Formononetin attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells

Molecules

Volumn 17, Issue 9, 2012, Pages 10052-10064

  Wang, Yao ^a,b   Zhu, Yunxia ^a   Gao, Lu ^a   Yin, Han ^b   Xie, Zuoling ^b   Wang, Dong ^b   Zhu, Zhengqiu ^b   Han, Xiao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Apoptosis; Formononetin; INOS; INS 1; NF B

Indexed keywords

CASPASE 3; FORMONONETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; ISOFLAVONE DERIVATIVE; PROTEIN BAX;

ANIMAL; APOPTOSIS; ARTICLE; DIABETES MELLITUS; DRUG EFFECT; INFLAMMATION; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; DIABETES MELLITUS; INFLAMMATION; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; ISOFLAVONES; NF-KAPPA B; RATS;

EID: 84866891041     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules170910052     Document Type: Article

References (45)

1. Wang, C.; Guan, Y.; Yang, J. Cytokines in the Progression of Pancreatic beta-Cell Dysfunction. Int. J. Endocrinol. 2010, 2010, 515136:1-515136:10.
2. Rabinovitch, A.; Suarez-Pinzon, W.L.; Strynadka, K.; Lakey, J.R.; Rajotte, R.V. Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J. Clin. Endocrinol. Metab. 1996, 81, 3197-3202.
3. Collier, J.J.; Burke, S.J.; Eisenhauer, M.E.; Lu, D.; Sapp, R.C.; Frydman, C.J.; Campagna, S.R. Pancreatic beta-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis. PLoS One 2011, 6, e22485.
4. Bowie, A.; O'Neill, L.A. The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for pro-inflammatory interleukins and microbial products. J. Leuk. Biol. 2000, 67, 508-514.
5. Ortis, F.; Miani, M.; Colli, M.L.; Cunha, D.A.; Gurzov, E.N.; Allagnat, F.; Chariot, A.; Eizirik, D.L. Differential usage of NF-kappaB activating signals by IL-1beta and TNF-alpha in pancreatic beta cells. FEBS Lett. 2012, 586, 984-989.
6. Eda, H.; Shimada, H.; Beidler, D.R.; Monahan, J.B. Proinflammatory cytokines, IL-1beta and TNF-alpha, Induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-kappaB pathway but not p38 pathway in osteoblasts. Rheumatol. Int. 2011, 31, 1525-1530.
7. Choi, E.M.; Lee, Y.S. Luteolin suppresses IL-1beta-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982. Food Chem. Toxicol. 2010, 48, 2607-2611.
8. Sandberg, J.O.; Eizirik, D.L.; Sandler, S. IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice. Clin. Exp. Immunol. 1997, 108, 314-317.
9. Sauter, N.S.; Schulthess, F.T.; Galasso, R.; Castellani, L.W.; Maedler, K. The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology 2008, 149, 2208-2218.
10. Mandrup-Poulsen, T.; Pickersgill, L.; Donath, M.Y. Blockade of interleukin 1 in type 1 diabetes mellitus. Nat. Rev. Endocrinol. 2010, 6, 158-166.
11. Lin, J.; Yan, G.T. Function of eukaryotic transcription factor NF-kappaB in the signal transduction of acute inflammatory response. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2003, 15, 45-48.
12. Gu, Q.; Kong, Y.; Yu, Z.B.; Bai, L.; Xiao, Y.B. Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-kappaB activation in congenital heart disease. Biochimie 2011, 93, 909-920.
13. Wang, Q.S.; Xiang, Y.; Cui, Y.L.; Lin, K.M.; Zhang, X.F. Dietary blue pigments derived from genipin, Attenuate inflammation by inhibiting LPS-Induced iNOS and COX-2 expression via the NF-kappaB inactivation. PLoS One 2012, 7, e34122.
14. Mattson, M.P.; Camandola, S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 2001, 107, 247-254.
15. Stark, L.A.; Dunlop, M.G. Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis. Mol. Cell. Biol. 2005, 25, 5985-6004.
16. Autieri, M.V.; Yue, T.L.; Ferstein, G.Z.; Ohlstein, E. Antisense oligonucleotides to the p65 subunit of NF-kB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries. Biochem. Biophys. Res. Commun. 1995, 213, 827-836.
17. Heimberg, H.; Heremans, Y.; Jobin, C.; Leemans, R.; Cardozo, A.K.; Darville, M.; Eizirik, D.L. Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes 2001, 50, 2219-2224.
18. Eizirik, D.L.; Darville, M.I. Beta-cell apoptosis and defense mechanisms: Lessons from type 1 diabetes. Diabetes 2001, 50 (Suppl. 1), S64-S69.
19. Spinas, G.A. The dual role of nitric oxide in islet beta-cells. News Physiol. Sci. 1999, 14, 49-54.
20. Welsh, N.; Eizirik, D.L.; Bendtzen, K.; Sandler, S. Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 1991, 129, 3167-3173.
21. Storling, J.; Binzer, J.; Andersson, A.K.; Zullig, R.A.; Tonnesen, M.; Lehmann, R.; Spinas, G.A.; Sandler, S.; Billestrup, N.; Mandrup-Poulsen, T. Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia 2005, 48, 2039-2050.
22. Marzocchella, L.; Fantini, M.; Benvenuto, M.; Masuelli, L.; Tresoldi, I.; Modesti, A.; Bei, R. Dietary flavonoids: Molecular mechanisms of action as anti-inflammatory agents. Recent Pat. Inflamm. Allergy Drug Discov. 2011, 5, 200-220.
23. Chen, C.Y.; Peng, W.H.; Tsai, K.D.; Hsu, S.L. Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci. 2007, 81, 1602-1614.
24. Hamalainen, M.; Nieminen, R.; Vuorela, P.; Heinonen, M.; Moilanen, E. Anti-inflammatory effects of flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein inhibit STAT-1 and NF-kappaB activations, Whereas flavone, Isorhamnetin, Naringenin, and Pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007, 2007, 45673.
25. Shams, M.E.; Al-Gayyar, M.M.; Barakat, E.A. Type 2 Diabetes mellitus-induced hyperglycemia in patients with nafld and normal LFTs: Relationship to lipid profile, Oxidative stress and pro-Inflammatory cytokines. Sci. Pharm. 2011, 79, 623-634.
26. Papaccio, G.; Graziano, A.; D'Aquino, R.; Valiante, S.; Naro, F. A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta. J. Cell. Physiol. 2005, 204, 124-130.
27. Castrillo, A.; Bodelon, O.G.; Bosca, L. Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: Involvement of phosphatidylinositol 3-kinase. Diabetes 2000, 49, 209-217.
28. Noguchi, A.; Takada, M.; Nakayama, K.; Ishikawa, T. cGMP-independent anti-apoptotic effect of nitric oxide on thapsigargin-induced apoptosis in the pancreatic beta-cell line INS-1. Life Sci. 2008, 83, 865-870.
29. Dinarello, C.A.; Donath, M.Y.; Mandrup-Poulsen, T. Role of IL-1beta in type 2 diabetes. Curr. Opin. Endocrinol. Diabetes Obes. 2010, 17, 314-321.
30. Doganay, S.; Evereklioglu, C.; Er, H.; Turkoz, Y.; Sevinc, A.; Mehmet, N.; Savli, H. Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus. Eye (Lond) 2002, 16, 163-170.
31. Cavelti-Weder, C.; Furrer, R.; Keller, C.; Babians-Brunner, A.; Solinger, A.M.; Gast, H.; Fontana, A.; Donath, M.Y.; Penner, I.K. Inhibition of IL-1beta improves fatigue in type 2 diabetes. Diabetes Care 2011, 34, e158.
32. O'Connor, J.C.; Satpathy, A.; Hartman, M.E.; Horvath, E.M.; Kelley, K.W.; Dantzer, R.; Johnson, R.W.; Freund, G.G. IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J. Immunol. 2005, 174, 4991-4997.
33. Yin, H.; Miao, J.; Ma, C.; Sun, G.; Zhang, Y. Beta-Casomorphin-7 cause decreasing in oxidative stress and inhibiting NF-kappaB-iNOS-NO signal pathway in pancreas of diabetes rats. J. Food Sci. 2012, 77, C278-C282.
34. Oriot, P.; Hermans, M.P.; Selvais, P.; Buysschaert, M.; de la Tribonniere, X. Exenatide improves weight loss insulin sensitivity and beta-cell function following administration to a type 2 diabetic HIV patient on antiretroviral therapy. Ann. Endocrinol. 2011, 72, 244-246.
35. Liadis, N.; Murakami, K.; Eweida, M.; Elford, A.R.; Sheu, L.; Gaisano, H.Y.; Hakem, R.; Ohashi, P.S.; Woo, M. Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol. Cell. Biol. 2005, 25, 3620-3629.
36. Gurzov, E.N.; Eizirik, D.L. Bcl-2 proteins in diabetes: Mitochondrial pathways of beta-cell death and dysfunction. Trends Cell Biol. 2011, 21, 424-431.
37. Li, Y.H.; Zhuo, Y.H.; Lu, L.; Chen, L.Y.; Huang, X.H.; Zhang, J.L.; Li, S.Y.; Wang, X.G. Caspase-dependent retinal ganglion cell apoptosis in the rat model of acute diabetes. Chin. Med. J. (Engl.) 2008, 121, 2566-2571.
38. Augstein, P.; Bahr, J.; Wachlin, G.; Heinke, P.; Berg, S.; Salzsieder, E.; Harrison, L.C. Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas. J. Autoimmun. 2004, 23, 301-309.
39. Ghosh, S.; Khazaei, M.; Moien-Afshari, F.; Ang, L.S.; Granville, D.J.; Verchere, C.B.; Dunn, S.R.; McCue, P.; Mizisin, A.; Sharma, K.; et al. Moderate exercise attenuates caspase-3 activity, Oxidative stress, And inhibits progression of diabetic renal disease in db/db mice. Am. J. Physiol. Renal Physiol. 2009, 296, F700-F708.
40. Sun, M.; Zhou, T.; Zhou, L.; Chen, Q.; Yu, Y.; Yang, H.; Zhong, K.; Zhang, X.; Xu, F.; Cai, S.; et al. Formononetin protects neurons against hypoxia-induced cytotoxicity through upregulation of ADAM10 and sAbetaPPalpha. J. Alzheimers Dis. 2012, 28, 795-808.
41. Wang, Q.Y.; Meng, Q.H.; Zhang, Z.T.; Tian, Z.J.; Liu, H. Synthesis, solubility, Lipids-lowering and liver-protection activities of sulfonated formononetin. Yao Xue Xue Bao 2009, 44, 386-389.
42. Harini, R.; Ezhumalai, M.; Pugalendi, K.V. Antihyperglycemic effect of biochanin A, A soy isoflavone, on streptozotocin-diabetic rats. Eur. J. Pharmacol. 2012, 676, 89-94.
43. Kole, L.; Giri, B.; Manna, S.K.; Pal, B.; Ghosh, S. Biochanin-A, An isoflavon, Showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFkappaB nuclear translocation. Eur. J. Pharmacol. 2011, 653, 8-15.
44. Han, X.; Sun, Y.; Scott, S.; Bleich, D. Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells. Diabetes 2001, 50, 1047-1055.
45. Wang, Y.; Gao, L.; Li, Y.; Chen, H.; Sun, Z. Nifedipine protects INS-1 beta-cell from high Glucose-induced ER stress and apoptosis. Int. J. Mol. Sci. 2011, 12, 7569-7580.