV1; SPIDER VENOM;

ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; INSECT; INSECTICIDAL ACTIVITY; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PURIFICATION; SPIDER; TOXICITY TESTING; TOXIN ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALIA; ARANEAE; INSECTA; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; ESCHERICHIA COLI; INSECTICIDES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE ALIGNMENT; SPIDER VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035854663     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102199200     Document Type: Article

References (42)

1. Gorell, J. M., Johnson, C. C., Rybicki, B. A., Peterson, E. L., and Richardson, R. J. (1998) Neurology 50, 1346-1350
2. Betarbet, R., Sherer, T. B., MacKenzie, G., Garcia-Osuna, M., Panov, A. V., and Greenamyre, J. T. (2000) Nat. Neurosci. 3, 1301-1306
3. Shelton, A. M., Tang, J. D., Roush, R. T., Metz, T. D., and Earle, E. D. (2000) Nat. Biotechnol. 18, 339-342
4. Cory, J. S., Hirst, M. L., Williams, T., Hails, R. S., Goulson, D., Green, B. M., Carty, T. M., Possee, R. D., Cayley, P. J., and Bishop, D. H. L. (1994) Nature 370, 138-140
5. Bonning, B. C., and Hammock, B. D. (1996) Annu. Rev. Entomol. 41, 191-210
6. Treacy, M. F. (1999) in Biopesticides: Uses and Delivery (Hall, F. R., and Menn, J. J., eds) pp. 321-340, Humana Press, Totowa, NJ
7. Atkinson, R. K., Mowden, M. E. H., Tyler, M. I., and Vonarx, E. J. (1993) Insecticidal toxins derived from funnel web spider (Atrax or Madronyche) spiders. International Patent Application PCT/AU93/00039 (WO 93/15108)
8. Miller, M. K., Whyte, I. M., White, J., and Keir, P. M. (2000) Toxicon 38, 409-427
9. Fletcher, J. I., Smith, R., O'Donoghue, S. I., Nilges, M., Connor, M., Howden, M. E. H., Christie, M. J., and King, G. F. (1997) Nat. Struct. Biol. 4, 559-566
10. Wang, X.-H., Smith, R., Fletcher, J. I., Wilson, H., Wood, C. J., Howden, M. E. H., and King, G. F. (1999) Eur. J. Biochem. 264, 488-494
11. Wang, X.-H., Connor, M., Smith, R., Maciejewski, M. W., Howden, M. E. H., Nicholson, G. M., Christie, M. J., and King, G. F. (2000) Nat. Struct. Biol. 7, 505-513
12. Zilberberg, N., Gordon, D., Pelhate, M., Adams, M. E., Norris, T. M., Zlotkin, E., and Gurevitz, M. (1996) Biochemistry 35, 10215-10222
13. Froy, O., Zilberberg, N., Gordon, D., Turkov, M., Gilles, N., Stankiewicz, M., Pelhate, M., Loret, E., Oren, D. A., Shaanan, B., and Gurevitz, M. (1999) J. Biol. Chem. 274, 5769-5776
14. Eitan, M., Fowler, E., Herrmann, R., Duval, A., Pelhate, M., and Zlotkin, E. (1990) Biochemistry 29, 5941-5947
15. Fletcher, J. I., Dingley, A. J., Smith, R., Connor, M., Christie, M. J., and King, G. F. (1999) Eur. J. Biochem. 264, 488-494
16. Piotto, M., Saudek, V., and Sklenár, V. (1992) J. Biomol. NMR 2, 661-665
17. Bartels, C., Xia, T.-H., Billeter, M., Güntert, P., and Wüthrich, K. (1995) J. Biomol. NMR 5, 1-10
18. Güntert, P., Mumenthaler, C., and Wüthrich, K. (1997) J. Mol. Biol. 273, 283-298
19. Szyperski, T., Güntert, P., Otting, G., and Wüthrich, K. (1992) J. Magn. Reson. 99, 552-560
20. Clubb, R. T., Ferguson, S. B., Walsh, C. T., and Wagner, G. (1994) Biochemistry 33, 2761-2722
21. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, Inc., New York
22. Kline, A. D., Braun, W., and Wüthrich, K. (1988) J. Mol. Biol. 204, 675-724
23. Brünger, A. T. (1992)X-PLOR Version 3.1., Yale University Press, New Haven
24. Koradi, R., Billeter, M., and Wüthrich, K. (1996) J. Mol. Graph. 14, 51-55
25. Riley, L. G., Junius, F. K., Swanton, M. K., Vesper, N. A., Williams, N. K., King, G. F., and Weiss, A. S. (1994) Eur. J. Biochem. 219, 877-886
26. Norton, R. S., and Pallaghy, P. K. (1998) Toxicon 36, 1573-1583
27. Craik, D. J., Daly, N. L., and Waine, C. (2001) Toxicon 39, 43-60
28. Olivera, B. M., and Cruz, L. J. (2001) Toxicon 39, 7-14
29. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
30. Hutchinson, E. G., and Thornton, J. M. (1996) Protein Sci. 5, 212-220
31. Stewart, L. M. D., Hirst, M., Ferber, M. L., Merryweather, A. T., Cayley, P. A., and Possee, R. D. (1991) Nature 352, 85-88
32. Stewart, E. J., Åslund, F., and Beckwith, J. (1998) EMBO J. 17, 5543-5550
33. Prinz, W. A., Åslund, F., Holmgren, A., and Beckwith, J. (1997) J. Biol. Chem. 272, 15661-15667
34. Derman, A. I., Printz, W. A., Belin, D., and Beckwith, J. (1993) Science 262, 1744-1747
35. Debarbieux, L., and Beckwith, J. (1999) Cell 99, 117-119
36. Hutchinson, E. G., and Thornton, J. M. (1994) Protein Sci. 3, 2207-2216
37. Woody, R. W. (1996) in Circular Dichroism and the Conformational Analysis of Biomolecules (Fasman, G. D., ed) pp. 25-67, Plenum Press, New York
38. Zilberberg, N., Froy, O., Loret, E., Cestèle, S., Arad, D., Gordon, D., and Gurevitz, M. (1997) J. Biol. Chem. 272, 14810-14816
39. Oerke, E.-C. (1994) in Crop Production and Crop Protection: Estimated Losses in Major Food and Cash Crops (Oerke, E.-C., Dehne, H.-W., Schönbeck, F., and Weber, A., eds) pp. 72-78, Elsevier, Amsterdam
40. Feyereisen, R. (1995) Toxicol. Lett. 82-83, 83-90
41. ffrench-Constant, R. H., Pittendringh, B., Vaughan, A., and Anthony, N. (1998) Philos. Trans. R. Soc. Lond-Biol. Sci. 353, 1685-1693
42. Olivera, B. M., Miljanich, G. P., Ramachandran, J., and Adams, M. E. (1994) Annu. Rev. Biochem. 63, 823-867