Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 138-144

  Kang, Jong S ^a   Jeon, Young J ^b   Kim, Hwan M ^c   Han, Seung H ^d   Yang, Kyu Hwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chosun University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d International Vaccine Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OKADAIC ACID; SILYMARIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CHLORAMPHENICOL O-ACETYLTRANSFERASE; ENZYME INHIBITORS; FLUORESCEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED BALB C; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OKADAIC ACID; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SILYMARIN; STIMULATION, CHEMICAL; TRANSFECTION;

EID: 0036085857     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.138     Document Type: Article

References (40)

1. The anti-inflammatory action of nepitrin, a flavonoid
2. Gastric anti-ulcer activity of silymarin, a lipoxygenase inhibitor, in rats
3. Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system
4. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: Comparison with silymarin
5. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7
6. Substitution of chloroform by bromochloropropane in the single-step method of RNA isolation
7. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells
8. Flavonoids; old and new aspects of a class of natural therapeutic drugs
9. A multiple comparison procedure for comparing several treatments with a control
10. Redox regulation of NF-κB activation
11. Milk thistle (Silybum marianum) for the therapy of liver disease
12. 15N]nitrate in biological fluids
13. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase
14. Acetylaminofluorene inhibits nitric oxide production in LPS-stimulated RAW 264.7 cells by blocking NF-κB/Rel activation
15. Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-κB/Rel in lipopolysaccharide-stimulated macrophages
16. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships
17. Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats
18. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations
19. Down-regulation of protein kinase C in murine splenocytes: A potential mechanism for 2-acetylaminofluorene-mediated immunosuppression
20. Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant
21. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
22. Silymarin suppresses TNF-induced activation of NF-κB, c-Jun N-terminal kinase and apoptosis
23. Flavonoids, leukocyte migration and eicosanoids
24. Suppression of arthritis by an inhibitor of nitric oxide synthase
25. 4 liver damage
26. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
27. Nitric oxide as a secretory product of mammalian cells
28. Vascular endothelial cells synthesize nitric oxide from L-arginine
29. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
30. Oligonucleotide that binds nuclear factor NF-κB acts as a lymphoid-specific and inducible enhancer element
31. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
32. In vivo control of NF-κB activation by IκBα
33. Selective inhibition of NF-κB activation by the flavanoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways
34. NF-κB activation: The IκB kinase revealed
35. Activation of NF-κB by phosphatase inhibitors involves the phosphorylatian of IκBα at phosphatase 2A-sensitive sites
36. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
37. Role of transcription factor NF·κB/Rel in induction of nitric oxide synthase
38. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
39. Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: Implications in cancer chemoprevention
40. Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin