Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis

Planta Medica

Volumn 68, Issue 10, 2002, Pages 875-880

  Danz, Henning ^a   Stoyanova, Stefka ^a   Thomet, Olivier A R ^b   Simon, Hans Uwe ^b   Dannhardt, Gerd ^c   Ulbrich, Holger ^c   Hamburger, Matthias ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

5 lipoxygenase; 6 keto PGF1a; BAECs; Brassicaceae; Cyclooxygenase 1; Cyclooxygenase 2; Granulocytes; HEL cells; Isatis tinctoria; LTB4; Mono Mac 6 cells; RAW 264.7; Thrombocytes; Tryptanthrin; TxB2

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ALKALOID; ARACHIDONATE 5 LIPOXYGENASE; CALCIUM IONOPHORE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; LEUKOTRIENE; LEUKOTRIENE B4; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN; THROMBOXANE B2; TRYPTANTHRIN; UNCLASSIFIED DRUG; ZILEUTON;

ARTERY ENDOTHELIUM; ARTICLE; BRASSICA; CALCIUM MOBILIZATION; CATTLE; CONTROLLED STUDY; CORONARY ARTERY; DOSE RESPONSE; ENZYME ASSAY; ENZYME PURIFICATION; HUMAN; HUMAN CELL; ISATIS TINCTORIA; NEUTROPHIL; PLANT; PROSTAGLANDIN SYNTHESIS; THROMBOCYTE;

ANIMALS; BRASSICACEAE; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOENZYMES; LEUKOTRIENE B4; MEMBRANE PROTEINS; NEUTROPHILS; PHYTOTHERAPY; PLANT EXTRACTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; QUINAZOLINES; SHEEP;

BOS TAURUS; BOVINAE; BRASSICA; BRASSICACEAE; ISATIS TINCTORIA; OVIS ARIES;

EID: 0036774774     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-34922     Document Type: Article

References (24)

1. Blumenthal M. The Complete German Commission E Monographs. Austin: American Botanical Council, 1998
2. Ernst E, Chrubasik S. Phyto-anti-inflammatories. A sytematic review of randomized, placebo controlled, double-blind trials. Rheum Dis Clin North Amer 2000; 26: 13-27
3. Hamburger M, Danz H. Medicament for Inhibiting NF-κB. WO0061159.
4. Danz H, Stoyanova S, Wippich P, Brattström A, Hamburger M. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta Med 2001; 67: 411-6
5. Thomet OAR, Wiesmann UR, Schapowal A, Bizer C, Simon HU. Role of petasin in the potential anti-inflammatory activity of a plant extract of Petasites hybridus. Biochem Pharmacol 2001; 61: 1041-7
6. Friedlaender P, Roschdestwensky N. Über ein oxydationsprodukt des indigblaus. Chem Ber 1915; 48: 1841-7
7. Berg J, Christoph T, Widerna M, Bodenteich A. Isoenzyme specific cyclooxygenase inhibitors: A whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6. J Pharmacol Toxicol Methods 1997; 37: 179-86
8. Dannhardt G, Lehr M. In-vitro evaluation of 5-lipoxygenase and cyclooxygenase inhibitors using bovine neutrophils and platelets and HPLC. J Pharm Pharmacol 1992; 44: 419-24
9. Dannhardt G, Ulbrich H. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cycloxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res 2001; 50: 262-9
10. Mitchell JA, Akarasereenont P, Thiemermann C, Roderick JF, Vane JR. Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1994; 90: 11693-7
11. Dannhardt G, Kiefer W. Cyclooxygenase inhibitors - current status and future prospects. Eur J Med Chem 2001; 36: 109-26
12. Katori M, Majima M. Cyclooxygenase-2: Its rich diversity of roles and possible application of its selective inhibitors. Inflammation Res 2000; 49: 367-92
13. Danz H. Untersuchungen zur Antiinflammatorischen Wirkung und Analytik von Tryptanthrin in Isatis Tinctoria L. PhD Thesis, Jena: 2001
14. Dannhardt G, Laufer S. Structural approaches to explain the selectivity of COX-2 inhibitors: Is there a common pharmacophore? Curr Med Chem 2000; 7: 1101-12
15. Ruengeler P, Lyss G, Castro V, Mora G, Pahl HL, Merfort I. Study of three sesquiterpene lactones from Thitonia diversifolia on their anti-inflammatory activity using transcription factor NF-κB and enzymes fo the arachidonic acid pathway as targets. Planta Med 1998; 64: 588-93
16. Yamamoto K, Wang J, Yamamoto S, Tobe H. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. FEBS Lett 2000; 465: 103-6
17. Subbarmaiah K, Chung WC, Michaluart P, Telang N, Tanabe T, Inoue H, Jang M, Pezzuto JP, Dannenberg AJ. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem 1998; 273: 21875-82
18. Bauer R. Cyclooxygenase and 5-lipoxygenase as targets for medicinal plant research. In: Bohlin L, Bruhn JG, editors. Bioassay Methods in Natural Product Research and Drug Development Dordrecht: Kluwer, 1999: P. 119-41
19. Ishihara T, Kohno K, Ushio S, Iwaki K, Ikeda M, Kurimoto M. Tryptanthrin inhibits nitric oxide and prostaglandin E2 synthesis by murine macrophages. Eur J Pharmacol 2000; 407: 197-204
20. Moon C, Murakami M, Kudo I, Son KH, Kim HP, Kang SS, Chang HW. A new class of COX-2 inhibitor, rutaecarpine, from Evodia rutaecarpa. Inflammation Res 1999; 48: 621-5
21. Laufer S, Augustin J, Dannhardt G, Kiefer W. (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem 1994; 37: 1894-7
22. Anonynous. Darbufelon mesilate. Drugs Fut 1999; 24: 853-7
23. Steinhilber D. 5-Lipoxygenase: A target for anti-inflammatory drugs revisited. Curr Med Chem 1999; 6: 71-85
24. Inagaki M, Tsuri T, Jyoyama H, Ono T, Yamada K, Kobayashi M, Hori Y, Arimura A, Yasui K, Ohno K, Kakudo K, Koizumi K, Suzuki R, Kato M, Kawai S, Matsumoto S. Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (g-sultam) skeleton: Cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase. J Med Chem 2000; 43: 2040-8