메뉴 건너뛰기




Volumn 70, Issue 2, 2013, Pages 181-203

Ceramide function in the brain: When a slight tilt is enough

Author keywords

Apoptosis; Ceramide; Neurodegeneration; Rafts; Sphingolipids

Indexed keywords

CERAMIDE; CERAMIDE 1 PHOSPHATE; CERAMIDE GLUCOSYLTRANSFERASE; PHOSPHATIDYLCHOLINE; PHOSPHORYLCHOLINE; SERINE PALMITOYLTRANSFERASE; SPHINGANINE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE;

EID: 84872284081     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1038-x     Document Type: Review
Times cited : (193)

References (312)
  • 1
    • 51449114084 scopus 로고    scopus 로고
    • Biodiversity of sphingoid bases (sphingosines) and related amino alcohols
    • 10.1194/jlr.R800012-JLR200 18499644 1:CAS:528:DC%2BD1cXovVCrs7Y%3D 10.1194/jlr.R800012-JLR200
    • Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr (2008) Biodiversity of sphingoid bases (sphingosines) and related amino alcohols. J Lipid Res 49(8):1621-1639. doi: 10.1194/jlr.R800012- JLR200
    • (2008) J Lipid Res , vol.49 , Issue.8 , pp. 1621-1639
    • Pruett, S.T.1    Bushnev, A.2    Hagedorn, K.3    Adiga, M.4    Haynes, C.A.5    Sullards, M.C.6    Liotta, D.C.7    Merrill, Jr.A.H.8
  • 2
    • 0036303786 scopus 로고    scopus 로고
    • The therapeutic potential of modulating the ceramide/sphingomyelin pathway
    • 10.1172/JCI16127 12093880 1:CAS:528:DC%2BD38XltF2rtLc%3D
    • Kolesnick R (2002) The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1):3-8. doi: 10.1172/JCI16127
    • (2002) J Clin Invest , vol.110 , Issue.1 , pp. 3-8
    • Kolesnick, R.1
  • 3
    • 0027527545 scopus 로고
    • Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide
    • 8253743 1:CAS:528:DyaK3sXmsVKmu7k%3D
    • Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA (1993) Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 268(35):26226-26232
    • (1993) J Biol Chem , vol.268 , Issue.35 , pp. 26226-26232
    • Bielawska, A.1    Crane, H.M.2    Liotta, D.3    Obeid, L.M.4    Hannun, Y.A.5
  • 4
    • 0030000464 scopus 로고    scopus 로고
    • Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis
    • 8612651 1:CAS:528:DyaK28XhslWmurg%3D 10.1111/j.1432-1033.1996.00729.x
    • Karasavvas N, Erukulla RK, Bittman R, Lockshin R, Zakeri Z (1996) Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur J Biochem 236(2):729-737
    • (1996) Eur J Biochem , vol.236 , Issue.2 , pp. 729-737
    • Karasavvas, N.1    Erukulla, R.K.2    Bittman, R.3    Lockshin, R.4    Zakeri, Z.5
  • 5
    • 0030844101 scopus 로고    scopus 로고
    • Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum
    • 10.1016/S0014-5793(97)01187-3 9369202 1:CAS:528:DyaK2sXntFajur4%3D 10.1016/S0014-5793(97)01187-3
    • Michel C, van Echten-Deckert G (1997) Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett 416(2):153-155. doi: 10.1016/S0014-5793(97)01187-3
    • (1997) FEBS Lett , vol.416 , Issue.2 , pp. 153-155
    • Michel, C.1    Van Echten-Deckert, G.2
  • 6
    • 0030963660 scopus 로고    scopus 로고
    • Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
    • 9312549 1:CAS:528:DyaK2sXlvFGisbc%3D 10.1074/jbc.272.36.22432
    • Michel C, van Echten-Deckert G, Rother J, Sandhoff K, Wang E, Merrill AH Jr (1997) Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J Biol Chem 272(36):22432-22437
    • (1997) J Biol Chem , vol.272 , Issue.36 , pp. 22432-22437
    • Michel, C.1    Van Echten-Deckert, G.2    Rother, J.3    Sandhoff, K.4    Wang, E.5    Merrill, Jr.A.H.6
  • 7
    • 1542723736 scopus 로고    scopus 로고
    • The structural requirements for ceramide activation of serine-threonine protein phosphatases
    • 10.1194/jlr.M300347-JLR200 14657198 1:CAS:528:DC%2BD2cXisFWgurs%3D 10.1194/jlr.M300347-JLR200
    • Chalfant CE, Szulc Z, Roddy P, Bielawska A, Hannun YA (2004) The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res 45(3):496-506. doi: 10.1194/jlr.M300347-JLR200
    • (2004) J Lipid Res , vol.45 , Issue.3 , pp. 496-506
    • Chalfant, C.E.1    Szulc, Z.2    Roddy, P.3    Bielawska, A.4    Hannun, Y.A.5
  • 8
    • 4444348709 scopus 로고    scopus 로고
    • The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior
    • 10.1529/biophysj.104.044529 15345551 1:CAS:528:DC%2BD2cXns1Sksrc%3D 10.1529/biophysj.104.044529
    • Brockman HL, Momsen MM, Brown RE, He L, Chun J, Byun HS, Bittman R (2004) The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior. Biophys J 87(3):1722-1731. doi: 10.1529/biophysj.104.044529
    • (2004) Biophys J , vol.87 , Issue.3 , pp. 1722-1731
    • Brockman, H.L.1    Momsen, M.M.2    Brown, R.E.3    He, L.4    Chun, J.5    Byun, H.S.6    Bittman, R.7
  • 9
    • 0036214899 scopus 로고    scopus 로고
    • Conformational characterization of ceramides by nuclear magnetic resonance spectroscopy
    • 10.1016/S0006-3495(02)75554-9 11916863 1:CAS:528:DC%2BD38XivFKisbY%3D 10.1016/S0006-3495(02)75554-9
    • Li L, Tang X, Taylor KG, DuPre DB, Yappert MC (2002) Conformational characterization of ceramides by nuclear magnetic resonance spectroscopy. Biophys J 82(4):2067-2080. doi: 10.1016/S0006-3495(02)75554-9
    • (2002) Biophys J , vol.82 , Issue.4 , pp. 2067-2080
    • Li, L.1    Tang, X.2    Taylor, K.G.3    Dupre, D.B.4    Yappert, M.C.5
  • 10
    • 1442299372 scopus 로고    scopus 로고
    • Sphingolipids in human lens membranes: An update on their composition and possible biological implications
    • 10.1016/j.chemphyslip2003.12.003 14998723 1:CAS:528:DC%2BD2cXhs12mtbw%3D 10.1016/j.chemphyslip.2003.12.003
    • Yappert MC, Borchman D (2004) Sphingolipids in human lens membranes: an update on their composition and possible biological implications. Chem Phys Lipids 129(1):1-20. doi: 10.1016/j.chemphyslip2003.12.003
    • (2004) Chem Phys Lipids , vol.129 , Issue.1 , pp. 1-20
    • Yappert, M.C.1    Borchman, D.2
  • 11
    • 0037440032 scopus 로고    scopus 로고
    • Ceramide: Second messenger or modulator of membrane structure and dynamics?
    • 10.1042/BJ20021528 12408751
    • van Blitterswijk WJ, van der Luit AH, Veldman RJ, Verheij M, Borst J (2003) Ceramide: second messenger or modulator of membrane structure and dynamics? Biochem J 369(Pt 2):199-211. doi: 10.1042/BJ20021528
    • (2003) Biochem J , vol.369 , Issue.PART 2 , pp. 199-211
    • Van Blitterswijk, W.J.1    Van Der Luit, A.H.2    Veldman, R.J.3    Verheij, M.4    Borst, J.5
  • 12
    • 0034308223 scopus 로고    scopus 로고
    • Ceramide as a second messenger: Sticky solutions to sticky problems
    • 10998592 1:CAS:528:DC%2BD3cXmsFyrsLc%3D 10.1016/S0962-8924(00)01830-4 pii: S0962-8924(00)01830-4
    • Venkataraman K, Futerman AH (2000) Ceramide as a second messenger: sticky solutions to sticky problems. Trends Cell Biol 10(10):408-412 pii: S0962-8924(00)01830-4
    • (2000) Trends Cell Biol , vol.10 , Issue.10 , pp. 408-412
    • Venkataraman, K.1    Futerman, A.H.2
  • 13
    • 0033884050 scopus 로고    scopus 로고
    • Compartmentalization of ceramide signaling: Physical foundations and biological effects
    • 10.1002/1097-4652(200009)184:3<285: AID-JCP2>3.0.CO;2-3 10911359 1:CAS:528:DC%2BD3cXlsl2murc%3D 10.1002/1097-4652(200009)184:3<285: AID-JCP2>3.0.CO;2-3
    • Kolesnick RN, Goni FM, Alonso A (2000) Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol 184(3):285-300. doi: 10.1002/1097-4652(200009)184:3<285:AID-JCP2>3.0.CO;2- 3
    • (2000) J Cell Physiol , vol.184 , Issue.3 , pp. 285-300
    • Kolesnick, R.N.1    Goni, F.M.2    Alonso, A.3
  • 14
    • 0025889011 scopus 로고
    • Characterization of a ceramide-Activated protein kinase: Stimulation by tumor necrosis factor alpha
    • 1946418 1:CAS:528:DyaK38XhvFGhsQ%3D%3D 10.1073/pnas.88.22.10009
    • Mathias S, Dressler KA, Kolesnick RN (1991) Characterization of a ceramide-Activated protein kinase: stimulation by tumor necrosis factor alpha. Proc Natl Acad Sci USA 88(22):10009-10013
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.22 , pp. 10009-10013
    • Mathias, S.1    Dressler, K.A.2    Kolesnick, R.N.3
  • 15
  • 16
    • 0037135626 scopus 로고    scopus 로고
    • The Ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • 10.1074/jbc.R200008200 12011103 1:CAS:528:DC%2BD38XlsFKrs74%3D 10.1074/jbc.R200008200
    • Hannun YA, Obeid LM (2002) The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277(29):25847-25850. doi: 10.1074/jbc.R200008200
    • (2002) J Biol Chem , vol.277 , Issue.29 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 17
    • 33847644133 scopus 로고    scopus 로고
    • On the presence of C2-ceramide in mammalian tissues: Possible relationship to etherphospholipids and phosphorylation by ceramide kinase
    • 10.1515/BC.2007.035 17338639 10.1515/BC.2007.035 1:CAS:528: DC%2BD2sXjtFyntbg%3D
    • Van Overloop H, Denizot Y, Baes M, Van Veldhoven PP (2007) On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. Biol Chem 388(3):315-324. doi: 10.1515/BC.2007.035
    • (2007) Biol Chem , vol.388 , Issue.3 , pp. 315-324
    • Van Overloop, H.1    Denizot, Y.2    Baes, M.3    Van Veldhoven, P.P.4
  • 18
    • 33646179776 scopus 로고    scopus 로고
    • Detergent-resistant, ceramide-enriched domains in sphingomyelin/ceramide bilayers
    • 10.1529/biophysj.105.067710 16284266 1:CAS:528:DC%2BD28XhtFGhs7s%3D 10.1529/biophysj.105.067710
    • Sot J, Bagatolli LA, Goni FM, Alonso A (2006) Detergent-resistant, ceramide-enriched domains in sphingomyelin/ceramide bilayers. Biophys J 90(3):903-914. doi: 10.1529/biophysj.105.067710
    • (2006) Biophys J , vol.90 , Issue.3 , pp. 903-914
    • Sot, J.1    Bagatolli, L.A.2    Goni, F.M.3    Alonso, A.4
  • 19
    • 0033029496 scopus 로고    scopus 로고
    • Use of sphingolipid analogs: Benefits and risks
    • 10395962 1:CAS:528:DyaK1MXltVyrsb8%3D 10.1016/S1388-1981(99)00074-8 S1388-1981(99)00074-8
    • Ghidoni R, Sala G, Giuliani A (1999) Use of sphingolipid analogs: benefits and risks. Biochim Biophys Acta 1439(1):17-39 S1388-1981(99)00074-8
    • (1999) Biochim Biophys Acta , vol.1439 , Issue.1 , pp. 17-39
    • Ghidoni, R.1    Sala, G.2    Giuliani, A.3
  • 20
    • 0034612304 scopus 로고    scopus 로고
    • Ceramide interaction with the respiratory chain of heart mitochondria
    • 10828984 10.1021/bi9924415 1:CAS:528:DC%2BD3cXjtVKntLY%3D pii: bi9924415
    • Di Paola M, Cocco T, Lorusso M (2000) Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 39(22):6660-6668 pii: bi9924415
    • (2000) Biochemistry , vol.39 , Issue.22 , pp. 6660-6668
    • Di Paola, M.1    Cocco, T.2    Lorusso, M.3
  • 21
    • 84943997802 scopus 로고
    • Elastic properties of lipid bilayers: Theory and possible experiments
    • 4273690 1:CAS:528:DyaE2cXnvFersA%3D%3D
    • Helfrich W (1973) Elastic properties of lipid bilayers: theory and possible experiments. Z Naturforsch C 28(11):693-703
    • (1973) Z Naturforsch C , vol.28 , Issue.11 , pp. 693-703
    • Helfrich, W.1
  • 22
    • 22744442219 scopus 로고    scopus 로고
    • ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif
    • 10.1038/sj.emboj.7600714 15944734 1:CAS:528:DC%2BD2MXlvVWqtr0%3D 10.1038/sj.emboj.7600714
    • Bigay J, Casella JF, Drin G, Mesmin B, Antonny B (2005) ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif. EMBO J 24(13):2244-2253. doi: 10.1038/sj.emboj.7600714
    • (2005) EMBO J , vol.24 , Issue.13 , pp. 2244-2253
    • Bigay, J.1    Casella, J.F.2    Drin, G.3    Mesmin, B.4    Antonny, B.5
  • 23
    • 2942555022 scopus 로고    scopus 로고
    • Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling
    • 10.1073/pnas.0400553101 15155902 1:CAS:528:DC%2BD2cXkvFOmsL0%3D 10.1073/pnas.0400553101
    • Jao CC, Der-Sarkissian A, Chen J, Langen R (2004) Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proc Natl Acad Sci USA 101(22):8331-8336. doi: 10.1073/pnas.0400553101
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.22 , pp. 8331-8336
    • Jao, C.C.1    Der-Sarkissian, A.2    Chen, J.3    Langen, R.4
  • 24
    • 0032939644 scopus 로고    scopus 로고
    • Ceramides in phospholipid membranes: Effects on bilayer stability and transition to nonlamellar phases
    • 10.1016/S0006-3495(99)77201-2 9876146 1:CAS:528:DyaK1MXjsFOlug%3D%3D 10.1016/S0006-3495(99)77201-2
    • Veiga MP, Arrondo JL, Goni FM, Alonso A (1999) Ceramides in phospholipid membranes: effects on bilayer stability and transition to nonlamellar phases. Biophys J 76(1 Pt 1):342-350. doi: 10.1016/S0006-3495(99)77201-2
    • (1999) Biophys J , vol.76 , Issue.1 PART 1 , pp. 342-350
    • Veiga, M.P.1    Arrondo, J.L.2    Goni, F.M.3    Alonso, A.4
  • 25
    • 0032535156 scopus 로고    scopus 로고
    • Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
    • 10.1021/bi980915e 9860872 1:CAS:528:DyaK1cXnsVGgurY%3D 10.1021/bi980915e
    • Holopainen JM, Subramanian M, Kinnunen PK (1998) Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. Biochemistry 37(50):17562-17570. doi: 10.1021/bi980915e
    • (1998) Biochemistry , vol.37 , Issue.50 , pp. 17562-17570
    • Holopainen, J.M.1    Subramanian, M.2    Kinnunen, P.K.3
  • 26
    • 0030868488 scopus 로고    scopus 로고
    • Lipid microdomains in dimyristoylphosphatidylcholine-ceramide liposomes
    • 9297850 1:CAS:528:DyaK2sXltl2ktbw%3D 10.1016/S0009-3084(97)00040-6 pii: S0009-3084(97)00040-6
    • Holopainen JM, Lehtonen JY, Kinnunen PK (1997) Lipid microdomains in dimyristoylphosphatidylcholine-ceramide liposomes. Chem Phys Lipids 88(1):1-13 pii: S0009-3084(97)00040-6
    • (1997) Chem Phys Lipids , vol.88 , Issue.1 , pp. 1-13
    • Holopainen, J.M.1    Lehtonen, J.Y.2    Kinnunen, P.K.3
  • 27
    • 0030743667 scopus 로고    scopus 로고
    • Measurement of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles
    • 10.1021/bi970145r 9220970 1:CAS:528:DyaK2sXkt1Ghsbs%3D 10.1021/bi970145r
    • Bai J, Pagano RE (1997) Measurement of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles. Biochemistry 36(29):8840-8848. doi: 10.1021/bi970145r
    • (1997) Biochemistry , vol.36 , Issue.29 , pp. 8840-8848
    • Bai, J.1    Pagano, R.E.2
  • 28
    • 0347611095 scopus 로고    scopus 로고
    • Molecular machinery for non-vesicular trafficking of ceramide
    • 10.1038/nature02188 14685229 1:CAS:528:DC%2BD3sXpvVGmtL8%3D 10.1038/nature02188
    • Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide. Nature 426(6968):803-809. doi: 10.1038/nature02188
    • (2003) Nature , vol.426 , Issue.6968 , pp. 803-809
    • Hanada, K.1    Kumagai, K.2    Yasuda, S.3    Miura, Y.4    Kawano, M.5    Fukasawa, M.6    Nishijima, M.7
  • 29
    • 19444377889 scopus 로고    scopus 로고
    • Molecular associations and surface-Active properties of short- and long-N-Acyl chain ceramides
    • 10.1016/j.bbamem.2005.02.014 15904658 1:CAS:528:DC%2BD2MXkt1Gjs7g%3D 10.1016/j.bbamem.2005.02.014
    • Sot J, Goni FM, Alonso A (2005) Molecular associations and surface-Active properties of short- and long-N-Acyl chain ceramides. Biochim Biophys Acta 1711(1):12-19. doi: 10.1016/j.bbamem.2005.02.014
    • (2005) Biochim Biophys Acta , vol.1711 , Issue.1 , pp. 12-19
    • Sot, J.1    Goni, F.M.2    Alonso, A.3
  • 30
    • 0027179487 scopus 로고
    • Phospholipids in animal eukaryotic membranes: Transverse asymmetry and movement
    • 8363559 1:CAS:528:DyaK3sXltlemu7w%3D
    • Zachowski A (1993) Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement. Biochem J 294(Pt 1):1-14
    • (1993) Biochem J , vol.294 , Issue.PART 1 , pp. 1-14
    • Zachowski, A.1
  • 32
    • 0014876152 scopus 로고
    • Sphingolipid long chain bases
    • 4921900 1:CAS:528:DyaE3MXivVWhtw%3D%3D 10.1007/BF02531119
    • Karlsson KA (1970) Sphingolipid long chain bases. Lipids 5(11):878-891
    • (1970) Lipids , vol.5 , Issue.11 , pp. 878-891
    • Karlsson, K.A.1
  • 33
    • 41449099770 scopus 로고    scopus 로고
    • Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: Inside-out sphingolipidomics
    • 10.1016/S0076-6879(07)32004-1 17954214 1:CAS:528:DC%2BD1cXhsVeru7o%3D 10.1016/S0076-6879(07)32004-1
    • Sullards MC, Allegood JC, Kelly S, Wang E, Haynes CA, Park H, Chen Y, Merrill AH Jr (2007) Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: inside-out sphingolipidomics. Methods Enzymol 432:83-115. doi: 10.1016/S0076-6879(07)32004- 1
    • (2007) Methods Enzymol , vol.432 , pp. 83-115
    • Sullards, M.C.1    Allegood, J.C.2    Kelly, S.3    Wang, E.4    Haynes, C.A.5    Park, H.6    Chen, Y.7    Merrill, Jr.A.H.8
  • 34
    • 0035158236 scopus 로고    scopus 로고
    • Parameters related to lipid metabolism as markers of myelination in mouse brain
    • 11145980 1:CAS:528:DC%2BD3MXhtVGlsL4%3D 10.1046/j.1471-4159.2001.00015.x
    • Muse ED, Jurevics H, Toews AD, Matsushima GK, Morell P (2001) Parameters related to lipid metabolism as markers of myelination in mouse brain. J Neurochem 76(1):77-86
    • (2001) J Neurochem , vol.76 , Issue.1 , pp. 77-86
    • Muse, E.D.1    Jurevics, H.2    Toews, A.D.3    Matsushima, G.K.4    Morell, P.5
  • 35
    • 0035933702 scopus 로고    scopus 로고
    • Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-Acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids
    • 10.1074/jbc.M011369200 11283017 1:CAS:528:DC%2BD3MXkvVant7g%3D 10.1074/jbc.M011369200
    • Togayachi A, Akashima T, Ookubo R, Kudo T, Nishihara S, Iwasaki H, Natsume A, Mio H, Inokuchi J, Irimura T, Sasaki K, Narimatsu H (2001) Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-Acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. J Biol Chem 276(25):22032-22040. doi: 10.1074/jbc.M011369200
    • (2001) J Biol Chem , vol.276 , Issue.25 , pp. 22032-22040
    • Togayachi, A.1    Akashima, T.2    Ookubo, R.3    Kudo, T.4    Nishihara, S.5    Iwasaki, H.6    Natsume, A.7    Mio, H.8    Inokuchi, J.9    Irimura, T.10    Sasaki, K.11    Narimatsu, H.12
  • 36
    • 0035839524 scopus 로고    scopus 로고
    • Cloning of a mouse beta 1,3 N-Acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis
    • 10.1074/jbc.M102979200 11384981 1:CAS:528:DC%2BD3MXmtFeht70%3D 10.1074/jbc.M102979200
    • Henion TR, Zhou D, Wolfer DP, Jungalwala FB, Hennet T (2001) Cloning of a mouse beta 1,3 N-Acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. J Biol Chem 276(32):30261-30269. doi: 10.1074/jbc.M102979200
    • (2001) J Biol Chem , vol.276 , Issue.32 , pp. 30261-30269
    • Henion, T.R.1    Zhou, D.2    Wolfer, D.P.3    Jungalwala, F.B.4    Hennet, T.5
  • 37
    • 0027429271 scopus 로고
    • Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling
    • 8396311 1:CAS:528:DyaK3sXmtVSitr0%3D
    • Hakomori S, Igarashi Y (1993) Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. Adv Lipid Res 25:147-162
    • (1993) Adv Lipid Res , vol.25 , pp. 147-162
    • Hakomori, S.1    Igarashi, Y.2
  • 38
    • 0026500351 scopus 로고
    • Glycolipid expression in prostatic tissue and analysis of the antigen recognized by antiprostatic monoclonal antibody APG1
    • 1376009 1:CAS:528:DyaK3sXpvFWrtQ%3D%3D 10.1159/000282290
    • Satoh M, Fukushi Y, Kawamura S, Ohyama C, Saito S, Orikasa S, Nudleman E, Hakamori S (1992) Glycolipid expression in prostatic tissue and analysis of the antigen recognized by antiprostatic monoclonal antibody APG1. Urol Int 48(1):20-24
    • (1992) Urol Int , vol.48 , Issue.1 , pp. 20-24
    • Satoh, M.1    Fukushi, Y.2    Kawamura, S.3    Ohyama, C.4    Saito, S.5    Orikasa, S.6    Nudleman, E.7    Hakamori, S.8
  • 39
    • 0037762571 scopus 로고    scopus 로고
    • Biosynthesis and degradation of mammalian glycosphingolipids
    • 10.1098/rstb.2003.1265 12803917 1:CAS:528:DC%2BD3sXlsFeru7s%3D 10.1098/rstb.2003.1265
    • Sandhoff K, Kolter T (2003) Biosynthesis and degradation of mammalian glycosphingolipids. Philos Trans R Soc Lond B Biol Sci 358(1433):847-861. doi: 10.1098/rstb.2003.1265
    • (2003) Philos Trans R Soc Lond B Biol Sci , vol.358 , Issue.1433 , pp. 847-861
    • Sandhoff, K.1    Kolter, T.2
  • 40
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • 8943189 1:CAS:528:DyaK28XnsFGisrc%3D 10.1126/science.274.5294.1855
    • Hannun YA (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274(5294):1855-1859
    • (1996) Science , vol.274 , Issue.5294 , pp. 1855-1859
    • Hannun, Y.A.1
  • 41
    • 0026712872 scopus 로고
    • Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-Acyltransferase in mouse liver
    • 1317856 1:CAS:528:DyaK38Xlt1ymt7c%3D
    • Mandon EC, Ehses I, Rother J, van Echten G, Sandhoff K (1992) Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-Acyltransferase in mouse liver. J Biol Chem 267(16):11144-11148
    • (1992) J Biol Chem , vol.267 , Issue.16 , pp. 11144-11148
    • Mandon, E.C.1    Ehses, I.2    Rother, J.3    Van Echten, G.4    Sandhoff, K.5
  • 42
    • 4544261024 scopus 로고    scopus 로고
    • Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-Associated membrane) and/or mitochondria?
    • 10.1042/BJ20031819 15144238 1:CAS:528:DC%2BD2cXmvVOntrk%3D
    • Bionda C, Portoukalian J, Schmitt D, Rodriguez-Lafrasse C, Ardail D (2004) Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-Associated membrane) and/or mitochondria? Biochem J 382(Pt 2):527-533. doi: 10.1042/BJ20031819
    • (2004) Biochem J , vol.382 , Issue.PART 2 , pp. 527-533
    • Bionda, C.1    Portoukalian, J.2    Schmitt, D.3    Rodriguez-Lafrasse, C.4    Ardail, D.5
  • 43
    • 0031800791 scopus 로고    scopus 로고
    • Partial purification and characterization of sphingosine N-Acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
    • 9655376 1:CAS:528:DyaK1cXktVShs70%3D 10.1007/s11745-998-0246-2
    • Shimeno H, Soeda S, Sakamoto M, Kouchi T, Kowakame T, Kihara T (1998) Partial purification and characterization of sphingosine N-Acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction. Lipids 33(6):601-605
    • (1998) Lipids , vol.33 , Issue.6 , pp. 601-605
    • Shimeno, H.1    Soeda, S.2    Sakamoto, M.3    Kouchi, T.4    Kowakame, T.5    Kihara, T.6
  • 44
    • 0035093829 scopus 로고    scopus 로고
    • Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type i
    • 10.1038/85879 11242114 1:CAS:528:DC%2BD3MXhslOju7c%3D 10.1038/85879
    • Dawkins JL, Hulme DJ, Brahmbhatt SB, Auer-Grumbach M, Nicholson GA (2001) Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I. Nat Genet 27(3):309-312. doi: 10.1038/85879
    • (2001) Nat Genet , vol.27 , Issue.3 , pp. 309-312
    • Dawkins, J.L.1    Hulme, D.J.2    Brahmbhatt, S.B.3    Auer-Grumbach, M.4    Nicholson, G.A.5
  • 45
    • 0016256120 scopus 로고
    • Studies on the desaturation of sphinganine. Ceramide and sphingomyelin metabolism in the rat and in BHK 21 cells in tissue culture
    • 4435766 1:CAS:528:DyaE2MXivFSnsQ%3D%3D 10.1515/bchm2.1974.355.2.911
    • Stoffel W, Bister K (1974) Studies on the desaturation of sphinganine. Ceramide and sphingomyelin metabolism in the rat and in BHK 21 cells in tissue culture. Hoppe Seylers Z Physiol Chem 355(8):911-923
    • (1974) Hoppe Seylers Z Physiol Chem , vol.355 , Issue.8 , pp. 911-923
    • Stoffel, W.1    Bister, K.2
  • 46
    • 33748746334 scopus 로고    scopus 로고
    • When do Lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis
    • 10.1074/jbc.R600010200 16793762 1:CAS:528:DC%2BD28XoslKmurg%3D 10.1074/jbc.R600010200
    • Pewzner-Jung Y, Ben-Dor S, Futerman AH (2006) When do Lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis. J Biol Chem 281(35):25001-25005. doi: 10.1074/jbc.R600010200
    • (2006) J Biol Chem , vol.281 , Issue.35 , pp. 25001-25005
    • Pewzner-Jung, Y.1    Ben-Dor, S.2    Futerman, A.H.3
  • 47
    • 0242353271 scopus 로고    scopus 로고
    • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors
    • 10.1074/jbc.M307104200 12912983 1:CAS:528:DC%2BD3sXosFSrs7g%3D 10.1074/jbc.M307104200
    • Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH (2003) Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem 278(44):43452-43459. doi: 10.1074/jbc.M307104200
    • (2003) J Biol Chem , vol.278 , Issue.44 , pp. 43452-43459
    • Riebeling, C.1    Allegood, J.C.2    Wang, E.3    Merrill, Jr.A.H.4    Futerman, A.H.5
  • 48
    • 26644468150 scopus 로고    scopus 로고
    • LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor
    • 10.1074/jbc.M506485200 16100120 1:CAS:528:DC%2BD2MXhtVKisbvI 10.1074/jbc.M506485200
    • Lahiri S, Futerman AH (2005) LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem 280(40):33735-33738. doi: 10.1074/jbc.M506485200
    • (2005) J Biol Chem , vol.280 , Issue.40 , pp. 33735-33738
    • Lahiri, S.1    Futerman, A.H.2
  • 50
    • 0040333713 scopus 로고    scopus 로고
    • Lipid distribution and transport across cellular membranes
    • 10.1006/scdb.2000.0231 11292380 1:CAS:528:DC%2BD3MXis1Sis7s%3D 10.1006/scdb.2000.0231
    • Pomorski T, Hrafnsdottir S, Devaux PF, van Meer G (2001) Lipid distribution and transport across cellular membranes. Semin Cell Dev Biol 12(2):139-148. doi: 10.1006/scdb.2000.0231
    • (2001) Semin Cell Dev Biol , vol.12 , Issue.2 , pp. 139-148
    • Pomorski, T.1    Hrafnsdottir, S.2    Devaux, P.F.3    Van Meer, G.4
  • 51
    • 0027346611 scopus 로고
    • Ganglioside metabolism-topology and regulation
    • 8379447 1:CAS:528:DyaK3sXmtVSitrs%3D
    • Sandhoff K, van Echten G (1993) Ganglioside metabolism-topology and regulation. Adv Lipid Res 26:119-142
    • (1993) Adv Lipid Res , vol.26 , pp. 119-142
    • Sandhoff, K.1    Van Echten, G.2
  • 52
    • 0026552908 scopus 로고
    • Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions
    • 1532799 1:CAS:528:DyaK38XitFWlt7w%3D 10.1083/jcb.117.2.259
    • Jeckel D, Karrenbauer A, Burger KN, van Meer G, Wieland F (1992) Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. J Cell Biol 117(2):259-267
    • (1992) J Cell Biol , vol.117 , Issue.2 , pp. 259-267
    • Jeckel, D.1    Karrenbauer, A.2    Burger, K.N.3    Van Meer, G.4    Wieland, F.5
  • 55
    • 0028288399 scopus 로고
    • Lactosylceramide is synthesized in the lumen of the Golgi apparatus
    • 8143857 1:CAS:528:DyaK2cXkslOhsr4%3D 10.1016/0014-5793(94)80591-1
    • Lannert H, Bunning C, Jeckel D, Wieland FT (1994) Lactosylceramide is synthesized in the lumen of the Golgi apparatus. FEBS Lett 342(1):91-96
    • (1994) FEBS Lett , vol.342 , Issue.1 , pp. 91-96
    • Lannert, H.1    Bunning, C.2    Jeckel, D.3    Wieland, F.T.4
  • 56
    • 0033593788 scopus 로고    scopus 로고
    • Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells
    • 10037789 1:CAS:528:DyaK1MXhvVWms7c%3D 10.1083/jcb.144.4.673
    • Fukasawa M, Nishijima M, Hanada K (1999) Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells. J Cell Biol 144(4):673-685
    • (1999) J Cell Biol , vol.144 , Issue.4 , pp. 673-685
    • Fukasawa, M.1    Nishijima, M.2    Hanada, K.3
  • 57
    • 0034730746 scopus 로고    scopus 로고
    • Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells
    • 10.1074/jbc.M004470200 10882735 1:CAS:528:DC%2BD3cXnt1ahtb8%3D 10.1074/jbc.M004470200
    • Funakoshi T, Yasuda S, Fukasawa M, Nishijima M, Hanada K (2000) Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells. J Biol Chem 275(39):29938-29945. doi: 10.1074/jbc.M004470200
    • (2000) J Biol Chem , vol.275 , Issue.39 , pp. 29938-29945
    • Funakoshi, T.1    Yasuda, S.2    Fukasawa, M.3    Nishijima, M.4    Hanada, K.5
  • 58
    • 0034717903 scopus 로고    scopus 로고
    • Sphingolipid transport in eukaryotic cells
    • 10856719 10.1016/S1388-1981(00)00054-8 pii: S1388-1981(00)00054-8
    • van Meer G, Holthuis JC (2000) Sphingolipid transport in eukaryotic cells. Biochim Biophys Acta 1486(1):145-170 pii: S1388-1981(00)00054-8
    • (2000) Biochim Biophys Acta , vol.1486 , Issue.1 , pp. 145-170
    • Van Meer, G.1    Holthuis, J.C.2
  • 59
    • 14844332032 scopus 로고    scopus 로고
    • CERT mediates intermembrane transfer of various molecular species of ceramides
    • 10.1074/jbc.M409290200 15596449 1:CAS:528:DC%2BD2MXhsV2qs7g%3D 10.1074/jbc.M409290200
    • Kumagai K, Yasuda S, Okemoto K, Nishijima M, Kobayashi S, Hanada K (2005) CERT mediates intermembrane transfer of various molecular species of ceramides. J Biol Chem 280(8):6488-6495. doi: 10.1074/jbc.M409290200
    • (2005) J Biol Chem , vol.280 , Issue.8 , pp. 6488-6495
    • Kumagai, K.1    Yasuda, S.2    Okemoto, K.3    Nishijima, M.4    Kobayashi, S.5    Hanada, K.6
  • 60
    • 34547453153 scopus 로고    scopus 로고
    • Ceramide transfer protein function is essential for normal oxidative stress response and lifespan
    • 10.1073/pnas.0705049104 17592126 1:CAS:528:DC%2BD2sXnvFOmsrk%3D 10.1073/pnas.0705049104
    • Rao RP, Yuan C, Allegood JC, Rawat SS, Edwards MB, Wang X, Merrill AH Jr, Acharya U, Acharya JK (2007) Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Proc Natl Acad Sci USA 104(27):11364-11369. doi: 10.1073/pnas.0705049104
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.27 , pp. 11364-11369
    • Rao, R.P.1    Yuan, C.2    Allegood, J.C.3    Rawat, S.S.4    Edwards, M.B.5    Wang, X.6    Merrill, Jr.A.H.7    Acharya, U.8    Acharya, J.K.9
  • 63
    • 50649122795 scopus 로고    scopus 로고
    • Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development
    • 10.1074/jbc.M801806200 18424781 1:CAS:528:DC%2BD1cXotlOhsrc%3D 10.1074/jbc.M801806200
    • Granero-Molto F, Sarmah S, O'Rear L, Spagnoli A, Abrahamson D, Saus J, Hudson BG, Knapik EW (2008) Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development. J Biol Chem 283(29):20495-20504. doi: 10.1074/jbc.M801806200
    • (2008) J Biol Chem , vol.283 , Issue.29 , pp. 20495-20504
    • Granero-Molto, F.1    Sarmah, S.2    O'Rear, L.3    Spagnoli, A.4    Abrahamson, D.5    Saus, J.6    Hudson, B.G.7    Knapik, E.W.8
  • 65
    • 0034704149 scopus 로고    scopus 로고
    • Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis
    • 10.1074/jbc.M002769200 11007769 1:CAS:528:DC%2BD3MXhsFekuw%3D%3D 10.1074/jbc.M002769200
    • Raya A, Revert-Ros F, Martinez-Martinez P, Navarro S, Rosello E, Vieites B, Granero F, Forteza J, Saus J (2000) Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis. J Biol Chem 275(51):40392-40399. doi: 10.1074/jbc.M002769200
    • (2000) J Biol Chem , vol.275 , Issue.51 , pp. 40392-40399
    • Raya, A.1    Revert-Ros, F.2    Martinez-Martinez, P.3    Navarro, S.4    Rosello, E.5    Vieites, B.6    Granero, F.7    Forteza, J.8    Saus, J.9
  • 66
    • 0036729568 scopus 로고    scopus 로고
    • Apoptosis and autoimmunity
    • 12440240
    • Zandman-Goddard G, Blank M (2002) Apoptosis and autoimmunity. Isr Med Assoc J 4(9):722-724
    • (2002) Isr Med Assoc J , vol.4 , Issue.9 , pp. 722-724
    • Zandman-Goddard, G.1    Blank, M.2
  • 67
    • 0015987808 scopus 로고
    • The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver
    • 4817756 1:CAS:528:DyaE2cXhsVWqtbk%3D
    • Ullman MD, Radin NS (1974) The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver. J Biol Chem 249(5):1506-1512
    • (1974) J Biol Chem , vol.249 , Issue.5 , pp. 1506-1512
    • Ullman, M.D.1    Radin, N.S.2
  • 68
    • 0842263750 scopus 로고    scopus 로고
    • Identification of a family of animal sphingomyelin synthases
    • 10.1038/sj.emboj.7600034 14685263 1:CAS:528:DC%2BD2cXhtVequr4%3D 10.1038/sj.emboj.7600034
    • Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC (2004) Identification of a family of animal sphingomyelin synthases. EMBO J 23(1):33-44. doi: 10.1038/sj.emboj.7600034
    • (2004) EMBO J , vol.23 , Issue.1 , pp. 33-44
    • Huitema, K.1    Van Den Dikkenberg, J.2    Brouwers, J.F.3    Holthuis, J.C.4
  • 69
    • 0025019247 scopus 로고
    • Sphingomyelin is synthesized in the cis Golgi
    • 2155131 1:CAS:528:DyaK3cXhslCiu7c%3D 10.1016/0014-5793(90)80659-7
    • Jeckel D, Karrenbauer A, Birk R, Schmidt RR, Wieland F (1990) Sphingomyelin is synthesized in the cis Golgi. FEBS Lett 261(1):155-157
    • (1990) FEBS Lett , vol.261 , Issue.1 , pp. 155-157
    • Jeckel, D.1    Karrenbauer, A.2    Birk, R.3    Schmidt, R.R.4    Wieland, F.5
  • 70
    • 0025323167 scopus 로고
    • Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus
    • 2187869 1:CAS:528:DyaK3cXksFCntb0%3D
    • Futerman AH, Stieger B, Hubbard AL, Pagano RE (1990) Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. J Biol Chem 265(15):8650-8657
    • (1990) J Biol Chem , vol.265 , Issue.15 , pp. 8650-8657
    • Futerman, A.H.1    Stieger, B.2    Hubbard, A.L.3    Pagano, R.E.4
  • 71
    • 33749576963 scopus 로고    scopus 로고
    • The multigenic sphingomyelin synthase family
    • 10.1074/jbc.R600021200 16905542 1:CAS:528:DC%2BD28XhtVahsLnF 10.1074/jbc.R600021200
    • Tafesse FG, Ternes P, Holthuis JC (2006) The multigenic sphingomyelin synthase family. J Biol Chem 281(40):29421-29425. doi: 10.1074/jbc.R600021200
    • (2006) J Biol Chem , vol.281 , Issue.40 , pp. 29421-29425
    • Tafesse, F.G.1    Ternes, P.2    Holthuis, J.C.3
  • 72
    • 0035937146 scopus 로고    scopus 로고
    • Interfacial regulation of acid ceramidase activity. Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins
    • 10.1074/jbc.M006846200 11104761 1:CAS:528:DC%2BD3MXhs1Kmt7o%3D 10.1074/jbc.M006846200
    • Linke T, Wilkening G, Sadeghlar F, Mozcall H, Bernardo K, Schuchman E, Sandhoff K (2001) Interfacial regulation of acid ceramidase activity. Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins. J Biol Chem 276(8):5760-5768. doi: 10.1074/jbc.M006846200
    • (2001) J Biol Chem , vol.276 , Issue.8 , pp. 5760-5768
    • Linke, T.1    Wilkening, G.2    Sadeghlar, F.3    Mozcall, H.4    Bernardo, K.5    Schuchman, E.6    Sandhoff, K.7
  • 73
    • 0025316462 scopus 로고
    • Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases
    • 2111818
    • van Echten G, Birk R, Brenner-Weiss G, Schmidt RR, Sandhoff K (1990) Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. J Biol Chem 265(16):9333-9339
    • (1990) J Biol Chem , vol.265 , Issue.16 , pp. 9333-9339
    • Van Echten, G.1    Birk, R.2    Brenner-Weiss, G.3    Schmidt, R.R.4    Sandhoff, K.5
  • 74
    • 0032497837 scopus 로고    scopus 로고
    • The role of ceramide in cell signaling
    • 9838138 1:CAS:528:DyaK1cXns1Klurg%3D S0005-2760(98)00145-3
    • Perry DK, Hannun YA (1998) The role of ceramide in cell signaling. Biochim Biophys Acta 1436(1-2):233-243 S0005-2760(98)00145-3
    • (1998) Biochim Biophys Acta , vol.1436 , Issue.1-2 , pp. 233-243
    • Perry, D.K.1    Hannun, Y.A.2
  • 75
    • 1542358155 scopus 로고    scopus 로고
    • Ceramide synthesis and metabolism as a target for cancer therapy
    • 10.1016/j.canlet.2003.08.034 15013522 1:CAS:528:DC%2BD2cXhvFaiu7c%3D 10.1016/j.canlet.2003.08.034
    • Reynolds CP, Maurer BJ, Kolesnick RN (2004) Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett 206(2):169-180. doi: 10.1016/j.canlet.2003.08.034
    • (2004) Cancer Lett , vol.206 , Issue.2 , pp. 169-180
    • Reynolds, C.P.1    Maurer, B.J.2    Kolesnick, R.N.3
  • 76
    • 0028124202 scopus 로고
    • Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
    • 8307965 1:CAS:528:DyaK2cXitFWiu7c%3D
    • Okazaki T, Bielawska A, Domae N, Bell RM, Hannun YA (1994) Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 269(6):4070-4077
    • (1994) J Biol Chem , vol.269 , Issue.6 , pp. 4070-4077
    • Okazaki, T.1    Bielawska, A.2    Domae, N.3    Bell, R.M.4    Hannun, Y.A.5
  • 77
    • 0032579258 scopus 로고    scopus 로고
    • Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development
    • 9446580 1:CAS:528:DyaK1cXnvFSmtg%3D%3D 10.1074/jbc.273.5.2738
    • Schissel SL, Jiang X, Tweedie-Hardman J, Jeong T, Camejo EH, Najib J, Rapp JH, Williams KJ, Tabas I (1998) Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development. J Biol Chem 273(5):2738-2746
    • (1998) J Biol Chem , vol.273 , Issue.5 , pp. 2738-2746
    • Schissel, S.L.1    Jiang, X.2    Tweedie-Hardman, J.3    Jeong, T.4    Camejo, E.H.5    Najib, J.6    Rapp, J.H.7    Williams, K.J.8    Tabas, I.9
  • 78
    • 0014027891 scopus 로고
    • Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain
    • 5916388 1:CAS:528:DyaF28XksVSiu70%3D
    • Barnholz Y, Roitman A, Gatt S (1966) Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain. J Biol Chem 241(16):3731-3737
    • (1966) J Biol Chem , vol.241 , Issue.16 , pp. 3731-3737
    • Barnholz, Y.1    Roitman, A.2    Gatt, S.3
  • 79
    • 0029014350 scopus 로고
    • Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)
    • 7600574 1:CAS:528:DyaK2MXms1Kmt74%3D 10.1016/S0092-8674(05)80010-8 pii: S0092-8674(05)80010-8
    • Otterbach B, Stoffel W (1995) Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease). Cell 81(7):1053-1061 pii: S0092-8674(05)80010-8
    • (1995) Cell , vol.81 , Issue.7 , pp. 1053-1061
    • Otterbach, B.1    Stoffel, W.2
  • 80
    • 0024478236 scopus 로고
    • 2+-stimulated sphingomyelinase in fetal bovine serum
    • 2538416 1:CAS:528:DyaL1MXhvVygsr4%3D
    • 2+-stimulated sphingomyelinase in fetal bovine serum. J Biol Chem 264(10):5358-5363
    • (1989) J Biol Chem , vol.264 , Issue.10 , pp. 5358-5363
    • Spence, M.W.1    Byers, D.M.2    Palmer, F.B.3    Cook, H.W.4
  • 81
    • 0029666484 scopus 로고    scopus 로고
    • Zn-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene
    • 8702487 1:CAS:528:DyaK28XkslCju7s%3D 10.1074/jbc.271.31.18431
    • Schissel SL, Schuchman EH, Williams KJ, Tabas I (1996) Zn-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J Biol Chem 271(31):18431-18436
    • (1996) J Biol Chem , vol.271 , Issue.31 , pp. 18431-18436
    • Schissel, S.L.1    Schuchman, E.H.2    Williams, K.J.3    Tabas, I.4
  • 82
    • 0032540959 scopus 로고    scopus 로고
    • The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene
    • 9660788 1:CAS:528:DyaK1cXkvVChurs%3D 10.1074/jbc.273.29.18250
    • Schissel SL, Keesler GA, Schuchman EH, Williams KJ, Tabas I (1998) The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J Biol Chem 273(29):18250-18259
    • (1998) J Biol Chem , vol.273 , Issue.29 , pp. 18250-18259
    • Schissel, S.L.1    Keesler, G.A.2    Schuchman, E.H.3    Williams, K.J.4    Tabas, I.5
  • 83
    • 0034102425 scopus 로고    scopus 로고
    • Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase
    • 10681556 1:CAS:528:DC%2BD3cXhsFKktL0%3D 10.1074/jbc.275.8.5710
    • Tomiuk S, Zumbansen M, Stoffel W (2000) Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase. J Biol Chem 275(8):5710-5717
    • (2000) J Biol Chem , vol.275 , Issue.8 , pp. 5710-5717
    • Tomiuk, S.1    Zumbansen, M.2    Stoffel, W.3
  • 84
    • 0034598965 scopus 로고    scopus 로고
    • A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum
    • 10708753 1:CAS:528:DC%2BD3cXhsFGrsbg%3D 10.1016/S0014-5793(00)01235-7 pii: S0014-5793(00)01235-7
    • Neuberger Y, Shogomori H, Levy Z, Fainzilber M, Futerman AH (2000) A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum. FEBS Lett 469(1):44-46 pii: S0014-5793(00)01235-7
    • (2000) FEBS Lett , vol.469 , Issue.1 , pp. 44-46
    • Neuberger, Y.1    Shogomori, H.2    Levy, Z.3    Fainzilber, M.4    Futerman, A.H.5
  • 85
    • 0032584153 scopus 로고    scopus 로고
    • Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?
    • 9520418 1:CAS:528:DyaK1cXitlKjsbg%3D 10.1073/pnas.95.7.3638
    • Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W (1998) Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc Natl Acad Sci USA 95(7):3638-3643
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.7 , pp. 3638-3643
    • Tomiuk, S.1    Hofmann, K.2    Nix, M.3    Zumbansen, M.4    Stoffel, W.5
  • 86
    • 0017230986 scopus 로고
    • Solubilization of sphingomyelinase by isotonic extraction of rat brain lysosomes
    • 176324 1:CAS:528:DyaE28XhslGlurw%3D 10.1111/j.1471-4159.1976.tb04498.x
    • Gatt S, Gottesdiner T (1976) Solubilization of sphingomyelinase by isotonic extraction of rat brain lysosomes. J Neurochem 26(2):421-422
    • (1976) J Neurochem , vol.26 , Issue.2 , pp. 421-422
    • Gatt, S.1    Gottesdiner, T.2
  • 87
    • 0017183372 scopus 로고
    • Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0
    • 9463 1:CAS:528:DyaE28XlsFGmtLo%3D
    • Rao BG, Spence MW (1976) Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0. J Lipid Res 17(5):506-515
    • (1976) J Lipid Res , vol.17 , Issue.5 , pp. 506-515
    • Rao, B.G.1    Spence, M.W.2
  • 88
    • 0038529730 scopus 로고    scopus 로고
    • Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism
    • 10.1074/jbc.M212262200 12566438 1:CAS:528:DC%2BD3sXjtVSit70%3D 10.1074/jbc.M212262200
    • Marchesini N, Luberto C, Hannun YA (2003) Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem 278(16):13775-13783. doi: 10.1074/jbc.M212262200
    • (2003) J Biol Chem , vol.278 , Issue.16 , pp. 13775-13783
    • Marchesini, N.1    Luberto, C.2    Hannun, Y.A.3
  • 89
    • 33744953581 scopus 로고    scopus 로고
    • Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-Anchored protein
    • 10.1074/jbc.M511306200 16517606 1:CAS:528:DC%2BD28Xkt1ymuro%3D 10.1074/jbc.M511306200
    • Krut O, Wiegmann K, Kashkar H, Yazdanpanah B, Kronke M (2006) Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-Anchored protein. J Biol Chem 281(19):13784-13793. doi: 10.1074/jbc.M511306200
    • (2006) J Biol Chem , vol.281 , Issue.19 , pp. 13784-13793
    • Krut, O.1    Wiegmann, K.2    Kashkar, H.3    Yazdanpanah, B.4    Kronke, M.5
  • 90
    • 0032885918 scopus 로고    scopus 로고
    • Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon
    • 10522612 1:CAS:528:DyaK1MXmslGhtro%3D 10.1080/003655299750025408
    • Cheng Y, Tauschel HD, Nilsson A, Duan RD (1999) Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon. Scand J Gastroenterol 34(9):915-920
    • (1999) Scand J Gastroenterol , vol.34 , Issue.9 , pp. 915-920
    • Cheng, Y.1    Tauschel, H.D.2    Nilsson, A.3    Duan, R.D.4
  • 91
    • 0034208346 scopus 로고    scopus 로고
    • Molecular structures of proteins involved in vesicle fusion
    • 11208133 1:CAS:528:DC%2BD3cXks1yku74%3D 10.1034/j.1600-0854.2000.010605.x
    • Ybe JA, Wakeham DE, Brodsky FM, Hwang PK (2000) Molecular structures of proteins involved in vesicle fusion. Traffic 1(6):474-479
    • (2000) Traffic , vol.1 , Issue.6 , pp. 474-479
    • Ybe, J.A.1    Wakeham, D.E.2    Brodsky, F.M.3    Hwang, P.K.4
  • 92
    • 0034188945 scopus 로고    scopus 로고
    • Molecular structures of proteins involved in vesicle coat formation
    • 11208125 1:CAS:528:DC%2BD3cXktl2nu70%3D 10.1034/j.1600-0854.2000.010504.x
    • Wakeham DE, Ybe JA, Brodsky FM, Hwang PK (2000) Molecular structures of proteins involved in vesicle coat formation. Traffic 1(5):393-398
    • (2000) Traffic , vol.1 , Issue.5 , pp. 393-398
    • Wakeham, D.E.1    Ybe, J.A.2    Brodsky, F.M.3    Hwang, P.K.4
  • 93
    • 0029098277 scopus 로고
    • Differential roles of de novo sphingolipid biosynthesis and turnover in the burst of free sphingosine and sphinganine, and their 1-phosphates and N-Acyl-derivatives, that occurs upon changing the medium of cells in culture
    • 7642524 1:CAS:528:DyaK2MXnsVOjt7Y%3D 10.1074/jbc.270.32.18749
    • Smith ER, Merrill AH Jr (1995) Differential roles of de novo sphingolipid biosynthesis and turnover in the burst of free sphingosine and sphinganine, and their 1-phosphates and N-Acyl-derivatives, that occurs upon changing the medium of cells in culture. J Biol Chem 270(32):18749-18758
    • (1995) J Biol Chem , vol.270 , Issue.32 , pp. 18749-18758
    • Smith, E.R.1    Merrill, Jr.A.H.2
  • 94
    • 0031661695 scopus 로고    scopus 로고
    • Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways
    • 9675221 1:CAS:528:DyaK1cXls1OmtLo%3D 10.1093/glycob/8.9.885
    • Gillard BK, Clement RG, Marcus DM (1998) Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways. Glycobiology 8(9):885-890
    • (1998) Glycobiology , vol.8 , Issue.9 , pp. 885-890
    • Gillard, B.K.1    Clement, R.G.2    Marcus, D.M.3
  • 95
    • 0031928816 scopus 로고    scopus 로고
    • Metabolic fate of exogenous sphingosine in neuroblastoma neuro2A cells. Dose-dependence and biological effects
    • 9668342 1:CAS:528:DyaK1cXks12htbg%3D 10.1111/j.1749-6632.1998.tb09661.x
    • Riboni L, Bassi R, Caminiti A, Prinetti A, Viani P, Tettamanti G (1998) Metabolic fate of exogenous sphingosine in neuroblastoma neuro2A cells. Dose-dependence and biological effects. Ann N Y Acad Sci 845:46-56
    • (1998) Ann N y Acad Sci , vol.845 , pp. 46-56
    • Riboni, L.1    Bassi, R.2    Caminiti, A.3    Prinetti, A.4    Viani, P.5    Tettamanti, G.6
  • 96
    • 0032502854 scopus 로고    scopus 로고
    • Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue
    • 9598987 1:CAS:528:DyaK1cXitFKhtLY%3D 10.1016/S0014-5793(98)00325-1 pii: S0014-5793(98)00325-1
    • Chatelut M, Leruth M, Harzer K, Dagan A, Marchesini S, Gatt S, Salvayre R, Courtoy P, Levade T (1998) Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue. FEBS Lett 426(1):102-106 pii: S0014-5793(98)00325-1
    • (1998) FEBS Lett , vol.426 , Issue.1 , pp. 102-106
    • Chatelut, M.1    Leruth, M.2    Harzer, K.3    Dagan, A.4    Marchesini, S.5    Gatt, S.6    Salvayre, R.7    Courtoy, P.8    Levade, T.9
  • 97
    • 0034602962 scopus 로고    scopus 로고
    • Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized
    • 10652340 1:CAS:528:DC%2BD3cXhtVygt74%3D 10.1074/jbc.275.5.3462
    • Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M (2000) Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. J Biol Chem 275(5):3462-3468
    • (2000) J Biol Chem , vol.275 , Issue.5 , pp. 3462-3468
    • Tani, M.1    Okino, N.2    Mitsutake, S.3    Tanigawa, T.4    Izu, H.5    Ito, M.6
  • 98
    • 0000675223 scopus 로고
    • Enzymic Hydrolysis and Synthesis of Ceramides
    • 14081938 1:STN:280:DyaF2c%2FjvFGrsg%3D%3D
    • Gatt S (1963) Enzymic Hydrolysis and Synthesis of Ceramides. J Biol Chem 238:3131-3133
    • (1963) J Biol Chem , vol.238 , pp. 3131-3133
    • Gatt, S.1
  • 99
    • 0016682741 scopus 로고
    • Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase
    • 238641 1:CAS:528:DyaE2MXkvFChtb4%3D 10.1016/0005-2760(75)90176-9
    • Sugita M, Willians M, Dulaney JT, Moser HW (1975) Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim Biophys Acta 398(1):125-131
    • (1975) Biochim Biophys Acta , vol.398 , Issue.1 , pp. 125-131
    • Sugita, M.1    Willians, M.2    Dulaney, J.T.3    Moser, H.W.4
  • 100
    • 0035116014 scopus 로고    scopus 로고
    • Molecular analysis of acid ceramidase deficiency in patients with Farber disease
    • 10.1002/humu.5 11241842 1:CAS:528:DC%2BD3MXitF2itrc%3D 10.1002/humu.5
    • Bar J, Linke T, Ferlinz K, Neumann U, Schuchman EH, Sandhoff K (2001) Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Hum Mutat 17(3):199-209. doi: 10.1002/humu.5
    • (2001) Hum Mutat , vol.17 , Issue.3 , pp. 199-209
    • Bar, J.1    Linke, T.2    Ferlinz, K.3    Neumann, U.4    Schuchman, E.H.5    Sandhoff, K.6
  • 101
    • 0034647935 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a human mitochondrial ceramidase
    • 10.1074/jbc.M002522200 10781606 10.1074/jbc.M002522200
    • El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (2000) Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem 275(28):21508-21513. doi: 10.1074/jbc.M002522200
    • (2000) J Biol Chem , vol.275 , Issue.28 , pp. 21508-21513
    • El Bawab, S.1    Roddy, P.2    Qian, T.3    Bielawska, A.4    Lemasters, J.J.5    Hannun, Y.A.6
  • 102
    • 0842280463 scopus 로고    scopus 로고
    • The presence of ceramidase activity in liver nuclear membrane
    • 12808285 1:CAS:528:DC%2BD3sXls1Kns74%3D 10.1248/bpb.26.775
    • Shiraishi T, Imai S, Uda Y (2003) The presence of ceramidase activity in liver nuclear membrane. Biol Pharm Bull 26(6):775-779
    • (2003) Biol Pharm Bull , vol.26 , Issue.6 , pp. 775-779
    • Shiraishi, T.1    Imai, S.2    Uda, Y.3
  • 103
    • 0033600850 scopus 로고    scopus 로고
    • Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain
    • 10488143 10.1074/jbc.274.39.27948
    • El Bawab S, Bielawska A, Hannun YA (1999) Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. J Biol Chem 274(39):27948-27955
    • (1999) J Biol Chem , vol.274 , Issue.39 , pp. 27948-27955
    • El Bawab, S.1    Bielawska, A.2    Hannun, Y.A.3
  • 104
    • 0035854766 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide
    • 10.1074/jbc.M102818200 11356846 1:CAS:528:DC%2BD3MXlsVKntLc%3D 10.1074/jbc.M102818200
    • Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (2001) Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem 276(28):26577-26588. doi: 10.1074/jbc.M102818200
    • (2001) J Biol Chem , vol.276 , Issue.28 , pp. 26577-26588
    • Mao, C.1    Xu, R.2    Szulc, Z.M.3    Bielawska, A.4    Galadari, S.H.5    Obeid, L.M.6
  • 105
    • 0036375662 scopus 로고    scopus 로고
    • Mitochondria and ceramide: Intertwined roles in regulation of apoptosis
    • 12123710 1:CAS:528:DC%2BD3sXoslyjsw%3D%3D 10.1016/S0065-2571(01)00026-7 pii: S0065257101000267
    • Birbes H, El Bawab S, Obeid LM, Hannun YA (2002) Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul 42:113-129 pii: S0065257101000267
    • (2002) Adv Enzyme Regul , vol.42 , pp. 113-129
    • Birbes, H.1    El Bawab, S.2    Obeid, L.M.3    Hannun, Y.A.4
  • 106
    • 0007715611 scopus 로고
    • Enzymic hydrolysis of sphingolipids: Hydrolysis of ceramide lactoside by an enzyme from rat brain
    • 16742444 1:CAS:528:DyaF28XltV2ntbg%3D
    • Gatt S, Rapport MM (1966) Enzymic hydrolysis of sphingolipids: Hydrolysis of ceramide lactoside by an enzyme from rat brain. Biochem J 101(3):680-686
    • (1966) Biochem J , vol.101 , Issue.3 , pp. 680-686
    • Gatt, S.1    Rapport, M.M.2
  • 107
    • 0035907364 scopus 로고    scopus 로고
    • Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase
    • 10.1074/jbc.M009331200 11278489 10.1074/jbc.M009331200
    • El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA (2001) Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem 276(20):16758-16766. doi: 10.1074/jbc.M009331200
    • (2001) J Biol Chem , vol.276 , Issue.20 , pp. 16758-16766
    • El Bawab, S.1    Birbes, H.2    Roddy, P.3    Szulc, Z.M.4    Bielawska, A.5    Hannun, Y.A.6
  • 108
    • 26444453262 scopus 로고    scopus 로고
    • Mitochondrial ceramide and the induction of apoptosis
    • 10.1007/s10863-005-6567-7 16167171 1:CAS:528:DC%2BD2MXhtVWiu77K 10.1007/s10863-005-6567-7
    • Siskind LJ (2005) Mitochondrial ceramide and the induction of apoptosis. J Bioenerg Biomembr 37(3):143-153. doi: 10.1007/s10863-005-6567-7
    • (2005) J Bioenerg Biomembr , vol.37 , Issue.3 , pp. 143-153
    • Siskind, L.J.1
  • 109
    • 0028128763 scopus 로고
    • Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
    • 8077214 1:CAS:528:DyaK2cXmtVWmsr4%3D
    • Ghosh TK, Bian J, Gill DL (1994) Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J Biol Chem 269(36):22628-22635
    • (1994) J Biol Chem , vol.269 , Issue.36 , pp. 22628-22635
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 110
    • 0033230364 scopus 로고    scopus 로고
    • Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
    • 10545499 1:CAS:528:DC%2BD3cXislyru7s%3D 10.1083/jcb.147.3.545
    • Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S (1999) Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 147(3):545-558
    • (1999) J Cell Biol , vol.147 , Issue.3 , pp. 545-558
    • Olivera, A.1    Kohama, T.2    Edsall, L.3    Nava, V.4    Cuvillier, O.5    Poulton, S.6    Spiegel, S.7
  • 111
    • 0014833032 scopus 로고
    • Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-Al and ethanolamine phosphate
    • 4317971 1:CAS:528:DyaE3cXkvFClu7w%3D 10.1515/bchm2.1970.351.2.1041
    • Stoffel W, Assmann G (1970) Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-Al and ethanolamine phosphate. Hoppe Seylers Z Physiol Chem 351(8):1041-1049
    • (1970) Hoppe Seylers Z Physiol Chem , vol.351 , Issue.8 , pp. 1041-1049
    • Stoffel, W.1    Assmann, G.2
  • 112
    • 0026726492 scopus 로고
    • Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide
    • 1400321 1:CAS:528:DyaK38XlsV2jtrc%3D
    • Ballou LR, Chao CP, Holness MA, Barker SC, Raghow R (1992) Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J Biol Chem 267(28):20044-20050
    • (1992) J Biol Chem , vol.267 , Issue.28 , pp. 20044-20050
    • Ballou, L.R.1    Chao, C.P.2    Holness, M.A.3    Barker, S.C.4    Raghow, R.5
  • 113
    • 0037401876 scopus 로고    scopus 로고
    • Signaling and biological actions of sphingosine 1-phosphate
    • 12676514 1:CAS:528:DC%2BD3sXisFWlsb8%3D 10.1016/S1043-6618(03)00046-X pii: S104366180300046X
    • Hla T (2003) Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res 47(5):401-407 pii: S104366180300046X
    • (2003) Pharmacol Res , vol.47 , Issue.5 , pp. 401-407
    • Hla, T.1
  • 114
    • 0029948396 scopus 로고    scopus 로고
    • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    • 10.1038/381800a0 8657285 1:CAS:528:DyaK28XjvVKnsro%3D 10.1038/381800a0
    • Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381(6585):800-803. doi: 10.1038/381800a0
    • (1996) Nature , vol.381 , Issue.6585 , pp. 800-803
    • Cuvillier, O.1    Pirianov, G.2    Kleuser, B.3    Vanek, P.G.4    Coso, O.A.5    Gutkind, S.6    Spiegel, S.7
  • 115
    • 0027434784 scopus 로고
    • The role of sphingosine in cell growth regulation and transmembrane signaling
    • 8368147 1:CAS:528:DyaK3sXmtVSitrw%3D
    • Spiegel S, Olivera A, Carlson RO (1993) The role of sphingosine in cell growth regulation and transmembrane signaling. Adv Lipid Res 25:105-129
    • (1993) Adv Lipid Res , vol.25 , pp. 105-129
    • Spiegel, S.1    Olivera, A.2    Carlson, R.O.3
  • 116
    • 0037189475 scopus 로고    scopus 로고
    • Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization
    • 10.1074/jbc.M201535200 11956206 1:CAS:528:DC%2BD38XltF2nsLo%3D 10.1074/jbc.M201535200
    • Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T (2002) Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem 277(26):23294-23300. doi: 10.1074/jbc.M201535200
    • (2002) J Biol Chem , vol.277 , Issue.26 , pp. 23294-23300
    • Sugiura, M.1    Kono, K.2    Liu, H.3    Shimizugawa, T.4    Minekura, H.5    Spiegel, S.6    Kohama, T.7
  • 117
    • 0024373904 scopus 로고
    • Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles
    • 2547795 1:CAS:528:DyaL1MXls12rsL0%3D
    • Bajjalieh SM, Martin TF, Floor E (1989) Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles. J Biol Chem 264(24):14354-14360
    • (1989) J Biol Chem , vol.264 , Issue.24 , pp. 14354-14360
    • Bajjalieh, S.M.1    Martin, T.F.2    Floor, E.3
  • 118
    • 0025185675 scopus 로고
    • Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity
    • 2172234 1:CAS:528:DyaK3cXmtVOhsLo%3D
    • Kolesnick RN, Hemer MR (1990) Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity. J Biol Chem 265(31):18803-18808
    • (1990) J Biol Chem , vol.265 , Issue.31 , pp. 18803-18808
    • Kolesnick, R.N.1    Hemer, M.R.2
  • 119
    • 38449122262 scopus 로고    scopus 로고
    • Ceramide kinase and ceramide-1-phosphate
    • 10.1016/S0076-6879(07)34015-9 17954253 1:CAS:528:DC%2BD1cXhtlyjt7s%3D 10.1016/S0076-6879(07)34015-9
    • Wijesinghe DS, Lamour NF, Gomez-Munoz A, Chalfant CE (2007) Ceramide kinase and ceramide-1-phosphate. Methods Enzymol 434:265-292. doi: 10.1016/S0076-6879(07)34015-9
    • (2007) Methods Enzymol , vol.434 , pp. 265-292
    • Wijesinghe, D.S.1    Lamour, N.F.2    Gomez-Munoz, A.3    Chalfant, C.E.4
  • 120
    • 0842282983 scopus 로고    scopus 로고
    • Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages
    • 10.1194/jlr.M300158-JLR200 14523050 1:CAS:528:DC%2BD2cXhsVSksbw%3D 10.1194/jlr.M300158-JLR200
    • Gomez-Munoz A, Kong JY, Salh B, Steinbrecher UP (2004) Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res 45(1):99-105. doi: 10.1194/jlr.M300158-JLR200
    • (2004) J Lipid Res , vol.45 , Issue.1 , pp. 99-105
    • Gomez-Munoz, A.1    Kong, J.Y.2    Salh, B.3    Steinbrecher, U.P.4
  • 122
    • 74249101513 scopus 로고    scopus 로고
    • Gomez-Munoz A Activation of protein kinase C-Alpha is essential for stimulation of cell proliferation by ceramide 1-phosphate
    • doi: 10.1016/j.febslet.2009.11.086
    • Gangoiti P, Granado MH, Arana L, Ouro A, Gomez-Munoz A Activation of protein kinase C-Alpha is essential for stimulation of cell proliferation by ceramide 1-phosphate. FEBS Lett 584 (3):517-524. doi: 10.1016/j.febslet.2009.11. 086
    • FEBS Lett , vol.584 , Issue.3 , pp. 517-524
    • Gangoiti, P.1    Granado, M.H.2    Arana, L.3    Ouro, A.4
  • 123
    • 0032739251 scopus 로고    scopus 로고
    • Ceramide kinase
    • 10563327 1:CAS:528:DC%2BD3cXms1Kqtw%3D%3D 10.1016/S0076-6879(00)11083-3
    • Bajjalieh S, Batchelor R (2000) Ceramide kinase. Methods Enzymol 311:207-215
    • (2000) Methods Enzymol , vol.311 , pp. 207-215
    • Bajjalieh, S.1    Batchelor, R.2
  • 124
    • 2342418547 scopus 로고    scopus 로고
    • Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells
    • 10.1074/jbc.M312885200 14769792 1:CAS:528:DC%2BD2cXjt1GntLo%3D 10.1074/jbc.M312885200
    • Mitsutake S, Kim TJ, Inagaki Y, Kato M, Yamashita T, Igarashi Y (2004) Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells. J Biol Chem 279(17):17570-17577. doi: 10.1074/jbc.M312885200
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17570-17577
    • Mitsutake, S.1    Kim, T.J.2    Inagaki, Y.3    Kato, M.4    Yamashita, T.5    Igarashi, Y.6
  • 125
    • 0027430787 scopus 로고
    • Ceramide 1-phosphate phosphatase activity in brain
    • 8245978 1:CAS:528:DyaK2cXivVSjsQ%3D%3D 10.1111/j.1471-4159.1993.tb07470.x
    • Shinghal R, Scheller RH, Bajjalieh SM (1993) Ceramide 1-phosphate phosphatase activity in brain. J Neurochem 61(6):2279-2285
    • (1993) J Neurochem , vol.61 , Issue.6 , pp. 2279-2285
    • Shinghal, R.1    Scheller, R.H.2    Bajjalieh, S.M.3
  • 126
    • 34548177098 scopus 로고    scopus 로고
    • Ceramide kinase uses ceramide provided by ceramide transport protein: Localization to organelles of eicosanoid synthesis
    • 10.1194/jlr.M700083-JLR200 17392267 1:CAS:528:DC%2BD2sXmtFGmt7s%3D 10.1194/jlr.M700083-JLR200
    • Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH Jr, Cho W, Chalfant CE (2007) Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. J Lipid Res 48(6):1293-1304. doi: 10.1194/jlr.M700083-JLR200
    • (2007) J Lipid Res , vol.48 , Issue.6 , pp. 1293-1304
    • Lamour, N.F.1    Stahelin, R.V.2    Wijesinghe, D.S.3    MacEyka, M.4    Wang, E.5    Allegood, J.C.6    Merrill, Jr.A.H.7    Cho, W.8    Chalfant, C.E.9
  • 127
    • 43749105380 scopus 로고    scopus 로고
    • Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: Comparative analysis to glucosylceramide and sphingomyelin
    • 10.1074/jbc.M707107200 18086664 1:CAS:528:DC%2BD1cXjsFCgsbo%3D 10.1074/jbc.M707107200
    • Boath A, Graf C, Lidome E, Ullrich T, Nussbaumer P, Bornancin F (2008) Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin. J Biol Chem 283(13):8517-8526. doi: 10.1074/jbc.M707107200
    • (2008) J Biol Chem , vol.283 , Issue.13 , pp. 8517-8526
    • Boath, A.1    Graf, C.2    Lidome, E.3    Ullrich, T.4    Nussbaumer, P.5    Bornancin, F.6
  • 128
    • 0034733910 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: Signaling inside and out
    • 10878250 1:CAS:528:DC%2BD3cXktlKqsbs%3D 10.1016/S0014-5793(00)01670-7 pii: S0014-5793(00)01670-7
    • Spiegel S, Milstien S (2000) Sphingosine-1-phosphate: signaling inside and out. FEBS Lett 476(1-2):55-57 pii: S0014-5793(00)01670-7
    • (2000) FEBS Lett , vol.476 , Issue.1-2 , pp. 55-57
    • Spiegel, S.1    Milstien, S.2
  • 129
    • 35649010379 scopus 로고    scopus 로고
    • Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function
    • 10.1016/j.semcdb.2007.07.010 17764993 1:CAS:528:DC%2BD2sXht1KjsbbF 10.1016/j.semcdb.2007.07.010
    • Sengupta P, Baird B, Holowka D (2007) Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function. Semin Cell Dev Biol 18(5):583-590. doi: 10.1016/j.semcdb.2007.07.010
    • (2007) Semin Cell Dev Biol , vol.18 , Issue.5 , pp. 583-590
    • Sengupta, P.1    Baird, B.2    Holowka, D.3
  • 130
    • 0032421354 scopus 로고    scopus 로고
    • Functions of lipid rafts in biological membranes
    • 10.1146/annurev.cellbio.14.1.111 9891780 1:CAS:528:DyaK1cXnvFyju7w%3D 10.1146/annurev.cellbio.14.1.111
    • Brown DA, London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111-136. doi: 10.1146/annurev.cellbio.14.1. 111
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 111-136
    • Brown, D.A.1    London, E.2
  • 131
    • 0024448087 scopus 로고
    • Lipid traffic in animal cells
    • 10.1146/annurev.cb.05.110189.001335 2688705 10.1146/annurev.cb.05.110189. 001335
    • van Meer G (1989) Lipid traffic in animal cells. Annu Rev Cell Biol 5:247-275. doi: 10.1146/annurev.cb.05.110189.001335
    • (1989) Annu Rev Cell Biol , vol.5 , pp. 247-275
    • Van Meer, G.1
  • 132
    • 0018369993 scopus 로고
    • Lipid asymmetry in membranes
    • 10.1146/annurev.bi.48.070179.000403 382989 1:CAS:528:DyaE1MXltVersrc%3D 10.1146/annurev.bi.48.070179.000403
    • Op den Kamp JA (1979) Lipid asymmetry in membranes. Annu Rev Biochem 48:47-71. doi: 10.1146/annurev.bi.48.070179.000403
    • (1979) Annu Rev Biochem , vol.48 , pp. 47-71
    • Op Den Kamp, J.A.1
  • 133
    • 0037401639 scopus 로고    scopus 로고
    • The roles of ceramide and complex sphingolipids in neuronal cell function
    • 12676515 1:CAS:528:DC%2BD3sXisFWlsbw%3D 10.1016/S1043-6618(03)00049-5 pii: S1043661803000495
    • Buccoliero R, Futerman AH (2003) The roles of ceramide and complex sphingolipids in neuronal cell function. Pharmacol Res 47(5):409-419 pii: S1043661803000495
    • (2003) Pharmacol Res , vol.47 , Issue.5 , pp. 409-419
    • Buccoliero, R.1    Futerman, A.H.2
  • 134
    • 0031888219 scopus 로고    scopus 로고
    • Gangliosides and glycosphingolipids of peripheral nervous system myelins-A minireview
    • 9482242 1:CAS:528:DyaK1cXos1Chsw%3D%3D 10.1023/A:1022497114813
    • Ogawa-Goto K, Abe T (1998) Gangliosides and glycosphingolipids of peripheral nervous system myelins-A minireview. Neurochem Res 23(3):305-310
    • (1998) Neurochem Res , vol.23 , Issue.3 , pp. 305-310
    • Ogawa-Goto, K.1    Abe, T.2
  • 135
    • 0032863720 scopus 로고    scopus 로고
    • Structure of dipalmitoylphosphatidylcholine/cholesterol bilayer at low and high cholesterol concentrations: Molecular dynamics simulation
    • 10.1016/S0006-3495(99)77049-9 10512828 1:CAS:528:DyaK1MXmtl2mtrw%3D 10.1016/S0006-3495(99)77049-9
    • Smondyrev AM, Berkowitz ML (1999) Structure of dipalmitoylphosphatidylcholine/cholesterol bilayer at low and high cholesterol concentrations: molecular dynamics simulation. Biophys J 77(4):2075-2089. doi: 10.1016/S0006-3495(99)77049-9
    • (1999) Biophys J , vol.77 , Issue.4 , pp. 2075-2089
    • Smondyrev, A.M.1    Berkowitz, M.L.2
  • 136
    • 0037201936 scopus 로고    scopus 로고
    • Role of sphingomyelinase and ceramide in modulating rafts: Do biophysical properties determine biologic outcome?
    • 12401201 1:CAS:528:DC%2BD38XotVOjtLs%3D 10.1016/S0014-5793(02)03489-0 pii: S0014579302034890
    • Cremesti AE, Goni FM, Kolesnick R (2002) Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? FEBS Lett 531(1):47-53 pii: S0014579302034890
    • (2002) FEBS Lett , vol.531 , Issue.1 , pp. 47-53
    • Cremesti, A.E.1    Goni, F.M.2    Kolesnick, R.3
  • 137
    • 1842482773 scopus 로고    scopus 로고
    • Model systems, lipid rafts, and cell membranes
    • 10.1146/annurev.biophys.32.110601.141803 15139814 1:CAS:528: DC%2BD2cXltlKkt78%3D 10.1146/annurev.biophys.32.110601.141803
    • Simons K, Vaz WL (2004) Model systems, lipid rafts, and cell membranes. Annu Rev Biophys Biomol Struct 33:269-295. doi: 10.1146/annurev.biophys.32. 110601.141803
    • (2004) Annu Rev Biophys Biomol Struct , vol.33 , pp. 269-295
    • Simons, K.1    Vaz, W.L.2
  • 138
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • 10.1038/42408 9177342 1:CAS:528:DyaK2sXktFCitrk%3D 10.1038/42408
    • Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387(6633):569-572. doi: 10.1038/42408
    • (1997) Nature , vol.387 , Issue.6633 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 139
    • 0036667737 scopus 로고    scopus 로고
    • Insights into lipid raft structure and formation from experiments in model membranes
    • 12163071 1:CAS:528:DC%2BD38XlvF2rtbs%3D 10.1016/S0959-440X(02)00351-2 pii: S0959440X02003512
    • London E (2002) Insights into lipid raft structure and formation from experiments in model membranes. Curr Opin Struct Biol 12(4):480-486 pii: S0959440X02003512
    • (2002) Curr Opin Struct Biol , vol.12 , Issue.4 , pp. 480-486
    • London, E.1
  • 140
    • 0028151351 scopus 로고
    • Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-Anchored proteins: GPI-Anchored proteins in liposomes and cells show similar behavior
    • 7991596 1:CAS:528:DyaK2MXisFyqu7k%3D 10.1073/pnas.91.25.12130
    • Schroeder R, London E, Brown D (1994) Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-Anchored proteins: GPI-Anchored proteins in liposomes and cells show similar behavior. Proc Natl Acad Sci USA 91(25):12130-12134
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.25 , pp. 12130-12134
    • Schroeder, R.1    London, E.2    Brown, D.3
  • 141
    • 0034611005 scopus 로고    scopus 로고
    • Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
    • 10704449 1:CAS:528:DC%2BD3cXhslans7s%3D 10.1083/jcb.148.5.997
    • Pralle A, Keller P, Florin EL, Simons K, Horber JK (2000) Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol 148(5):997-1008
    • (2000) J Cell Biol , vol.148 , Issue.5 , pp. 997-1008
    • Pralle, A.1    Keller, P.2    Florin, E.L.3    Simons, K.4    Horber, J.K.5
  • 142
    • 29144483525 scopus 로고    scopus 로고
    • Toward understanding the dynamics of membrane-raft-based molecular interactions
    • 10.1016/j.bbamcr.2005.10.001 16368465 1:CAS:528:DC%2BD2MXhtlCqtLvN 10.1016/j.bbamcr.2005.10.001
    • Kusumi A, Suzuki K (2005) Toward understanding the dynamics of membrane-raft-based molecular interactions. Biochim Biophys Acta 1746(3):234-251. doi: 10.1016/j.bbamcr.2005.10.001
    • (2005) Biochim Biophys Acta , vol.1746 , Issue.3 , pp. 234-251
    • Kusumi, A.1    Suzuki, K.2
  • 144
    • 0026512314 scopus 로고
    • Sorting of GPI-Anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
    • 1531449 1:CAS:528:DyaK38Xht1Gntbc%3D 10.1016/0092-8674(92)90189-J pii: 0092-8674(92)90189-J
    • Brown DA, Rose JK (1992) Sorting of GPI-Anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68(3):533-544 pii: 0092-8674(92)90189-J
    • (1992) Cell , vol.68 , Issue.3 , pp. 533-544
    • Brown, D.A.1    Rose, J.K.2
  • 145
    • 22744437388 scopus 로고    scopus 로고
    • Detergent-resistant membranes should not be identified with membrane rafts
    • 10.1016/j.tibs.2005.06.004 15996869 1:CAS:528:DC%2BD2MXmvVChs7s%3D 10.1016/j.tibs.2005.06.004
    • Lichtenberg D, Goni FM, Heerklotz H (2005) Detergent-resistant membranes should not be identified with membrane rafts. Trends Biochem Sci 30(8):430-436. doi: 10.1016/j.tibs.2005.06.004
    • (2005) Trends Biochem Sci , vol.30 , Issue.8 , pp. 430-436
    • Lichtenberg, D.1    Goni, F.M.2    Heerklotz, H.3
  • 146
    • 20444404267 scopus 로고    scopus 로고
    • Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells
    • 10.1016/j.cell.2005.04.009 15960980 1:CAS:528:DC%2BD2MXls1GksLw%3D 10.1016/j.cell.2005.04.009
    • Douglass AD, Vale RD (2005) Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell 121(6):937-950. doi: 10.1016/j.cell.2005. 04.009
    • (2005) Cell , vol.121 , Issue.6 , pp. 937-950
    • Douglass, A.D.1    Vale, R.D.2
  • 147
    • 0031750335 scopus 로고    scopus 로고
    • Lipid domain structure of the plasma membrane revealed by patching of membrane components
    • 9585412 1:CAS:528:DyaK1cXjt1Knsro%3D 10.1083/jcb.141.4.929
    • Harder T, Scheiffele P, Verkade P, Simons K (1998) Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol 141(4):929-942
    • (1998) J Cell Biol , vol.141 , Issue.4 , pp. 929-942
    • Harder, T.1    Scheiffele, P.2    Verkade, P.3    Simons, K.4
  • 148
    • 0346997045 scopus 로고    scopus 로고
    • The fence and picket structure of the plasma membrane of live cells as revealed by single molecule techniques (Review)
    • 12745919 1:CAS:528:DC%2BD3sXkslahur0%3D 10.1080/0968768021000055698 pii: 2V247XX9PK6UGLGK
    • Ritchie K, Iino R, Fujiwara T, Murase K, Kusumi A (2003) The fence and picket structure of the plasma membrane of live cells as revealed by single molecule techniques (Review). Mol Membr Biol 20(1):13-18 pii: 2V247XX9PK6UGLGK
    • (2003) Mol Membr Biol , vol.20 , Issue.1 , pp. 13-18
    • Ritchie, K.1    Iino, R.2    Fujiwara, T.3    Murase, K.4    Kusumi, A.5
  • 149
    • 0033759973 scopus 로고    scopus 로고
    • Membrane dynamics in endocytosis: Structure-function relationship
    • 11208063 10.1034/j.1600-0854.2000.010112.x pii: tra010112
    • Gagescu R, Gruenberg J, Smythe E (2000) Membrane dynamics in endocytosis: structure-function relationship. Traffic 1(1):84-88 pii: tra010112
    • (2000) Traffic , vol.1 , Issue.1 , pp. 84-88
    • Gagescu, R.1    Gruenberg, J.2    Smythe, E.3
  • 150
    • 0035947599 scopus 로고    scopus 로고
    • Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes
    • 10.1074/jbc.M101113200 11279173 1:CAS:528:DC%2BD3MXktFWmtbw%3D 10.1074/jbc.M101113200
    • Dermine JF, Duclos S, Garin J, St-Louis F, Rea S, Parton RG, Desjardins M (2001) Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. J Biol Chem 276(21):18507-18512. doi: 10.1074/jbc.M101113200
    • (2001) J Biol Chem , vol.276 , Issue.21 , pp. 18507-18512
    • Dermine, J.F.1    Duclos, S.2    Garin, J.3    St-Louis, F.4    Rea, S.5    Parton, R.G.6    Desjardins, M.7
  • 151
    • 0036683515 scopus 로고    scopus 로고
    • Differential sorting and fate of endocytosed GPI-Anchored proteins
    • 10.1093/emboj/cdf398 12145200 1:CAS:528:DC%2BD38XnvVGntb0%3D 10.1093/emboj/cdf398
    • Fivaz M, Vilbois F, Thurnheer S, Pasquali C, Abrami L, Bickel PE, Parton RG, van der Goot FG (2002) Differential sorting and fate of endocytosed GPI-Anchored proteins. EMBO J 21(15):3989-4000. doi: 10.1093/emboj/cdf398
    • (2002) EMBO J , vol.21 , Issue.15 , pp. 3989-4000
    • Fivaz, M.1    Vilbois, F.2    Thurnheer, S.3    Pasquali, C.4    Abrami, L.5    Bickel, P.E.6    Parton, R.G.7    Van Der Goot, F.G.8
  • 152
    • 2342494362 scopus 로고    scopus 로고
    • Lipid rafts and apical membrane traffic
    • 15153431 10.1196/annals.1294.017 1:CAS:528:DC%2BD2cXkvVehtr4%3D
    • Fullekrug J, Simons K (2004) Lipid rafts and apical membrane traffic. Ann N Y Acad Sci 1014:164-169
    • (2004) Ann N y Acad Sci , vol.1014 , pp. 164-169
    • Fullekrug, J.1    Simons, K.2
  • 153
    • 0021272476 scopus 로고
    • Detection of membrane cholesterol by filipin in isolated rat liver coated vesicles is dependent upon removal of the clathrin coat
    • 6145719 1:CAS:528:DyaL2cXkvVKjt7k%3D 10.1083/jcb.99.1.315
    • Steer CJ, Bisher M, Blumenthal R, Steven AC (1984) Detection of membrane cholesterol by filipin in isolated rat liver coated vesicles is dependent upon removal of the clathrin coat. J Cell Biol 99(1 Pt 1):315-319
    • (1984) J Cell Biol , vol.99 , Issue.1 PART 1 , pp. 315-319
    • Steer, C.J.1    Bisher, M.2    Blumenthal, R.3    Steven, A.C.4
  • 154
    • 0027155888 scopus 로고
    • Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: A cytochemical freeze-fracture study
    • 8371064 1:CAS:528:DyaK3sXlsFOlsL4%3D
    • Coxey RA, Pentchev PG, Campbell G, Blanchette-Mackie EJ (1993) Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: a cytochemical freeze-fracture study. J Lipid Res 34(7):1165-1176
    • (1993) J Lipid Res , vol.34 , Issue.7 , pp. 1165-1176
    • Coxey, R.A.1    Pentchev, P.G.2    Campbell, G.3    Blanchette-Mackie, E.J.4
  • 155
    • 38049011141 scopus 로고    scopus 로고
    • Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
    • 10.1371/journal.pone.0000851 17786222 10.1371/journal.pone.0000851 1:CAS:528:DC%2BD2sXhtFGnurbF
    • Sobo K, Le Blanc I, Luyet PP, Fivaz M, Ferguson C, Parton RG, Gruenberg J, van der Goot FG (2007) Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking. PLoS ONE 2(9):e851. doi: 10.1371/journal.pone.0000851
    • (2007) PLoS ONE , vol.2 , Issue.9 , pp. 851
    • Sobo, K.1    Le Blanc, I.2    Luyet, P.P.3    Fivaz, M.4    Ferguson, C.5    Parton, R.G.6    Gruenberg, J.7    Van Der Goot, F.G.8
  • 156
    • 0037084502 scopus 로고    scopus 로고
    • Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex
    • 11865038 1:CAS:528:DC%2BD38Xit1Gisbo%3D
    • Eberle HB, Serrano RL, Fullekrug J, Schlosser A, Lehmann WD, Lottspeich F, Kaloyanova D, Wieland FT, Helms JB (2002) Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. J Cell Sci 115(Pt 4):827-838
    • (2002) J Cell Sci , vol.115 , Issue.PART 4 , pp. 827-838
    • Eberle, H.B.1    Serrano, R.L.2    Fullekrug, J.3    Schlosser, A.4    Lehmann, W.D.5    Lottspeich, F.6    Kaloyanova, D.7    Wieland, F.T.8    Helms, J.B.9
  • 157
    • 33845309656 scopus 로고    scopus 로고
    • Lipid rafts, detergent-resistant membranes, and raft targeting signals
    • 10.1152/physiol.00032.2006 1:CAS:528:DC%2BD2sXitF2nug%3D%3D 10.1152/physiol.00032.2006
    • Brown DA (2006) Lipid rafts, detergent-resistant membranes, and raft targeting signals. Physiology (Bethesda) 21:430-439. doi: 10.1152/physiol.00032. 2006
    • (2006) Physiology (Bethesda) , vol.21 , pp. 430-439
    • Brown, D.A.1
  • 158
    • 0035903231 scopus 로고    scopus 로고
    • Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains
    • 10.1074/jbc.M102039200 11406621 1:CAS:528:DC%2BD3MXmsVaqt7o%3D 10.1074/jbc.M102039200
    • Abrami L, Fivaz M, Kobayashi T, Kinoshita T, Parton RG, van der Goot FG (2001) Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains. J Biol Chem 276(33):30729-30736. doi: 10.1074/jbc.M102039200
    • (2001) J Biol Chem , vol.276 , Issue.33 , pp. 30729-30736
    • Abrami, L.1    Fivaz, M.2    Kobayashi, T.3    Kinoshita, T.4    Parton, R.G.5    Van Der Goot, F.G.6
  • 159
    • 0035859804 scopus 로고    scopus 로고
    • Flotillas of lipid rafts fore and aft
    • 10.1073/pnas.181353098 11504934 1:CAS:528:DC%2BD3MXmtlCnt7c%3D 10.1073/pnas.181353098
    • Pierini LM, Maxfield FR (2001) Flotillas of lipid rafts fore and aft. Proc Natl Acad Sci USA 98(17):9471-9473. doi: 10.1073/pnas.181353098
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.17 , pp. 9471-9473
    • Pierini, L.M.1    Maxfield, F.R.2
  • 160
    • 0034304851 scopus 로고    scopus 로고
    • Lipid rafts and signal transduction
    • 10.1038/35036052 11413487 1:CAS:528:DC%2BD3MXivVGjtbo%3D 10.1038/35036052
    • Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1(1):31-39. doi: 10.1038/35036052
    • (2000) Nat Rev Mol Cell Biol , vol.1 , Issue.1 , pp. 31-39
    • Simons, K.1    Toomre, D.2
  • 161
    • 0038527555 scopus 로고    scopus 로고
    • Membrane raft microdomains mediate front-rear polarity in migrating cells
    • 10.1093/emboj/18.22.6211 10562533 1:CAS:528:DyaK1MXns1OrsLg%3D 10.1093/emboj/18.22.6211
    • Manes S, Mira E, Gomez-Mouton C, Lacalle RA, Keller P, Labrador JP, Martinez AC (1999) Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J 18(22):6211-6220. doi: 10.1093/emboj/18.22.6211
    • (1999) EMBO J , vol.18 , Issue.22 , pp. 6211-6220
    • Manes, S.1    Mira, E.2    Gomez-Mouton, C.3    Lacalle, R.A.4    Keller, P.5    Labrador, J.P.6    Martinez, A.C.7
  • 162
    • 0038050291 scopus 로고    scopus 로고
    • Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review)
    • 12893531 1:CAS:528:DC%2BD3sXmtVelu7w%3D pii: PTRP84BE92YEE71X
    • Holthuis JC, van Meer G, Huitema K (2003) Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review). Mol Membr Biol 20(3):231-241 pii: PTRP84BE92YEE71X
    • (2003) Mol Membr Biol , vol.20 , Issue.3 , pp. 231-241
    • Holthuis, J.C.1    Van Meer, G.2    Huitema, K.3
  • 163
    • 1842484428 scopus 로고    scopus 로고
    • Lipid rafts and the regulation of exocytosis
    • 10.1111/j.1600-0854.2004.0162.x 15030567 10.1111/j.1600-0854.2004.0162.x
    • Salaun C, James DJ, Chamberlain LH (2004) Lipid rafts and the regulation of exocytosis. Traffic 5(4):255-264. doi: 10.1111/j.1600-0854.2004.0162.x
    • (2004) Traffic , vol.5 , Issue.4 , pp. 255-264
    • Salaun, C.1    James, D.J.2    Chamberlain, L.H.3
  • 164
    • 21244500528 scopus 로고    scopus 로고
    • Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells
    • 10.1074/jbc.M501923200 15769746 10.1074/jbc.M501923200 1:CAS:528:DC%2BD2MXktFyms70%3D
    • Salaun C, Gould GW, Chamberlain LH (2005) Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells. J Biol Chem 280(20):19449-19453. doi: 10.1074/jbc.M501923200
    • (2005) J Biol Chem , vol.280 , Issue.20 , pp. 19449-19453
    • Salaun, C.1    Gould, G.W.2    Chamberlain, L.H.3
  • 165
    • 0035793590 scopus 로고    scopus 로고
    • Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway
    • 10.1074/jbc.M007717200 11073951 1:CAS:528:DC%2BD3MXhtFWjtbg%3D 10.1074/jbc.M007717200
    • Mendez AJ, Lin G, Wade DP, Lawn RM, Oram JF (2001) Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway. J Biol Chem 276(5):3158-3166. doi: 10.1074/jbc.M007717200
    • (2001) J Biol Chem , vol.276 , Issue.5 , pp. 3158-3166
    • Mendez, A.J.1    Lin, G.2    Wade, D.P.3    Lawn, R.M.4    Oram, J.F.5
  • 166
    • 0037036135 scopus 로고    scopus 로고
    • A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains
    • 10.1126/science.1068886 12052946 1:CAS:528:DC%2BD38Xktl2rt78%3D 10.1126/science.1068886
    • Anderson RG, Jacobson K (2002) A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296(5574):1821-1825. doi: 10.1126/science.1068886
    • (2002) Science , vol.296 , Issue.5574 , pp. 1821-1825
    • Anderson, R.G.1    Jacobson, K.2
  • 167
    • 74849118341 scopus 로고    scopus 로고
    • Lipid rafts as a membrane-organizing principle
    • doi: 10.1126/science.1174621
    • Lingwood D, Simons K Lipid rafts as a membrane-organizing principle. Science 327 (5961):46-50. doi: 10.1126/science.1174621
    • Science , vol.327 , Issue.5961 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 168
    • 0034531102 scopus 로고    scopus 로고
    • Functional roles of glycosphingolipids in signal transduction via lipid rafts
    • 11201786 1:CAS:528:DC%2BD3MXns1Grug%3D%3D 10.1023/A:1026576804247
    • Kasahara K, Sanai Y (2000) Functional roles of glycosphingolipids in signal transduction via lipid rafts. Glycoconj J 17(3-4):153-162
    • (2000) Glycoconj J , vol.17 , Issue.3-4 , pp. 153-162
    • Kasahara, K.1    Sanai, Y.2
  • 169
    • 0033525077 scopus 로고    scopus 로고
    • Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated
    • 9920947 1:CAS:528:DyaK1MXhtVemtbg%3D 10.1074/jbc.274.6.3910
    • Melkonian KA, Ostermeyer AG, Chen JZ, Roth MG, Brown DA (1999) Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated. J Biol Chem 274(6):3910-3917
    • (1999) J Biol Chem , vol.274 , Issue.6 , pp. 3910-3917
    • Melkonian, K.A.1    Ostermeyer, A.G.2    Chen, J.Z.3    Roth, M.G.4    Brown, D.A.5
  • 170
    • 0033179849 scopus 로고    scopus 로고
    • Membrane microdomains and caveolae
    • 10449327 1:CAS:528:DyaK1MXls12rtrg%3D 10.1016/S0955-0674(99)80061-1 pii: cbb401
    • Kurzchalia TV, Parton RG (1999) Membrane microdomains and caveolae. Curr Opin Cell Biol 11(4):424-431 pii: cbb401
    • (1999) Curr Opin Cell Biol , vol.11 , Issue.4 , pp. 424-431
    • Kurzchalia, T.V.1    Parton, R.G.2
  • 171
    • 0036325769 scopus 로고    scopus 로고
    • Modulating signaling events in smooth muscle: Cleavage of annexin 2 abolishes its binding to lipid rafts
    • 10.1096/fj.02-0070com 12153985 1:CAS:528:DC%2BD38XlslWrs7o%3D 10.1096/fj.02-0070com
    • Babiychuk EB, Monastyrskaya K, Burkhard FC, Wray S, Draeger A (2002) Modulating signaling events in smooth muscle: cleavage of annexin 2 abolishes its binding to lipid rafts. FASEB J 16(10):1177-1184. doi: 10.1096/fj.02-0070com
    • (2002) FASEB J , vol.16 , Issue.10 , pp. 1177-1184
    • Babiychuk, E.B.1    Monastyrskaya, K.2    Burkhard, F.C.3    Wray, S.4    Draeger, A.5
  • 172
    • 29144469318 scopus 로고    scopus 로고
    • Ceramide-enriched membrane domains
    • 10.1016/j.bbamcr.2005.09.001 16226325 1:CAS:528:DC%2BD2MXhtlCqtLvJ 10.1016/j.bbamcr.2005.09.001
    • Bollinger CR, Teichgraber V, Gulbins E (2005) Ceramide-enriched membrane domains. Biochim Biophys Acta 1746(3):284-294. doi: 10.1016/j.bbamcr.2005.09.001
    • (2005) Biochim Biophys Acta , vol.1746 , Issue.3 , pp. 284-294
    • Bollinger, C.R.1    Teichgraber, V.2    Gulbins, E.3
  • 173
    • 1642293929 scopus 로고    scopus 로고
    • Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): Implications for lipid raft structure and function
    • 10.1074/jbc.M309992200 14699154 1:STN:280:DC%2BD2c7hsVSgsw%3D%3D
    • Megha London E (2004) Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function. J Biol Chem 279(11):9997-10004. doi: 10.1074/jbc.M309992200
    • (2004) J Biol Chem , vol.279 , Issue.11 , pp. 9997-10004
    • Megha, L.E.1
  • 174
    • 0037120891 scopus 로고    scopus 로고
    • Observation of topical catalysis by sphingomyelinase coupled to microspheres
    • 12371852 1:CAS:528:DC%2BD38Xns1Ckur4%3D 10.1021/ja017807r pii: ja017807r
    • Nurminen TA, Holopainen JM, Zhao H, Kinnunen PK (2002) Observation of topical catalysis by sphingomyelinase coupled to microspheres. J Am Chem Soc 124(41):12129-12134 pii: ja017807r
    • (2002) J Am Chem Soc , vol.124 , Issue.41 , pp. 12129-12134
    • Nurminen, T.A.1    Holopainen, J.M.2    Zhao, H.3    Kinnunen, P.K.4
  • 175
    • 34548486456 scopus 로고    scopus 로고
    • Effect of ceramide N-Acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts)
    • 10.1016/j.bbamem.2007.05.007 17574203 1:CAS:528:DC%2BD2sXhtVCgu7rL 10.1016/j.bbamem.2007.05.007
    • Megha Sawatzki P, Kolter T, Bittman R, London E (2007) Effect of ceramide N-Acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts). Biochim Biophys Acta 1768(9):2205-2212. doi: 10.1016/j.bbamem.2007.05.007
    • (2007) Biochim Biophys Acta , vol.1768 , Issue.9 , pp. 2205-2212
    • Megha, S.P.1    Kolter, T.2    Bittman, R.3    London, E.4
  • 176
    • 0023062987 scopus 로고
    • Inositol trisphosphate and diacylglycerol: Two interacting second messengers
    • 10.1146/annurev.bi.56.070187.001111 3304132 1:CAS:528:DyaL2sXltFWiu7s%3D 10.1146/annurev.bi.56.070187.001111
    • Berridge MJ (1987) Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu Rev Biochem 56:159-193. doi: 10.1146/annurev.bi.56.070187.001111
    • (1987) Annu Rev Biochem , vol.56 , pp. 159-193
    • Berridge, M.J.1
  • 177
    • 0343832379 scopus 로고
    • Rapid formation of diacylglycerol from phosphatidylcholine: A pathway for generation of a second messenger
    • 3462727 1:CAS:528:DyaL28Xls12mt7s%3D 10.1073/pnas.83.18.6785
    • Besterman JM, Duronio V, Cuatrecasas P (1986) Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger. Proc Natl Acad Sci USA 83(18):6785-6789
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.18 , pp. 6785-6789
    • Besterman, J.M.1    Duronio, V.2    Cuatrecasas, P.3
  • 178
    • 77954809178 scopus 로고    scopus 로고
    • Ceramide: From lateral segregation to mechanical stress
    • doi: 10.1016/j.bbamem.2009.12.007
    • Lopez-Montero I, Monroy F, Velez M, Devaux PF Ceramide: from lateral segregation to mechanical stress. Biochim Biophys Acta 1798 (7):1348-1356. doi: 10.1016/j.bbamem.2009.12.007
    • Biochim Biophys Acta , vol.1798 , Issue.7 , pp. 1348-1356
    • Lopez-Montero, I.1    Monroy, F.2    Velez, M.3    Devaux, P.F.4
  • 179
    • 34250163933 scopus 로고    scopus 로고
    • Diacylglycerols, multivalent membrane modulators
    • 10.1016/j.chemphyslip.2007.04.003 17560968 1:CAS:528:DC%2BD2sXmsFKqsLw%3D 10.1016/j.chemphyslip.2007.04.003
    • Gomez-Fernandez JC, Corbalan-Garcia S (2007) Diacylglycerols, multivalent membrane modulators. Chem Phys Lipids 148(1):1-25. doi: 10.1016/j.chemphyslip. 2007.04.003
    • (2007) Chem Phys Lipids , vol.148 , Issue.1 , pp. 1-25
    • Gomez-Fernandez, J.C.1    Corbalan-Garcia, S.2
  • 180
    • 0024582146 scopus 로고
    • Physiological levels of diacylglycerols in phospholipid membranes induce membrane fusion and stabilize inverted phases
    • 2751991 1:CAS:528:DyaL1MXhvVyju7c%3D 10.1021/bi00435a012
    • Siegel DP, Banschbach J, Alford D, Ellens H, Lis LJ, Quinn PJ, Yeagle PL, Bentz J (1989) Physiological levels of diacylglycerols in phospholipid membranes induce membrane fusion and stabilize inverted phases. Biochemistry 28(9):3703-3709
    • (1989) Biochemistry , vol.28 , Issue.9 , pp. 3703-3709
    • Siegel, D.P.1    Banschbach, J.2    Alford, D.3    Ellens, H.4    Lis, L.J.5    Quinn, P.J.6    Yeagle, P.L.7    Bentz, J.8
  • 181
    • 1842432039 scopus 로고    scopus 로고
    • Membrane domains in lymphocytes - From lipid rafts to protein scaffolds
    • 10.1111/j.1600-0854.2003.00163.x 15030568 1:CAS:528:DC%2BD2cXjtVeiurc%3D 10.1111/j.1600-0854.2003.00163.x
    • Harder T, Engelhardt KR (2004) Membrane domains in lymphocytes - from lipid rafts to protein scaffolds. Traffic 5(4):265-275. doi: 10.1111/j.1600-0854.2003.00163.x
    • (2004) Traffic , vol.5 , Issue.4 , pp. 265-275
    • Harder, T.1    Engelhardt, K.R.2
  • 182
    • 0042335762 scopus 로고    scopus 로고
    • Ceramide-mediated clustering is required for CD95-DISC formation
    • 10.1038/sj.onc.1206540 12934106 1:CAS:528:DC%2BD3sXmsFWhurk%3D 10.1038/sj.onc.1206540
    • Grassme H, Cremesti A, Kolesnick R, Gulbins E (2003) Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene 22(35):5457-5470. doi: 10.1038/sj.onc.1206540
    • (2003) Oncogene , vol.22 , Issue.35 , pp. 5457-5470
    • Grassme, H.1    Cremesti, A.2    Kolesnick, R.3    Gulbins, E.4
  • 183
    • 0345130002 scopus 로고    scopus 로고
    • Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes
    • 10.1093/emboj/18.7.1761 10202140 1:CAS:528:DyaK1MXivVylu7Y%3D 10.1093/emboj/18.7.1761
    • Ledesma MD, Brugger B, Bunning C, Wieland FT, Dotti CG (1999) Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes. EMBO J 18(7):1761-1771. doi: 10.1093/emboj/18.7.1761
    • (1999) EMBO J , vol.18 , Issue.7 , pp. 1761-1771
    • Ledesma, M.D.1    Brugger, B.2    Bunning, C.3    Wieland, F.T.4    Dotti, C.G.5
  • 184
    • 0037429689 scopus 로고    scopus 로고
    • Molecular characterization of the detergent-insoluble cholesterol-rich membrane microdomain (raft) of the central nervous system
    • pii: S0005273603000233
    • Maekawa S, Iino S, Miyata S (2003) Molecular characterization of the detergent-insoluble cholesterol-rich membrane microdomain (raft) of the central nervous system. Biochim Biophys Acta 1610 (2):261-270. pii: S0005273603000233
    • (2003) Biochim Biophys Acta , vol.1610 , Issue.2 , pp. 261-270
    • Maekawa, S.1    Iino, S.2    Miyata, S.3
  • 186
    • 13844272574 scopus 로고    scopus 로고
    • Synaptic proteins and SNARE complexes are localized in lipid rafts from rat brain synaptosomes
    • 10.1016/j.bbrc.2005.01.111 15721282 1:CAS:528:DC%2BD2MXhsFSju7Y%3D 10.1016/j.bbrc.2005.01.111
    • Gil C, Soler-Jover A, Blasi J, Aguilera J (2005) Synaptic proteins and SNARE complexes are localized in lipid rafts from rat brain synaptosomes. Biochem Biophys Res Commun 329(1):117-124. doi: 10.1016/j.bbrc.2005.01.111
    • (2005) Biochem Biophys Res Commun , vol.329 , Issue.1 , pp. 117-124
    • Gil, C.1    Soler-Jover, A.2    Blasi, J.3    Aguilera, J.4
  • 187
    • 41749101449 scopus 로고    scopus 로고
    • Lipid rafts association of synaptotagmin i on synaptic vesicles
    • pii:BCM73030349
    • Lv JH, He L, Sui SF (2008) Lipid rafts association of synaptotagmin I on synaptic vesicles. Biochemistry (Mosc) 73 (3):283-288. pii:BCM73030349
    • (2008) Biochemistry (Mosc) , vol.73 , Issue.3 , pp. 283-288
    • Lv, J.H.1    He, L.2    Sui, S.F.3
  • 188
    • 0037996880 scopus 로고    scopus 로고
    • Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability
    • pii: 23/8/3262
    • Hering H, Lin CC, Sheng M (2003) Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J Neurosci 23 (8):3262-3271. pii: 23/8/3262
    • (2003) J Neurosci , vol.23 , Issue.8 , pp. 3262-3271
    • Hering, H.1    Lin, C.C.2    Sheng, M.3
  • 189
    • 0035862961 scopus 로고    scopus 로고
    • Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons
    • pii: 21/2/504
    • Bruses JL, Chauvet N, Rutishauser U (2001) Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons. J Neurosci 21 (2):504-512. pii: 21/2/504
    • (2001) J Neurosci , vol.21 , Issue.2 , pp. 504-512
    • Bruses, J.L.1    Chauvet, N.2    Rutishauser, U.3
  • 190
    • 0035178823 scopus 로고    scopus 로고
    • The gamma-Aminobutyric acid receptor B, but not the metabotropic glutamate receptor type-1, associates with lipid rafts in the rat cerebellum
    • 11723171 1:CAS:528:DC%2BD3MXosl2ksLo%3D 10.1046/j.1471-4159.2001.00614.x
    • Becher A, White JH, McIlhinney RA (2001) The gamma-Aminobutyric acid receptor B, but not the metabotropic glutamate receptor type-1, associates with lipid rafts in the rat cerebellum. J Neurochem 79(4):787-795
    • (2001) J Neurochem , vol.79 , Issue.4 , pp. 787-795
    • Becher, A.1    White, J.H.2    McIlhinney, R.A.3
  • 191
    • 0035906258 scopus 로고    scopus 로고
    • Biochemical evidence for localization of AMPA-type glutamate receptor subunits in the dendritic raft
    • pii:S0169328X01000511
    • Suzuki T, Ito J, Takagi H, Saitoh F, Nawa H, Shimizu H (2001) Biochemical evidence for localization of AMPA-type glutamate receptor subunits in the dendritic raft. Brain Res Mol Brain Res 89 (1-2):20-28. pii:S0169328X01000511
    • (2001) Brain Res Mol Brain Res , vol.89 , Issue.1-2 , pp. 20-28
    • Suzuki, T.1    Ito, J.2    Takagi, H.3    Saitoh, F.4    Nawa, H.5    Shimizu, H.6
  • 192
    • 16244400106 scopus 로고    scopus 로고
    • Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain
    • 10.1111/j.1471-4159.2004.03009.x 15773918 1:CAS:528:DC%2BD2MXjtFCgtL0%3D 10.1111/j.1471-4159.2004.03009.x
    • Besshoh S, Bawa D, Teves L, Wallace MC, Gurd JW (2005) Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain. J Neurochem 93(1):186-194. doi: 10.1111/j.1471-4159.2004.03009.x
    • (2005) J Neurochem , vol.93 , Issue.1 , pp. 186-194
    • Besshoh, S.1    Bawa, D.2    Teves, L.3    Wallace, M.C.4    Gurd, J.W.5
  • 193
    • 84954358231 scopus 로고    scopus 로고
    • The neural cell adhesion molecule NCAM and lipid rafts
    • 10.1007/s11064-008-9759-9 18548347
    • Povlsen GK, Ditlevsen DK (2008) The neural cell adhesion molecule NCAM and lipid rafts. Neurochem Res. doi: 10.1007/s11064-008-9759-9
    • (2008) Neurochem Res
    • Povlsen, G.K.1    Ditlevsen, D.K.2
  • 194
    • 0037104768 scopus 로고    scopus 로고
    • The neural cell adhesion molecule regulates cell-surface delivery of G-protein-Activated inwardly rectifying potassium channels via lipid rafts
    • 12177211 1:CAS:528:DC%2BD38XmsF2gsb8%3D pii: 2002670222/16/7154
    • Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M (2002) The neural cell adhesion molecule regulates cell-surface delivery of G-protein-Activated inwardly rectifying potassium channels via lipid rafts. J Neurosci 22(16):7154-7164 pii: 2002670222/16/7154
    • (2002) J Neurosci , vol.22 , Issue.16 , pp. 7154-7164
    • Delling, M.1    Wischmeyer, E.2    Dityatev, A.3    Sytnyk, V.4    Veh, R.W.5    Karschin, A.6    Schachner, M.7
  • 195
    • 84856454195 scopus 로고    scopus 로고
    • Building excitable membranes: Lipid rafts and multiple controls on trafficking of electrogenic molecules
    • doi: 10.1177/1073858410393977
    • Pristera A, Okuse K Building excitable membranes: lipid rafts and multiple controls on trafficking of electrogenic molecules. Neuroscientist. doi: 10.1177/1073858410393977
    • Neuroscientist
    • Pristera, A.1    Okuse, K.2
  • 196
    • 33746478573 scopus 로고    scopus 로고
    • The region-specific activities of lipid rafts during axon growth and guidance
    • 10.1111/j.1471-4159.2006.03888.x 16805828 1:CAS:528:DC%2BD28Xot1OmsrY%3D 10.1111/j.1471-4159.2006.03888.x
    • Kamiguchi H (2006) The region-specific activities of lipid rafts during axon growth and guidance. J Neurochem 98(2):330-335. doi: 10.1111/j.1471-4159. 2006.03888.x
    • (2006) J Neurochem , vol.98 , Issue.2 , pp. 330-335
    • Kamiguchi, H.1
  • 198
    • 0035058466 scopus 로고    scopus 로고
    • Activation of cell-cycle-Associated proteins in neuronal death: A mandatory or dispensable path?
    • pii: S0166223600016635
    • Copani A, Uberti D, Sortino MA, Bruno V, Nicoletti F, Memo M (2001) Activation of cell-cycle-Associated proteins in neuronal death: a mandatory or dispensable path? Trends Neurosci 24 (1):25-31. pii: S0166223600016635
    • (2001) Trends Neurosci , vol.24 , Issue.1 , pp. 25-31
    • Copani, A.1    Uberti, D.2    Ma, S.3    Bruno, V.4    Nicoletti, F.5    Memo, M.6
  • 199
    • 0033143917 scopus 로고    scopus 로고
    • Ceramide and apoptosis
    • author reply 227. pii: S0968-0004(99)01408-5
    • Kolesnick R, Hannun YA (1999) Ceramide and apoptosis. Trends Biochem Sci 24 (6):224-225; author reply 227. pii: S0968-0004(99)01408-5
    • (1999) Trends Biochem Sci , vol.24 , Issue.6 , pp. 224-225
    • Kolesnick, R.1    Hannun, Y.A.2
  • 200
    • 0027511687 scopus 로고
    • Programmed cell death induced by ceramide
    • 8456305 1:CAS:528:DyaK3sXisFagtbg%3D 10.1126/science.8456305
    • Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993) Programmed cell death induced by ceramide. Science 259(5102):1769-1771
    • (1993) Science , vol.259 , Issue.5102 , pp. 1769-1771
    • Obeid, L.M.1    Linardic, C.M.2    Karolak, L.A.3    Hannun, Y.A.4
  • 201
    • 18144404605 scopus 로고    scopus 로고
    • Positively charged ceramide is a potent inducer of mitochondrial permeabilization
    • 10.1074/jbc.M411707200 15722351 1:CAS:528:DC%2BD2MXjtleit7g%3D 10.1074/jbc.M411707200
    • Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM (2005) Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem 280(16):16096-16105. doi: 10.1074/jbc.M411707200
    • (2005) J Biol Chem , vol.280 , Issue.16 , pp. 16096-16105
    • Novgorodov, S.A.1    Szulc, Z.M.2    Luberto, C.3    Jones, J.A.4    Bielawski, J.5    Bielawska, A.6    Hannun, Y.A.7    Obeid, L.M.8
  • 202
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • pii: 0092-8674(95)90429-8
    • Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R (1995) Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82 (3):405-414. pii: 0092-8674(95)90429-8
    • (1995) Cell , vol.82 , Issue.3 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 204
    • 16044364385 scopus 로고    scopus 로고
    • Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
    • S0092-8674(00)80091-4 8706124 1:CAS:528:DyaK28Xks1GnsrY%3D 10.1016/S0092-8674(00)80091-4
    • Santana P, Pena LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, Cordon-Cardo C, Schuchman EH, Fuks Z, Kolesnick R (1996) Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86(2):189-199. doi: S0092-8674(00)80091-4
    • (1996) Cell , vol.86 , Issue.2 , pp. 189-199
    • Santana, P.1    Pena, L.A.2    Haimovitz-Friedman, A.3    Martin, S.4    Green, D.5    McLoughlin, M.6    Cordon-Cardo, C.7    Schuchman, E.H.8    Fuks, Z.9    Kolesnick, R.10
  • 205
    • 0026317132 scopus 로고
    • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
    • 1860857 1:CAS:528:DyaK3MXlt12luro%3D
    • Wang E, Norred WP, Bacon CW, Riley RT, Merrill AH Jr (1991) Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266(22):14486-14490
    • (1991) J Biol Chem , vol.266 , Issue.22 , pp. 14486-14490
    • Wang, E.1    Norred, W.P.2    Bacon, C.W.3    Riley, R.T.4    Merrill, Jr.A.H.5
  • 206
    • 0027787984 scopus 로고
    • Fumonisin B1 inhibits sphingosine (sphinganine) N-Acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
    • 8262970 1:CAS:528:DyaK2cXis1enurk%3D
    • Merrill AH Jr, van Echten G, Wang E, Sandhoff K (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-Acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J Biol Chem 268(36):27299-27306
    • (1993) J Biol Chem , vol.268 , Issue.36 , pp. 27299-27306
    • Merrill, Jr.A.H.1    Van Echten, G.2    Wang, E.3    Sandhoff, K.4
  • 207
    • 0031866963 scopus 로고    scopus 로고
    • Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells
    • 9648886 1:CAS:528:DyaK1cXktFamtrk%3D 10.1046/j.1471-4159.1998.71010366.x
    • Furuya S, Mitoma J, Makino A, Hirabayashi Y (1998) Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells. J Neurochem 71(1):366-377
    • (1998) J Neurochem , vol.71 , Issue.1 , pp. 366-377
    • Furuya, S.1    Mitoma, J.2    Makino, A.3    Hirabayashi, Y.4
  • 208
    • 0034631827 scopus 로고    scopus 로고
    • Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology
    • 10893264 1:CAS:528:DC%2BD3cXltVGhtro%3D 10.1083/jcb.150.1.155
    • Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ (2000) Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology. J Cell Biol 150(1):155-164
    • (2000) J Cell Biol , vol.150 , Issue.1 , pp. 155-164
    • Tepper, A.D.1    Ruurs, P.2    Wiedmer, T.3    Sims, P.J.4    Borst, J.5    Van Blitterswijk, W.J.6
  • 209
    • 34547156711 scopus 로고    scopus 로고
    • Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells
    • 10.1080/15287390701434364 17654249 1:CAS:528:DC%2BD2sXotV2ksb8%3D 10.1080/15287390701434364
    • Son JH, Yoo HH, Kim DH (2007) Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. J Toxicol Environ Health A 70(15-16):1310-1318. doi: 10.1080/15287390701434364
    • (2007) J Toxicol Environ Health A , vol.70 , Issue.15-16 , pp. 1310-1318
    • Son, J.H.1    Yoo, H.H.2    Kim, D.H.3
  • 210
    • 0033729123 scopus 로고    scopus 로고
    • De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase
    • 10.1096/fj.00-0122com 11053253 1:CAS:528:DC%2BD3MXht1KgtLw%3D 10.1096/fj.00-0122com
    • Blazquez C, Galve-Roperh I, Guzman M (2000) De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J 14(14):2315-2322. doi: 10.1096/fj.00-0122com
    • (2000) FASEB J , vol.14 , Issue.14 , pp. 2315-2322
    • Blazquez, C.1    Galve-Roperh, I.2    Guzman, M.3
  • 211
    • 0034708594 scopus 로고    scopus 로고
    • Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
    • 10722759 1:CAS:528:DC%2BD3cXit1emtLw%3D 10.1074/jbc.275.12.9078
    • Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA (2000) Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 275(12):9078-9084
    • (2000) J Biol Chem , vol.275 , Issue.12 , pp. 9078-9084
    • Perry, D.K.1    Carton, J.2    Shah, A.K.3    Meredith, F.4    Uhlinger, D.J.5    Hannun, Y.A.6
  • 212
    • 0028108015 scopus 로고
    • Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
    • 7923351 1:CAS:528:DyaK2cXmt1ynt7g%3D 10.1016/0092-8674(94)90275-5 pii: 0092-8674(94)90275-5
    • Wiegmann K, Schutze S, Machleidt T, Witte D, Kronke M (1994) Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78(6):1005-1015 pii: 0092-8674(94)90275-5
    • (1994) Cell , vol.78 , Issue.6 , pp. 1005-1015
    • Wiegmann, K.1    Schutze, S.2    MacHleidt, T.3    Witte, D.4    Kronke, M.5
  • 213
    • 0028790239 scopus 로고
    • Multiple pathways originate at the Fas/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal
    • 8846779 1:CAS:528:DyaK2MXhtVSmur3E
    • Cifone MG, Roncaioli P, De Maria R, Camarda G, Santoni A, Ruberti G, Testi R (1995) Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J 14(23):5859-5868
    • (1995) EMBO J , vol.14 , Issue.23 , pp. 5859-5868
    • Cifone, M.G.1    Roncaioli, P.2    De Maria, R.3    Camarda, G.4    Santoni, A.5    Ruberti, G.6    Testi, R.7
  • 214
    • 15844383383 scopus 로고    scopus 로고
    • A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway
    • 8663014 1:CAS:528:DyaK28Xjs1Ohs7k%3D 10.1074/jbc.271.24.14617
    • Adam D, Wiegmann K, Adam-Klages S, Ruff A, Kronke M (1996) A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway. J Biol Chem 271(24):14617-14622
    • (1996) J Biol Chem , vol.271 , Issue.24 , pp. 14617-14622
    • Adam, D.1    Wiegmann, K.2    Adam-Klages, S.3    Ruff, A.4    Kronke, M.5
  • 215
    • 0031779350 scopus 로고    scopus 로고
    • Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor
    • 9620659 1:CAS:528:DyaK1cXjs1Sntrk%3D
    • Adam-Klages S, Schwandner R, Adam D, Kreder D, Bernardo K, Kronke M (1998) Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. J Leukoc Biol 63(6):678-682
    • (1998) J Leukoc Biol , vol.63 , Issue.6 , pp. 678-682
    • Adam-Klages, S.1    Schwandner, R.2    Adam, D.3    Kreder, D.4    Bernardo, K.5    Kronke, M.6
  • 216
    • 0027275490 scopus 로고
    • A novel domain within the 55 kd TNF receptor signals cell death
    • 8397073 1:CAS:528:DyaK2cXhvV2gsrc%3D 10.1016/0092-8674(93)90464-2 pii: 0092-8674(93)90464-2
    • Tartaglia LA, Ayres TM, Wong GH, Goeddel DV (1993) A novel domain within the 55 kd TNF receptor signals cell death. Cell 74(5):845-853 pii: 0092-8674(93)90464-2
    • (1993) Cell , vol.74 , Issue.5 , pp. 845-853
    • Tartaglia, L.A.1    Ayres, T.M.2    Wong, G.H.3    Goeddel, D.V.4
  • 217
    • 0030032106 scopus 로고    scopus 로고
    • TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    • 8565075 1:CAS:528:DyaK28Xnt1egtA%3D%3D 10.1016/S0092-8674(00)80984-8 pii: S0092-8674(00)80984-8
    • Hsu H, Shu HB, Pan MG, Goeddel DV (1996) TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84(2):299-308 pii: S0092-8674(00)80984-8
    • (1996) Cell , vol.84 , Issue.2 , pp. 299-308
    • Hsu, H.1    Shu, H.B.2    Pan, M.G.3    Goeddel, D.V.4
  • 218
    • 0033605293 scopus 로고    scopus 로고
    • Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase
    • 10026132 1:CAS:528:DyaK1MXhsFamtbk%3D 10.1074/jbc.274.9.5267
    • Wiegmann K, Schwandner R, Krut O, Yeh WC, Mak TW, Kronke M (1999) Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase. J Biol Chem 274(9):5267-5270
    • (1999) J Biol Chem , vol.274 , Issue.9 , pp. 5267-5270
    • Wiegmann, K.1    Schwandner, R.2    Krut, O.3    Yeh, W.C.4    Mak, T.W.5    Kronke, M.6
  • 219
    • 0034809593 scopus 로고    scopus 로고
    • Molecular mechanisms of ceramide-mediated CD95 clustering
    • 10.1006/bbrc.2001.5045 11409897 1:CAS:528:DC%2BD3MXktl2msb0%3D 10.1006/bbrc.2001.5045
    • Grassme H, Schwarz H, Gulbins E (2001) Molecular mechanisms of ceramide-mediated CD95 clustering. Biochem Biophys Res Commun 284(4):1016-1030. doi: 10.1006/bbrc.2001.5045
    • (2001) Biochem Biophys Res Commun , vol.284 , Issue.4 , pp. 1016-1030
    • Grassme, H.1    Schwarz, H.2    Gulbins, E.3
  • 220
    • 34249657837 scopus 로고    scopus 로고
    • Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation
    • 10.1074/jbc.M609424200 17303575 1:CAS:528:DC%2BD2sXjvFagtbs%3D 10.1074/jbc.M609424200
    • Zeidan YH, Hannun YA (2007) Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem 282(15):11549-11561. doi: 10.1074/jbc.M609424200
    • (2007) J Biol Chem , vol.282 , Issue.15 , pp. 11549-11561
    • Zeidan, Y.H.1    Hannun, Y.A.2
  • 222
    • 0033529534 scopus 로고    scopus 로고
    • Differential modulation of apoptosis sensitivity in CD95 type i and type II cells
    • 10428830 1:CAS:528:DyaK1MXlt1CnsLg%3D 10.1074/jbc.274.32.22532
    • Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH, Peter ME (1999) Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 274(32):22532-22538
    • (1999) J Biol Chem , vol.274 , Issue.32 , pp. 22532-22538
    • Scaffidi, C.1    Schmitz, I.2    Zha, J.3    Korsmeyer, S.J.4    Krammer, P.H.5    Peter, M.E.6
  • 224
    • 0029551316 scopus 로고
    • Identification of p55 tumor necrosis factor receptor-Associated proteins that couple to signaling pathways not initiated by the death domain
    • 8913930 1:CAS:528:DyaK28XntVCqsbs%3D
    • Adam D, Adam-Klages S, Kronke M (1995) Identification of p55 tumor necrosis factor receptor-Associated proteins that couple to signaling pathways not initiated by the death domain. J Inflamm 47(1-2):61-66
    • (1995) J Inflamm , vol.47 , Issue.1-2 , pp. 61-66
    • Adam, D.1    Adam-Klages, S.2    Kronke, M.3
  • 225
    • 0032508379 scopus 로고    scopus 로고
    • Purification and characterization of ceramide-Activated protein phosphatases
    • 10.1021/bi980911+ 9698369 1:CAS:528:DyaK1cXltVWmt7c%3D 10.1021/bi980911+
    • Galadari S, Kishikawa K, Kamibayashi C, Mumby MC, Hannun YA (1998) Purification and characterization of ceramide-Activated protein phosphatases. Biochemistry 37(32):11232-11238. doi: 10.1021/bi980911+
    • (1998) Biochemistry , vol.37 , Issue.32 , pp. 11232-11238
    • Galadari, S.1    Kishikawa, K.2    Kamibayashi, C.3    Mumby, M.C.4    Hannun, Y.A.5
  • 226
    • 0027428283 scopus 로고
    • Ceramide-Activated protein phosphatase: Partial purification and relationship to protein phosphatase 2A
    • 8396314 1:CAS:528:DyaK3sXmt1Sju7Y%3D
    • Dobrowsky RT, Hannun YA (1993) Ceramide-Activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res 25:91-104
    • (1993) Adv Lipid Res , vol.25 , pp. 91-104
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 227
    • 0028934811 scopus 로고
    • Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
    • 7877980 1:CAS:528:DyaK2MXktFWktr0%3D 10.1073/pnas.92.5.1347
    • Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA (1995) Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci USA 92(5):1347-1351
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.5 , pp. 1347-1351
    • Dbaibo, G.S.1    Pushkareva, M.Y.2    Jayadev, S.3    Schwarz, J.K.4    Horowitz, J.M.5    Obeid, L.M.6    Hannun, Y.A.7
  • 228
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • 10400650 1:CAS:528:DyaK1MXks1OjsL0%3D 10.1074/jbc.274.29.20296
    • Ruvolo PP, Deng X, Ito T, Carr BK, May WS (1999) Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J Biol Chem 274(29):20296-20300
    • (1999) J Biol Chem , vol.274 , Issue.29 , pp. 20296-20300
    • Ruvolo, P.P.1    Deng, X.2    Ito, T.3    Carr, B.K.4    May, W.S.5
  • 229
    • 0028122397 scopus 로고
    • Role of ceramide-Activated protein phosphatase in ceramide-mediated signal transduction
    • 8034729 1:CAS:528:DyaK2cXltlWqurc%3D
    • Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA (1994) Role of ceramide-Activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 269(30):19605-19609
    • (1994) J Biol Chem , vol.269 , Issue.30 , pp. 19605-19609
    • Wolff, R.A.1    Dobrowsky, R.T.2    Bielawska, A.3    Obeid, L.M.4    Hannun, Y.A.5
  • 231
    • 38049098527 scopus 로고    scopus 로고
    • A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury
    • 10.1096/fj.07-8967com 17698617 1:CAS:528:DC%2BD1cXkslWgsQ%3D%3D 10.1096/fj.07-8967com
    • Zeidan YH, Wu BX, Jenkins RW, Obeid LM, Hannun YA (2008) A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J 22(1):183-193. doi: 10.1096/fj.07-8967com
    • (2008) FASEB J , vol.22 , Issue.1 , pp. 183-193
    • Zeidan, Y.H.1    Wu, B.X.2    Jenkins, R.W.3    Obeid, L.M.4    Hannun, Y.A.5
  • 232
    • 0033973670 scopus 로고    scopus 로고
    • Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes
    • 10666416 1:CAS:528:DC%2BD3cXht1Cktr0%3D 10.1161/01.RES.86.2.198
    • Hernandez OM, Discher DJ, Bishopric NH, Webster KA (2000) Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ Res 86(2):198-204
    • (2000) Circ Res , vol.86 , Issue.2 , pp. 198-204
    • Hernandez, O.M.1    Discher, D.J.2    Bishopric, N.H.3    Webster, K.A.4
  • 233
    • 55549135019 scopus 로고    scopus 로고
    • Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells
    • 10.1074/jbc.M801597200 18676372 1:CAS:528:DC%2BD1cXhtFejsbfP 10.1074/jbc.M801597200
    • Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, Hsu YT (2008) Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem 283(39):26509-26517. doi: 10.1074/jbc.M801597200
    • (2008) J Biol Chem , vol.283 , Issue.39 , pp. 26509-26517
    • Jin, J.1    Hou, Q.2    Mullen, T.D.3    Zeidan, Y.H.4    Bielawski, J.5    Kraveka, J.M.6    Bielawska, A.7    Obeid, L.M.8    Hannun, Y.A.9    Hsu, Y.T.10
  • 234
    • 0031851003 scopus 로고    scopus 로고
    • Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
    • 10.1038/sj.cdd.4400330 10200462 1:CAS:528:DyaK1cXhtlGisLY%3D 10.1038/sj.cdd.4400330
    • Bruno AP, Laurent G, Averbeck D, Demur C, Bonnet J, Bettaieb A, Levade T, Jaffrezou JP (1998) Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death Differ 5(2):172-182. doi: 10.1038/sj.cdd.4400330
    • (1998) Cell Death Differ , vol.5 , Issue.2 , pp. 172-182
    • Bruno, A.P.1    Laurent, G.2    Averbeck, D.3    Demur, C.4    Bonnet, J.5    Bettaieb, A.6    Levade, T.7    Jaffrezou, J.P.8
  • 235
    • 18644379261 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase
    • 10.1074/jbc.M206747200 12154098 1:CAS:528:DC%2BD38XnvFymsL8%3D 10.1074/jbc.M206747200
    • Luberto C, Hassler DF, Signorelli P, Okamoto Y, Sawai H, Boros E, Hazen-Martin DJ, Obeid LM, Hannun YA, Smith GK (2002) Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem 277(43):41128-41139. doi: 10.1074/jbc.M206747200
    • (2002) J Biol Chem , vol.277 , Issue.43 , pp. 41128-41139
    • Luberto, C.1    Hassler, D.F.2    Signorelli, P.3    Okamoto, Y.4    Sawai, H.5    Boros, E.6    Hazen-Martin, D.J.7    Obeid, L.M.8    Hannun, Y.A.9    Smith, G.K.10
  • 238
  • 240
    • 0037237733 scopus 로고    scopus 로고
    • Defective TNF-Alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice
    • 10.1172/JCI16010 12531875 1:CAS:528:DC%2BD3sXlsVGrtA%3D%3D
    • Garcia-Ruiz C, Colell A, Mari M, Morales A, Calvo M, Enrich C, Fernandez-Checa JC (2003) Defective TNF-Alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 111(2):197-208. doi: 10.1172/JCI16010
    • (2003) J Clin Invest , vol.111 , Issue.2 , pp. 197-208
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Calvo, M.5    Enrich, C.6    Fernandez-Checa, J.C.7
  • 242
    • 0033662390 scopus 로고    scopus 로고
    • Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells
    • 11093963 1:CAS:528:DC%2BD3MXjsFClsw%3D%3D
    • Liu JJ, Wang JY, Hertervig E, Cheng Y, Nilsson A, Duan RD (2000) Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells. Alcohol Alcohol 35(6):569-573
    • (2000) Alcohol Alcohol , vol.35 , Issue.6 , pp. 569-573
    • Liu, J.J.1    Wang, J.Y.2    Hertervig, E.3    Cheng, Y.4    Nilsson, A.5    Duan, R.D.6
  • 243
    • 33646127797 scopus 로고    scopus 로고
    • NSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis
    • 10.1016/j.bbrc.2006.04.013 16631623 1:CAS:528:DC%2BD28XktVOqtrY%3D 10.1016/j.bbrc.2006.04.013
    • Levy M, Castillo SS, Goldkorn T (2006) nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. Biochem Biophys Res Commun 344(3):900-905. doi: 10.1016/j.bbrc.2006.04.013
    • (2006) Biochem Biophys Res Commun , vol.344 , Issue.3 , pp. 900-905
    • Levy, M.1    Castillo, S.S.2    Goldkorn, T.3
  • 245
    • 0142095498 scopus 로고    scopus 로고
    • Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
    • 10.1038/nm823 12563314 1:CAS:528:DC%2BD3sXhsFGgs70%3D 10.1038/nm823
    • Grassme H, Jendrossek V, Riehle A, von Kurthy G, Berger J, Schwarz H, Weller M, Kolesnick R, Gulbins E (2003) Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med 9(3):322-330. doi: 10.1038/nm823
    • (2003) Nat Med , vol.9 , Issue.3 , pp. 322-330
    • Grassme, H.1    Jendrossek, V.2    Riehle, A.3    Von Kurthy, G.4    Berger, J.5    Schwarz, H.6    Weller, M.7    Kolesnick, R.8    Gulbins, E.9
  • 246
    • 0035175328 scopus 로고    scopus 로고
    • Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells
    • 11595832 1:STN:280:DC%2BD3MrkvVCrtw%3D%3D 10.1023/A:1012445925628
    • Esen M, Schreiner B, Jendrossek V, Lang F, Fassbender K, Grassme H, Gulbins E (2001) Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells. Apoptosis 6(6):431-439
    • (2001) Apoptosis , vol.6 , Issue.6 , pp. 431-439
    • Esen, M.1    Schreiner, B.2    Jendrossek, V.3    Lang, F.4    Fassbender, K.5    Grassme, H.6    Gulbins, E.7
  • 247
    • 22544476850 scopus 로고    scopus 로고
    • Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms
    • 10.1074/jbc.M500835200 15888438 1:CAS:528:DC%2BD2MXlvFymtLo%3D 10.1074/jbc.M500835200
    • Grassme H, Riehle A, Wilker B, Gulbins E (2005) Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms. J Biol Chem 280(28):26256-26262. doi: 10.1074/jbc.M500835200
    • (2005) J Biol Chem , vol.280 , Issue.28 , pp. 26256-26262
    • Grassme, H.1    Riehle, A.2    Wilker, B.3    Gulbins, E.4
  • 248
    • 0036534724 scopus 로고    scopus 로고
    • De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
    • 11903061 1:CAS:528:DC%2BD38Xjt1aksLg%3D 10.1042/0264-6021:3630183
    • Gomez del Pulgar T, Velasco G, Sanchez C, Haro A, Guzman M (2002) De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 363(Pt 1):183-188
    • (2002) Biochem J , vol.363 , Issue.PART 1 , pp. 183-188
    • Gomez Del Pulgar, T.1    Velasco, G.2    Sanchez, C.3    Haro, A.4    Guzman, M.5
  • 249
    • 0026534541 scopus 로고
    • Elevated ceramide levels in GH4C1 cells treated with retinoic acid
    • 1567913 1:CAS:528:DyaK38XisFaktLo%3D 10.1016/0005-2760(92)90160-W pii: 0005-2760(92)90160-W
    • Kalen A, Borchardt RA, Bell RM (1992) Elevated ceramide levels in GH4C1 cells treated with retinoic acid. Biochim Biophys Acta 1125(1):90-96 pii: 0005-2760(92)90160-W
    • (1992) Biochim Biophys Acta , vol.1125 , Issue.1 , pp. 90-96
    • Kalen, A.1    Borchardt, R.A.2    Bell, R.M.3
  • 250
    • 0035957921 scopus 로고    scopus 로고
    • Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    • 10.1074/jbc.M009517200 11278517 1:CAS:528:DC%2BD3MXjt12kt7c%3D
    • Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA (2001) Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem 276(17):13606-13614. doi: 10.1074/jbc.M009517200
    • (2001) J Biol Chem , vol.276 , Issue.17 , pp. 13606-13614
    • Kroesen, B.J.1    Pettus, B.2    Luberto, C.3    Busman, M.4    Sietsma, H.5    De Leij, L.6    Hannun, Y.A.7
  • 251
    • 0037401647 scopus 로고    scopus 로고
    • Regulation of death receptor signaling and apoptosis by ceramide
    • 12676513 1:CAS:528:DC%2BD3sXisFWlsb4%3D 10.1016/S1043-6618(03)00052-5 pii: S1043661803000525
    • Gulbins E (2003) Regulation of death receptor signaling and apoptosis by ceramide. Pharmacol Res 47(5):393-399 pii: S1043661803000525
    • (2003) Pharmacol Res , vol.47 , Issue.5 , pp. 393-399
    • Gulbins, E.1
  • 253
    • 0036545980 scopus 로고    scopus 로고
    • How does the brain control lifespan?
    • 12039436 1:CAS:528:DC%2BD38XosFSmtLk%3D 10.1016/S1568-1637(01)00003-4 pii: S1568163701000034
    • Mattson MP, Duan W, Maswood N (2002) How does the brain control lifespan? Ageing Res Rev 1(2):155-165 pii: S1568163701000034
    • (2002) Ageing Res Rev , vol.1 , Issue.2 , pp. 155-165
    • Mattson, M.P.1    Duan, W.2    Maswood, N.3
  • 254
    • 0035880016 scopus 로고    scopus 로고
    • Sphingomyelin and ceramide as regulators of development and lifespan
    • 11348657 1:CAS:528:DC%2BD3MXjtlegurw%3D 10.1016/S0047-6374(01)00246-9 pii: S0047-6374(01)00246-9
    • Cutler RG, Mattson MP (2001) Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev 122(9):895-908 pii: S0047-6374(01)00246-9
    • (2001) Mech Ageing Dev , vol.122 , Issue.9 , pp. 895-908
    • Cutler, R.G.1    Mattson, M.P.2
  • 255
    • 33845343984 scopus 로고    scopus 로고
    • Sphingolipid metabolism diseases
    • 10.1016/j.bbamem.2006.05.027 16854371 1:CAS:528:DC%2BD28Xht12kt7zF 10.1016/j.bbamem.2006.05.027
    • Kolter T, Sandhoff K (2006) Sphingolipid metabolism diseases. Biochim Biophys Acta 1758(12):2057-2079. doi: 10.1016/j.bbamem.2006.05.027
    • (2006) Biochim Biophys Acta , vol.1758 , Issue.12 , pp. 2057-2079
    • Kolter, T.1    Sandhoff, K.2
  • 256
    • 0035197535 scopus 로고    scopus 로고
    • Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae
    • 11694577 1:CAS:528:DC%2BD3MXovFOmsrc%3D
    • Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell 12(11):3417-3427
    • (2001) Mol Biol Cell , vol.12 , Issue.11 , pp. 3417-3427
    • Schorling, S.1    Vallee, B.2    Barz, W.P.3    Riezman, H.4    Oesterhelt, D.5
  • 258
    • 7244244035 scopus 로고    scopus 로고
    • Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas
    • 10.1074/jbc.M406920200 15317812 1:CAS:528:DC%2BD2cXosFyms7k%3D 10.1074/jbc.M406920200
    • Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B (2004) Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 279(43):44311-44319. doi: 10.1074/jbc.M406920200
    • (2004) J Biol Chem , vol.279 , Issue.43 , pp. 44311-44319
    • Koybasi, S.1    Senkal, C.E.2    Sundararaj, K.3    Spassieva, S.4    Bielawski, J.5    Osta, W.6    Day, T.A.7    Jiang, J.C.8    Jazwinski, S.M.9    Hannun, Y.A.10    Obeid, L.M.11    Ogretmen, B.12
  • 259
    • 35248872133 scopus 로고    scopus 로고
    • Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1
    • 10.1096/fj.07-8621com 17548428 1:CAS:528:DC%2BD2sXhtFKntbbO 10.1096/fj.07-8621com
    • Wooten-Blanks LG, Song P, Senkal CE, Ogretmen B (2007) Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. FASEB J 21(12):3386-3397. doi: 10.1096/fj.07-8621com
    • (2007) FASEB J , vol.21 , Issue.12 , pp. 3386-3397
    • Wooten-Blanks, L.G.1    Song, P.2    Senkal, C.E.3    Ogretmen, B.4
  • 260
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • 10.1038/33345 9560153 1:CAS:528:DyaK1cXis1Smu7o%3D 10.1038/33345
    • Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA (1998) Essential role of mouse telomerase in highly proliferative organs. Nature 392(6676):569-574. doi: 10.1038/33345
    • (1998) Nature , vol.392 , Issue.6676 , pp. 569-574
    • Lee, H.W.1    Blasco, M.A.2    Gottlieb, G.J.3    Horner II, J.W.4    Greider, C.W.5    Depinho, R.A.6
  • 261
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • 7544492 1:CAS:528:DyaK2MXnvVeqtLY%3D 10.1126/science.7544492
    • Blasco MA, Funk W, Villeponteau B, Greider CW (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science 269(5228):1267-1270
    • (1995) Science , vol.269 , Issue.5228 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.2    Villeponteau, B.3    Greider, C.W.4
  • 262
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • 7761406 1:CAS:528:DyaK2MXlvFyis7o%3D 10.1073/pnas.92.11.4818
    • Prowse KR, Greider CW (1995) Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci USA 92(11):4818-4822
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.11 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 263
    • 0042160196 scopus 로고    scopus 로고
    • Telomerase activity in the subventricular zone of adult mice
    • 12932448 1:CAS:528:DC%2BD3sXmsVCksrg%3D 10.1016/S1044-7431(03)00103-9 pii: S1044743103001039
    • Caporaso GL, Lim DA, Alvarez-Buylla A, Chao MV (2003) Telomerase activity in the subventricular zone of adult mice. Mol Cell Neurosci 23(4):693-702 pii: S1044743103001039
    • (2003) Mol Cell Neurosci , vol.23 , Issue.4 , pp. 693-702
    • Caporaso, G.L.1    Lim, D.A.2    Alvarez-Buylla, A.3    Chao, M.V.4
  • 264
    • 0029562453 scopus 로고
    • Role of ceramide in cellular senescence
    • 8530509 1:CAS:528:DyaK28XhtFKksw%3D%3D 10.1074/jbc.270.51.30701
    • Venable ME, Lee JY, Smyth MJ, Bielawska A, Obeid LM (1995) Role of ceramide in cellular senescence. J Biol Chem 270(51):30701-30708
    • (1995) J Biol Chem , vol.270 , Issue.51 , pp. 30701-30708
    • Venable, M.E.1    Lee, J.Y.2    Smyth, M.J.3    Bielawska, A.4    Obeid, L.M.5
  • 265
    • 71949111376 scopus 로고    scopus 로고
    • Ceramide induces endothelial cell senescence
    • 10.1002/cbf.1605 19842094 1:CAS:528:DC%2BD1MXhsV2mtbzI 10.1002/cbf.1605
    • Venable ME, Yin X (2009) Ceramide induces endothelial cell senescence. Cell Biochem Funct 27(8):547-551. doi: 10.1002/cbf.1605
    • (2009) Cell Biochem Funct , vol.27 , Issue.8 , pp. 547-551
    • Venable, M.E.1    Yin, X.2
  • 266
    • 33645880445 scopus 로고    scopus 로고
    • Shift in sphingolipid metabolism leads to an accumulation of ceramide in senescence
    • 10.1016/j.mad.2006.01.003 16499950 1:CAS:528:DC%2BD28XjvVWmsL4%3D 10.1016/j.mad.2006.01.003
    • Venable ME, Webb-Froehlich LM, Sloan EF, Thomley JE (2006) Shift in sphingolipid metabolism leads to an accumulation of ceramide in senescence. Mech Ageing Dev 127(5):473-480. doi: 10.1016/j.mad.2006.01.003
    • (2006) Mech Ageing Dev , vol.127 , Issue.5 , pp. 473-480
    • Venable, M.E.1    Webb-Froehlich, L.M.2    Sloan, E.F.3    Thomley, J.E.4
  • 267
    • 70350676840 scopus 로고    scopus 로고
    • Increase in sphingolipid catabolic enzyme activity during aging
    • 10.1038/aps.2009.136 19749786 1:CAS:528:DC%2BD1MXht1Whs73E 10.1038/aps.2009.136
    • Sacket SJ, Chung HY, Okajima F, Im DS (2009) Increase in sphingolipid catabolic enzyme activity during aging. Acta Pharmacol Sin 30(10):1454-1461. doi: 10.1038/aps.2009.136
    • (2009) Acta Pharmacol Sin , vol.30 , Issue.10 , pp. 1454-1461
    • Sacket, S.J.1    Chung, H.Y.2    Okajima, F.3    Im, D.S.4
  • 268
    • 70449185285 scopus 로고
    • Niemann-Pick disease: A review of eighteen patients
    • 1:STN:280:DyaG1c%2FlvV2qtA%3D%3D 10.1097/00005792-195802000-00001
    • Crocker AC, Farber S (1958) Niemann-Pick disease: a review of eighteen patients. Medicine (Baltimore) 37(1):1-95
    • (1958) Medicine (Baltimore) , vol.37 , Issue.1 , pp. 1-95
    • Crocker, A.C.1    Farber, S.2
  • 269
    • 0015498606 scopus 로고
    • Ceramidase deficiency in Farber's disease (lipogranulomatosis)
    • 4678225 1:STN:280:DyaE3s%2Fkt1ygsA%3D%3D 10.1126/science.178.4065.1100
    • Sugita M, Dulaney JT, Moser HW (1972) Ceramidase deficiency in Farber's disease (lipogranulomatosis). Science 178(65):1100-1102
    • (1972) Science , vol.178 , Issue.65 , pp. 1100-1102
    • Sugita, M.1    Dulaney, J.T.2    Moser, H.W.3
  • 270
    • 0028971307 scopus 로고
    • Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells
    • 8747852 1:STN:280:DyaK28zktFGitw%3D%3D 10.1016/0022-510X(95)00231-0
    • Levade T, Moser HW, Fensom AH, Harzer K, Moser AB, Salvayre R (1995) Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells. J Neurol Sci 134(1-2):108-114
    • (1995) J Neurol Sci , vol.134 , Issue.1-2 , pp. 108-114
    • Levade, T.1    Moser, H.W.2    Fensom, A.H.3    Harzer, K.4    Moser, A.B.5    Salvayre, R.6
  • 271
    • 37549022394 scopus 로고    scopus 로고
    • Farber disease: Clinical presentation, pathogenesis and a new approach to treatment
    • 10.1186/1546-0096-5-15 17603888 10.1186/1546-0096-5-15
    • Ehlert K, Frosch M, Fehse N, Zander A, Roth J, Vormoor J (2007) Farber disease: clinical presentation, pathogenesis and a new approach to treatment. Pediatr Rheumatol Online J 5:15. doi: 10.1186/1546-0096-5-15
    • (2007) Pediatr Rheumatol Online J , vol.5 , pp. 15
    • Ehlert, K.1    Frosch, M.2    Fehse, N.3    Zander, A.4    Roth, J.5    Vormoor, J.6
  • 272
    • 0017075792 scopus 로고
    • The granulomatous inflammatory response
    • 1:STN:280:DyaE283ivFWltQ%3D%3D
    • Adams DO (1976) The granulomatous inflammatory response. A review. Am J Pathol 84(1):164-192
    • (1976) A Review. Am J Pathol , vol.84 , Issue.1 , pp. 164-192
    • Adams, D.O.1
  • 273
    • 0022035244 scopus 로고
    • Genetic galactosylceramidase deficiency (globoid cell leukodystrophy, Krabbe disease) in different mammalian species
    • 3895053 1:CAS:528:DyaL2MXks12itrw%3D 10.1007/BF02834075
    • Suzuki K (1985) Genetic galactosylceramidase deficiency (globoid cell leukodystrophy, Krabbe disease) in different mammalian species. Neurochem Pathol 3(1):53-68
    • (1985) Neurochem Pathol , vol.3 , Issue.1 , pp. 53-68
    • Suzuki, K.1
  • 275
    • 66049163058 scopus 로고    scopus 로고
    • Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture
    • 10.1523/JNEUROSCI.5597-08.2009 19439584 1:CAS:528:DC%2BD1MXmt1Cmtbw%3D 10.1523/JNEUROSCI.5597-08.2009
    • White AB, Givogri MI, Lopez-Rosas A, Cao H, van Breemen R, Thinakaran G, Bongarzone ER (2009) Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture. J Neurosci 29(19):6068-6077. doi: 10.1523/JNEUROSCI.5597-08.2009
    • (2009) J Neurosci , vol.29 , Issue.19 , pp. 6068-6077
    • White, A.B.1    Givogri, M.I.2    Lopez-Rosas, A.3    Cao, H.4    Van Breemen, R.5    Thinakaran, G.6    Bongarzone, E.R.7
  • 276
    • 34247330919 scopus 로고    scopus 로고
    • Modulation of inflammation in brain: A matter of fat
    • 10.1111/j.1471-4159.2006.04371.x 17257165 1:CAS:528:DC%2BD2sXlsV2ks78%3D 10.1111/j.1471-4159.2006.04371.x
    • Farooqui AA, Horrocks LA, Farooqui T (2007) Modulation of inflammation in brain: a matter of fat. J Neurochem 101(3):577-599. doi: 10.1111/j.1471-4159. 2006.04371.x
    • (2007) J Neurochem , vol.101 , Issue.3 , pp. 577-599
    • Farooqui, A.A.1    Horrocks, L.A.2    Farooqui, T.3
  • 277
    • 0028360514 scopus 로고
    • A genetic demyelinating disease globoid cell leukodystrophy: Studies with animal models
    • 8021709 1:STN:280:DyaK2c3ptlSnsQ%3D%3D 10.1097/00005072-199407000-00006
    • Suzuki K (1994) A genetic demyelinating disease globoid cell leukodystrophy: studies with animal models. J Neuropathol Exp Neurol 53(4):359-363
    • (1994) J Neuropathol Exp Neurol , vol.53 , Issue.4 , pp. 359-363
    • Suzuki, K.1
  • 278
    • 0013927537 scopus 로고
    • Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease
    • 10.1172/JCI105417 5338605 1:CAS:528:DyaF28XksVWnsLg%3D 10.1172/JCI105417
    • Brady RO, Kanfer JN, Bradley RM, Shapiro D (1966) Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease. J Clin Invest 45(7):1112-1115. doi: 10.1172/JCI105417
    • (1966) J Clin Invest , vol.45 , Issue.7 , pp. 1112-1115
    • Brady, R.O.1    Kanfer, J.N.2    Bradley, R.M.3    Shapiro, D.4
  • 279
    • 0036387220 scopus 로고    scopus 로고
    • Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: Correlation with phenotype and genotype
    • 12208131 1:CAS:528:DC%2BD38Xms1Wmsrk%3D 10.1016/S1096-7192(02)00117-8 pii: S1096719202001178
    • Orvisky E, Park JK, LaMarca ME, Ginns EI, Martin BM, Tayebi N, Sidransky E (2002) Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype. Mol Genet Metab 76(4):262-270 pii: S1096719202001178
    • (2002) Mol Genet Metab , vol.76 , Issue.4 , pp. 262-270
    • Orvisky, E.1    Park, J.K.2    Lamarca, M.E.3    Ginns, E.I.4    Martin, B.M.5    Tayebi, N.6    Sidransky, E.7
  • 280
    • 0013881132 scopus 로고
    • The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae
    • 5220952 1:CAS:528:DyaF28XhtVOku7k%3D 10.1073/pnas.55.2.366
    • Brady RO, Kanfer JN, Mock MB, Fredrickson DS (1966) The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae. Proc Natl Acad Sci USA 55(2):366-369
    • (1966) Proc Natl Acad Sci USA , vol.55 , Issue.2 , pp. 366-369
    • Brady, R.O.1    Kanfer, J.N.2    Mock, M.B.3    Fredrickson, D.S.4
  • 282
    • 0015182981 scopus 로고
    • Altered plasma membranes in experimental scrapie
    • 4942441 1:STN:280:DyaE38%2Fmt1aisw%3D%3D 10.1007/BF00688486
    • Lampert P, Hooks J, Gibbs CJ Jr, Gajdusek DC (1971) Altered plasma membranes in experimental scrapie. Acta Neuropathol 19(2):81-93
    • (1971) Acta Neuropathol , vol.19 , Issue.2 , pp. 81-93
    • Lampert, P.1    Hooks, J.2    Gibbs, Jr.C.J.3    Gajdusek, D.C.4
  • 283
    • 0025941678 scopus 로고
    • Membrane lipids in the aging human brain
    • 2027013 1:CAS:528:DyaK3MXktVGksL0%3D 10.1111/j.1471-4159.1991.tb03466.x
    • Svennerholm L, Bostrom K, Helander CG, Jungbjer B (1991) Membrane lipids in the aging human brain. J Neurochem 56(6):2051-2059
    • (1991) J Neurochem , vol.56 , Issue.6 , pp. 2051-2059
    • Svennerholm, L.1    Bostrom, K.2    Helander, C.G.3    Jungbjer, B.4
  • 284
    • 70249130546 scopus 로고    scopus 로고
    • Early stages of oxidative stress-induced membrane permeabilization: A neutron reflectometry study
    • 10.1021/ja807680m 19275260 1:CAS:528:DC%2BD1MXit1elsLk%3D 10.1021/ja807680m
    • Smith HL, Howland MC, Szmodis AW, Li Q, Daemen LL, Parikh AN, Majewski J (2009) Early stages of oxidative stress-induced membrane permeabilization: a neutron reflectometry study. J Am Chem Soc 131(10):3631-3638. doi: 10.1021/ja807680m
    • (2009) J Am Chem Soc , vol.131 , Issue.10 , pp. 3631-3638
    • Smith, H.L.1    Howland, M.C.2    Szmodis, A.W.3    Li, Q.4    Daemen, L.L.5    Parikh, A.N.6    Majewski, J.7
  • 285
    • 77953280950 scopus 로고
    • Thinakaran G Membrane rafts in Alzheimer's disease beta-Amyloid production
    • 10.1016/j.bbalip.2010.03.007
    • Vetrivel KS (1801) Thinakaran G Membrane rafts in Alzheimer's disease beta-Amyloid production. Biochim Biophys Acta 8:860-867. doi: 10.1016/j.bbalip.2010.03.007
    • (1801) Biochim Biophys Acta , vol.8 , pp. 860-867
    • Vetrivel, K.S.1
  • 286
    • 0141482022 scopus 로고    scopus 로고
    • Exclusively targeting beta-secretase to lipid rafts by GPI-Anchor addition up-regulates beta-site processing of the amyloid precursor protein
    • 10.1073/pnas.1635130100 14504402 1:CAS:528:DC%2BD3sXotFKmtbY%3D 10.1073/pnas.1635130100
    • Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ (2003) Exclusively targeting beta-secretase to lipid rafts by GPI-Anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci USA 100(20):11735-11740. doi: 10.1073/pnas.1635130100
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.20 , pp. 11735-11740
    • Cordy, J.M.1    Hussain, I.2    Dingwall, C.3    Hooper, N.M.4    Turner, A.J.5
  • 287
    • 0036674082 scopus 로고    scopus 로고
    • Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway
    • 10.1007/s12031-002-0007-5 12212790 1:CAS:528:DC%2BD38XmvFCqtb0%3D 10.1007/s12031-002-0007-5
    • Tun H, Marlow L, Pinnix I, Kinsey R, Sambamurti K (2002) Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. J Mol Neurosci 19(1-2):31-35. doi: 10.1007/s12031-002-0007-5
    • (2002) J Mol Neurosci , vol.19 , Issue.1-2 , pp. 31-35
    • Tun, H.1    Marlow, L.2    Pinnix, I.3    Kinsey, R.4    Sambamurti, K.5
  • 288
    • 0642371716 scopus 로고    scopus 로고
    • Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP)
    • 10.1385/JMN:20:3:233 14501002 1:CAS:528:DC%2BD3sXnslGrs7o%3D 10.1385/JMN:20:3:233
    • Marlow L, Cain M, Pappolla MA, Sambamurti K (2003) Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J Mol Neurosci 20(3):233-239. doi: 10.1385/JMN:20:3:233
    • (2003) J Mol Neurosci , vol.20 , Issue.3 , pp. 233-239
    • Marlow, L.1    Cain, M.2    Pappolla, M.A.3    Sambamurti, K.4
  • 289
    • 21844448354 scopus 로고    scopus 로고
    • Spatial segregation of gamma-secretase and substrates in distinct membrane domains
    • 10.1074/jbc.M503570200 15886206 1:CAS:528:DC%2BD2MXlslyksLc%3D 10.1074/jbc.M503570200
    • Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem 280(27):25892-25900. doi: 10.1074/jbc.M503570200
    • (2005) J Biol Chem , vol.280 , Issue.27 , pp. 25892-25900
    • Vetrivel, K.S.1    Cheng, H.2    Kim, S.H.3    Chen, Y.4    Barnes, N.Y.5    Parent, A.T.6    Sisodia, S.S.7    Thinakaran, G.8
  • 291
    • 0028885854 scopus 로고
    • GM1 ganglioside-bound amyloid beta-protein (A beta): A possible form of preamyloid in Alzheimer's disease
    • 7489364 1:CAS:528:DyaK2MXosVGgu7c%3D 10.1038/nm1095-1062
    • Yanagisawa K, Odaka A, Suzuki N, Ihara Y (1995) GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. Nat Med 1(10):1062-1066
    • (1995) Nat Med , vol.1 , Issue.10 , pp. 1062-1066
    • Yanagisawa, K.1    Odaka, A.2    Suzuki, N.3    Ihara, Y.4
  • 292
    • 77952510090 scopus 로고    scopus 로고
    • Surface-induced phase separation of a sphingomyelin/cholesterol/ ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Abeta oligomerization
    • doi: 10.1016/j.bbamem.2010.03.003
    • Mao Y, Shang Z, Imai Y, Hoshino T, Tero R, Tanaka M, Yamamoto N, Yanagisawa K, Urisu T Surface-induced phase separation of a sphingomyelin/ cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Abeta oligomerization. Biochim Biophys Acta 1798 (6):1090-1099. doi: 10.1016/j.bbamem.2010.03.003
    • Biochim Biophys Acta , vol.1798 , Issue.6 , pp. 1090-1099
    • Mao, Y.1    Shang, Z.2    Imai, Y.3    Hoshino, T.4    Tero, R.5    Tanaka, M.6    Yamamoto, N.7    Yanagisawa, K.8    Urisu, T.9
  • 293
    • 0031054785 scopus 로고    scopus 로고
    • The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes
    • 9037173 1:CAS:528:DyaK2sXptlShtg%3D%3D 10.1016/S0014-5793(96)01504-9 pii: S0014-5793(96)01504-9
    • Choo-Smith LP, Surewicz WK (1997) The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes. FEBS Lett 402(2-3):95-98 pii: S0014-5793(96)01504-9
    • (1997) FEBS Lett , vol.402 , Issue.2-3 , pp. 95-98
    • Choo-Smith, L.P.1    Surewicz, W.K.2
  • 294
    • 33644847633 scopus 로고    scopus 로고
    • Glycosylation and GPI anchorage of the prion protein
    • 10.1007/0-387-25515-X-14 16400810 1:STN:280:DC%2BD28%2FhsFWqtw%3D%3D 10.1007/0-387-25515-X-14
    • Hooper NM (2005) Glycosylation and GPI anchorage of the prion protein. Adv Exp Med Biol 564:95-96. doi: 10.1007/0-387-25515-X-14
    • (2005) Adv Exp Med Biol , vol.564 , pp. 95-96
    • Hooper, N.M.1
  • 295
    • 0030894380 scopus 로고    scopus 로고
    • Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform
    • 9045652 1:CAS:528:DyaK2sXhvVOnt7Y%3D 10.1074/jbc.272.10.6324
    • Naslavsky N, Stein R, Yanai A, Friedlander G, Taraboulos A (1997) Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform. J Biol Chem 272(10):6324-6331
    • (1997) J Biol Chem , vol.272 , Issue.10 , pp. 6324-6331
    • Naslavsky, N.1    Stein, R.2    Yanai, A.3    Friedlander, G.4    Taraboulos, A.5
  • 296
    • 18044377435 scopus 로고    scopus 로고
    • Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein
    • 10.1042/BST0330335 15787600 1:CAS:528:DC%2BD2MXivFWjsLo%3D
    • Hooper NM (2005) Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein. Biochem Soc Trans 33(Pt 2):335-338. doi: 10.1042/BST0330335
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 2 , pp. 335-338
    • Hooper, N.M.1
  • 297
    • 3342951965 scopus 로고    scopus 로고
    • Lipid rafts mediate the synaptic localization of alpha-synuclein
    • 10.1523/JNEUROSCI.1594-04.2004 15282274 1:CAS:528:DC%2BD2cXmsVCksb4%3D 10.1523/JNEUROSCI.1594-04.2004
    • Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 24(30):6715-6723. doi: 10.1523/JNEUROSCI.1594-04.2004
    • (2004) J Neurosci , vol.24 , Issue.30 , pp. 6715-6723
    • Fortin, D.L.1    Troyer, M.D.2    Nakamura, K.3    Kubo, S.4    Anthony, M.D.5    Edwards, R.H.6
  • 298
    • 84855973361 scopus 로고    scopus 로고
    • Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease
    • doi: 10.2119/molmed.2011.00119
    • Fabelo N, Martin V, Santpere G, Marin R, Torrent L, Ferrer I, Diaz M Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Mol Med 17 (9-10):1107-1118. doi: 10.2119/molmed.2011.00119
    • Mol Med , vol.17 , Issue.9-10 , pp. 1107-1118
    • Fabelo, N.1    Martin, V.2    Santpere, G.3    Marin, R.4    Torrent, L.5    Ferrer, I.6    Diaz, M.7
  • 299
    • 77049118002 scopus 로고    scopus 로고
    • Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex
    • doi: 10.3233/JAD-2010-1242
    • Martin V, Fabelo N, Santpere G, Puig B, Marin R, Ferrer I, Diaz M Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex. J Alzheimers Dis 19 (2):489-502. doi: 10.3233/JAD-2010-1242
    • J Alzheimers Dis , vol.19 , Issue.2 , pp. 489-502
    • Martin, V.1    Fabelo, N.2    Santpere, G.3    Puig, B.4    Marin, R.5    Ferrer, I.6    Diaz, M.7
  • 300
    • 0031905956 scopus 로고    scopus 로고
    • Role of sphingolipid-mediated cell death in neurodegenerative diseases
    • 9469581 1:CAS:528:DyaK1cXmtFKnsw%3D%3D
    • Ariga T, Jarvis WD, Yu RK (1998) Role of sphingolipid-mediated cell death in neurodegenerative diseases. J Lipid Res 39(1):1-16
    • (1998) J Lipid Res , vol.39 , Issue.1 , pp. 1-16
    • Ariga, T.1    Jarvis, W.D.2    Yu, R.K.3
  • 301
    • 0033083559 scopus 로고    scopus 로고
    • Neuronal cell death: A demise with different shapes
    • 10101962 1:CAS:528:DyaK1MXksVygu7s%3D 10.1016/S0165-6147(99)01304-8 pii: S0165-6147(99)01304-8
    • Nicotera P, Leist M, Manzo L (1999) Neuronal cell death: a demise with different shapes. Trends Pharmacol Sci 20(2):46-51 pii: S0165-6147(99)01304-8
    • (1999) Trends Pharmacol Sci , vol.20 , Issue.2 , pp. 46-51
    • Nicotera, P.1    Leist, M.2    Manzo, L.3
  • 302
    • 10044250982 scopus 로고    scopus 로고
    • Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis
    • 10.1016/j.neuroscience.2004.08.056 15590150 1:CAS:528:DC%2BD2cXhtVKlsbnE 10.1016/j.neuroscience.2004.08.056
    • Satoi H, Tomimoto H, Ohtani R, Kitano T, Kondo T, Watanabe M, Oka N, Akiguchi I, Furuya S, Hirabayashi Y, Okazaki T (2005) Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis. Neuroscience 130(3):657-666. doi: 10.1016/j.neuroscience.2004.08.056
    • (2005) Neuroscience , vol.130 , Issue.3 , pp. 657-666
    • Satoi, H.1    Tomimoto, H.2    Ohtani, R.3    Kitano, T.4    Kondo, T.5    Watanabe, M.6    Oka, N.7    Akiguchi, I.8    Furuya, S.9    Hirabayashi, Y.10    Okazaki, T.11
  • 303
    • 0036677303 scopus 로고    scopus 로고
    • Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: Potential role in disease pathogenesis
    • pii: 0997
    • Han X, D MH, McKeel DW, Jr., Kelley J, Morris JC (2002) Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J Neurochem 82 (4):809-818. pii: 0997
    • (2002) J Neurochem , vol.82 , Issue.4 , pp. 809-818
    • Han, X.1    Mh, D.2    McKeel Jr., D.W.3    Kelley, J.4    Morris, J.C.5
  • 304
    • 0026279740 scopus 로고
    • Regional distribution of brain gangliosides in Alzheimer's disease
    • 1751644 1:STN:280:DyaK38%2FovFentg%3D%3D
    • Kalanj S, Kracun I, Rosner H, Cosovic C (1991) Regional distribution of brain gangliosides in Alzheimer's disease. Neurol Croat 40(4):269-281
    • (1991) Neurol Croat , vol.40 , Issue.4 , pp. 269-281
    • Kalanj, S.1    Kracun, I.2    Rosner, H.3    Cosovic, C.4
  • 305
    • 10944261866 scopus 로고    scopus 로고
    • Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain
    • 10.1111/j.1460-9568.2004.03852.x 15610181 10.1111/j.1460-9568.2004.03852. x
    • Huang Y, Tanimukai H, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX (2004) Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. Eur J Neurosci 20(12):3489-3497. doi: 10.1111/j.1460-9568.2004.03852.x
    • (2004) Eur J Neurosci , vol.20 , Issue.12 , pp. 3489-3497
    • Huang, Y.1    Tanimukai, H.2    Liu, F.3    Iqbal, K.4    Grundke-Iqbal, I.5    Gong, C.X.6
  • 306
    • 74149083982 scopus 로고    scopus 로고
    • Deregulation of sphingolipid metabolism in Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2008.05.010
    • He X, Huang Y, Li B, Gong CX, Schuchman EH Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging 31 (3):398-408. doi: 10.1016/j.neurobiolaging.2008.05.010
    • Neurobiol Aging , vol.31 , Issue.3 , pp. 398-408
    • He, X.1    Huang, Y.2    Li, B.3    Gong, C.X.4    Schuchman, E.H.5
  • 308
    • 0033215974 scopus 로고    scopus 로고
    • Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons
    • 10493721 1:CAS:528:DyaK1MXmt1aqurs%3D
    • Brann AB, Scott R, Neuberger Y, Abulafia D, Boldin S, Fainzilber M, Futerman AH (1999) Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons. J Neurosci 19(19):8199-8206
    • (1999) J Neurosci , vol.19 , Issue.19 , pp. 8199-8206
    • Brann, A.B.1    Scott, R.2    Neuberger, Y.3    Abulafia, D.4    Boldin, S.5    Fainzilber, M.6    Futerman, A.H.7
  • 309
    • 0030953594 scopus 로고    scopus 로고
    • Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth
    • 9096129 1:CAS:528:DyaK2sXislaiur8%3D
    • Schwarz A, Futerman AH (1997) Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth. J Neurosci 17(9):2929-2938
    • (1997) J Neurosci , vol.17 , Issue.9 , pp. 2929-2938
    • Schwarz, A.1    Futerman, A.H.2
  • 310
    • 0028046589 scopus 로고
    • Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells
    • 7989341 1:CAS:528:DyaK2cXmvFyju78%3D
    • Jarvis WD, Fornari FA Jr, Browning JL, Gewirtz DA, Kolesnick RN, Grant S (1994) Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol Chem 269(50):31685-31692
    • (1994) J Biol Chem , vol.269 , Issue.50 , pp. 31685-31692
    • Jarvis, W.D.1    Fornari, Jr.F.A.2    Browning, J.L.3    Gewirtz, D.A.4    Kolesnick, R.N.5    Grant, S.6
  • 311
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • 10.1146/annurev.physiol.60.1.643 9558480 1:CAS:528:DyaK1cXitVOhsbg%3D 10.1146/annurev.physiol.60.1.643
    • Kolesnick RN, Kronke M (1998) Regulation of ceramide production and apoptosis. Annu Rev Physiol 60:643-665. doi: 10.1146/annurev.physiol.60.1.643
    • (1998) Annu Rev Physiol , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 312
    • 0030026613 scopus 로고    scopus 로고
    • Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity
    • 8592164 1:CAS:528:DyaK28XnsFGjtg%3D%3D 10.1046/j.1471-4159.1996.66020869. x
    • Goodman Y, Mattson MP (1996) Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity. J Neurochem 66(2):869-872
    • (1996) J Neurochem , vol.66 , Issue.2 , pp. 869-872
    • Goodman, Y.1    Mattson, M.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.