Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 3, 2007, Pages 624-631

  Fki, Ines ^a   Sahnoun, Zouhair ^b   Sayadi, Sami ^a  

^a CENTRE DE BIOTECHNOLOGIE DE SFAX   (Tunisia)

^b UNIVERSITY OF SFAX   (Tunisia)

Author keywords

Antioxidant enzymes; Cholesterol fed rat; Hydroxytyrosol; Hypocholesterolemic; Olive mill wastewaters extract; Serum lipid levels

Indexed keywords

RATTUS; RATTUS NORVEGICUS;

3,4-DIHYDROXYPHENYLETHANOL; ANTIOXIDANT; CATALASE; DRUG DERIVATIVE; HYDROXYTYROSOL; HYPOCHOLESTEROLEMIC AGENT; LIPID; PHENETHYL ALCOHOL; PHENOL DERIVATIVE; PLANT EXTRACT; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; CHOLESTEROL INTAKE; ENZYMOLOGY; INDUSTRIAL WASTE; LIVER; MALE; METABOLISM; OLIVE TREE; RAT; WISTAR RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CATALASE; CHOLESTEROL, DIETARY; INDUSTRIAL WASTE; LIPIDS; LIVER; MALE; OLEA; PHENOLS; PHENYLETHYL ALCOHOL; PLANT EXTRACTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 34247843014     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0623586     Document Type: Article

References (47)

1. WHO. The World Health Report 1998-Life in the 21st Century: A Vision for All; WHO: Geneva, Switzerland, xxxx.
2. Orford, J. L.; Selwyn, A. P.; Ganz, P.; Popma, J. J.; Rogers, C. The comparative pathobiology of atherosclerosis and restenosis. Am. J. Cardiol. 2000, 86, 6-11.
3. Esterbauer, H.; Waeg, G.; Puhl, H. Lipid peroxidation and its role in atherosclerosis. Br. Med. Bull. 1993, 49, 566-576.
4. Berliner, J. A.; Heinecke, J. W. The role of oxidized lipoproteins in atherogenesis. Free Radical Biol. Med. 1996, 20, 707-727.
5. Malavasi, B.; Rasetti, M. F.; Roma, P.; Fogliatto, R.; Allevi, P.; Catapano, A. L.; Galli, G. Evidence for the presence of 7-hydroperoxycholest-5- en-3 betanol in oxidized human LDL. Chem. Phys. Lipids 1992, 62, 209-214.
6. Porkkala-Sarataho, E.; Salonen, J. T.; Nyyssonen, K.; Kaikkonen, J.; Salonen, R.; Ristonmaa, U.; Diczfalusy, U.; Brigelius-Flohe, R.; Loft, S.; Poulsen, H. E. Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-OXO-2 -deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler., Thromb., Vasc. Biol. 2000, 20, 2087-2093.
7. Knekt, P.; Ritz, J.; Pereira, M. A.; O'Reilly, E. J.; Augustsson, K.; Fraser, G. E.; Goldbourt, U.; Heitmann, B. L.; Hallmans, G.; Liu, S.; Pietinen, P.; Spiegelman, D.; Stevens, J.; Virtamo, J.; Willett, W. C.; Rimm, E. B.; Ascherio, A. Antioxidant vitamins and coronary heart disease risk: A pooled analysis of 9 cohorts. Am. J. Clin. Nutr. 2004, 80 (6), 1508-1520.
8. Keys, A. Mediterranean diet and public health: personal reflections. Am. J. Clin. Nutr. 1995, 61 (Suppl.), 1321-1323.
9. Capasso, R. The chemistry, biotechnology and ecotoxicology of the polyphenols naturally occurring in vegetable wastes. Curr. Top. Phytochem. 1997, 1, 145-156.
10. Servilli, M.; Baldioli, M.; Selvaggini, R.; Minitiati, E.; Macchioni, A.; Montedoro, G. F. HPLC evaluation of phenols in virgin olive oil, vegetation waters and pomace and 1D- and 2D-NMR characterisation. J. Am. Oil. Chem. Soc. 1999, 76, 873-882.
11. Visioli, F.; Romani, A.; Mulinacci, N.; Zarini, S.; Conte, D.; Vincieri, F. F.; Galli, C. Antioxidant and other biological activities of olive mill waste waters. J. Agric. Food Chem. 1999, 41, 3397-3401.
12. Gorinstein, S.; Leontowicz, H.; Lojek, A.; Leontowicz, M.; Ciz, M.; Krzeminski, R.; Gralak, M.; Czerwinski, J.; Jastrzebski, Z.; Trakhtenberg, S.; Grigelmo-Miguel, N.; Soliva-Fortuny, R. Olive oils improve lipid metabolism and increase antioxidant potential in rats fed diets containing cholesterol. J. Agric. Food Chem. 2002, 50, 6102-6108.
13. Petroni, A.; Blasevich, M.; Salami, M.; Papini, N.; Montedero, G. F.; Galli, C. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb. Res. 1995, 78, 151-160.
14. De la Puerta, R.; Ruiz-Gutierrez, V.; Hoult, J. R. Inhibition of leukocyte 5-lipoxygynase by phenolics from virgin olive oil. Biochem. Pharmacol. 1999, 57, 445-449.
15. Miro-Casas, E.; Covas, M. L; Farre, M. Hydroxytyrosol disposition in humans. Clin. Chem. 2003, 49 (6), 945-952.
16. Vissers, M. N.; Zock, P. L.; Roodenburg, A. J. C.; Leenen, R.; Katan, M. B. Olive oil phenols are absorbed in humans. J. Nutr. 2002, 132, 409-417.
17. Allouche, N.; Fki, L; Sayadi, S. Toward a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters. J. Agri. Food Chem. 2004, 52, 267-273.
18. Fki, I.; Allouche, N.; Sayadi. S. The use of polyphenolic extract, purified hydroxytyrosol and 3,4-dihydroxyphenyl acetic acid from olive mill wastewater for the stabilization of refined oils: A potential alternative to synthetic antioxidants. Food Chem 2005, 93, 197-204.
19. Friedwald, W. T.; Levy, R. I.; Fradrickson, D. S. Estimation of concentration of low-density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin. Chem. 1972, 18, 494-502.
20. Bradford, M. M. A rapid and a sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 1976, 72, 248- 254.
21. Regoli, F.; Principato, G. Glutathione, glutathione-dependant and antioxidant enzymes in mussel, Mytilus galloprovincilis exposed to metals in different field and laboratory condition. Implications for a proper use of biochemical markers. Aquat. Toxicol. 1995, 31, 143-164.
22. Park, S. Y.; Bok. S. H.; Jeon, S. M.; Park, Y. B.; Lee. S. J.; Jeong, T. S.; Choi, M. S. Effect of rutin and tannic acid supplements on cholesterol metabolism in rats. Nutr. Res. 2002, 22, 283-295.
23. Dreosti, I. E. Antioxidant polyphenols in tea, cocoa and wine. Nutrition 2000, 16, 671-692.
24. Rice-Evans, C. A.; Miller, N. J.; Paganga, G. Structure-antioxidant relationships of flavonoids, and phenolic acids. Free Radical Biol. Med. 1996, 20, 933-956.
25. Bouaziz, M.; Grayer, R. J.; Simmonds, M. S. J.; Damak, M.; Sayadi, S. Identification and antioxidant potential of flavonoids and low molecular weight phenols in olive cultivar Chemlali growing in Tunisia. J. Agric. Food Chem. 2005, 53, 236-241.
26. Tuk, K. L.; Haybal, P. J. Major phenolic compounds in olive oil: Metabolism and health effects. J. Nutr. Biochem. 2002, 13, 636-644.
27. Lee, J. S.; Choi, M. S.; Jeon, S. M.; Jeong, T. S.; Park, Y. B.; Lee, M. K.; Bok, S. H. Lipid-lowering and antioxidative activities of 3,4-di OH-cinnamate and 3,4-di OH-hydrocinnamate in cholesterol-fed rats. Clin. Chim. Acta 2001, 314, 221-229.
28. Libby, P.; Aikawa, M.; Schonbeck, U. Cholesterol and atherosclerosis. Biochim. Biophys. Acta 2000, 1529, 299-309.
29. Krzeminski, R.; Gorinstein, S.; Leontowicz, H.; Leontowicz, M.; Gralak, M.; Czerwinski, J.; Lojek, A.; Ciz, M.; Martin-Belloso, O.; Gligelmo-Miguel, N.; Trakhtenberg, S. Effect of different olive oils on bile excretion in rats fed cholesterol-containing and cholesterol-free diets. J. Agric. Food Chem. 2003, 51, 5774- 5779.
30. Yokozawa, T.; Nakagawa, T.; Kitani, K. Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J. Agric. Food Chem. 2002, 50, 3549-3552.
31. Yugarani, T.; Tan, B. K.; Teh, M.; Das, N. P. Effects of polyphenolic natural products on the lipid profiles of rats fed high fat diets. Lipids 1992, 27, 181-186.
32. Yee, W. L.; Wang, Q.; Agdinaoay, T.; Dang, K.; Chang, H.; Grandinetti, A.; Franke, A. A.; Theriault, A. Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells. Mol. Cell Biochem. 2002, 229, 85-92.
33. Vidal, R, Hernandez-Vallej, S.; Pauquai, T.; Texier, O.; Rousset, M.; Chambaz, J.; Demignot, S.; Lacorte, J. M. Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes. J. Lipid Res. 2005, 46, 258-268.
34. Raederstorff, D. G.; Schlachter. M. F.; Eiste, V.; Weber, P. Effect of EGCG on lipid absorption and plasma lipid levels in rats. J. Nutr. Biochem. 2003, 14, 326-332.
35. Botham, K. M.; Zheng, X.; Napolitano, M.; Avella, M.; Cavallari, C.; Rivabene, R.; Bravo, E. The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very low- density lipoprotein by the liver: modulation by cellular oxidative state. Exp. Biol. Med. (Maywood) 2003, 228, 143-151.
36. Stein, O.; Stein, Y. Atheroprotective mechanisms of HDL. Atherosclerosis 1999, 144 (2), 285-301.
37. Young. C. E.; Karas, R. H.; Kuvin, J. T. High-density lipoprotein cholesterol and coronary heart disease. Cardiol. Rev. 2004, 12 (2), 107-119.
38. Mora, A.; Paya, M.; Rios, J. L.; Alcaraz, M. J. Structure activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymes lipid peroxidaiton. Biochem. Pharmacol. 1990, 40, 793-797.
39. Prasad, K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secosisolariciresinol diglucoside isolated from flaxseed. Circulation 1999, 99, 1355-1362.
40. Yokozawa, T.; Ishida, A.; Cho, E. J.; Nakagawa, T. The effects of Coptidio Rhizoma extract on a hypercholesterolemic animal model. Phytomedicine 2003, 10, 17-22.
41. Bouaziz, M.; Sayadi, S. Isolation and evaluation of antioxidants from a Tunisian cultivar olive tree leaves. Eur. J. Lipid. Sci. Technol. 2005, 107, 497-504.
42. Manna, C.; Galletti, P.; Montedoro, G.; Zappia, V. Olive oil hydroxytyrosol protects human erythrocytes against oxidative damage. J. Nutr. Biochem. 1999, 10, 159-165.
43. Visioli, F.; Bellome, G.; Galli, C. Free radical-scavenging properties of olive oil polyphenols. Biochem. Biophys. Res. Commun. 1998, 247, 60-64.
44. Halliwell, B. Free radicals, antioxidants and human diseases: Curiosity, cause or consequence? Lancet 1994, 344, 721-724.
45. Anila, L.; Vijayalakshmi, N. R. Antioxidant action of flavonids from Mangifera indica and Embilica officinalis in hypercholesterolemic rats. Food Chem. 2003, 83, 569-574.
46. Kima, H. J.; Ohb, G. T.; Parke, Y. B.; Leed, M. K.; Seoa, H. J.; Choia, M. S. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. Life Sci. 2004, 74, 1621 - 1634.
47. Shukla, R.; Gupta, S.; Gambhir. J. K.; Prabhu, K. M.; Murthy, P. S. Antioxidant effect of aqueous extract of the bark of Ficus bengalensis in hypercholesterolaemic rabbits. J. Ethnopharmacol. 2004, 92, 47-51.