Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms

Life Sciences

Volumn 78, Issue 23, 2006, Pages 2689-2696

  Wu, Yu Qing ^a   Zhou, Cheng Hua ^b   Tao, Jin ^a   Li, Sheng Nan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Airway inflammation; Apoptosis; Asthma; Eosinophil; Eotaxin; Fas; Nobiletin

Indexed keywords

ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; EOSIN; EOTAXIN; FAS ANTIGEN; FLAVONOID; HEMATOXYLIN; MESSENGER RNA; NOBILETIN; OVALBUMIN; POLYMETHOXYFLAVONOID; UNCLASSIFIED DRUG;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASTHMA; BLOOD ANALYSIS; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIA; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MICROSCOPY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RESPIRATORY TRACT INFLAMMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ANTIGENS, CD95; ANTIOXIDANTS; APOPTOSIS; ASTHMA; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES, CC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; FLAVONES; INJECTIONS, INTRAPERITONEAL; MALE; OVALBUMIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

ANIMALIA;

EID: 33646040117     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.10.029     Document Type: Article

References (41)

1. Allakhverdi Z., Lamkhioued B., Olivenstein R., Hamid O., and Renzi P.M. CD8 depletion-induced late airway response is characterized by eosinophilia, increased Eotaxin, and decreased IFN-γ expression in rats. American Journal of Respiratory and Critical Care Medicine 162 (2000) 1123-1131
2. Amin K., Ludviksdottir D., and Janson C. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. American Journal of Respiratory and Critical Care Medicine 162 (2000) 2295-2301
3. Bousquet J., Jeffery P.K., Busse W.W., Jhonson M., and Vignola A.M. Asthma: From bronchoconstriction to airways inflammation and remodeling. American Journal of Respiratory and Critical Care Medicine 161 (2000) 1720-1745
4. Busse W.W., and Lemanske R.J. Asthma. The New England Journal of Medicine 344 (2001) 350-362
5. Cain H. Bronchoprovocation testing. Clinics in Chest Medicine 22 (2001) 651-659
6. Chang C.Y., Huang L.J., Wang J.P., Teng C.M., Chen S.C., and Kuo S.C. Synthesis and anti-platelet, anti-inflammatory and anti-allergic activities of methoxyiso-flavanquinone and related compounds. Chemical and Pharmaceutical Bulletin 48 (2000) 964-973
7. Chen J., Montanari A.M., and Widmer W.W. Two new polymethoxylated flavonoids, a class of compounds with potential anticancer activity, isolated from cold pressed Dancy tangerine peel oil solids. Journal of Agricultural and Food Chemistry 45 (1997) 364-368
8. Das M., Ram A., and Ghosh B. Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice. Inflammation Research 52 (2003) 101-106
9. Daugherty B.L., Siciliano S.J., DeMartino J.A., Malkowitz L., Sirotina A., and Springer M.S. Cloning, expression, and characterization of the human eosinophil Eotaxin receptor. The Journal of Experimental Medicine 183 (1996) 2349-2354
10. Duan W., Chun K.I., Sathiyamoorthy S., Kaw Y.C., Boon H.B., and Fredwong W.S. Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma. American Journal of Respiratory and Critical Care Medicine 167 (2003) 185-192
11. Gartner I. Separation of human eosinophils in density gradients of polyvinylphrro-lidone-coated silica gel (Percoll). Immunology 40 (1980) 133-136
12. Haslett C. Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. Clinical Science 83 (1992) 639-648
13. Hendriks J.J., Alblas J., Van der Pol S.M., Van Tol E.A., Dijkstra C.D., and De Vries H.E. Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. Journal of Experimental Medicine 200 (2004) 1667-1672
14. Higa S., Hirano T., Kotani M., Matsumoto M., Fujita A., Suemura M., Kawase I., and Tanaka T. Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. Journal of Allergy and Clinical Immunology 111 (2003) 1299-1306
15. Hirano T., Higa S., Arimitsu J., Naka T., Shima Y., Ohshima S., Fujimoto M., Yamadori T., Kawase I., and Tanaka T. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. International Archives of Allergy and Immunology 134 (2004) 135-140
16. Jawien J., Olszanecki R., Lorkowska B., and Korbut R. Effect of aspirin on cysteinyl leukotrienes production by eosinophils co-cultured with epithelial cells. Journal of Physiology and Pharmacology 55 (2004) 765-772
17. Kimata M., Shichijo M., Miura T., Serizawa I., Inagaki N., and Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clinical and Experimental Allergy 30 (2000) 501-508
18. Kotani M., Matsumoto M., Fujita A., Higa S., Wang W., Suemura M., Kishimoto T., and Tanaka T. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. Journal of Allergy and Clinical Immunology 106 (2000) 159-166
19. Kumar R.K. Understanding airway wall remodeling in asthma: a basis for improvements in therapy?. Pharmacology and Therapeutics 91 (2001) 93-104
20. Lamkhioued B., Renzi P.M., Abi-Younes S., Garcia-Zepada E.A., Allakhverdi Z., Ghaffar O., Rothenberg M.D., Luster A.D., and Hamid Q. Increased expression of Eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. Journal of Immunology 159 (1997) 4593-4601
21. Maddox L., and Schwartz D.A. The pathophysiology of asthma. Annual Review of Medicine 53 (2002) 477-498
22. Masu K., Ohno I., Suzuki K., Okada S., Hattori T., and Shirato K. Proliferative effects of eosinophil lysates on cultured human airway smooth muscle cells. Clinical and Experimental Allergy 32 (2002) 595-601
23. Middleton E.J., and Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochemical Pharmacology 43 (1992) 1167-1179
24. Middleton E.J., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews 52 (2000) 673-751
25. Nagata S. Apoptosis by death factor. Cell 88 (1997) 355-365
26. Nagata S., and Golstein P. The Fas death factor. Science 267 (1995) 1449-1456
27. Ogasawara H., Fujitani T., Drzewiecki G., and Middleton E.J. The role of hydrogen peroxide in basophil histamine release and the effect of selected flavonoids. The Journal of Allergy and Clinical Immunology 78 (1986) 321-328
28. Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., and Mackay C.R. Molecular cloning and characterization of a human Eotaxin receptor expressed selectively on eosinophils. The Journal of Experimental Medicine 183 (1996) 2437-2448
29. Rankin S.M., Conroy D.M., and Williams T.J. Eotaxin and eosinophil recruitment: implications for human disease. Molecular Medicine 6 (2000) 20-27
30. Roughton S.A., Lareu R.R., Bittles A.H., and Dharmarajan A.M. Fas and Fas ligand messenger ribonucleic acid and protein expression in the rat corpus luteum during apoptosis-mediated luteolysis. Biology of Reproduction 60 (1999) 797-804
31. Shichijo M., Yamamoto N., Tsujishita H., Kimata M., Nagai H., and Kokubo T. Inhibition of syk activity and degranulation of human mast cells by flavonoids. Biological and Pharmaceutical Bulletin 26 (2003) 1685-1690
32. Simon H.U., Yousefi S., Dibbert B., Hebestreit H., Weber M., Branch D.R., Blaser K., Levi-Schaffer F., and Anderson G.P. Role for tyrosine phosphorylation and Lyn tyrosine kinase in fas receptor-mediated apoptosis in eosinophils. Blood 92 (1998) 547-557
33. Stern M., Meagher L., Savill J., and Haslett C. Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. Journal of Immunology 148 (1992) 3543-3549
34. Tai P.C., Sun L., and Spry C.J. Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro. Clinical and Experimental Immunology 85 (1991) 312-316
35. Theoharides T.C., Alexandrakis M., Kempuraj D., and Lytinas M. Anti-inflammatory actions of flavonoids and structural requirements for new design. International Journal of Immunopathology and Pharmacology 14 (2001) 119-127
36. Wang X.Z., Zhang S.J., Chen Y.X., Chen Z.X., Huang Y.H., and Zhang L.J. Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro. World Journal of Gastroenterology 10 (2004) 2706-2710
37. Way W., Kazuko M.A., Gen T.A., Ko S.U., Keiko O.H., Kaori O.K., Kunio S.H., Motoaki T.A., and Isao O.H. Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis. Biological and Pharmaceutical Bulletin 28 (2005) 515-519
38. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annual Review of Immunology 17 (1999) 255-281
39. Yamaguchi Y., Suda T., Ohta S., Tominaga K., Miura Y., and Kasahara T. Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood 178 (1991) 2542-2547
40. Ying S. C-C chemokine expression in atopic and nonatopic asthma. Chemistry and Immunology 78 (2000) 178-188
41. Ying S., Robinson D.S., Meng Q., Rottman J., Kennedy R., Ringler D.J., Mackay C.R., Daugherty B.L., Springer M.S., and Durham S.R. Enhanced expression of Eotaxin and CCR3 mRNA and protein in atopic asthma, association with airway hyperresponsiveness and predominant co-localization of Eotaxin mRNA to bronchial epithelial and endothelial cells. European Journal of Immunology 27 (1997) 3507-3516