Luteolin suppresses inflammatory mediator expression by blocking the Akt/NFκB pathway in acute lung injury induced by lipopolysaccharide in mice

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Li, Yi Ching ^a,b   Yeh, Chung Hsin ^c,d   Yang, Ming Ling ^a   Kuan, Yu Hsiang ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LUTEOLIN; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVATION; HISTOPATHOLOGY; IN VIVO STUDY; LUNG EDEMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84862926489     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/383608     Document Type: Article

References (34)

1. Hasday J. D., Bascom R., Costa J. J., Fitzgerald T., Dubin W., Bacterial endotoxin is an active component of cigarette smoke Chest 1999 115 3 829 835 (Pubitemid 29129968)
2. Reutershan J., Basit A., Galkina E. V., Ley K., Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury American Journal of PhysiologyLung Cellular and Molecular Physiology 2005 289 5 L807 L815
3. Bhatia M., Moochhala S., Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome Journal of Pathology 2004 202 2 145 156 (Pubitemid 38208651)
4. Zhou Z., Kozlowski J., Schuster D. P., Physiologic, biochemical, and imaging characterization of acute lung injury in mice American Journal of Respiratory and Critical Care Medicine 2005 172 3 344 351 (Pubitemid 41026145)
5. Tak P. P., Firestein G. S., NF- B: a key role in inflammatory diseases Journal of Clinical Investigation 2001 107 1 7 11
6. He Z., Zhu Y., Jiang H., Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study Respiratory Research 2009 10 126
7. Lpez-Lzaro M., Distribution and biological activities of the flavonoid luteolin Mini-Reviews in Medicinal Chemistry 2009 9 1 31 59
8. Harris G. K., Qian Y., Leonard S. S., Sbarra D. C., Shi X., Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells Journal of Nutrition 2006 136 6 1517 1521 (Pubitemid 43765355)
9. Lu H. W., Sugahara K., Sagara Y., Masuoka N., Asaka Y., Manabe M., Kodama H., Effect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil Archives of Biochemistry and Biophysics 2001 393 1 73 77 (Pubitemid 32808361)
10. Kotanidou A., Xagorari A., Bagli E., Kitsanta P., Fotsis T., Papapetropoulos A., Roussos C., Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice American Journal of Respiratory and Critical Care Medicine 2002 165 6 818 823 (Pubitemid 34229653)
11. Lee J. P., Li Y. C., Chen H. Y., Lin R. H., Huang S. S., Chen H. L., Kuan P. C., Liao M. F., Chen C. J., Kuan Y. H., Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils Acta Pharmacologica Sinica 2010 31 7 831 838
12. Pan P. H., Lin S. Y., Ou Y. C., Chen W. Y., Chuang Y. H., Yen Y. J., Liao S. L., Raung S. L., Chen C. J., Stearic acid attenuates cholestasis-induced liver injury Biochemical and Biophysical Research Communications 2010 391 3 1537 1542
13. Reutershan J., Morris M. A., Burcin T. L., Smith D. F., Chang D., Saprito M. S., Ley K., Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung Journal of Clinical Investigation 2006 116 3 695 702 (Pubitemid 43326878)
14. Shang Y., Li X., Prasad P. V., Xu S., Yao S., Liu D., Yuan S., Feng D., Erythropoietin attenuates lung injury in lipopolysaccharide treated rats1 Journal of Surgical Research 2009 155 1 104 110
15. Fukunaga K., Kohli P., Bonnans C., Fredenburgh L. E., Levy B. D., Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury Journal of Immunology 2005 174 8 5033 5039
16. Fan J., Ye R. D., Malik A. B., Transcriptional mechanisms of acute lung injury American Journal of PhysiologyLung Cellular and Molecular Physiology 2001 281 5 L1037 L1050
17. Hayden M. S., West A. P., Ghosh S., NF- B and the immune response Oncogene 2006 25 51 6758 6780
18. Wymann M. P., Zvelebil M., Laffargue M., Phosphoinositide 3-kinase signallingwhich way to target? Trends in Pharmacological Sciences 2003 24 7 366 376 (Pubitemid 37315529)
19. Chen H., Bai C., Wang X., The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine Expert Review of Respiratory Medicine 2010 4 6 773 783
20. Driscoll K. E., Costa D. L., Hatch G., Henderson R., Oberdorster G., Salem H., Schlesinger R. B., Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations Toxicological Sciences 2000 55 1 24 35 (Pubitemid 30252432)
21. Burnham E. L., Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome? Anesthesiology 2008 108 3 354 356 (Pubitemid 351304227)
22. Khair O. A., Davies R. J., Devalia J. L., Bacterial-induced release of inflammatory mediators by bronchial epithelial cells European Respiratory Journal 1996 9 9 1913 1922 (Pubitemid 26294765)
23. Wang N., Gates K. L., Trejo H., Elevated CO 2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage Journal of the Federation of American Societies for Experimental Biology 2010 24 7 2178 2190
24. Abraham E., Neutrophils and acute lung injury Critical Care Medicine 2003 31 4 supplement S195 S199
25. Chen C. Y., Peng W. H., Wu L. C., Wu C. C., Hsu S. L., Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis Journal of Agricultural and Food Chemistry 2010 58 22 11653 11661
26. Giebelen A., van Westerloo D. J., LaRosa G. J., de Vos A. F., van der Poll T., Local stimulation of 7 cholinergic receptors inhibits LPS-induced TNF- release in the mouse lung Shock 2007 28 6 700 703 (Pubitemid 350135475)
27. Marsh C. B., Wewers M. D., The response to gram-negative pathogenesis of sepsis. Factors that modulate bacterial infection Clinics in Chest Medicine 1996 17 2 183 197 (Pubitemid 26188607)
28. Agouridakis P., Kyriakou D., Alexandrakis M. G., Prekates A., Perisinakis K., Karkavitsas N., Bouros D., The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome Respiratory Research 2002 3 25 33
29. Chen C. Y., Peng W. H., Tsai K. D., Hsu S. L., Luteolin suppresses inflammation-associated gene expression by blocking NF- B and AP-1 activation pathway in mouse alveolar macrophages Life Sciences 2007 81 23-24 1602 1614
30. Farley K. S., Wang L. F., Razavi H. M., Law C., Rohan M., McCormack D. G., Mehta S., Effects of macrophage inducible nitric oxide synthase in murine septic lung injury American Journal of PhysiologyLung Cellular and Molecular Physiology 2006 290 6 L1164 L1172
31. Speyer C. L., Neff T. A., Warner R. L., Guo R. F., Sarma J. V., Riedemann N. C., Murphy M. E., Murphy H. S., Ward P. A., Regulatory effects of iNOS on acute lung inflammatory responses in mice American Journal of Pathology 2003 163 6 2319 2328 (Pubitemid 37466475)
32. Baeuerle P. A., Henkel T., Function and activation of NF- B in the immune system Annual Review of Immunology 1994 12 141 179
33. Martin T. R., Frevert C. W., Innate immunity in the lungs Proceedings of the American Thoracic Society 2005 2 5 403 411 (Pubitemid 43128033)
34. Ardeshna K. M., Pizzey A. R., Devereux S., Khwaja A., The PI3 kinase, p38 SAP kinase, and NF- b signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells Blood 2000 96 3 1039 1046 (Pubitemid 30616871)