Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents

Molecular Pharmacology

Volumn 61, Issue 5, 2002, Pages 953-963

  Sheehan, Maeve ^a   Wong, Hector R ^a   Hake, Paul W ^a   Malhotra, Vivek ^a   O'Connor, Michael ^a   Zingarelli, Asilia ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; DNA; ESCHERICHIA COLI ENDOTOXIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; NORADRENALIN; PARTHENOLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HEMODYNAMICS; HYPOTENSION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; RAT; SEPTIC SHOCK; SURVIVAL; THORACIC AORTA; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AORTA; APOPTOSIS; DISEASE MODELS, ANIMAL; DNA; DNA-BINDING PROTEINS; ENDOTOXINS; ENZYME ACTIVATION; HYPERTENSION; I-KAPPA B PROTEINS; LUNG; MALE; NEUTROPHILS; NF-KAPPA B; NITRATES; NITRIC OXIDE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; SESQUITERPENES; SHOCK, SEPTIC; TYROSINE;

EID: 0036237368     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.5.953     Document Type: Article

References (41)

1. Predictive value of nuclear factor κB activity and plasma cytokine levels in patients with sepsis
2. IκB-NF-κB structures: At the interface of inflammation control
3. Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock
4. Role of NF-κB in the mortality of sepsis
5. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB
6. Heat shock induces IκBα and prevents stress-induced endothelial cell apoptosis
7. Pathophysiology of nitric oxide and related species: Free radical reactions and modification of biomolecules
8. The effect of sodium salicylate and aspirin on NF-κB
9. Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
10. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
11. Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones
12. Mode of action of sesquiterpene lactones as anti-inflammatory agents
13. Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive a-methylenebutyrolactone functions
14. Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β
15. The anti-inflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex
16. Ethnopharmacology of Mexican Asteraceae (compositae)
17. The IκB kinase (I 75 K) and NF-κB key elements of proinflammatory signalling
18. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
19. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
20. In vivo inhibition of nuclear factor-κB activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock
21. Pyrrolidine dithiocarbamate prevents IκB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs
22. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65
23. Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium
24. Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives
25. Myeloperoxisade activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
26. Pathogenetic mechanisms of septic shock
27. Increased nuclear factor κB activation in critically ill patients who die
28. Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione
29. Nitric oxide and circulatory shock
30. Anti-inflammatory effects of South American Tanacetum vulgare
31. Nuclear factor κB: An oxidative stress-responsive transcription factor of eukaryotic cells
32. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells
33. Activation of transcription factor NF-κB is suppressed by curcumin
34. Role of poly (ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
35. Effect of dehydroleucodine in experimental colitis in rats and mice
36. Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells
37. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB
38. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
39. Sesquiterpene lactone parthenolide, an inhibitor of IκB kinase complex and nuclear factor-κB, exerts beneficial effects in myocardial reperfusion injury
40. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
41. Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxin shock: Potential involvement of poly-ADP ribosyl synthase