Interfacial Regulation of Acid Ceramidase Activity: Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins

Journal of Biological Chemistry

Volumn 276, Issue 8, 2001, Pages 5760-5768

  Linke, Thomas ^a   Wilkening, Gundo ^a   Sadeghlar, Farsaneh ^a   Mozcall, Heidi ^a   Bernardo, Katussevani ^a,c   Schuchman, Edward ^b   Sandhoff, Konrad ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Inst Med Mikrobiol Immunol/Hyg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOLOGICAL MEMBRANES; CELL CULTURE; DISEASES; HYDROLYSIS; LIPIDS; SURFACE PLASMON RESONANCE;

INTERFACIAL REGULATION;

ENZYMES;

ACYLSPHINGOSINE DEACYLASE; CERAMIDE; DOLICHOL PHOSPHATE; GLYCEROPHOSPHATE; LIPOSOME; PHOSPHATIDYLINOSITOL; PROSAPOSIN; SPHINGOLIPID ACTIVATOR PROTEIN; SPHINGOLIPID ACTIVATOR PROTEIN A; SPHINGOLIPID ACTIVATOR PROTEIN C; SPHINGOLIPID ACTIVATOR PROTEIN D; UNCLASSIFIED DRUG; ANION; GALACTOSYLGALACTOSYLGLUCOSYLCERAMIDASE; GLYCOPROTEIN; LYSOBISPHOSPHATIDIC ACID; LYSOPHOSPHOLIPID; MONOACYLGLYCEROL; PHOSPHOLIPID;

ARTICLE; CATALYSIS; CELL CULTURE; ENZYME ACTIVITY; ENZYME REGULATION; FIBROBLAST; HYDROLYSIS; LIPID BILAYER; LIPID DEGRADATION; LYSOSOME; MEMBRANE VESICLE; PRIORITY JOURNAL; PROSAPOSIN DEFICIENCY; PROTEIN DEFICIENCY; PROTEIN LIPID INTERACTION; SURFACE PLASMON RESONANCE; METABOLISM; PH; PROTEIN BINDING;

ANIONS; CERAMIDE TRIHEXOSIDASE; CERAMIDES; DOLICHOL PHOSPHATES; GLYCOPROTEINS; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; LYSOPHOSPHOLIPIDS; LYSOSOMES; MONOGLYCERIDES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPIDS; PROTEIN BINDING; SAPOSINS; SPHINGOLIPID ACTIVATOR PROTEINS;

EID: 0035937146     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006846200     Document Type: Article

References (43)

1. Hakamori, S. (1981) Annu. Rev. Biochem. 50, 733-764
2. Sandhoff, K., and Kolter, T. (1996) Trends Cell Biol. 6, 98-103
3. Bernardo, K., Hurwitz, R., Zenk, T., Desnick, R. J., Ferlinz, K., Schuchmann, E. H., and Sandhoff, K. (1995) J. Biol. Chem. 270, 11098-11102
4. Moser H. W. (1995) in The Metabolic Basis of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. L., and Valle, D., eds) 7th Ed., pp. 2589-2599, McGraw Hill Inc., New York
5. Fürst, W., and Sandhoff, K. (1992) Biochim. Biophys. Acta 1126, 1-16
6. Ponting, C. P. (1994) Protein Sci. 3, 359-361
7. Vaccaro, A, M., Salvioli, R., Barca, A., Tatti; M., Ciaffoni, F., Maras, B., Siciliano, R., and Zappacosta, F. (1995) J. Biol. Chem. 270, 9953-9960
8. Tatti, M., Salvioli, R., Ciaffoni, F., Pucci, P., Andolfo, A., Amoresanp, A., and Vaccaro, A. M. (1999) Eur. J. Biochem. 263, 486-494
9. Klein, A., Henseler, M., Klein, C., Suzuki, K., Harzer, K., and Sandhoff, K. (1994) Biochem. Biophys. Res. Commun. 200, 1440-1448
10. Zschoche, A., Fürst, W., Schwarzmann, G., and Sandhoff, K. (1994) Eur. J. Biochem. 222, 83-90
11. Vaccaro, A. M., Tatti, M., Salvioli, R., Ciaffoni, F., and Gallozzi, E. (1990) Biochim. Biophys. Acta 1033, 73-79
12. Wilkening, G., Linke, T., and Sandhoff, K. (1998) J. Biol. Chem. 273, 30271-30278
13. Linke, T., Wilkening, G., Lansmann, S., Moczall, H., Bartelsen, O., Weisgerber, J., and Sandhoff, K. (2000) Biol. Chem. in press
14. Wherret, J. R., and Huterer, S. (1972) J. Biol. Chem. 247, 4114-4120
15. Stremmel, W., and Debuch, H. (1976) Hoppe-Seylers Z. Physiol. Chem. 357, 803-810
16. Bleistein, J., Heidrich, H. G., and Debuch, H. (1980) Hoppe-Seylers Z. Physiol. Chem. 361, 595-597
17. Kobayashi, T., Stang, E., Fang, K. S., de Moerlose, P., Parton, R. G., and Gruenberg, J. (1998) Nature 392, 193-197
18. Dang, Q. Q., Rogalle, P., Salvayre, R., and Douste, B. (1982) Lipids 17, 798-602
19. Okazaki, T., Bielaswka, A., Bell, R. M., and Hannun, Y. A. (1990) J. Biol. Chem. 265, 15823-15831
20. Linke, T., Lansmann, S., and Sandhoff, K. (2000) Methods Enzymol. 311, 201-207
21. MacDonald, R, C., MacDonald, R. I., Menco, B. P. M., Takeshita, K., Subbarao, N. K., and Hu, L. (1991) Biochim. Biophys. Acta 1061, 297-300
22. Becker, E. (1999) Magnetic Isolation of Lysosomes from Fibroblasts. Ph.D. thesis, University of Bonn, Germany
23. Chojnacki, T., and Dallner, G. (1988) Biochem. J. 251, 1-9
24. Bradova, V. F., Smid, F., Ulrich, B., Roggendorf, W., Paton, B. C., and Harzer, K. (1993) Hum. Genet. 92, 143-152
25. Burkhardt, J. K., Hüttler, S., Klein, A., Möbius, W., Habermann, A., Griffiths, G., and Sandhoff, K. (1997) Eur. J. Cell Biol. 73, 10-18
26. Gelb, M. H., Jain, M. K., Hanel, A. M., and Berg, O. G. (1995) Annu. Rev. Biochem. 64, 653-688
27. Tatulian, S. A. (1993) in Phospholipids Handbook (Cevc, G., ed) pp. 511-552, Marcel Decker, Inc., New York
28. Wilkening, G., Linke, T., Ulhorn-Dierks, G., and Sandhoff K. (2000) J. Biol. Chem. 275, 35814-35819
29. Buckland, A. G., and Wilton, D. (2000) Biochim. Biophys. Acta 1483, 199-216
30. Wrobe, D., Henseler, M., Hüttler, S., Pascual, S. I., Chabas, A., and Sandhoff, K. (2000) J. Inherited Metab. Dis. 23, 63-76
31. Cristomanou, H., Aignesberg, A., and Linke, R. P. (1986) Biol. Chem. Hoppe-Seyler 367, 879-890
32. Schnabel, D., Schroeder, M., and Sandhoff, K. (1991) FEBS Lett. 284, 57-59
33. Al, B. J., Tiffany, C. W. Gomes de Mesquita, D, S., Moser, H. W., Tager, J. M., and Schram, A. W. (1989) Biochim. Biophys. Acta 1004, 245-251
34. Hauser, H. (1993) in Phospholipid Handbook (Cevc, G., ed) pp. 603-637, Marcel Dekker, Inc., New York
35. Marsh, D. (1996) Biochim. Biophys. Acta 1286, 183-223
36. Qi, X., and Grabowski, G. A. (1998) Biochemistry 37, 11544-11554
37. Slater, J. L., and Huang, C. H. (1992) in The Structure of Biological Membranes (Yeagle, P., ed.) pp. 175-211, CRC Press, Inc., Boca Raton, FL
38. Azuma, N., O'Brien, J. S., Mose, H. W., and Kishimoto, Y. (1994) Arch. Biochem. Biophys. 311, 354-357
39. Wu, Y. Y., Lockyer, J. M., Sugiyama, E., Pavlova, N. V., Li, Y. T., and Li, S. C. (1994) J. Biol. Chem. 269, 16276-16283
40. Vaccaro, A. M., Ciaffoni, F., Tatti, M., Salvioli, R., Tognozzi, D., and Scerch, C. (1995) J. Biol. Chem. 270, 30576-30580
41. Leippe, M., Tannich, R., Nickel, G., van der Goot, F., Pattus, R. D., Horstmann, H., and Müller-Eberhard, J. (1992) EMBO J. 11, 3501-3506
42. Nag, K., Munro, J. G., Inchley, K., Schurch, S., Petersen, N. O., and Possmayer, F. (1999) Am. J. Physiol. 277, 1179-1189
43. Andersson, M., Gunne, H., Agerberth, B., Boman, A., Bergman, T., Sillard, R., Jornvall, H., Mutt, V., Olsson, B., Wigzell, H., Dagerlind, A., Boman, H. G., and Gudmundsson, G. H. (1995) EMBO J. 14, 1615-1625