Molecular mechanism underlying anti-inflammatory and anti-Allergic activities of phytochemicals: An update

Molecules

Volumn 18, Issue 1, 2013, Pages 322-353

  Bellik, Yuva ^a,b   Boukraâ, Laïd ^a,c   Alzahrani, Hasan A ^c,d   Bakhotmah, Balkees A ^c   Abdellah, Fatiha ^a   Hammoudi, Si M ^a   Iguer Ouada, Mokrane ^b  

^a UNIVERSITY OF TIARET   (Algeria)

^b UNIVERSITY OF BEJAIA   (Algeria)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^d Aziz University   (Saudi Arabia)

Author keywords

Anti Allergic; Anti inflammatory; Molecular mechanisms; Phytochemicals

Indexed keywords

EID: 84872867153     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18010322     Document Type: Review

References (236)

1. Fabricant, D.S.; Farnsworth, N.R. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect. 2001, 109, 69-75.
2. Jachak, S.M.; Saklani, A. Challenges and opportunities in drug discovery from plants. Curr. Sci. 2007, 92, 1251-1257.
3. Harvey, A. Strategies for discovering drugs from previously unexplored natural products. Drug Discov. Today 2000, 5, 294-300.
4. Bakhotmah, B.A.; Alzahrani, H.A. Self-reported use of complementary and alternative medicine (CAM) products in topical treatment of diabetic foot disorders by diabetic patients in Jeddah, Western Saudi Arabia. BMC Res. Notes 2010, 2010, 254.
5. Bellik, Y.; Hammoudi, S.M.; Abdellah, F.; Iguer-Ouada, M.; Boukraâ, L. Phytochemicals to prevent inflammation and allergy. Recent Pat. Inflamm. Allergy Drug Discov. 2012, 6, 147-158.
6. Kim, Y.S.; Young, M.R.; Bobe, G.; Colburn, N.H.; Milner, J.A. Bioactive food components, inflammatory targets, and cancer prevention. Cancer Prev. Res. 2009, 2, 200-208.
7. Gautam, R.; Jachak, S.M. Recent developments in anti-infammatory natural products. Med. Res. Rev. 2009, 29, 767-820.
8. Calixto, J.B.; Otuki, M.F.; Santos Adair, R.S. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor -B (NF-B). Planta Med. 2003, 69, 973-983.
9. Akiyama, H.; Barger, S.; Barnum, S.; Bradt, B.; Bauer, J.; Cole, G.M.; Cooper, N.R.; Eikelenboom, P.; Emmerling, M.; Fiebich, B.L.; et al. Inflammation and Alzheimer's disease. Neurobiol. Aging 2000, 21, 383-421.
10. Libby, P.; Ridker, P.M.; Maseri, A. Inflammation and atherosclerosis. Circulation 2002, 105, 1135-1143.
11. Cragg, G.M.; Newman, D.J.; Snader, K.M. Natural products in drug discovery and development. J. Nat. Prod. 1997, 60, 52-60.
12. Brito, F.A.; Lima, L.A.; Ramos, M.F.S.; Nakamura, M.J.; Cavalher-Machado, S.C.; Siani, A.C.; Henriques, M.G.M.O.; Sampaio, A.L.F. Pharmacological study of anti-Allergic activity of Syzygium cumini (L.) Skeels. Braz. J. Med. Biol. Res. 2007, 40, 105-115.
13. Nettis, E.; Colanardi, M.C.; Ferrannini, A.; Tursi, A. Antihistamines as important tools for regulating inflammation. Curr. Med. Chem. Anti Inflamm. Anti Allergy Agents 2005, 4, 81-89.
14. Tewtrakul, S.; Itharat, A. Anti-Allergic substances from the rhizomes of Dioscorea membranacea. Bioorg. Med. Chem. 2006, 14, 8707-8711.
15. Croteau, R.; Kutchan, T.M.; Lewis, N.G. Natural Products (Secondary Metabolites). In Biochemistry & Molecular Biology of Plants; Buchanan, B., Gruissem, W., Jones, R., Eds.; Wiley: Hoboken, NJ, USA, 2000; Chapter 24, pp. 1250-1318.
16. Liu, R.H. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J. Nutr. 2004, 134, 3479S-3485S.
17. Calabrese, V.; Cornelius, C.; Dinkova-Kostova, A.T.; Iavicoli, I.; Di Paola, R.; Koverech, A.; Cuzzocrea, S.; Rizzarelli, E.; Calabrese, E.J. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim. Biophys. Acta. 2012, 1822, 753-783.
18. Nichenametla, S.N.; Taruscio, T.G.; Barney, D.L.; Exon, J.H. A Review of the effects and mechanisms of polyphenolics in cancer. Crit. Rev. Food Sci. Nutr. 2006, 46, 161-183.
19. Arya, V.; Arya, M.L. A Review on anti-inflammatory plant barks. Int. J. Pharm.Tech. Res. 2011, 3, 899-908.
20. Vauzour, D. Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects. Oxid. Med. Cell. Longev. 2012, doi:10.1155/2012/914273.
21. Alía, M.; Ramos, S.; Mateos, R.; Granado-Serrano, A.B.; Bravo, L.; Goya, L. Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol. Appl. Pharmacol. 2006, 212, 110-118.
22. Pandey, K.B.; Rizvi, S.I. Protective effect of resveratrol on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative insult. Phytother. Res. 2010, 24, S11-S14.
23. Scharf, G.; Prustomersky, S.; Knasmuller, S.; Schulte-Hermann, R.; Huber, W.W. Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr. Cancer 2003, 45, 74-83.
24. Gulcin, I. Antioxidant properties of resveratrol: A structure-Activity insight. Innovat. Food Sci. Emerg Tech. 2010, 11, 210-218.
25. Fki, I.; Sahnoun, Z.; Sayadi, S. Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet. J. Agric. Food. Chem. 2007, 55, 624-631.
26. Du, Y.; Guo, H.; Lou, H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J. Agric. Food. Chem. 2007, 55, 1695-1701.
27. Rodrigo, R.; Miranda, A.; Vergara, L. Modulation of endogenous antioxidant system by wine polyphenols in human disease. Clin. Chim. Acta 2011, 412, 410-424.
28. Leung, H.W.; Kuo, C.L.; Yang, W.H.; Lin, C.H.; Lee, H.Z. Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis. Eur. J. Pharmacol. 2006, 534, 12-18.
29. Vanhees, K.; van Schooten, F.J.; Moonen, E.J.; Maas, L.M.; van Waalwijk van Doorn-Khosrovani, S.B.; Godschalk, R.W.L. Maternal intake of quercetin during gestation alters ex vivo benzo[a] pyrene metabolism and DNA adduct formation in adult offspring. Mutagenesis 2012, 27, 445-451.
30. Shen, S.Q.; Zhang, Y.; Xiang, J.J.; Xiong, C.L. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J. Gastroenterol. 2007, 13, 1953-1961.
31. Hong, J.; Smith, T.J.; Ho, C.T.; August, D.A.; Yang, C.S. Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem. Pharmacol. 2001, 62, 1175-1183.
32. Park, J.B. Effects of typheramide and alfrutamide found in Allium species on cyclooxygenases and lipoxygenases. J. Med. Food 2011, 14, 226-231.
33. Schewe, T.; Sadik, C.; Klotz, L.O.; Yoshimoto, T.; Kuhn, H.; Sies, H. Polyphenols of cocoa: Inhibition of mammalian 15-lipoxygenase. Biol. Chem. 2001, 382, 1687-1696.
34. Fernandez, M.A.; de las Heras, B.; Garcia, M.D.; Saenz, M.T.; Villar, A. New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. J. Pharm. Pharmacol. 2001, 53, 1533-1539.
35. Rangkadilok, N.; Sitthimonchai, S.; Worasuttayangkurn, L.; Mahidol, C.; Ruchirawat, M.; Satayavivad, J. Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract. Food Chem. Toxicol. 2007, 45, 328-336.
36. Leopoldini, M.; Russo, N.; Toscano, M. The molecular basis of working mechanism of natural polyphenolic antioxidants. Food Chem. 2011, 125, 288-306.
37. Cadenas, S.; Barja, G. Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3. Free Radic. Biol. Med. 1999, 26, 1531-1537.
38. Hanaski, Y.; Ogawa, S.; Fukui, S. The correlation between active oxygen scavenging and antioxidative effects of flavonoids. Free Radic. Biol. Med. 1994, 16, 845-850.
39. Mascio, P.D.; Murphy, M.E.; Sies, H. Antioxidant defense systems: The role of carotenoids, tocopherols, and thiols. Am. J. Clin. Nutr. 1991, 53, 194S-200S.
40. Chen, Y.; Tsai, Y.H.; Tseng, S.H. The potential of tetrandrine as a protective agent for ischemic stroke. Molecules 2011, 16, 8020-8032.
41. Srinivasan, M.; Sudheer, A.R.; Pillai, K.R.; Kumar, P.R.; Sudhakaran, P.R.; Menon, V.P. Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro. Biochim. Biophys. Acta 2007, 1770, 659-665.
42. Yang, S.C.; Huang, C.C.; Chu, J.S.; Chen, J.R. Effects of ß-carotene on cell viability and antioxidant status of hepatocytes from chronically ethanol-fed rats. Br. J. Nutr. 2004, 92, 209-215.
43. Manna, S.K. Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases. Biochem. Pharmacol. 2012, 15, 1383-1392.
44. Trevillyan, J.M.; Lu, Y.L.; Atluru, D.; Phillips, C.A.; Bjorndahl, J.M. Differential inhibition of T cell receptor signal transduction and early activation events by selective inhibitor of protein-tyrosine kinase. J. Immunol. 1990, 145, 3223-3230.
45. Comalada, M.; Ballester, I.; Bailon, E.; Sierra, S.; Xaus, J.; Galvez, J.; de Medina, F.S.; Zarzuelo, A. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure-Activity relationship. Biochem. Pharmacol. 2006, 72, 1010-1021.
46. Pecivová, J.; Macicková, T.; Sviteková, K.; Nosá, R. Quercetin inhibits degranulation and superoxide generation in PMA stimulated neutrophils. Interdiscip. Toxicol. 2012, 5, 81-83.
47. Kanashiro, A.; Souza, J.G.; Kabeya, L.M.; Azzolini, A.E.; Lucisano-Valim, Y.M. Elastase release by stimulet neutrophils inhibited by flavonoids: Importance of the catechol group. Z. Naturforsch. C 2007, 62, 357-361.
48. Tordera, M.; Ferrandiz, M.L.; Alcaraz, M.J. Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils. Z. Naturforsch. C 1994, 49, 235-240.
49. Berton, G.; Schneider, C.; Romeo, D. Inhibition by quercetin of activation of polymorphonuclear leukocyte functions. Stimulus-specific effects. Biochim. Biophys. Acta 1980, 595, 47-55.
50. Lee, T-P.; Matteliano, M.L.; Middletone, E. Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism. Life Sci. 1982, 31, 2765-2774.
51. Selloum, L.; Bouriche, H.; Tigrine, C.; Boudoukha, C. Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. Exp. Toxicol. Pathol. 2003, 54, 313-318.
52. Lanni, C.; Becker, E.L. Inhibition of neutrophil phospholipase A2 by p-bromophenylacyl bromide, nordihydroguaiaretic acid, 5,8,11,14- eicosatetrayenoic acid and quercetin. Int. Arch. Allergy Appl. Immunol. 1985, 76, 214-217.
53. Chiou, Y.L.; Lin, S.R.; Hu, W.P.; Chang, L.S. Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2. J. Biosci. 2012, 37, 277-87.
54. Gil, B.; Sanz, M.J.; Terencio, M.C.; Ferrandiz, M.L.; Bustos, G.; Paya, M.; Gunasegaran, R.; Alcaraz, M.J. Effects of flavonoids on Naja naja and human recombinant synovial phospholipase A2 and inflammatory responses in mice. Life Sci. 1994, 54, PL333-PL338.
55. Chang, H.W.; Baek, S.H.; Chung, K.W.; Son, K.H.; Kim, H.P.; Kang, S.S. Inactivation of phospholipase A2 by naturally occurring biflavonoid, ochnaflavone. Biochem. Biophys. Res. Commun. 1994, 205, 843-849.
56. Gil, B.; Sanz, M.J.; Terencio, M.C.; Gunasegaran, R.; Paya, M.; Alcaraz, M.J. Morelloflavone, a novel biflavonoid inhibitor of human secretory phospholipase A2 with anti-inflammatory activity. Biochem. Pharmacol. 1997, 53,733-740.
57. Baek, S.H.; Yun, S.S.; Kwon, T.K.; Kim, J.R.; Chang, H.W.; Kwak, J.Y.; Kim, J.H.; Kwun, K.B. The effects of two new antagonists of secretory PLA2 on TNF-A, iNOS, and COX-2 expression in activated macrophages. Shock 1999, 12, 473-478.
58. Hong, J.; Bose, M.; Ju, J.; Ryu, J.H.; Chen, X.; Sang, S.; Lee, M.J.; Yang, C.S. Modulation of arachidonic acid metabolism by curcumin and related beta diketone derivatives: Effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 2004, 25, 1671-1679.
59. Kwak, W.-J.; Moon, T.C.; Lin, C.X.; Rhyn, H.G.; Jung, H.; Lee, E.; Kwon, D.Y.; Son, K.H.; Kim, H.P.; Kang, S.S.; et al. Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. Biol. Pharm. Bull. 2003, 26, 299-302.
60. Bauman, J.; von Bruchhausen, F.V.; Wurm, G. Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation. Prostaglandins 1980, 20, 627-639.
61. Landorfi, R.; Mower, R.L.; Steiner, M. Modification of platelet function and arachidonic acid metabolism by biflavonoids. Structure-Activity relations. Biochem. Pharmacol. 1984, 33, 1525-1530.
62. Akhtar, N.; Haqqi, T.M. Epigallocatechin-3-gallate suppresses the global interleukin-1betainduced inflammatory response in human chondrocytes. Arthritis Res. Ther. 2011, 13, R93.
63. Kimura, Y.; Okuda, H.; Nomura, T.; Fukai, T.; Arichi, S. Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets. J. Nat. Prod. 1986, 49, 639-644.
64. Lin, C.N.; Lu, C.M.; Lin, H.C.; Fang, S.C.; Shieh, B.J.; Hsu, M.F.; Wang, J.P.; Ko, F.N.; Teng, C.M. Novel antiplatelet constituents from Formosan Moraceous plants. J. Nat. Prod. 1996, 59, 834-838.
65. Gerhauser, C.; Klimo, K.; Heiss, E.; Neumann, I.; Gamal-Eldeen, A.; Knauft, J.; Liu, G.Y.; Sitthimonchai, S.; Frank, N. Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat. Res. 2003, 523-524, 163-172.
66. Csaki, C.; Keshishzadeh, N.; Fischer, K.; Shakibaei, M. Regulation of inflammation signaling by resveratrol in human chondrocytes in vitro. Biochem. Pharmacol. 2008, 75, 677-687.
67. Ferrandiz, M.L.; Ramachandran Nair, A.G.; Alcaraz, M.J. Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. Pharmazie 1990, 45, 206-208.
68. You, K.M.; Jong, H.; Kim, H.P. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from the several medicinal plants. Arch. Pharm. Res. 1999, 22, 18-24.
69. Chi, Y.S.; Jong, H.; Son, K.H.; Chang, H.W.; Kang, S.S.; Kim, H.P. Effects of naturally occurring prenylated flavonoids on arachidonic acid metabolizing enzymes: Cylooxygenases and lipoxygenases. Biochem. Pharmacol. 2001, 62, 1185-1191.
70. Moon, T.C.; Murakami, M.; Kudo, I.; Son, K.H.; Kim, H.P.; Kang, S.S.; Chang, H.W. A new class of Cox-2 inhibitor, rutaecarpine from Evoida rutaecarpa. Inflamm. Res. 1999, 48, 621-625.
71. Hou, C.-C.; Chen, Y.-P.; Wu, J.-H.; Huang, C.-C.; Wang, S.-Y.; Yang, N.-S.; Shyur, L.-F. A Galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma. Cancer Res. 2007, 67, 6907-6915.
72. Noreen, Y.; Serrano, G.; Perera, P.; Bohlin, L. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis. Planta Med. 1998, 64, 520-524.
73. Jang, D.S.; Cuendet, M.; Hawthorne, M.E. Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2. Phytochemistry 2002, 61, 867-872.
74. Likhiwitayawuid, K.; Sawasdee, K.; Kirtikara, K. Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri. Planta Med. 2002, 68, 841-843.
75. Sailer, E.R.; Subramanian, L.R.; Rall, B.; Hoernlein, R.F.; Ammon, H.P.; Safayhi, H. Acetyl-11- keto-beta-boswellic acid (AKBA): Structure requirements for binding and 5-lipoxygenase inhibitory activity. Br. J. Pharmcol. 1996, 117, 615-618.
76. Safayhi, H.; Boden, S.E.; Schweizer, S.; Ammon, H.P. Concentration- dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL. Planta Med. 2000, 66, 110-113.
77. Prieto, J.M.; Giner, R.M.; Recio, M.M.C.; Schinella, G.; Manez, S.; Rios, J.L. Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum. Planta Med. 2002, 68, 359-360.
78. Nakadate, T.; Yamamoto, S.; Aizu, E.; Kato, R. Effects of flavonoids and antioxidants on 12-O-tetradecanoylphorbol 13-Acetate induced epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds. Gann 1984, 75, 214-222.
79. Laughton, M.J.; Evans, P.J.; Moroney, M.A.; Hoult, J.R.S.; Halliwell, B. Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary additives. Biochem. Pharmacol. 1991, 42, 1673-1681.
80. Kim, H.P.; Indu, M.; Iversen, L.; Ziboh, V.A. Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostaglandins Leukot. Essent. Fatty Acids 1998, 58, 17-24.
81. Yoshimoto, T.; Furukawa, M.; Yamamoto, S.; Horie, T.; Watanabe-Kohno, S. Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase. Biochem. Biophys. Res. Commun. 1983, 116, 612-618.
82. Reddy, G.R.; Ueda, N.; Hada, T.; Sackeyfio, A.C.; Yamamoto, S.; Hana, Y. A prenylatedflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor. Biochem. Pharmacol. 1991, 41, 115-118.
83. Kinaci, M.K.; Erkasap, N.; Kucuk, A.; Koken, T.; Tosun, M. Effects of quercetin on apoptosis, NF-B and NOS gene expression in renal ischemia/reperfusion injury. Exp. Ther. Med. 2012, 3, 249-254.
84. Wang, Y.; Zhu, Y.; Gao, L.; Yin, H.; Xie, Z.; Wang, D.; Zhu, Z.; Han, X. Formononetin attenuates IL-1ß-induced apoptosis and NF-B activation in INS-1 cells. Molecules 2012, 17, 10052-10064.
85. Sadowska-Krowicka, H.; Mannick, E.E.; Oliver, P.D.; Sandoval, M.; Zhang, X.J.; Eloby-Childess, S.; Clark, D.A.; Miller, M.J. Genistein and gut inflammation: Role of nitric oxide. Proc. Soc. Exp. Biol. Med. 1998, 217, 351-357.
86. Soliman, K.F.A.; Mazzio, E.A. In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proc. Soc. Exp. Biol. Med. 1998, 218, 390-397.
87. Kim, H.; Kim, Y.S.; Kim, S.Y.; Suk, K. The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production. Neurosci. Lett. 2001, 309, 67-71.
88. Kao, T.K.; Ou, Y.C.; Raung, S.L.; Lai, C.Y.; Liao, S.L.; Chen, C.J. Inhibition of nitric oxide production by quercetin in endotoxin/cytokine- stimulated microglia. Life Sci. 2010, 86, 315-321.
89. Fu, P.K.; Wu, C.L.; Tsai, T.H.; Hsieh, C.L. Anti-Inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats. Evid. Based Complement. Alternat. Med. 2012, doi:10.1155/2012/837513.
90. Geng, Y.; Zhang, B.; Lotz, M. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J. Immunol. 1993, 151, 6692-6700.
91. Yoon, J.S.; Chae, M.K.; Lee, S.Y.; Lee, E.J. Anti-inflammatory effect of quercetin in a whole orbital tissue culture of Graves' orbitopathy. Br. J. Ophthalmol. 2012, 96, 1117-1121.
92. Jang, S.; Dilger, R.N.; Johnson, R.W. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J. Nutr. 2010, 140, 1892-1898.
93. Lin, N.; Sato, T.; Takayama, Y.; Mimaki, Y.; Sashida, Y.; Yano, M.; Ito, A. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem. Pharmacol. 2003, 65, 2065-2071.
94. Krakauer, T. The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines. Immunopharmacol. Immunotoxicol. 2002, 24, 113-119.
95. Hong, J.J.; Jeong, T.S.; Choi, J.H.; Park, J.H.; Lee, K.Y.; Seo, Y.J.; Oh, S.R.; Oh, G.T. Hematein inhibits tumor necrotic factor-Alpha-induced vascular cell adhesion molecule-1 and NF-kappaBdependent gene expression in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 2001, 281, 1127-1133.
96. Jeong, H.J.; Koo, H.N.; Na, H.J.; Kim, M.S.; Hong, S.H.; Eom, J.W.; Kim, K.S.; Shin, T.Y.; Kim, H.M. Inhibition of TNF-Alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells. Cytokine 2002, 18, 252-259.
97. An, S.J.; Pae, H.O.; Oh, G.S.; Choi, B.M.; Jeong, S.; Jang, S.I.; Oh, H.; Kwon, T.O.; Song, C.E.; Chung, H.T. Inhibition of TNF-Alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-Activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). Int. Immunopharmacol. 2002, 2, 1173-1181.
98. Choi, H.S.; Kim, H.S.; Min, K.R.; Kim, Y.; Lim, H.K.; Chang, Y.K.; Chung, M.W. Antiinflammatory effects of fangchinoline and tetrandrine. J. Ethnopharmacol. 2000, 69, 173-179.
99. Onai, N.; Tsunokawa, Y.; Suda, M.; Watanabe, N.; Nakamura, K.; Sugimoto, Y.; Kobayashi, Y. Inhibitory effects of bisbenzylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-Alpha. Planta Med. 1995, 61, 497-501 100 Kiraz, S.; Ertenli, I.; Arici, M.; Calguneri, M.; Haznedaroglu, I.; Celik, I.; Pay, S.; Kirazli, S. Effects of colchicine on inflammatory cytokines and selectins in familial Mediterranean fever. Clin. Exp. Rheumatol. 1998, 16, 721-724.
100. Chiou, W.F.; Peng, C.H.; Chen, C.F.; Chou, C.J. Anti-inflammatory properties of piperlactam S: Modulation of complement 5a-induced chemotaxis and inflammatory cytokines production in macrophages. Planta Med. 2003, 69, 9-14.
101. Sun, J.; Han, J.; Zhao, Y.; Zhu, Q.; Hu, J. Curcumin induces apoptosis in tumor necrosis factor-Alpha-treated HaCaT cells. Int. Immunopharmacol. 2012, 13, 170-174.
102. Ding, J.; Polier, G.; Köhler, R.; Giaisi, M.; Krammer, P.H.; Li-Weber, M. Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. J. Biol. Chem. 2012, 2, 641-649.
103. Wadsworth, T.L.; McDonald, T.L.; Koop, D.R. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-A. Biochem. Pharmacol. 2001, 62, 963-974.
104. Morikawa, K.; Nonaka, M.; Narahara, M.; Torii, I.; Kawaguchi, K.; Yoshikawa, T.; Kumazawa, Y.; Morikawa, S. Inhibitory effect of quercetin on carrageenan-induced inflammation in rats. Life Sci. 2003, 74, 709-721.
105. Dien, M.V.; Takahashi, K.; Mu, M.M.; Koide, N.; Sugiyama, T.; Mori, I.; Yoshida, T.; Yokochi, T. Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice. Microbiol. Immunol. 2001, 45, 751-756.
106. Takahashi, K.; Morikawa, A.; Kato, Y.; Sugiyama, T.; Koide, N.; Mu, M.M.; Yoshida, T.; Yokochi, T. Flavonoids protect mice from two types of lethal shock induced by endotoxin. FEMS Immunol. Med. Microbiol. 2001, 31, 29-33.
107. Shin, D.K.; Kim, M.H.; Lee, S.H.; Kim, T.H.; Kim, S.Y. Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model. Acta Biomater. 2012, 8, 3524-3351.
108. Kim, J.E.; Son, J.E.; Jang, Y.J.; Lee, D.E.; Kang, N.J.; Jung, S.K.; Heo, Y.S.; Lee, K.; Lee, H.J. Luteolin, a novel natural inhibitor of TPL2 kinase, inhibits tumor necrosis factor-A-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J. Pharmacol. Exp. Ther. 2011, 338, 1013-1022.
109. Ueda, H.; Yamazaki, C.; Yamazaki, M. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-A production. Biosci. Biotechnol. Biochem. 2004, 68, 119-125.
110. Li, Y.C.; Yeh, C.H.; Yang, M.L.; Kuan, Y.H. Luteolin suppresses inflammatory mediator expression by blocking the Akt/NF-B pathway in acute lung injury induced by lipopolysaccharide in mice. Evid. Based Complement. Alternat. Med. 2012, doi:10.1155/2012/383608.
111. Kumazawa, Y.; Kawaguchi, K.; Takimoto, H. Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor a. Curr. Pharm. Des. 2006, 12, 4271-4279.
112. Okabe, S.; Suganuma, M.; Imayoshi, Y.; Taniguchi, S.; Yoshida, T.; Fujiki, H. New TNFa releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-Ki. Biol. Pharm. Bull. 2001, 10, 1145-1148.
113. Cho, J.Y.; Park, J.; Yoo, E.S.; Yoshikawa, K.; Baik, K.U.; Lee, J.; Park, M.H. Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-Alpha production in lipopolysaccharide- stimulated RAW264.7 cells. Arch. Pharmacol. Res. 1998, 21, 12-16.
114. Cho, J.Y.; Baik, K.U.; Yoo, E.S.; Yoshikawa, K.; Park, M.H. In vitro anti-inflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica. J. Nat. Prod. 2000, 63, 1205-1209.
115. Hart, P.H.; Brand, C.; Carson, C.F.; Riley, T.V.; Prager, R.H.; Finlay-Jones, J.J. Terpinen-4-ol, the main component of the essential oil of Malaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflamm. Res. 2000, 49, 619-626.
116. Soares, M.B.; Bellintani, M.C.; Ribeiro, I.M.; Tomassini, T.C.; Ribeiro dos Santos, R. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. Eur. J. Pharmacol. 2003, 459, 107-112.
117. Lin, N.; Sato, T.; Ito, A. Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. F., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts. Arthritis Rheum. 2001, 44, 193-2200.
118. Liacini, A.; Sylvester, J.; Zafarullah, M. Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochem. Biophys. Res. Commun. 2005, 327, 320-327.
119. Ha, S.K.; Moon, E.; Ju, M.S.; Kim, D.H.; Ryu, J.H.; Oh, M.S.; Kim, S.Y. 6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection. Neuropharmacology 2012, 63, 211-223.
120. Shany, S.; Levy, Y.; Lahav-Cohen, M. The effects of 1a, 24(S)-dihydroxyvitamin D2 analog on cancer cell proliferation and cytokine expression. Steroids 2001, 66, 319-325.
121. Ono, M.; Tanaka, N.; Moriyasu, T. Anti-inflammatory action of cepharanthine ointment ingredient in experimental animals: Studies on chronic inflammation and TNF-Alpha production. Ensho 1994, 14, 425-429.
122. Parmely, M.J.; Zhou, W.W.; Edwards, C.K., III; Borcherding, D.R.; Silverstein, R.; Morrison, D.C. Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-Alpha production and protect mice against endotox challenge. J. Immunol. 1993, 151, 389-396.
123. Gerritsen, M.E.; Carley, W.W.; Ranges, G.E.; Shen, C.P.; Phan, S.A.; Ligon, G.F.; Perry, C.A. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am. J. Pathol. 1995, 147, 278-292.
124. Nakamura, N.; Hayasaka, S.; Zhang, X.Y.; Nagaki, Y.; Matsumoto, M.; Hayasaka, Y.; Terasawa, K. Effects of baicalin, baicalein and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-B binding activities induced by interleukin-1ß in human retinal pigmant epithelial cell line. Exp. Eye Res. 2003, 77, 195-202.
125. Atluru, D.; Jackson, T.M.; Atluru, S. Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells. Clin. Immunol. Immunopathol. 1991, 59, 379-387.
126. Hernandez, V.; del Carmen Recio, M.; Manez, S.; Prieto, J.M.; Giner, R.M.; Rios, J.L. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Med. 2001, 67, 726-731.
127. Danz, H.; Stoyanova, S.; Thomet, O.A.; Simon, H.U.; Dannhardt, G.; Ulbrich, H.; Hamburger, M. Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. Planta Med. 2002, 68, 875-880.
128. Bermejo, B.P.; Abad Martinez, M.J.; Silvan Sen, A.M.; Sanz Gomez, A.; Fernandez Matellano, L.; Sanchez Contreras, S.; Diaz Lanza, A.M. In vivo and in vitro anti-inflammatory activity of saikosaponins. Life Sci. 1998, 63, 1147-1156.
129. Bermejo, B.P.; Diaz Lanza, A.M.; Silvan Sen, A.M.; de Santos Galindez, J.; Fernandez Matellano, L.; Sanz Gomez, A.; Abad Martinez, M.J. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Med. 2000, 66, 324-328.
130. Giner-Larza, E.M.; Manez, S.; Giner, R.M.; Recio, M.C.; Prieto, J.M.; Cerda-Nicolas, M.; Rios, J.L. Anti-inflammatory triterpenes from Pistacia terebinthus galls. Planta Med. 2002, 68, 311-315.
131. Diaz Lanza, A.M.; Abad Martinez, M.J.; Fernandez Matellano, L.; Recuero Carretero, C.; Villaescusa Castillo, L.; Silvan Sen, A.M.; Bermejo Benito, P. Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. Planta Med. 2001, 67, 219-223.
132. Kim, Y.P.; Yamada, M.; Lim, S.S.; Lee, S.H.; Ryu, N.; Shin, K.H. Inhibition of tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages. Biochim. Biophys. Acta 1999, 1438, 399-407.
133. Kim, Y.P.; Lee, E.B.; Kim, S.Y.; Li, D.; Ban, H.S.; Lim, S.S.; Shin, K.H.; Ohuchi, K. Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum. Planta Med. 2001, 67, 362-364.
134. Hong, C.H.; Noh, M.S.; Lee, W.Y.; Lee, S.K. Inhibitory effects of natural sesquiterpenoids isolated from the rhizomes of Curcuma zedoaria on prostaglandin E2 and nitric oxide production. Planta Med. 2002, 68, 545-547.
135. Woo, H.G.; Lee, C.H.; Noh, M.S.; Lee, J.J.; Jung, Y.S.; Baik, E.J.; Moon, C.H.; Lee, S.H. Rutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages. Planta Med. 2001, 67, 505-509.
136. Nakajima, T.; Imanishi, M.; Yamamoto, K.; Cyong, J.C.; Hirai, K. Inhibitory effect of baicalein, a flavonoid in Scutellaria root, on eotaxin production by human dermal fibroblasts. Planta Med. 2001, 67, 132-135.
137. Chi, Y.S.; Cheon, B.S.; Kim, H.P. Effect of wogonin, a plant flavones from Scutellaria radix, on the suppression of cyclooxygenase and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem. Pharmacol. 2001, 61, 1195-1203.
138. Kim, H.K.; Cheon, B.S.; Kim, Y.H.; Kim, S.Y.; Kim, H.P. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structural-Activity relationships. Biochem. Pharmacol. 1999, 58, 759-765.
139. Liang, Y.C.; Huang, Y.T.; Tsai, S.H.; Lin-Shiau, S.Y.; Chen, C.F.; Lin, J.K. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 1999, 20, 1945-1952.
140. Murakami, A.; Nakamura, Y.; Torikai, K.; Tanaka, T.; Koshiba, T.; Koshimizu, K.; Kuwahara, S.; Takahashi, Y.; Ogawa, K.; Yano, M.; Tokuda, H.; et al. Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res. 2000, 60, 5059-5066.
141. Chen, Y.C.; Yang, L.L.; Lee, T.J.F. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-B activation. Biochem. Pharmacol. 2000, 59, 1445-1457.
142. Raso, G.M.; Meli, R.; di Carlo, G.; Pacillio, M.; di Carlo, R. Inhibiton of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 2001, 68, 921-931.
143. Shen, S.C.; Lee, W.R.; Lin, H.Y.; Huang, H.C.; Ko, C.H.; Yang, L.L.; Chen, Y.C. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production. Eur. J. Pharmacol. 2002, 446, 187-194.
144. Singh, R.; Ahmed, S.; Islam, N.; Goldberg, V.M.; Haqqi, T.M. Epigallocatechin-3-gallate inhibits interleukin-1ß-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes. Suppression of nuclear factor -B by degradation of the inhibitor of nuclear factor -B. J. Rheumatol. 2002, 46, 2079-2086.
145. Chan, M.M.; Fong, D.; Ho, C.T.; Huang, H.T. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. Biochem. Pharmacol. 1997, 54, 1281-1286.
146. Takahashi, T.; Takasuka, N.; Ligo, M.; Baba, M.; Nishino, H.; Tsuda, H. Isoliquilitigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci. 2004, 95, 448-453.
147. Kang, J.S.; Jeon, Y.J.; Kim, H.M.; Han, S.H.; Yang, K.H. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide- stimulated macrophages. J. Pharmacol. Exp. Ther. 2002, 302, 138-144.
148. Chan, M.M.; Huang, H.I.; Fenton, M.R.; Fong, D. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 1998, 55, 1955-1962.
149. Hamalainen, M.; Nieminen, R.; Vuorela, P.; Heinonen, M.; Moilanen, E. Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaBactivations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with theirinhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007, 2007, 45673.
150. Lee, H.; Kim, Y.O.; Kim, H.; Kim, S.Y.; Noh, H.S.; Kang, S.S. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J. 2003, 17, 1943-1944.
151. Qureshi, A.A.; Guan, X.Q.; Reis, J.C.; Papasian, C.J.; Jabre, S.; Morrison, D.C.; Qureshi, N. Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor. Lipids Health Dis. 2012, 11, 76.
152. Wang, B.; Ma, L.; Tao, X.; Lipsky, P.E. Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription. Arthritis Rheum. 2004, 50, 2995-3003.
153. Suh, N.; Honda, T.; Finlay, H.J.; Barchowsky, A.; Williams, C.; Benoit, N.E.; Xie, Q.W.; Nathan, C.; Gribble, G.W.; Sporn, M.B. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res. 1998, 58, 717-723.
154. Stempelj, M.; Kedinger, M.; Augenlicht, L.; Klampfer, L. Essential role of the JAK/STAT1 signaling pathway in the expression of inducible and its regulation by butyrate. J. Biol. Chem. 2007, 282, 9797-804.
155. Palombo, P.; Fabrizi, G.; Ruocco, V. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: A double-blind, placebo-controlled study. Skin Pharmacol. Physiol. 2007, 20, 199-210.
156. Kang, N.J.; Shin, S.H.; Lee, H.J.; Lee, K.W. Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis. Pharmacol. Ther. 2011, 130, 310-324.
157. Hooshmand, S.; Soung do, Y.; Lucas, E.A.; Madihally, S.V.; Levenson, C.W.; Arjmandi, B.H. Genistein reduces the production of proinflammatory molecules in human chondrocytes. J. Nutr. Biochem. 2007, 18, 609-614.
158. Kwak, W.J.; Han, C.K.; Son, K.H.; Chang, H.W.; Kang, S.S.; Park, B.K.; Kim, H.P. Effects of ginkgetin from Ginkgo biloba leaves on cyclooxygenases and in vivo skin inflammation. Planta Med. 2002, 68, 316-321.
159. Mutoh, M.; Takahashi, M.; Fukuda, K.; Komatsu, H.; Enya, T.; Matsushima-Hibiya, Y.; Mutoh, H.; Sugimura, T.; Wakabayashi, K. Suppression by flavonoids of cyclooxygenase-2 promotor-dependent transcriptional activity in colon cancer cells: Structural-Activity relationship. Jpn. J. Cancer Res. 2000, 91, 686-691.
160. Chen, C.Y.; Peng, W.H.; Tsai, K.D.; Hsu, S.L. Luteolin suppresses inflammation-Associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci. 2007, 81, 1602-1614.
161. Wakabayashi, I.; Yasui, K. Wogonin inhibits inducible prostaglandin E2 production in macrophages. Eur. J. Pharmacol. 2000, 406, 477-481.
162. Park, B.K.; Heo, M.Y.; Park, H.; Kim, H.P. Inhibition of TPA-induced cyclooxygenase-2 and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur. J. Pharmacol. 2001, 425, 153-157.
163. Banerjee, T.; Valacchi, G.; Ziboh, V.A.; van der Vliet, A. Inhibition of TNFa-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-B activation in A549 cells. Mol. Cell. Biochem. 2002, 238, 105-110.
164. Tong, X.; Yin, L.; Joshi, S.; Rosenberg, D.W.; Giardina, C. Cyclooxygenase-2 regulation in colon cancer cells: Modulation of RNA polymerase II elongation by histone deacetylase inhibitors. J. Biol. Chem. 2005, 280, 15503-15509.
165. Subbaramaiah, K.; Michaluart, P.; Sporn, M.B.; Dannenberg, A.J. Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Cancer Res. 2000, 60, 2399-2404.
166. Suksamrarn, A.; Kumpun, S.; Kirtikara, K.; Yingyongnarongkul, B.; Suksamrarn, S. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002, 68, 72-73.
167. Hirata, A.; Murakami, Y.; Atsumi, T.; Shoji, M.; Ogiwara, T.; Shibuya, K.; Ito, S.; Yokoe, I.; Fujisawa, S. Ferulic acid dimer inhibits lipopolysaccharide-stimulated cyclooxygenase-2 expression in macrophages. In Vivo 2005, 19, 849-853.
168. Kim, S.O.; Kundu, J.K.; Shin, Y.K.; Park, J.H.; Cho, M.H.; Kim, T.Y.; Surh, Y.J. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-B in phorbol ester stimulated mouse skin. Oncogene 2005, 24, 2558-2567.
169. Kim, J.K.; Kim, Y.; Na, K.M.; Surh, Y.J.; Kim, T.Y. [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radic. Res. 2007, 41, 603-614.
170. Kundu, J.K.; Shin, Y.K.; Kim, S.H.; Surh, Y.J. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-B in mouse skin by blocking I-B kinase activity. Carcinogenesis 2006, 27, 1465-1474.
171. Peng, G.; Dixon, D.A.; Muga, S.J.; Smith, T.J.; Wargovich, M.J. Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Mol. Carcinog. 2006, 45, 309-319.
172. Donnelly, L.E.; Newton, R.; Kennedy, G.E.; Fenwick, P.S.; Leung, R.H.F.; Ito, K.; Russell, R.E.K.; Barnes, P.J. Anti-inflammatory effects of resveratrol in lung epithelial cells: Molecular mechanisms. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 287, L774-L783.
173. Haridas, V.; Arntzen, C.J.; Gutterman, J.U. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA. Proc. Natl. Acad. Sci. USA 2001, 98, 11557-11562.
174. Sheehan, M.; Wong, H.R.; Hake, P.W.; Malhotra, V.; O'Connor, M.; Zingarelli, B. Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Mol. Pharmacol. 2002, 61, 953-963.
175. Feng, R.; Lu, Y.; Bowman, L.L.; Qian, Y.; Castranova, V.; Ding, M. Inhibition of AP-1, NF-kB and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 2005, 280, 2888-2895.
176. Qiu, D.; Zhao, G.; Aoki, Y.; Shi, L.; Uyei, A.; Nazarian, S.; Ng, J.C.-H.; Kao, P.N. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NFkappaB transcriptional activation. J. Biol. Chem. 1999, 274, 13443-13450.
177. Han, S.S.; Keum, Y.S.; Chun, K.S.; Surh, Y.J. Suppression of phorbol ester-induced NF-jB activation by capsaicin in cultured human promyelocytic leukemia cells. Arch. Pharm. Res. 2002, 25, 475-479.
178. Lührs, H.; Gerke, T.; Müller, J.G.; Melcher, R.; Schauber, J.; Boxberge, F.; Scheppach, W.; Menzel, T. Butyrate inhibits NF-B activation in lamina propria macrophages of patients with ulcerative colitis. Scand. J. Gastroenterol. 2002, 37, 458-466.
179. Kim, J.S.; Jobin, C. The flavonoid luteolin prevents lipopolysaccharide- induced NK-kappaB signaling and gene expression by blocking I-kappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology 2005, 115, 373-387.
180. Jobin, C.; Bradham, C.A.; Russo, M.P.; Juma, B.; Narula, A.S.; Brenner, D.A.; Sartor, R.B. Curcumin blocks cytokine-mediated NF-B activation and pro-inflammatory gene expression by inhibiting inhibitory factor I-B kinase activity. J. Immunol. 1999, 163, 3474-3483.
181. Hunter, M.S.; Corley, D.G.; Carron, C.P.; Rowold, E.; Kilpatrick, B.F.; Durley, R.C. Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1. J. Nat. Prod. 1997, 60, 894-899.
182. Asahina, A.; Tada, Y.; Nakamura, K.; Tamaki, K. Colchicine and griseofulvin inhibit VCAM-1 expression on human vascular endothelial cells-evidence for the association of VCAM-1 expression with microtubules. J. Dermatol. Sci. 2001, 25, 1-9.
183. Goel, A.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin as "Curecumin": From kitchen to clinic. Biochem. Pharmacol. 2008, 75, 787-809.
184. Kwak, W.J.; Cho, Y.B.; Han, C.K.; Shin, H.J.; Ryu, K.H.; Yoo, H.; Rhee, H.I. Extraction and purification method of active constituents from stem of Lonicera japonica thunb, its usage for anti-inflammatory and analgesic drug. US20087314644, 1 January 2008.
185. Kealey, K.S.; Snyder, R.M.; Romanczyk, L.J.; Geyet, H.M.; Myers, M.E.; Whitacre, E.J.; Schmitz, H.H. Treatment of inflammation. US20080188550, 7 August 2008.
186. Olalde Rangel, J.A. Arthritis phyto-nutraceutical synergistic composition. US20087416748, 26 August 2008.
187. Gokaraju, G.R.; Gokaraju, R.R.; Gottumukkala, V.S.; Golakoti, T. Dietary supplement formulation for controlling inflammation and cancer. US20087455860, 25 December 2008.
188. Gokaraju, G.R.; Gokaraju, R.R.; Gottumukkala, V.S.; Somepalli, V. Pharmaceutically Active Extracts of Vitex Leucoxylon, a Process of Extracting the Same and a Method of Treating Diabetes and Inflammatory Diseases Therewith. US20080199543, 21 August 2008.
189. Lockwood, S.F.; Mason, P.R. Use of carotenoids and/or carotenoid derivatives/analogs for reduction/inhibition of certain negative effects of COX inhibitors. US20080293679, 27 November 2008.
190. Li, Y. Herbal compositions for prevention and treatment of rheumatic and inflammatory diseases and method of preparing the same. US20097553506, 3 July 2009.
191. Buchholz, H.; Wirth, C.; Carola, C.; Alves Fontes, R. Flavonoid derivates. US20097588783, 15 September 2009.
192. Miyake, Y.; Yoko, I. Anti-inflammatory agent. US20100120903, 13 May 2010.
193. Gokaraju, G.R.; Gokaraju, R.R.; Golakoti, T.; Chirravuri, V.R.; Alluri, V.K.R.; Bhupathiraju, K. Use of Aphanamixis polystacha extracts or fractions against 5-lipoxygenase mediated diseases. US20100178288, 15 July 2010.
194. Hillwig, M.L. Anti-inflammatory and anti-HIV compositions and methods of use. US20107854946, 21 December 2010.
195. Theoharides, T.C. Anti-inflammatory compositions for treating multiple sclerosis. US20117906153, 15 March 2011.
196. Mumper, R.J.; Dai, J.; Gallicchio, V.S. Berry preparations and extracts. US20117964223, 21 June 2011.
197. Jia, Q.; Nichols, T.C.; Rhoden, E.E.; Walte, S. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors. US20110245333, 6 October 2011.
198. Kimata, M.; Shichijo, M.; Miura, T.; Serizawa, I.; Inagaki, N.; Nagai, H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin. Exp. Allergy 2000, 30, 501-508.
199. Yano, S.; Tachibana, H.; Yamada, K. Flavones suppress the expression of the high-Affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells. J. Agric. Food Chem. 2005, 53, 1812-1817.
200. Wu, S.J.; Ng, L.T. Tetrandrine inhibits proinflammatory cytokines, iNOS and COX-2 expression in human monocytic cells. Biol. Pharm. Bull. 2007, 30, 59-62.
201. Otsuka, H.; Hirai, Y.; Nagao, T.; Yamasaki, K. Antiinflammatory activity of benzoxazinoids from roots of Coix lachryma-jobi var. ma-yuen. J. Nat. Prod. 1988, 51, 74-79.
202. Wang, M.; Huang, Y.J.; Zhang, T.H.; Tong, Z.Q. Anti-Allergic, anti-histamine and anti-inflammatory effects of compound pseudoephedrine. J. Shenyang Pharm. Univ. 1996, 132, 129-133.
203. Daikonya, A.; Katsuki, S.; Wu, J.-B.; Kitanaka, S. Anti-Allergic agents from natural sources (41)): Anti-Allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae). Chem. Pharm. Bull. 2002, 50, 1566-1659.
204. Cheong, H.; Ryu, S.Y.; Oak, M.H.; Cheon, S.H.; Yoo, G.S.; Kim, K.M. Studies of structure activity relationship of flavonoids for the anti-Allergic actions. Arch. Pharm. Res. 1998, 21, 478-480.
205. Fewtrell, C.M.; Gomperts, B.D. Effect of flavone inhibitors on transport ATPases on histamine secretion from rat mast cells. Nature 1977, 265, 635-636.
206. Middleton, E.J.; Drzewiecki, G.; Krishnarao, D. Quercetin: An inhibitor of antigen-induced human basophil histamine release. J. Immunol. 1981, 127, 546-550.
207. Fernandez, J.; Reyes, R.; Ponce, H.; Oropeza, M.; Vancalsteren, M.R.; Jankowski, C.; Campos, M.G. Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. Eur. J. Pharmacol. 2005, 522, 108-115.
208. Kawai, M.; Hirano, T.; Higa, S.; Arimitsu, J.; Maruta, M.; Kuwahara, Y.; Ohkawara, T.; Hagihara, K.; Yamadori, T.; Shima, Y.; et al. Flavonoids and related compounds as anti-Allergic substances Allergol. Int. 2007, 56, 113-123.
209. Hirano, T.; Arimitsu, J.; Higa, S.; Naka, T.; Ogata, A.; Shima, Y.; Fujimoto, M.; Yamadori, T; Ohkawara, T.; Kuwabara, Y.; et al. Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils. Int. Arch. Allergy Immunol. 2006, 140, 150-156.
210. Wu, Y.Q.; Zhou, C.H.; Tao, J.; Li, S.N. Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. Life Sci. 2006, 78, 2689-2696.
211. Magrone, T.; Jirillo, E. Influence of polyphenols on allergic immune reactions: Mechanisms of action. Proc. Nutr. Soc. 2012, 71, 316-321.
212. Joskova, M.; Franova, S.; Sadlonova, V. Acute bronchodilator effect of quercetin in experimental allergic asthma. Bratisl. Lek. Listy 2011, 112, 9-12.
213. Franova, S.; Strapkova, A.; Mokry, J.; Šutovska, M.; Joškova, M.; Sadlonova, V.; Antošova, M.; Pavelcikova, D.; Fleškova, D.; Nosalova, G. Pharmacologic modulation of experimentally induced allergic asthma. Interdiscp. Toxicol. 2011, 4, 27-32.
214. Joskova, M.; Sadlonova, V.; Nosalova, G.; Novakova, E.; Franova, S. Polyphenols and their components in experimental allergic asthma. Adv. Exp. Med. Biol. 2013, 756, 91-98.
215. Ikarashi, N.; Sato, W.; Toda, T.; Ishii, M.; Ochiai, W.; Sugiyama, K. Inhibitory effect of polyphenol-rich fraction from the bark of Acacia mearnsii on itching associated with allergic dermatitis. Evid. Based Complement. Alternat. Med. 2012, doi:10.1155/2012/120389.
216. Kim, M.J.; Choung, S.Y. Mixture of polyphenols and anthocyanins from Vaccinium uliginosum L. alleviates DNCB-induced atopic dermatitis in NC/Nga Mice. Evid. Based Complement Alternat. Med. 2012, doi:10.1155/2012/461989.
217. Riccio, P.; Rossano, R.; Liuzzi, G.M. May diet and dietary supplements improve the wellness of multiple sclerosis patients- A molecular approach. Autoimmune Dis. 2010, 2010, 249842.
218. Riccio, P. The molecular basis of nutritional intervention inmultiplesclerosis: A narrative review. Complement. Ther. Med. 2011, 19, 228-237.
219. Xie, L.; Li, X.K.; Takahara, S. Curcumin has bright prospects for the treatment of multiplesclerosis. Int. Immunopharmacol. 2011, 11, 323-330.
220. Yoshida, S. Preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, or health food for prevention or improvement or reduction of symptoms thereof. US20046811796, 2 November 2004.
221. Palpu, P.; Rao, C.V.; Rawat, A.K.S.; Ojha, S.K.; Reddy, G.D. Anti-Allergic herbal formulation. US20087344739, 18 March 2008.
222. Menon, G.R.; Fast, D.J.; Krempin, D.W.; Goolsby, J.N. Anti-Allergy composition and related method. US20087384654, 10 June 2008.
223. Frimman Berg, K. Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract. US20118003688, 23 August 2011.
224. Olszanecki, R.; Gebska, A.; Kozlovski, V.I.; Gryglewski, R.J. Flavonoids and nitric oxide synthase. J. Physiol. Pharmacol. 2002, 53, 571-584.
225. Matsuda, H.; Tokuoka, K.; Wu, J.; Shiomoto, H.; Kubo, M. Inhibitory effects of dehydrocorydaline isolated from Corydalis Tuber against type I-IV allergic models. Biol. Pharm. Bull. 1997, 20, 431-434.
226. Havsteen, B.H. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 2002, 96, 67-202.
227. Carboni, G.P.; Contri, P.; Davalli, R. Allergic contact dermatitis from apomorphine. Contact Derm. 1997, 36, 177-178.
228. Waclawski, E.R.; Aldridge, R. Occupational dermatitis from thebaine and codeine. Contact Derm. 1995, 33, 51.
229. Tanaka, S.; Otsuki, T.; Matsumoto, Y.; Hayakawa, R.; Sugiura, M. Allergic contact dermatitis from enoxolone. Contact Derm. 2001, 44, 192.
230. Basketter, D.A.; Wright, Z.M.; Colson, N.R.; Patlewicz, G.Y.; Pease, C.K. Investigation of the skin sensitizing activity of linalool. Contact Derm. 2002, 47, 161-164.
231. Ríos, J.L.; Bas, E.; Recio, M.C. Effects of natural products on contact dermatitis. Curr. Med. Chem. Anti Inflamm. Anti Allergy Agents 2005, 4, 65-80.
232. Olthof, M.R.; Hollman, P.C.; Zock, P.L.; Katan, M.B. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am. J. Clin. Nutr. 2001, 73, 532-538.
233. Muller, T.; Woitalla, D.; Hauptmann, B.; Fowler, B.; Kuhn, W. Decrease of methionine and S-Adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease. Neurosci. Lett. 2001, 308, 54-56.
234. Hegarty, V.M.; May, H.M.; Khaw, K.T. Tea drinking and bone mineral density in older women. Am. J. Clin. Nutr. 2000, 71, 1003-1425.
235. Estruch, R.; Sacanella, E.; Mota, F.; Chiva-Blanch, G.; Antúnez, E.; Casals, E.; Deulofeu, R.; Rotilio, D.; Andres-Lacueva, C.; Lamuela-Raventos, R.M.; et al. Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: A randomised crossover trial. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 46-53.
236. Ward, N.C.; Hodgson, J.M.; Croft, K.D.; Burke, V.; Beilin, L.J.; Puddey, I.B. The combination of vitamin C and grape-seed polyphenols increases blood pressure: A randomized, double-blind, placebo-controlled trial. J. Hypertens. 2005, 23, 427-434.